SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 01/19/2007
Date Updated: 01/26/2006
Version 1.5
Section 1 - Product and Company Information
Product Name 6-ANILINOQUINOLINE-5,8-QUINONE
Product Number A6563
Brand SIGMA
Company Sigma-Aldrich
Address 3050 Spruce Street
SAINT LOUIS MO 63103 US
Technical Phone: 800-325-5832
Fax: 800-325-5052
Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
6-ANILINOQUINOLINE-5,8-QUINONE 91300-60-6 Yes
Ingredient Name CAS # Percent SARA 313
CHLOROFORM 67-66-3 2 Yes
ETHYL ALCOHOL, NON-DENATURED, 200 64-17-5 1 No
PROOF
N-HEXANE 110-54-3 2 Yes
The hazards identified with this None
product are those associated with the
residual solvents that are used in
the manufacturing process.
Formula C15H10N2O2
Synonyms 6-(Phenylamino)-5,8-quinolinedione * LY-83,583
Composition Health and physical hazards based on components
comment: listed above.
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Harmful.
Harmful if swallowed. Irritating to eyes, respiratory system and
skin. Limited evidence of a carcinogenic effect. Harmful: danger
of serious damage to health by prolonged exposure through
inhalation and if swallowed. Possible risk of impaired fertility.
Harmful: may cause lung damage if swallowed.
Target organ(s): Nerves. Liver. Calif. Prop. 65 carcinogen.
Probable Carcinogen (US).
HMIS RATING
HEALTH: 2*
FLAMMABILITY: 3
REACTIVITY: 0
NFPA RATING
HEALTH: 2
FLAMMABILITY: 3
REACTIVITY: 0
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious
amounts of water.
EYE EXPOSURE
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
Section 5 - Fire Fighting Measures
FLAMMABLE HAZARDS
Flammable Hazards: Yes
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Flammable solid.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
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raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin,
on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed.
Store at 2-8癈
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN
(EU). Where risk assessment shows air-purifying respirators are
appropriate use a full-face particle respirator type N100 (US) or
type P3 (EN 143) respirator cartridges as a backup to engineering
controls. If the respirator is the sole means of protection, use a
full-face supplied air respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
Molecular Weight 250.3 AMU
pH N/A
BP/BP Range N/A
MP/MP Range N/A
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
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Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May decompose on exposure to light.
Materials to Avoid: Strong oxidizing agents Incompatible with:
chlorine, fluorine, and magnesium perchlorate, Strong bases,
Magnesium, Sodium, Lithium.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide,
and nitrogen oxides, Hydrogen chloride gas, Phosphine.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: Skin absorption may occur. May be harmful if
absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Testes. Blood. Liver. Kidneys. Peripheral nervous system. Heart.
Cardiovascular system. Central nervous system.
SIGNS AND SYMPTOMS OF EXPOSURE
Can cause CNS depression. Coughing, chest pains, difficulty in
breathing. Lung irritation, chest pain, and edema which may be
fatal. Damage to the heart. Narcotic effect. Exposure can cause:
Exposure to and/or consumption of alcohol may increase toxic
effects. To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly
investigated. Headache, dizziness, drowsiness, incoordination,
slowed reaction time, slurred speech, giddiness and
unconsciousness. Prolonged or repeated contact with skin can
cause defatting and dermatitis. Contact with eyes can cause
redness, tearing, and blurred vision. Ingestion may cause
gastrointestinal irritation. Vomiting. Nausea. Dizziness.
Gastrointestinal disturbances. Warning: contains n-hexane
(CAS#110-54-3) a suspected neurotoxin.
CHRONIC EXPOSURE - CARCINOGEN
Result: The National Cancer Institute (NCI) has found clear
evidence for carcinogenicity. This product is or contains a
component that has been reported to be probably carcinogenic
based on its IARC, OSHA, ACGIH, NTP, or EPA classification.
IRIS/EPA CARCINOGEN LIST
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Rating: Group B2
Species: Rat, mouse
Route: Gavage
CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations. (DN)Requires special label: "Contains a
substance which is regulated by Dannish work environmental law due
to the risk of carcinogenic properties."
Section 14 - Transport Information
DOT
Proper Shipping Name: None
Non-Hazardous for Transport: This substance is
considered to be non-hazardous for transport.
IATA
Non-Hazardous for Air Transport: Non-hazardous for air
transport.
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
Symbol of Danger: Xn
Indication of Danger: Harmful.
R: 40
Risk Statements: Limited evidence of a carcinogenic effect.
S: 36/37
Safety Statements: Wear suitable protective clothing and gloves.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Harmful.
Risk Statements: Harmful if swallowed. Irritating to eyes,
respiratory system and skin. Limited evidence of a carcinogenic
effect. Harmful: danger of serious damage to health by prolonged
exposure through inhalation and if swallowed. Possible risk of
impaired fertility. Harmful: may cause lung damage if swallowed.
Safety Statements: In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable protective clothing, gloves, and eye/face protection.
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible). If swallowed, do
not induce vomiting: seek medical advice immediately and show
this container or label.
US Statements: Target organ(s): Nerves. Liver. Calif. Prop. 65
carcinogen. Probable Carcinogen (US).
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UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
NOTES: This product is or contains a component that is subject
to SARA313 reporting requirements.
UNITED STATES - STATE REGULATORY INFORMATION
CALIFORNIA PROP - 65
California Prop - 65: This product is or contains chemical(s)
known to the state of California to cause cancer.
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2007 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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