Methyl Magnesium Bromide 2.0M in THF/Toluene
Material Safety Data Sheet
Arkema Inc.
1 PRODUCT AND COMPANY IDENTIFICATION
EMERGENCY PHONE NUMBERS:
Functional Additives
Chemtrec: (800) 424-9300 (24hrs) or (703) 527-3887
2000 Market Street
Medical: Rocky Mountain Poison Control Center
21st Floor
(866) 767-5089 (24Hrs)
Philadelphia, PA 19103-3222
Information Telephone Numbers Phone Number Available Hrs
Customer Service Number (800) 331-7654 8:00 AM - 5:00 PM EST
Product Name Methyl Magnesium Bromide 2.0M in THF/Toluene
Product Synonym(s)
Chemical Family Organometallic compound
Chemical Formula NA
Chemical Name NA
EPA Reg Num NA
Product Use Grignard
2 COMPOSITION / INFORMATION ON INGREDIENTS
Ingredient Name CAS RegistryNumber Typical % OSHA
Methyl magnesium bromide 75-16-1 25 Y
Toluene 108-88-3 35-40 Y
Tetrahydrofuran 109-99-9 35-40 Y
The substance(s) marked with a "Y" in the OSHA column, are identified as hazardous chemicals according to the
criteria of the OSHA Hazard Communication Standard (29 CFR 1910.1200)
The components of this product are all on the TSCA Inventory list.
3 HAZARDS IDENTIFICATION
Emergency Overview
Clear grey liquid with a characteristic odor
DANGER!
REACTS VIOLENTLY WITH WATER.
CAUSES EYE BURNS. MAY CAUSE BLINDNESS.
CAUSES SKIN IRRITATION.
CAUSES RESPIRATORY TRACT IRRITATION.
HARMFUL IF ABSORBED THROUGH SKIN.
EXTREMELY FLAMMABLE LIQUID AND VAPOR.
VAPOR MAY CAUSE FLASH FIRE.
MAY CAUSE LUNG DAMAGE
Potential Health Effects
Inhalation and skin contact are expected to be the primary routes of occupational exposure to this material. Based on
single exposure animal tests, it is considered to be moderately irritating to eyes and skin and may produce eye damage
if not removed promptly. It is rapidly absorbed after inhalation exposure and skin contact. Prolonged or repeated
contact may remove oils from the skin and may dry skin and cause irritation, redness and rash. High vapor
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Methyl Magnesium Bromide 2.0M in THF/Toluene
Material Safety Data Sheet
Arkema Inc.
concentrations are be irritating to the eyes and respiratory tract, and may result in central nervous system (CNS) effects
such as headache, dizziness, nausea, vomiting, drowsiness and, in severe exposures, loss of consciousness. Extreme
exposures may produce irregular heartbeat, fatigue, loss of coordination, decreases in visual accuracy, extreme
weakness, tremors, impaired speech, hearing and vision, as well as pronounced loss of coordination and impairment of
reaction time. Long-term, repeated exposures may produce nervousness, muscular fatigue and persistent
sleeplessness. If swallowed, this material may cause mouth and throat irritation, nausea, vomiting and CNS effects as
noted above. Mild to severe lung injury can occur if this material is drawn into the lungs (aspirated) during swallowing,
or during vomiting after swallowing. Symptoms of injury may include increased breathing and heart rate, coughing and
related signs of respiratory distress. Inhalation and skin contact are expected to be the primary routes of occupational
exposure to this material. Based on single exposure animal tests, it is considered to be corrosive to eyes, moderately
irritating to skin and severely irritating to the respiratory tract. This material may be absorbed through the skin in toxic
amounts. Prolonged or repeated contact may remove oils from the skin and may dry skin and cause irritation, redness
and rash. High vapor concentrations are irritating to the eyes and respiratory tract, and may result in central nervous
system (CNS) effects such as headache, dizziness, nausea, drowsiness and, in severe exposures, loss of
consciousness. Medical conditions which may be aggravated by exposure to this material include lung disease or
limited respiratory capacity.
4 FIRST AID MEASURES
IN CASE OF CONTACT, immediately flush with plenty of water for at least 15 minutes while removing
contaminated clothing and shoes. Get medical attention. Call a Poison Control Center. Wash clothing
before reuse. Destroy contaminated shoes.
IF INHALED, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give
oxygen. Get medical attention.
IF SWALLOWED, do NOT induce vomiting. Give water to drink. Get medical attention immediately. NEVER
GIVE ANYTHING BY MOUTH TO AN UNCONSCIOUS PERSON.
5 FIRE FIGHTING MEASURES
Fire and Explosive Properties
Auto-Ignition Temperature 321 deg C as THF
Flash Point 1 deg F, as THF (N/A) Flash Point Method
Flammable Limits- Upper 7.0 as toluene
1.0 as toluene
Lower
Extinguishing Media
Do NOT use water. carbon dioxide Use dry chemical foam dry chemical
Fire Fighting Instructions
Contain run-off from fire. Fire fighters and others who may be exposed to products of combustion should wear
full fire fighting turn out gear (full Bunker Gear) and self-contained breathing apparatus (pressure demand
NIOSH approved or equivalent). Fire fighting equipment should be thoroughly decontaminated after use.
Fire and Explosion Hazards
Vapors can travel to a source of ignition and flash back. When burned, the following hazardous products of
combustion can occur: Carbon monoxide Carbon dioxide Chloride Avoid breathing fumes from fire exposed
material. Avoid needless exposures to gas, fume or vapor. If practical, remain upwind when approaching a fire
outdoors, even when wearing a respirator.
6 ACCIDENTAL RELEASE MEASURES
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Methyl Magnesium Bromide 2.0M in THF/Toluene
Material Safety Data Sheet
Arkema Inc.
6 ACCIDENTAL RELEASE MEASURES
In Case of Spill or Leak
Stop the leak, if possible. Ventilate the space involved. Contain, sweep up, place in container for disposal.
Shut off or remove all ignition sources. Prevent waterway contamination. Construct a dike to prevent
spreading. If waterway contamination occurs, contact appropriate authorities. Collect run-off water and
transfer to drums or tanks for later disposal. Consult a regulatory specialist to determine appropriate state or
local reporting requirements, for assistance in waste characterization and/or hazardous waste disposal and
other requirements listed in pertinent environmental permits.
Clean up procedures: Transfer to containers, preparatory for later disposal. Avoid generation of vapors.
Place in non-sparking containers for recovery or disposal. Remove from spill location. Decontaminate area.
7 HANDLING AND STORAGE
Handling
Do not get in eyes, on skin or on clothing. Avoid breathing vapor. Use only with adequate ventilation. Wash
thoroughly after handling. Keep away from heat, sparks and flame. CONTAINER HAZARDOUS WHEN
EMPTY. Emptied container retains vapor and product residue. Follow labeled warnings even after container
is emptied. RESIDUAL VAPORS MAY EXPLODE ON IGNITION. DO NOT CUT, DRILL GRIND OR WELD
ON OR NEAR THIS CONTAINER. Improper disposal or reuse of this container may be dangerous and/or
illegal.
Storage
Store away from excessive heat, sources of ignition, and reactive materials. Ground all metal containers
during storage. Limit indoor storage to areas equipped with a non-aqueous automatic fire suppression
system. This product is water reactive.
8 EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering Controls
Investigate engineering techniques to reduce exposures below airborne exposure limits. Provide ventilation
if necessary to control exposure levels below airborne exposure limits (see below). If practical, use local
mechanical exhaust ventilation at sources of air contamination such as open process equipment. Consult
ACGIH ventilation manual or NFPA Standard 91 for design of exhaust systems.
Eye / Face Protection
Where there is potential for eye contact, wear chemical goggles and have eye flushing equipment
immediately available.
Skin Protection
Wear appropriate chemical resistant protective clothing and chemical resistant gloves to prevent skin
contact. Consult glove manufacturer to determine appropriate type glove material for given application.
Wear chemical goggles, a face shield, and chemical resistant clothing such as a rubber apron when
splashing may occur. Rinse immediately if skin is contaminated. Remove contaminated clothing promptly
and wash before reuse. Clean protective equipment before reuse. Provide a safety shower at any location
where skin contact can occur. Wash skin thoroughly after handling.
Respiratory Protection
Avoid breathing vapor or mist. When airborne exposure limits are exceeded (see below), use NIOSH
approved full face respirator with an organic vapor/acid gas cartridge coupled with an N 95 particulate filter
(full facepiece recomended). If used, full facepiece replaces need for face shield and/or chemical goggles.
Consult respirator manufacturer if exposure levels are greater than ten times the recommended exposure
limits. Observe respirator use limitations specified by NIOSH or the manufacturer. For emergency and other
conditions where exposure limit may be significantly exceeded, use an approved full face positive-pressure,
self-contained breathing apparatus or positive-pressure airline with auxiliary self-contained air supply.
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Methyl Magnesium Bromide 2.0M in THF/Toluene
Material Safety Data Sheet
Arkema Inc.
8 EXPOSURE CONTROLS / PERSONAL PROTECTION
Respiratory protection programs must comply with 29 CFR ?1910.134.
Airborne Exposure Guidelines for Ingredients
Exposure Limit Value
Toluene
ACGIH Skin designator - Y
ACGIH TWA - 50 ppm 188 mg/m3
OSHA Ceiling PEL - 300 ppm
OSHA TWA PEL - 200 ppm
Tetrahydrofuran
ACGIH Skin designator - Y
ACGIH STEL - 100 ppm
ACGIH TWA - 50 ppm
ARKEMA 12-hour TWA - 40 ppm
OSHA TWA PEL - 200 ppm (590 mg/m3)
-Only those components with exposure limits are printed in this section.
-Skin contact limits designated with a "Y" above have skin contact effect. Air sampling alone is insufficient to accurately quantitate
exposure. Measures to prevent significant cutaneous absorption may be required.
-ACGIH Sensitizer designator with a value of "Y" above means that exposure to this material may cause allergic reactions.
-WEEL-AIHA Sensitizer designator with a value of "Y" above means that exposure to this material may cause allergic skin reactions.
9 PHYSICAL AND CHEMICAL PROPERTIES
Appearance/Odor
Clear grey liquid with a characteristic odor
pH NE
Specific Gravity 1.07
Vapor Pressure NE
Vapor Density NE
Melting Point 5-7 deg C
Freezing Point 5-7 deg C
Boiling Point Approx. 65 deg C
Solubility In Water Water Reactive
Solubility in Other Materials NE
Evaporation Rate NE
Particle Size NE
Percent Volatile 75 (approx)
Molecular Weight 119.26
n-Octanol/Water Partition Coefficient NE
Oil/Water Partition Coefficient NE
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Methyl Magnesium Bromide 2.0M in THF/Toluene
Material Safety Data Sheet
Arkema Inc.
10 STABILITY AND REACTIVITY
Stability
This material is chemically stable under normal and anticipated storage and handling conditions.
Hazardous Polymerization
Does not occur.
Incompatibility
Reacts violently with water or atmospheric moisture.
Hazardous Decomposition Products
None known
11 TOXICOLOGICAL INFORMATION
Toxicological Information
Data on this material and/or its components are summarized below.
Single exposure (acute) studies indicate:
Oral - Slightly Toxic to Rats & Mice (LD50 2,000-3,197 mg/kg)
Inhalation - Practically Non-toxic to Rats (3-hr LC50 21,000 ppm)
Eye Irritation - Corrosive to Rabbits
Skin Irritation - Moderately Irritating to Rabbits
Tetrahydrofuran
Occupational exposure to vapor is irritating to the eyes, skin and respiratory tract, while high concentrations
have produced signs of liver damage such as hepatitis and fatty degeneration. Acute inhalation exposure
produced effects on behavior (slow righting reflex, a pattern of decreased motor activity followed by increased
motor activity, etc.). This material rapidly penetrates the skin of rats and rabbits resulting in death. A drying
effect on the skin with no evidence of allergic skin reaction was observed in guinea pigs. Repeated inhalation
by rats and mice produced loss of coordination with evidence of transient sedation and decreases in thymus
and spleen weights. In mice, liver, forestomach, adrenal and uterine effects as well as anesthesia were
observed. Other inhalation studies in rats and mice have shown irritation to eyes, skin and the upper respiratory
tract and changes in liver function and blood chemistry. Repeated oral administration to mice produced no
significant effects. Repeated administration to rats in the drinking water produced no adverse toxic effects. An
increased incidence of kidney tumors in male rats and liver tumors in female mice were observed following long-
term inhalation exposure. Studies in rats and mice have shown developmental effects only at exposure levels
producing toxic effects in the mother. No genetic changes were observed in tests using bacteria, animal cells or
animals.
Single exposure (acute) studies indicate:
Oral - Slightly Toxic to Practically Non-toxic to Rats (LD50 2,600-7,530 mg/kg)
Dermal - Practically Non-toxic to Rabbits (LD50 14,000 mg/kg)
Inhalation - Practically Non-toxic to Rats (4-hr LC50 8,000 ppm)
Eye Irritation - Moderately Irritating to Rabbits
Skin Irritation - Moderately to Slightly Irritating to Rabbits
Toluene
Intentional exposures by repeated inhalation ("glue sniffing") have resulted in brain damage. Recent studies
with pregnant women addicted "glue sniffing" suggest an increased risk for fetal injury, although the significance
of this gross exposure (>10,000 ppm) may have little relevance in the industrial setting.
This material has been administered to several animal species by various routes of exposure. Repeated oral
administration produced liver and kidney changes, digestive tract irritation and blood changes (rat). Repeated
skin application produced lung irritation and damage (rat), blood changes (rat, mouse), minor liver changes
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Methyl Magnesium Bromide 2.0M in THF/Toluene
Material Safety Data Sheet
Arkema Inc.
11 TOXICOLOGICAL INFORMATION
(mouse, rat, rabbit), decreased resistance to lung infection (mouse), and various brain effects including subtle
behavioral changes and hearing loss (mouse, rat). In long-term inhalation studies with rats and mice, no
evidence of carcinogenic effects was reported. In rats, toxic effects were limited to the nasal cavity. Application
to the skin of mice showed no treatment related tumor growth or significant tumor promoting activity.Birth
defects were reported in rats exposed by oral administration at levels that produced no adverse effects in the
mother.
Birth defects were reported in rats exposed by inhalation, but only at levels that produced adverse effects on the
mothers. A similar study reported no birth defects in rats and mice exposed by inhalation at levels that
produced adverse effects and mortality in the mothers and toxic effects in the offspring. No treatment related
effects on survival or reproductive parameters were observed when two generations of mice were exposed by
inhalation. Generally, no genetic changes were observed in tests using bacteria, animal cells or animals.
Several questionable studies using animals or human cells have produced both positive and negative results.
12 ECOLOGICAL INFORMATION
Ecotoxicological Information
Data on this material and/or its components are summarized below.
Tetrahydrofuran
This material is practically non-toxic to water flea (48-hr LC50 3,485 mg/l) and fathead minnow (96-hr LC50
2,160 mg/l).
Toluene
This material is slightly toxic to fathead minnow (96-hr LC50 26-63 mg/l), sheepshead minnow (96-hr LC50 13
mg/l), bluegill (96-hr LC50 12.7-24 mg/l), guppies (96-hr LC50 59 mg/l) and mysid shrimp (96-hr LC50 56.3
mg/l). It is practically non-toxic to Daphnia magna (48-hr EC50 313 mg/l) and algae (96-hr EC50 >433 mg/l),
and is moderately toxic to bay shrimp (96-hr LC50 3.7 mg/l). The 28-day NOEL for sheepshead minnow is 3.2-
7.7 mg/l and the 32-day NOEL for fathead minnow is 4-6 mg/l.
Chemical Fate Information
This material is not expected to bioconcentrate in fish or other aquatic organisms due to its low log
octanol/water partition coefficient (log Kow 0.47).
13 DISPOSAL CONSIDERATIONS
Waste Disposal
Recover, reclaim or recycle when practical. Dispose of in an approved landfill if allowed locally. Comply with
federal, state, and local regulations. Dispose of in a permitted waste management facility if incineration or
landfill is not practical.
14 TRANSPORT INFORMATION
DOT Name Organometallic Substance, Liquid, Water reactive, flammable
DOT Technical Name (methyl magnesium bromide, tetrahydrofuran, toluene)
DOT Hazard Class 4.3, 3
UN Number UN3399
DOT Packing Group PG I
RQ 1000 lbs. (Toluene); 1000 lbs.
(Tetrahydrofuran)
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Methyl Magnesium Bromide 2.0M in THF/Toluene
Material Safety Data Sheet
Arkema Inc.
15 REGULATORY INFORMATION
Hazard Categories Under Criteria of SARA Title III Rules (40 CFR Part 370)
Immediate (Acute) Health Y Fire Y
Reactive
Delayed (Chronic) Health Y Y
Sudden Release of Pressure N
The components of this product are all on the TSCA Inventory list.
Ingredient Related Regulatory Information:
CERCLA RQ SARA TPQ
SARA Reportable Quantities
Toluene 1000 LBS
Methyl magnesium bromide NE
Tetrahydrofuran 1000 LBS
SARA Title III, Section 313
This product does contain chemical(s) which are defined as toxic chemicals under and subject to the reporting requirements of, Section
313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 and 40 CFR Part 372. See Section 2
Toluene
DEA - precursor element
This product does contain the following chemical(s), as indicated below, currrently on the DEA Final Precursors and Essential
Chemicals Listed Components list.
Toluene
California Prop 65 - Developmental Toxin
This product does contain the following chemical(s), as indicated below, currently on the California List of Developmental Toxins.
Toluene
Massachusetts Right to Know
This product does contain the following chemicals(s), as indicated below, currently on the Massachusetts Right to Know Substance
List.
Tetrahydrofuran
Toluene
New Jersey Right to Know
This product does contain the following chemical(s), as indicated below, currently on the New Jersey Right-to-Know Substances List.
Methyl magnesium bromide
Tetrahydrofuran
Toluene
Pennsylvania Environmental Hazard
This product does contain the following chemical(s), as indicated below, currently on the Pennsylvania Environmental Hazard List.
Tetrahydrofuran
Toluene
Pennsylvania Right to Know
This product does contain the following chemical(s), as indicated below, currently on the Pennsylvania Hazardous Substance List.
Tetrahydrofuran
Toluene
16 OTHER INFORMATION
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Methyl Magnesium Bromide 2.0M in THF/Toluene
Material Safety Data Sheet
Arkema Inc.
Revision Information
Revision Number 10
02 JAN 2007
Revision Date
Supercedes Revision Dated 07-DEC-2005
Revision Summary
The name of this business group has changed to Functional Additives.
Key
NE= Not Established NA= Not Applicable (R) = Registered Trademark
Arkema Inc. believes that the information and recommendations contained herein (including data and
statements) are accurate as of the date hereof. NO WARRANTY OF FITNESS FOR ANY PARTICULAR
PURPOSE, WARRANTY OF MERCHANTABILITY, OR ANY OTHER WARRANTY, EXPRESSED OR
IMPLIED, IS MADE CONCERNING THE INFORMATION PROVIDED HEREIN. The information provided
herein relates only to the specific product designated and may not be valid where such product is used in
combination with any other materials or in any process. Further, since the conditions and methods of use are
beyond the control of Arkema Inc., Arkema Inc. expressly disclaims any and all liability as to any results
obtained or arising from any use of the product or reliance on such information.
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