SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/JUL/2005
Date Updated: 24/MAY/2004
Version 1.5
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name N,N-DIMETHYLFORMAMIDE, ANHYDROUS, 99.8%
Product Number 227056
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
DIMETHYLFORMAMIDE 68-12-2 200-679-5 616-001-00-X
Formula C3H7NO
Molecular Weight 73.1 AMU
Synonyms Dimethylamid kyseliny mravenci (Czech) *
Dimethylformamid (German) * Dimethyl formamide *
N,N-Dimethyl formamide * Dimethylformamide
(ACGIH:OSHA) * N,N-Dimethylmethanamide *
Dimetilformamide (Italian) * Dimetylformamidu
(Czech) * DMF * DMFA * Dwumetyloformamid
(Polish) * N-Formyldimethylamine * NCI-C60913 *
NSC 5356 * U-4224
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause harm to the unborn child. Harmful by inhalation and in
contact with skin. Irritating to eyes.
Repr. Cat.2
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not
breathe mist. Do not get in eyes, on skin, on clothing. Avoid
prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat
and open flame. Store in a cool dry place.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse. Discard contaminated shoes.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 10 MG/M3
Poland NDSCh -
Poland NDSP -
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EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 30 mg/m3
10 ppm
Remarks: HK
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 30 mg/m3
10 ppm
Remarks: 4
Remarks: H
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 30 mg/m3
10 ppm
Remarks: H
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level30 mg/m3
10 ppm
Remarks: H, R
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 30 mg/m3
10 ppm
Remarks: H B M
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 30 mg/m3
10 ppm
OEL STEL 61 mg/m3
20 ppm
Remarks: Skin
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Color: Colorless
Form: Clear liquid
Odor: Fishy
Property Value At Temperature or Pressure
pH 6.7
BP/BP Range 153 - 155 掳C
MP/MP Range -61 掳C
Flash Point 58 掳C Method: closed cup
Flammability N/A
Autoignition Temp 445 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 2.2 %
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Upper: 15.2 %
Vapor Pressure 2.7 mmHg 20 掳C
SG/Density 0.948 g/cm3
Partition Coefficient Log Kow: -1.01
Viscosity < 0.001 Pas 20 掳C
Vapor Density 2.5 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Miscible.
Other Solvents: ALCOHOL, ETHER, ACETONE
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide,
and nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: LQ2100000
ACUTE TOXICITY
LD50
Skin
Rabbit
4,720 mg/kg
LD50
Oral
Rat
2,800 mg/kg
Inhalation
Rat
6,000 ppm
6 HR
LD50
Oral
Rat
2800 mg/kg
LD50
Intraperitoneal
Rat
1400 MG/KG
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Muscle weakness. Nutritional and Gross
Metabolic:Weight loss or decreased weight gain.
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LD50
Subcutaneous
Rat
3800 MG/KG
LD50
Intravenous
Rat
2 GM/KG
LD50
Oral
Mouse
2900 mg/kg
LC50
Inhalation
Mouse
9,400 mg/m3
2H
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Muscle weakness. Lungs, Thorax, or
Respiration:Dyspnea.
LD50
Intraperitoneal
Mouse
650 MG/KG
LD50
Subcutaneous
Mouse
4500 MG/KG
LD50
Intravenous
Mouse
2500 MG/KG
LD50
Intramuscular
Mouse
3900 MG/KG
LD50
Intravenous
Dog
470 MG/KG
LD50
Intraperitoneal
Cat
500 MG/KG
Remarks: Liver:Other changes. Kidney, Ureter, Bladder:Other
changes in urine composition. Blood:Changes in cell count
(unspecified).
LD50
Oral
Rabbit
5000 mg/kg
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LD50
Skin
Rabbit
4720 mg/kg
LD50
Intraperitoneal
Rabbit
1 GM/KG
Remarks: Liver:Other changes. Kidney, Ureter, Bladder:Other
changes in urine composition. Blood:Changes in cell count
(unspecified).
LD50
Intravenous
Rabbit
1800 MG/KG
LD50
Intravenous
Guinea pig
1050 MG/KG
IRRITATION DATA
Skin
Human
100 %
24H
Remarks: Mild irritation effect
Eyes
Rabbit
100 mg
Remarks: Rinsed
SIGNS AND SYMPTOMS OF EXPOSURE
Warning: intolerance for alcohol can occur up to 4 days after
dimethylformamide exposure. N,N-dimethylformamide is considered
to be a potent liver toxin. Exposure can cause: Stomach pains,
vomiting, diarrhea. To the best of our knowledge, the chemical,
physical, and toxicological properties have not been thoroughly
investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: Readily absorbed through skin. Harmful if
absorbed through skin.
Eye Contact: Causes eye irritation.
Inhalation: Harmful if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Liver. Kidneys. Central nervous system. Cardiovascular system.
Blood.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
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IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Human
12300 UG/M3/Y
Inhalation
Cytogenetic analysis
Human
100 NMOL/L
Cell Type: lymphocyte
Cytogenetic analysis
Rat
10700 UG/M3
Inhalation
Dominant lethal test
Mouse
500 UG/KG
Intraperitoneal
24H
Micronucleus test
Mouse
40 UMOL/KG
Intraperitoneal
Cytogenetic analysis
Mouse
5 GM/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Mouse
4250 UG/KG
Cell Type: S. typhimurium
Host-mediated assay
CHRONIC EXPOSURE - TERATOGEN
Result: May cause congenital malformation in the fetus.
Species: Rat
Dose: 5330 UL/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Rat
Dose: 300 PPM/6H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 3600 MG/KG
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Route of Application: Skin
Exposure Time: (11-13D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Rat
Dose: 7552 MG/KG
Route of Application: Skin
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Other effects
to embryo.
Species: Mouse
Dose: 1820 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Mouse
Dose: 15120 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1-14D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Other developmental abnormalities.
Species: Rabbit
Dose: 2600 MG/KG
Route of Application: Oral
Exposure Time: (6-18D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Body wall.
Specific Developmental Abnormalities: Musculoskeletal system.
Species: Rabbit
Dose: 2600 MG/KG
Route of Application: Oral
Exposure Time: (6-18D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rabbit
Dose: 450 PPM/6H
Route of Application: Inhalation
Exposure Time: (7-19D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities: Body
wall. Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Rabbit
Dose: 5200 MG/KG
Route of Application: Skin
Exposure Time: (6-18D PREG)
Result: Effects on Embryo or Fetus: Other effects to embryo.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 5030 MG/KG
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Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Extra embryonic structures (e.g.,
placenta, umbilical cord). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus).
Species: Rat
Dose: 800 PPM/6H
Route of Application: Inhalation
Exposure Time: (13W PRE)
Result: Maternal Effects: Other effects. Endocrine:Effect on
menstrual cycle.
Species: Rat
Dose: 50 PPM/6H
Route of Application: Inhalation
Exposure Time: (13W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Rat
Dose: 4 MG/M3/4H
Route of Application: Inhalation
Exposure Time: (1-19D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus). Effects on
Embryo or Fetus: Fetal death.
Species: Rat
Dose: 600 MG/M3/24H
Route of Application: Inhalation
Exposure Time: (1-19D PREG)
Result: Effects on Newborn: Behavioral.
Species: Rat
Dose: 287 PPM/6H
Route of Application: Inhalation
Exposure Time: (0-19D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Extra embryonic structures (e.g.,
placenta, umbilical cord). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus).
Species: Rat
Dose: 20 GM/KG
Route of Application: Skin
Exposure Time: (6-15D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Fertility:
Post-implantation mortality (e.g., dead and/or resorbed implants
per total number of implants). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus).
Species: Rat
Dose: 20 GM/KG
Route of Application: Skin
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Exposure Time: (1-20D PREG)
Result: Effects on Fertility: Female fertility index (e.g., #
females pregnant per # sperm positive females; # females
pregnant per # females mated ). Effects on Newborn: Delayed
effects.
Species: Mouse
Dose: 200 PPM/6H
Route of Application: Inhalation
Exposure Time: (13W PRE)
Result: Maternal Effects: Other effects. Endocrine:Effect on
menstrual cycle.
Species: Mouse
Dose: 2100 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (11D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
Species: Rabbit
Dose: 450 PPM/8H
Route of Application: Inhalation
Exposure Time: (7-19D PREG)
Result: Maternal Effects: Other effects. Specific Developmental
Abnormalities: Musculoskeletal system. Specific Developmental
Abnormalities: Gastrointestinal system.
12 - Ecological Information
No data available.
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 9,600 - 13,100 mg/l
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: 6,700 - 7,500 mg/l
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 9,000 - 13,000 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 10,400 - 10,800 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
This combustible material may be burned in a chemical incinerator
equipped with an afterburner and scrubber. Observe all federal,
state, and local environmental regulations.
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14 - Transport Information
RID/ADR
UN#: 2265
Class: 3
PG: III
Proper Shipping Name: N,N-Dimethylformamide
IMDG
UN#: 2265
Class: 3
PG: III
Proper Shipping Name: N,N-Dimethylformamide
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2265
Class: 3
PG: III
Proper Shipping Name: N,N-Dimethylformamide
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 616-001-00-X
NOTA: E
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 61 20/21 36
May cause harm to the unborn child. Harmful by inhalation and
in contact with skin. Irritating to eyes.
S-PHRASES: 53 45
Restricted to professional users. Attention - Avoid exposure -
obtain special instructions before use. In case of accident or
if you feel unwell, seek medical advice immediately (show the
label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 3
NORWAY
Declaration Number: 7376
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
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or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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