SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 02/NOV/2005
Date Updated: 30/SEP/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name DIMETHYL PHOSPHITE, 98%
Product Number D178454
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
DIMETHYL PHOSPHITE 868-85-9 212-783-8 None
Formula C2H7O3P
Molecular Weight 110.05 AMU
Synonyms Bis(hydroxymethyl)phosphine oxide *
Dimethoxyphosphine oxide * Dimethyl acid
phosphite * Dimethylester kyseliny fosforite
(Czech) * Dimethylfosfit (Czech) *
Dimethylfosfonat (Czech) *
Dimethylhydrogenphosphite * Dimethyl hydrogen
phosphonate * Dimethyl phosphite * Dimethyl
phosphonate * Dimethyl phosphorous acid *
Hydrogen dimethyl phosphite * Methyl phosphonate
((MeO)2HPO) * NCI-C54773 * Phosphorous acid
dimethyl ester
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Flammable. Irritating to eyes.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid contact with eyes, skin, and
clothing. Do not breathe vapor. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep container closed. Keep away from
heat, sparks, and open flame.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
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PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Color: Colorless
Form: Clear liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 171.0 - 172.0 掳C
MP/MP Range N/A
Flash Point 29 掳C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure 2.5 mmHg 38 掳C
SG/Density 1.201 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May decompose on exposure to moist air
or water.
Materials to Avoid: Acid chlorides, Strong acids, Strong bases,
Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Thermal decomposition may
produce toxic fumes of phosphorus oxides and/or phosphine Carbon
monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: SZ7710000
ACUTE TOXICITY
LD50
Oral
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Rat
3040 mg/kg
LC50
Inhalation
Rat
> 20,000 mg/m3
LD50
Subcutaneous
Rat
2970 MG/KG
LD50
Oral
Mouse
1831 mg/kg
Remarks: Gastrointestinal:Changes in structure or function of
salivary glands. Lungs, Thorax, or Respiration:Respiratory
stimulation. Autonomic Nervous System:Other (direct)
parasympathomimetic.
LD50
Subcutaneous
Mouse
2610 MG/KG
LD50
Skin
Rabbit
681 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Ataxia.
LD50
Oral
Guinea pig
900 mg/kg
Remarks: Autonomic Nervous System:Other (direct)
parasympathomimetic. Lungs, Thorax, or Respiration:Respiratory
stimulation. Gastrointestinal:Changes in structure or function
of salivary glands.
IRRITATION DATA
Unreported
Man
DURING WORKING OURS
PLANT EXPOSURE
Skin
Rabbit
500 mg
24H
Remarks: Mild irritation effect
Eyes
Rabbit
20 mg
24H
Remarks: Moderate irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
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Nausea, headache, and vomiting. Exposure can cause: To the best
of our knowledge, the chemical, physical, and toxicological
properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Eyes. Kidneys. Nerves.
CHRONIC EXPOSURE - CARCINOGEN
Result: The National Cancer Institute (NCI) has found clear
evidence for carcinogenicity. This product is or contains a
component that is not classifiable as to its carcinogenicity
based on its IARC, ACGIH, NTP, or EPA classification.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Lungs,
Thorax, or Respiration:Tumors. Gastrointestinal:Tumors.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Mouse
1500 MG/KG
Intraperitoneal
3D
Micronucleus test
Mouse
1700 MG/L (+S9)
Cell Type: lymphocyte
Mutation in microorganisms
Mouse
2100 MG/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
1600 MG/L
Cell Type: ovary
Cytogenetic analysis
Hamster
250 MG/L
Cell Type: ovary
Sister chromatid exchange
12 - Ecological Information
No data available.
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13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1993
Class: 3
PG: III
Proper Shipping Name: Flammable liquid, n.o.s.
IMDG
UN#: 1993
Class: 3
PG: III
Proper Shipping Name: Flammable liquid, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 1993
Class: 3
PG: III
Proper Shipping Name: Flammable liquid, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xi
Irritant.
R-PHRASES: 10-36
Flammable. Irritating to eyes.
S-PHRASES: 26
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
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or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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