CG2 Page 1 of 12
Hazard Alert Code:
COTY CUTEX NAIL POLISH REMOVER (NPR) ACETONE FREE 100ML HIGH
Chemwatch Material Safety Data Sheet (REVIEW) Revision No: 2 Chemwatch 7115-64
Issue Date: 16-Aug-2006 CD 2006/3
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME: COTY CUTEX NAIL POLISH REMOVER (NPR) ACETONE FREE 100ML
SYNONYMS
"nail enamel remover"
PROPER SHIPPING NAME
PERFUMERY PRODUCTS with flammable solvents
PRODUCT USE
Liquid applied to nails for the purpose of removing nail enamel.
SUPPLIER
Company: Coty Australia Pty Limited
Address:
Level 31, 1 Market Street
Sydney
NSW, 2000
AUS
Fax: +61 2 9267 5452
HAZARD RATINGS
Min Max
Flammability: 3
Toxicity: 2
Body Contact: 2 Min/Nil=0
Low=1
Reactivity: 1 Moderate=2
High=3
Chronic: 2
Extreme=4
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
HAZARDOUS SUBSTANCE. DANGEROUS GOODS. According to the Criteria of NOHSC, and the ADG Code.
POISONS SCHEDULE
None
RISK SAFETY
Highly flammable. Keep away from sources of ignition. No smoking.
Harmful if swallowed. Do not breathe gas/fumes/vapour/spray.
Irritating to eyes. Avoid contact with eyes.
Possible respiratory sensitiser*. Wear suitable protective clothing.
* (limited evidence). Use only in well ventilated areas.
Keep container in a well ventilated place.
Do not empty into drains.
To clean the floor and all objects contaminated by this
material, use water.
Keep away from food, drink and animal feeding stuffs.
Take off immediately all contaminated clothing.
In case of contact with eyes, rinse with plenty of water and
contact Doctor or Poisons Information Centre.
If swallowed, IMMEDIATELY contact Doctor or Poisons
Information Centre. (show this container or label).
This material and its container must be disposed of as
hazardous waste.
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
alcohol denatured, as
ethanol 64-17-5 Notspec
methyl ethyl ketone 78-93-3 Notspec
cocos nucifera Notspec
denatonium benzoate 3734-33-6 Notspec
benzophenone 119-61-9 Notspec
FD&C Yellow No.5, as
C.I. Acid Yellow 23 1934-21-0 Notspec
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CG2 Page 2 of 12
Hazard Alert Code:
COTY CUTEX NAIL POLISH REMOVER (NPR) ACETONE FREE 100ML HIGH
Chemwatch Material Safety Data Sheet (REVIEW) Revision No: 2 Chemwatch 7115-64
Issue Date: 16-Aug-2006 CD 2006/3
D&C Red No. 17, as
C.I. Solvent Red 23 85-86-9 Notspec
water 7732-18-5 Notspec
Section 4 - FIRST AID MEASURES
SWALLOWED
IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY.
For advice, contact a Poisons Information Centre or a doctor.
Urgent hospital treatment is likely to be needed.
In the mean time, qualified first-aid personnel should treat the patient following observation and employing supportive measures as
indicated by the patient's condition.
If the services of a medical officer or medical doctor are readily available, the patient should be placed in his/her care and a copy of
the MSDS should be provided. Further action will be the responsibility of the medical specialist.
If medical attention is not available on the worksite or surroundings send the patient to a hospital together with a copy of the
MSDS.
Where Medical attention is not immediately available or where the patient is more than 15 minutes from a hospital or unless
instructed otherwise:
INDUCE vomiting with fingers down the back of the throat, ONLY IF CONSCIOUS. Lean patient forward or place on left side
(head-down position, if possible) to maintain open airway and prevent aspiration.
NOTE: Wear a protective glove when inducing vomiting by mechanical means.
EYE
If this product comes in contact with the eyes:
Wash out immediately with fresh running water.
Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by occasionally lifting the
upper and lower lids.
If pain persists or recurs seek medical attention.
Removal of contact lenses after an eye injury should only be undertaken by skilled personnel.
SKIN
If skin or hair contact occurs:
Flush skin and hair with running water (and soap if available).
Seek medical attention in event of irritation.
INHALED
If fumes or combustion products are inhaled remove from contaminated area.
Other measures are usually unnecessary.
NOTES TO PHYSICIAN
Treat symptomatically.
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
Foam.
Dry chemical powder.
BCF (where regulations permit).
Carbon dioxide.
Water spray or fog - Large fires only.
FIRE FIGHTING
Alert Fire Brigade and tell them location and nature of hazard.
May be violently or explosively reactive.
Wear breathing apparatus plus protective gloves.
Prevent, by any means available, spillage from entering drains or water course.
Consider evacuation (or protect in place).
Fight fire from a safe distance, with adequate cover.
If safe, switch off electrical equipment until vapour fire hazard removed.
Use water delivered as a fine spray to control the fire and cool adjacent area.
Avoid spraying water onto liquid pools.
Do not approach containers suspected to be hot.
Cool fire exposed containers with water spray from a protected location.
If safe to do so, remove containers from path of fire.
FIRE/EXPLOSION HAZARD
Liquid and vapour are highly flammable.
Severe fire hazard when exposed to heat, flame and/or oxidisers.
Vapour may travel a considerable distance to source of ignition.
Heating may cause expansion or decomposition leading to violent rupture of containers.
On combustion, may emit toxic/ irritating fumes.
FIRE INCOMPATIBILITY
Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine bleaches, pool chlorine etc. as ignition may result.
HAZCHEM
3[Y]E
Personal Protective Equipment
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CG2 Page 3 of 12
Hazard Alert Code:
COTY CUTEX NAIL POLISH REMOVER (NPR) ACETONE FREE 100ML HIGH
Chemwatch Material Safety Data Sheet (REVIEW) Revision No: 2 Chemwatch 7115-64
Issue Date: 16-Aug-2006 CD 2006/3
Gas tight chemical resistant suit.
Limit exposure duration to 1 BA set30 mins.
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
Remove all ignition sources.
Clean up all spills immediately.
Avoid breathing vapours and contact with skin and eyes.
Control personal contact by using protective equipment.
Contain and absorb small quantities with vermiculite or other absorbent material.
Wipe up.
Collect residues in a flammable waste container.
MAJOR SPILLS
Clear area of personnel and move upwind.
Alert Fire Brigade and tell them location and nature of hazard.
May be violently or explosively reactive.
Wear breathing apparatus plus protective gloves.
Prevent, by any means available, spillage from entering drains or water course.
Consider evacuation (or protect in place).
No smoking, naked lights or ignition sources.
Increase ventilation.
Stop leak if safe to do so.
Water spray or fog may be used to disperse /absorb vapour.
Contain spill with sand, earth or vermiculite.
Use only spark-free shovels and explosion proof equipment.
Collect recoverable product into labelled containers for recycling.
Absorb remaining product with sand, earth or vermiculite.
Collect solid residues and seal in labelled drums for disposal.
Wash area and prevent runoff into drains.
If contamination of drains or waterways occurs, advise emergency services.
PROTECTIVE ACTIONS FOR SPILL
From IERG (Canada/Australia)
Isolation Distance 25 metres
Downwind Protection Distance 300 metres
IERG Number 14
FOOTNOTES
1 PROTECTIVE ACTION ZONE is defined as the area in which people are at risk of harmful exposure. This zone assumes that random changes in wind direction
confines the vapour plume to an area within 30 degrees on either side of the predominant wind direction, resulting in a crosswind protective action distance equal to the
downwind protective action distance.
2 PROTECTIVE ACTIONS should be initiated to the extent possible, beginning with those closest to the spill and working away from the site in the downwind direction.
Within the protective action zone a level of vapour concentration may exist resulting in nearly all unprotected persons becoming incapacitated and unable to take
protective action and/or incurring serious or irreversible health effects.
3 INITIAL ISOLATION ZONE is determined as an area, including upwind of the incident, within which a high probability of localised wind reversal may expose nearly all
persons without appropriate protection to life-threatening concentrations of the material.
4 SMALL SPILLS involve a leaking package of 200 litres (55 US gallons) or less, such as a drum (jerrican or box with inner containers). Larger packages leaking less
than 200 litres and compressed gas leaking from a small cylinder are also considered "small spills". LARGE SPILLS involve many small leaking packages or a leaking
package of greater than 200 litres, such as a cargo tank, portable tank or a "one-tonne" compressed gas cylinder.
5 Guide 127 is taken from the US DOT emergency response guide book.
6 IERG information is derived from CANUTEC - Transport Canada.
SAFE STORAGE WITH OTHER CLASSIFIED CHEMICALS
+ X X X X +
X: Must not be stored together
O: May be stored together with specific preventions
+: May be stored together
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CG2 Page 4 of 12
Hazard Alert Code:
COTY CUTEX NAIL POLISH REMOVER (NPR) ACETONE FREE 100ML HIGH
Chemwatch Material Safety Data Sheet (REVIEW) Revision No: 2 Chemwatch 7115-64
Issue Date: 16-Aug-2006 CD 2006/3
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
Avoid all personal contact, including inhalation.
Wear protective clothing when risk of exposure occurs.
Use in a well-ventilated area.
Prevent concentration in hollows and sumps.
DO NOT enter confined spaces until atmosphere has been checked.
Avoid smoking, naked lights, heat or ignition sources.
When handling, DO NOT eat, drink or smoke.
Vapour may ignite on pumping or pouring due to static electricity.
DO NOT use plastic buckets.
Earth and secure metal containers when dispensing or pouring product.
Use spark-free tools when handling.
Avoid contact with incompatible materials.
Keep containers securely sealed.
Avoid physical damage to containers.
Always wash hands with soap and water after handling.
Work clothes should be laundered separately.
Use good occupational work practice.
Observe manufacturer's storing and handling recommendations.
Atmosphere should be regularly checked against established exposure standards to ensure safe working conditions.
SUITABLE CONTAINER
Packing as supplied by manufacturer. Plastic containers may only be used if approved for flammable liquid. Check that containers are
clearly labelled and free from leaks.
For low viscosity materials (i) : Drums and jerry cans must be of the non-removable head type. (ii) : Where a can is to be used as
an inner package, the can must have a screwed enclosure.
For materials with a viscosity of at least 2680 cSt. (23 deg. C)
For manufactured product having a viscosity of at least 250 cSt. (23 deg. C)
Manufactured product that requires stirring before use and having a viscosity of at least 20 cSt (25 deg. C)
(i) : Removable head packaging;
(ii) : Cans with friction closures and
(iii) : low pressure tubes and cartridges may be used.
Where combination packages are used, and the inner packages are of glass, there must be sufficient inert cushioning material in
contact with inner and outer packages
In addition, where inner packagings are glass and contain liquids of packing group I there must be sufficient inert absorbent to
absorb any spillage, unless the outer packaging is a close fitting moulded plastic box and the substances are not incompatible with
the plastic.
STORAGE INCOMPATIBILITY
Avoid reaction with oxidising agents.
STORAGE REQUIREMENTS
Store in original containers in approved flame-proof area.
No smoking, naked lights, heat or ignition sources.
DO NOT store in pits, depressions, basements or areas where vapours may be trapped.
Keep containers securely sealed.
Store away from incompatible materials in a cool, dry well ventilated area.
Protect containers against physical damage and check regularly for leaks.
Observe manufacturer's storing and handling recommendations.
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
TWA TWA STEL STEL Peak Peak TWA
Source Material
ppm mg/m? ppm mg/m? ppm mg/m? F/CC
Australia Exposure
ethanol (Ethyl alcohol) 1,000 1,880
Standards
Australia Exposure methyl ethyl ketone (Methyl ethyl
150 445 300 890
Standards ketone (MEK))
Australia Exposure denatonium benzoate (Inspirable dust
10
Standards (Not specified))
Australia Exposure C.I. Acid Yellow 23 (Inspirable dust (Not
10
Standards specified))
Australia Exposure C.I. Solvent Red 23 (Inspirable dust
10
Standards (Not specified))
The following materials had no OELs on our record under the following CAS or Chemwatch
(CW) numbers
?Coty Cutex Nail Polish Remover (NPR) Acetone Free 100ml: No data available for
CW:7115-64
?denatonium benzoate: No data available for CAS:3734-33-6
?benzophenone: No data available for CAS:119-61-9
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CG2 Page 5 of 12
Hazard Alert Code:
COTY CUTEX NAIL POLISH REMOVER (NPR) ACETONE FREE 100ML HIGH
Chemwatch Material Safety Data Sheet (REVIEW) Revision No: 2 Chemwatch 7115-64
Issue Date: 16-Aug-2006 CD 2006/3
?C.I. Acid Yellow 23: No data available for CAS:1934-21-0
?C.I. Solvent Red 23: No data available for CAS:85-86-9
?water: No data available for CAS:7732-18-5
EMERGENCY EXPOSURE LIMITS
Material Revised IDLH Value (mg/m3) Revised IDLH Value (ppm)
ethanol 3,300 [LEL]
methyl ethyl ketone 3,000 [Unch]
NOTES
Values marked LEL indicate that the IDLH was based on 10% of the lower explosive limit
for safety considerations even though the relevant toxicological data indicated that
irreversible health effects or impairment of escape existed only at higher
concentrations.
ODOUR SAFETY FACTOR (OSF)
OSF=6 (ETHANOL)
Exposed individuals are NOT reasonably expected to be warned, by smell, that the Exposure Standard is being exceeded.
Odour Safety Factor (OSF) is determined to fall into either Class C, D or E.
The Odour Safety Factor (OSF) is defined as:
OSF= Exposure Standard (TWA) ppm/ Odour Threshold Value (OTV) ppm
Classification into classes follows:
Class OSF Description
Over 90% of exposed individuals are aware
by smell that the Exposure Standard (TLV-
A 550
TWA for example) is being reached, even
when distracted by working activities
As "A" for 50-90% of persons being
B 26-550
distracted
As "A" for less than 50% of persons being
C 1-26
distracted
10-50% of persons aware of being tested
D 0.18-1 perceive by smell that the Exposure
Standard is being reached
As "D" for less than 10% of persons aware
E <0.18
of being tested
.
REPRODUCTIVE HEALTH GUIDELINES
Established occupational exposure limits frequently do not take into consideration reproductive end points that are clearly below the
thresholds for other toxic effects. Occupational reproductive guidelines (ORGs) have been suggested as an additional standard. These
have been established after a literature search for the reproductive no-observed-adverse effect-level (NOAEL) and the lowest-
observed-adverse-effect-level (LOAEL). In addition the US EPA's procedures for risk assessment for hazard identification and dose-
response assessment as applied by NIOSH were used in the creation of such limits. Uncertainty factors (UFs) have also been
incorporated.
Ingredient ORG UF Endpoint CR TLV Adeq
ethanol 1880 mg/m? NA NA NA Yes
methyl ethyl ketone 590 mg/m? NA NA NA Yes
These exposure guidelines have been derived from a screening level of risk assessment and should not be construed as
unequivocally safe limits. ORGS represent an 8-hour time-weighted average unless specified otherwise.
CR = Cancer Risk/10000; UF = Uncertainty factor:
TLV believed to be adequate to protect reproductive health:
LOD: Limit of detection
Toxic endpoints have also been identified as:
D = Developmental; R = Reproductive; TC = Transplacental carcinogen
Jankovic J., Drake F.: A Screening Method for Occupational Reproductive
American Industrial Hygiene Association Journal 57: 641-649 (1996).
INGREDIENT DATA
ETHANOL:
Odour Threshold Value: 49-716 ppm (detection), 101 ppm (recognition) Eye and respiratory tract irritation do not appear to occur at
exposure levels of less than 5000 ppm and the TLV-TWA is thought to provide an adequate margin of safety against such effects.
Experiments in man show that inhalation of 1000 ppm caused slight symptoms of poisoning and 5000 ppm caused strong stupor and
morbid sleepiness. Subjects exposed to 5000 ppm to 10000 ppm experienced smarting of the eyes and nose and coughing.
Symptoms disappeared within minutes. Inhalation also causes local irritating effects to the eyes and upper respiratory tract,
headaches, sensation of heat intraocular tension, stupor, fatigue and a need to sleep. At 15000 ppm there was continuous
lachrymation and coughing.
METHYL ETHYL KETONE:
Odour Threshold Value: Variously reported as 2 ppm and 4.8 ppm Odour threshold: 2 ppm (detection); 5 ppm (recognition) 25 ppm
(easy recognition); 300 ppm IRRITATING Exposures at or below the recommended TLV-TWA are thought to prevent injurious
systemic effects and to minimise objections to odour and irritation. Where synergism or potentiation may occur stringent control of the
primary toxin (e.g. n-hexane or methyl butyl ketone) is desirable and additional consideration should be given to lowering MEK
exposures.
For each of the following
DENATONIUM BENZOATE:
C.I. ACID YELLOW 23:
C.I. SOLVENT RED 23:
These "dusts" have little adverse effect on the lungs and do not produce toxic effects or organic disease. Although there is no dust
which does not evoke some cellular response at sufficiently high concentrations, the cellular response caused by P.N.O.C.s has the
following characteristics:
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Hazard Alert Code:
COTY CUTEX NAIL POLISH REMOVER (NPR) ACETONE FREE 100ML HIGH
Chemwatch Material Safety Data Sheet (REVIEW) Revision No: 2 Chemwatch 7115-64
Issue Date: 16-Aug-2006 CD 2006/3
the architecture of the air spaces remain intact,
scar tissue (collagen) is not synthesised to any degree,
tissue reaction is potentially reversible.
Extensive concentrations of P.N.O.C.s may:
seriously reduce visibility,
cause unpleasant deposits in the eyes, ears and nasal passages,
contribute to skin or mucous membrane injury by chemical or mechanical action, per se, or by the rigorous skin cleansing
procedures necessary for their removal. [ACGIH]
This limit does not apply:
to brief exposures to higher concentrations
nor does it apply to those substances that may cause physiological impairment at lower concentrations but for which a TLV has as
yet to be determined.
This exposure standard applies to particles which
are insoluble or poorly soluble* in water or, preferably, in aqueous lung fluid (if data is available) and
have a low toxicity (i.e.. are not cytotoxic, genotoxic, or otherwise chemically reactive with lung tissue, and do not emit ionizing
radiation, cause immune sensitization, or cause toxic effects other than by inflammation or by a mechanism of lung overload)
BENZOPHENONE:
CEL TWA: 5 mg/m?(compare WEEL TWA) While benzophenone appears to be of low toxicity, the absence of inhalation data and
reports of some toxicity has lead the AIHA to recommend a workplace environmental exposure level (WEEL).
WATER:
No exposure limits set by NOHSC or ACGIH.
PERSONAL PROTECTION
EYE
Safety glasses with side shields.
Chemical goggles.
Contact lenses may pose a special hazard; soft contact lenses may absorb and concentrate irritants. A written policy document,
describing the wearing of lens or restrictions on use, should be created for each workplace or task. This should include a review of
lens absorption and adsorption for the class of chemicals in use and an account of injury experience. Medical and first-aid
personnel should be trained in their removal and suitable equipment should be readily available. In the event of chemical exposure,
begin eye irrigation immediately and remove contact lens as soon as practicable. Lens should be removed at the first signs of eye
redness or irritation - lens should be removed in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59]
HANDS/FEET
Wear chemical protective gloves, eg. PVC.
Wear safety footwear or safety gumboots, eg. Rubber.
OTHER
Overalls.
PVC Apron.
PVC protective suit may be required if exposure severe.
Eyewash unit.
Ensure there is ready access to a safety shower.
RESPIRATOR
Selection of the Class and Type of respirator will depend upon the level of breathing zone contaminant and the chemical nature of the
contaminant. Protection Factors (defined as the ratio of contaminant outside and inside the mask) may also be important.
Breathing Zone Level ppm
Maximum Protection Factor Half-face Respirator Full-Face Respirator
(volume)
1000 10 A-AUS -
1000 50 - A-AUS
5000 50 Airline * -
5000 100 - A-2
10000 100 - A-3
100+ Airline**
* - Continuous Flow ** - Continuous-flow or positive pressure demand.
The local concentration of material, quantity and conditions of use determine the type of personal protective equipment required.
For further information consult site specific CHEMWATCH data (if available), or your Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
For flammable liquids and flammable gases, local exhaust ventilation or a process enclosure ventilation system may be required.
Ventilation equipment should be explosion-resistant.
Air contaminants generated in the workplace possess varying "escape" velocities which, in turn, determine the "capture velocities" of
fresh circulating air required to effectively remove the contaminant.
Type of Contaminant: Air Speed:
solvent, vapours, degreasing etc., evaporating from tank (in still
0.25-0.5 m/s (50-100 f/min.)
air).
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Hazard Alert Code:
COTY CUTEX NAIL POLISH REMOVER (NPR) ACETONE FREE 100ML HIGH
Chemwatch Material Safety Data Sheet (REVIEW) Revision No: 2 Chemwatch 7115-64
Issue Date: 16-Aug-2006 CD 2006/3
aerosols, fumes from pouring operations, intermittent container
filling, low speed conveyer transfers, welding, spray drift, plating
0.5-1 m/s (100-200 f/min.)
acid fumes, pickling (released at low velocity into zone of active
generation)
direct spray, spray painting in shallow booths, drum filling,
conveyer loading, crusher dusts, gas discharge (active generation 1-2.5 m/s (200-500 f/min.)
into zone of rapid air motion)
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range
1: Room air currents minimal or favourable to capture 1: Disturbing room air currents
2: Contaminants of low toxicity or of nuisance value only. 2: Contaminants of high toxicity
3: Intermittent, low production. 3: High production, heavy use
4: Large hood or large air mass in motion 4: Small hood-local control only
Simple theory shows that air velocity falls rapidly with distance away from the opening of a simple extraction pipe. Velocity generally
decreases with the square of distance from the extraction point (in simple cases). Therefore the air speed at the extraction point should
be adjusted, accordingly, after reference to distance from the contaminating source. The air velocity at the extraction fan, for example,
should be a minimum of 1-2 m/s (200-400 f/min.) for extraction of solvents generated in a tank 2 meters distant from the extraction
point. Other mechanical considerations, producing performance deficits within the extraction apparatus, make it essential that
theoretical air velocities are multiplied by factors of 10 or more when extraction systems are installed or used.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
Orange coloured, highly flammable liquid with a characteristic odour; mixes with water.
PHYSICAL PROPERTIES
Liquid.
Mixes with water.
Molecular Weight: Not Applicable Boiling Range (癈): Not Available
Melting Range (癈): Not Available Specific Gravity (water=1): Not Available
Solubility in water (g/L): Miscible pH (as supplied): Not Available
pH (1% solution): Not Available Vapour Pressure (kPa): Not Available
Volatile Component (%vol): Not Available Evaporation Rate: Not Available
Relative Vapour Density (air=1): Not Available Flash Point (癈): <23
Lower Explosive Limit (%): Not Available Upper Explosive Limit (%): Not Available
Autoignition Temp (癈): Not Available Decomposition Temp (癈): Not Available
State: Liquid Viscosity: Not Available
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
Presence of incompatible materials.
Product is considered stable.
Hazardous polymerisation will not occur.
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or
may produce serious damage to the health of the individual.
Ingestion of ethanol (ethyl alcohol, "alcohol") may produce nausea, vomiting, bleeding from the digestive tract, abdominal pain, and
diarrhoea. Effects on the body:
Blood concentration Effects
Mild: impaired vision, co-ordination and reaction time; emotional
<1.5 g/L
instability
Moderate: Slurred speech, confusion, inco-ordination, emotional
instability, disturbances in perception and senses, possible
blackouts, and impaired objective performance in standardized
tests. Possible double vision, flushing, fast heart rate, sweating
1.5-3.0 g/L
and incontinence. Slow breathing may occur rarely and fast
breathing may develop in cases of metabolic acidosis, low blood
sugar and low blood potassium. Central nervous system
depression may progress to coma.
Severe: cold clammy skin, low body temperature and low blood
pressure. Atrial fibrillation and heart block have been reported.
Depression of breathing may occur, respiratory failure may follow
3-5 g/L
serious poisoning, choking on vomit may result in lung
inflammation and swelling. Convulsions due to severe low blood
sugar may also occur. Acute liver inflammation may develop.
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Hazard Alert Code:
COTY CUTEX NAIL POLISH REMOVER (NPR) ACETONE FREE 100ML HIGH
Chemwatch Material Safety Data Sheet (REVIEW) Revision No: 2 Chemwatch 7115-64
Issue Date: 16-Aug-2006 CD 2006/3
.
Concentrated solutions of many cationics may cause corrosive damage to mucous membranes and the oesophagus. Nausea and
vomiting (sometimes bloody) may follow ingestion. Serious exposures may produce an immediate burning sensation of the mouth,
throat and abdomen with profuse salivation, ulceration of mucous membranes, signs of circulatory shock (hypotension, laboured
breathing, and cyanosis) and a feeling of apprehension, restlessness, confusion and weakness. Weak convulsive movements may
precede central nervous system depression. Erosion, ulceration, and petechial haemorrhage may occur through the small intestine
with glottic, brain and pulmonary oedema. Death may result from asphyxiation due to paralysis of the muscles of respiration or
cardiovascular collapse. Fatal poisoning may arise even when the only pathological signs are visceral congestion, swallowing, mild
pulmonary oedema or varying signs of gastrointestinal irritation. Individuals who survive a period of severe hypertension may develop
kidney failure. Cloudy swelling, patchy necrosis and fatty infiltration in such visceral organs as the heart, liver and kidneys shows at
death.
EYE
This material can cause eye irritation and damage in some persons.
SKIN
Skin contact is not thought to produce harmful health effects (as classified under EC Directives using animal models). Systemic harm,
however, has been identified following exposure of animals by at least one other route and the material may still produce health
damage following entry through wounds, lesions or abrasions. Good hygiene practice requires that exposure be kept to a minimum
and that suitable gloves be used in an occupational setting.
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects.
Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.
INHALED
The material is not thought to produce either adverse health effects or irritation of the respiratory tract following inhalation (as classified
by EC Directives using animal models). Nevertheless, adverse systemic effects have been produced following exposure of animals by
at least one other route and good hygiene practice requires that exposure be kept to a minimum and that suitable control measures be
used in an occupational setting.
CHRONIC HEALTH EFFECTS
Long-term exposure to the product is not thought to produce chronic effects adverse to the health (as classified by EC Directives using
animal models); nevertheless exposure by all routes should be minimised as a matter of course.
One ingredient of the product has caused skin sensitisation reactions, shown as localised reddening and hives, or may produce
respiratory sensitisation characterised by asthma-like symptoms and runny nose.
TOXICITY AND IRRITATION
Not available. Refer to individual constituents.
unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances
TOXICITY IRRITATION
ETHANOL:
Oral (rat) LD50: 7060 mg/kg Skin (rabbit):20 mg/24hr- Moderate
Oral (human) LDLo: 1400 mg/kg Skin (rabbit):400 mg (open)- Mild
Oral (man) TDLo: 50 mg/kg Eye (rabbit):100mg/24hr- Moderate
Oral (man) TDLo: 1.40 mg/kg Eye (rabbit): 500 mg SEVERE
Oral (woman) TDLo: 256 mg/kg/12 wks
Inhalation (rat) LC50: 20, 000 ppm/10h
Inhalation (rat) LC50: 64000 ppm/4h
METHYL ETHYL KETONE:
Oral (rat) LD50: 2737 mg/kg Eye (human): 350 ppm - Irritant
Inhalation (human) TCLo: 100 ppm/5 m Eye (rabbit): 80 mg - Irritant
Inhalation (rat) LD50: 23500 mg/m?8 hr Skin (rabbit): 402 mg/24 hr - Mild
Dermal (rabbit) LD50: 6480 mg/kg Skin (rabbit):13.78mg/24 hr Open
Inhalation (man) TCLo: 10 mg/m?6 hr - Mild
Inhalation (rat) LC50: 50100 mg/m?8 hr
Dermal (rabbit) LD50: 20000 mg/kg
DENATONIUM BENZOATE:
Oral (rat) LD50: 584 mg/kg Nil Reported
Oral (rabbit) LD50: 508 mg/kg
Somnolence, tremor, ataxia recorded.
BENZOPHENONE:
Oral (rat) LD50: > 10, 000 mg/kg Nil Reported
Oral (mouse) LD50: 2895 mg/kg
Dermal (rabbit) LD50: 3535 mg/kg
C.I. ACID YELLOW 23:
Oral (human) TDLo: 0.014 mg/kg* Nil Reported
Suspected allergen *[Hawley's]
C.I. SOLVENT RED 23:
No Oral (rat) data No data
Substance has been investigated as a tumorigen and mutagen in
micro-organisms and rodents.
IARC Review is continuing.
WATER:
No significant acute toxicological data identified in literature search.
MATERIAL CARCINOGEN REPROTOXIN SENSITISER SKIN
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Hazard Alert Code:
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Chemwatch Material Safety Data Sheet (REVIEW) Revision No: 2 Chemwatch 7115-64
Issue Date: 16-Aug-2006 CD 2006/3
ethanol ILOM
methyl ethyl ketone ILOEl
C.I. Solvent Red 23 IARC:Group 3: Not
classifiable as to
carcinogenicity to
humans
REPROTOXIN
ILOM: ILO Agents toxic to the male reproductive system: ethanol
REPROTOXIN
ILOEl: ILO Chemicals in the electronics industry that have toxic effects on
reproduction: methyl ethyl ketone
CARCINOGEN
IARC: International Agency for Research on Cancer (IARC) Carcinogens: C.I. Solvent Red
23 Category: Group 3: Not classifiable as to carcinogenicity to humans
Section 12 - ECOLOGICAL INFORMATION
Marine Pollutant:Not Determined
DO NOT discharge into sewer or waterways.
Refer to data for ingredients, which follows:
ETHANOL:
Fish LC50 (96hr.) (mg/l): 13480
Algae IC50 (72hr.) (mg/l): 1450
log Kow (Sangster 1997): - 0.3
BOD5: 63%
ThOD: 2.1
Half- life Soil - High (hours): 24
Half- life Soil - Low (hours): 2.6
Half- life Air - High (hours): 122
Half- life Air - Low (hours): 12.2
Half- life Surface water - High (hours): 26
Half- life Surface water - Low (hours): 6.5
Half- life Ground water - High (hours): 52
Half- life Ground water - Low (hours): 13
Aqueous biodegradation - Aerobic - High (hours): 26
Aqueous biodegradation - Aerobic - Low (hours): 6.5
Aqueous biodegradation - Anaerobic - High (hours): 104
Aqueous biodegradation - Anaerobic - Low (hours): 26
Aqueous biodegradation - Removal secondary treatment - High (hours): 67%
Photooxidation half- life water - High (hours): 3.20E+05
Photooxidation half- life water - Low (hours): 8020
Photooxidation half- life air - High (hours): 122
Photooxidation half- life air - Low (hours): 12.2
DO NOT discharge into sewer or waterways.
log Kow: -0.31- -0.32
Half-life (hr) air: 144
Half-life (hr) H2O surface water: 144
Henry's atm m?/mol: 6.29E-06
BOD 5 if unstated: 0.93-1.67,63%
COD: 1.99-2.11,97%
ThOD: 2.1
When ethanol is released into the soil it readily and quickly biodegrades
but may leach into ground water; most is lost by evaporation. When
released into water the material readily evaporates and is biodegradable.
Ethanol does not bioaccumulate to an appreciable extent.
The material is readily degraded by reaction with photochemically produced
hydroxy radicals; release into air will result in photodegradation and wet
deposition.
METHYL ETHYL KETONE:
Hazardous Air Pollutant: Yes
Fish LC50 (96hr.) (mg/l): 1690- 5640
Algae IC50 (72hr.) (mg/l): 110- 4300
log Kow (Prager 1995): 0.26- 0.29
log Kow (Sangster 1997): 0.29
log Pow (Verschueren 1983): 0.26
BOD5: 1.92
COD: 2.2
ThOD: 2.44
Half- life Soil - High (hours): 168
Half- life Soil - Low (hours): 24
Half- life Air - High (hours): 642
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Hazard Alert Code:
COTY CUTEX NAIL POLISH REMOVER (NPR) ACETONE FREE 100ML HIGH
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Half- life Air - Low (hours): 64.2
Half- life Surface water - High (hours): 168
Half- life Surface water - Low (hours): 24
Half- life Ground water - High (hours): 336
Half- life Ground water - Low (hours): 48
Aqueous biodegradation - Aerobic - High (hours): 168
Aqueous biodegradation - Aerobic - Low (hours): 24
Aqueous biodegradation - Anaerobic - High (hours): 672
Aqueous biodegradation - Anaerobic - Low (hours): 96
Aqueous biodegradation - Removal secondary treatment - High (hours): 100%
Aqueous biodegradation - Removal secondary treatment - Low (hours): 86%
Photooxidation half- life water - High (hours): 7.10E+05
Photooxidation half- life water - Low (hours): 1.80E+04
Photooxidation half- life air - High (hours): 642
Photooxidation half- life air - Low (hours): 64.2
First order hydrolysis half- life (hours): >50 YR
DO NOT discharge into sewer or waterways.
log Kow: 0.26-0.69
log Koc: 0.69
Koc: 34
Half-life (hr) air: 2.3
Half-life (hr) H2O surface water: 72-288
Henry's atm m?/mol: 1.05E-05
BOD 5 if unstated: 1.5-2.24,46%
COD: 2.2-2.31,100%
ThOD: 2.44
BCF: 1
Toxicity Fish: LC50(96)13.16-277.8mg/L
Toxicity invertebrate: LD0 1g/L
Bioaccumulation: not sig
Anaerobic effects: some degrad
Effects on algae and plankton: algae LD0 125mg/L
Degradation Biological: sig
processes Abiotic: photox,RxnOH*,hydrl photol/deg notsig
DENATONIUM BENZOATE:
Cationic substances, and their polymers and those polymers that are reasonably anticipated to become cationic in the natural aquatic
environment (pH range 4-9) may be environmental hazards.
Exempt from this concern are those polymers to be used only in solid phase, such as ion-exchange resins, and where the FGEW
(Functional Group Equivalent Weight) of cationic groups is not 5000 and above.
Cationic groups such as alkylsulfoniums, alkylphosphoniums and quaternary ammonium polymers are highly toxic to fish and other
aquatic organisms. Similarly potentially cationic groups such as amines and isocyanates are of concern. Some cationics, however,
may fall into the category of PLCs (polymers of low concern) provided they possess low charge density, and/or are not water-soluble
or are not self-dispersing polycarboxylates or poly- (aromatic or aliphatic) sulfonate polymers.
BENZOPHENONE:
Inhibitory concentration on respiration of aerobic waste water bacterial:
IC20: >1000 ppm
IC50: >1000 ppm
IC80: >1000 ppm [Double Bond]
C.I. ACID YELLOW 23:
DO NOT discharge into sewer or waterways.
Section 13 - DISPOSAL CONSIDERATIONS
If container can not be cleaned sufficiently well to ensure none of the original product remains or if the container cannot be used to
store the same product, then puncture containers, to prevent re-use, and bury at an authorised landfill.
Section 14 - TRANSPORTATION INFORMATION
Labels Required: FLAMMABLE LIQUID
HAZCHEM: 3[Y]E
UNDG:
Dangerous Goods Class: 3 Subrisk: None
UN Number: 1266 Packing Group: II
Shipping Name:PERFUMERY PRODUCTS with flammable solvents
Air Transport IATA:
ICAO/IATA Class: 3 ICAO/IATA Subrisk: None
UN/ID Number: 1266 Packing Group: II
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Hazard Alert Code:
COTY CUTEX NAIL POLISH REMOVER (NPR) ACETONE FREE 100ML HIGH
Chemwatch Material Safety Data Sheet (REVIEW) Revision No: 2 Chemwatch 7115-64
Issue Date: 16-Aug-2006 CD 2006/3
ERG Code: 3L
Shipping Name: Perfumery products with flammable solvents
Maritime Transport IMDG:
IMDG Class: 3 IMDG Subrisk: None
UN Number: 1266 Packing Group: II
EMS Number: F-E,S-D Marine Pollutant: Not Determined
Shipping Name: PERFUMERY PRODUCTS with flammable solvents
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE
None
REGULATIONS
ethanol (CAS: 64- 17- 5) is found on the following regulatory lists;
Australia - Australia New Zealand Food Standards Code - Food Additives -
Schedule 1 Permitted uses of food additives by food type
Australia - Australia New Zealand Food Standards Code - Processing Aids -
Generally permitted
Australia - Australia New Zealand Food Standards Code - Processing Aids -
Permitted carriers, solvents and diluents
Australia Exposure Standards
Australia High Volume Industrial Chemical List (HVICL)
Australia Inventory of Chemical Substances (AICS)
Australia National Pollutant Inventory
Australia Poisons Schedule
IMO MARPOL 73/78 (Annex II) - List of Other Liquid Substances
International Air Transport Association (IATA) Dangerous Goods Regulations
International Council of Chemical Associations (ICCA) - High Production Volume
List
OECD Representative List of High Production Volume (HPV) Chemicals
methyl ethyl ketone (CAS: 78- 93- 3) is found on the following regulatory lists;
Australia - Australia New Zealand Food Standards Code - Processing Aids -
Permitted extraction solvents
Australia Exposure Standards
Australia High Volume Industrial Chemical List (HVICL)
Australia Illicit Drug Reagents/Essential Chemicals - Category III
Australia Inventory of Chemical Substances (AICS)
Australia National Pollutant Inventory
Australia Poisons Schedule
IMO MARPOL 73/78 (Annex II) - List of Noxious Liquid Substances Carried in Bulk
OECD Representative List of High Production Volume (HPV) Chemicals
United Nations List of Precursors and Chemicals Frequently used in the Illicit
Manufacture of Narcotic Drugs and Psychotropic Substances Under International
Control - Table II (English)
denatonium benzoate (CAS: 3734- 33- 6) is found on the following regulatory
lists;
Australia Exposure Standards
Australia Inventory of Chemical Substances (AICS)
benzophenone (CAS: 119- 61- 9) is found on the following regulatory lists;
Australia Inventory of Chemical Substances (AICS)
Australia Therapeutic Goods Administration (TGA) Sunscreening agents permitted
as active ingredients in listed products - Under Review
International Council of Chemical Associations (ICCA) - High Production Volume
List
OECD Representative List of High Production Volume (HPV) Chemicals
C.I. Acid Yellow 23 (CAS: 1934- 21- 0) is found on the following regulatory
lists;
Australia - Australia New Zealand Food Standards Code - Food Additives -
Schedule 4 Colours permitted to a maximum of 70 mg/L in beverages and 290 mg/kg
in foods other than beverages specified in Schedule 1
Australia Exposure Standards
Australia Inventory of Chemical Substances (AICS)
OECD Representative List of High Production Volume (HPV) Chemicals
C.I. Solvent Red 23 (CAS: 85- 86- 9) is found on the following regulatory lists;
Australia Exposure Standards
Australia Inventory of Chemical Substances (AICS)
International Agency for Research on Cancer (IARC) Carcinogens
water (CAS: 7732- 18- 5) is found on the following regulatory lists;
Australia Inventory of Chemical Substances (AICS)
OECD Representative List of High Production Volume (HPV) Chemicals
Section 16 - OTHER INFORMATION
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or criticism, as permitted
under the Copyright Act, no part may be reproduced by any process without written permission from CHEMWATCH. TEL (+61 3) 9572
4700.
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Hazard Alert Code:
COTY CUTEX NAIL POLISH REMOVER (NPR) ACETONE FREE 100ML HIGH
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Issue Date: 16-Aug-2006 CD 2006/3
Issue Date: 16-Aug-2006
Print Date: 6-Sep-2006
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