SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/JUL/2005
Date Updated: 01/MAR/2005
Version 1.7
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name DIISOPROPYL ETHER, ANHYDROUS, 99%
Product Number 296856
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
DIISOPROPYL ETHER 108-20-3 203-560-6 None
Formula C6H14O
Molecular Weight 102.18 AMU
Synonyms Diisopropyl oxide * Ether, isopropyl * Ether
isopropylique (French) * 2-Isopropoxypropane *
Isopropyl ether (ACGIH:OSHA) * Izopropylowy eter
(Polish) * Isopropyl Ether
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. May form explosive peroxides. Repeated exposure
may cause skin dryness or cracking. Vapors may cause drowsiness
and dizziness.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame. Store in a cool dry place. Store under
nitrogen.
Unsuitable: Forms explosive peroxides on prolonged storage
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
GENERAL HYGIENE MEASURES
Remove and wash contaminated clothing promptly. Wash thoroughly
after handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 1000 MG/M3
Poland NDSCh 1300 MG/M3
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Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 1,050 mg/m3
250 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 2,100 mg/m3
500 ppm
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 525 mg/m3
125 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 1,050 mg/m3
250 ppm
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 1,060 mg/m3
250 ppm
OEL STEL 1,310 mg/m3
310 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 67 - 69 掳C
MP/MP Range -85 掳C
Flash Point -29 掳C Method: closed cup
Flammability N/A
Autoignition Temp 442 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1 %
Upper: 21 %
Vapor Pressure 120 mmHg 20 掳C
SG/Density 0.724 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 3.5 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
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Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:0.1 M in H2O
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Caution: forms explosive peroxides on
prolonged storage.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: TZ5425000
ACUTE TOXICITY
LD50
Oral
Rat
8470 mg/kg
LC50
Inhalation
Rat
162,000 mg/m3
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Change in motor activity (specific assay).
Behavioral:Muscle contraction or spasticity.
LC50
Inhalation
Mouse
131,000 mg/m3
Remarks: Behavioral:General anesthetic. Behavioral:Change in
motor activity (specific assay). Behavioral:Muscle contraction
or spasticity.
LD50
Intraperitoneal
Mouse
812 MG/KG
LC50
Inhalation
Rabbit
121,000 mg/m3
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Change in motor activity (specific assay).
Behavioral:Muscle contraction or spasticity.
LD50
Skin
Rabbit
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20 ML/KG
LD50
Oral
Mammal
6000 mg/kg
LC50
Inhalation
Mammal
130,000 mg/m3
IRRITATION DATA
Skin
Rabbit
363 mg
Remarks: Mild irritation effect
Skin
Rabbit
363 mg
Remarks: Open irritation test
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Nausea, headache, and vomiting. Narcotic
effect.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 3095 PPM/6H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Maternal Effects: Other effects. Specific Developmental
Abnormalities: Musculoskeletal system.
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Carassius auratus (Goldfish)
Time: 24 h
Value: 380 mg/l
ADDITIONAL ECOLOGICAL INFORMATION
BOD: 19 %
COD: 175 %
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
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afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1159
Class: 3
PG: II
Proper Shipping Name: Diisopropyl ether
IMDG
UN#: 1159
Class: 3
PG: II
Proper Shipping Name: Diisopropyl ether
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1159
Class: 3
PG: II
Proper Shipping Name: Diisopropyl ether
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: F
Highly Flammable.
R-PHRASES: 11 19 66 67
Highly flammable. May form explosive peroxides. Repeated
exposure may cause skin dryness or cracking. Vapors may cause
drowsiness and dizziness.
S-PHRASES: 9 16 29 33
Keep container in a well-ventilated place. Keep away from
sources of ignition - no smoking. Do not empty into drains.
Take precautionary measures against static discharges.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
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paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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