SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/JUL/2005
Date Updated: 13/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name N,N-DIMETHYLETHANOLAMINE, 99.5+%
Product Number 471453
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
N,N-DIMETHYLETHANOLAMINE 108-01-0 203-542-8 603-047-00-0
Formula C4H11NO
Molecular Weight 89.14 AMU
Synonyms Amietol M 21 * Bimanol * Deanol *
Dimethylaethanolamin (German) *
Dimethylaminoaethanol (German) *
Dimethylaminoethanol * beta-Dimethylaminoethanol
* N-Dimethylaminoethanol *
N,N-Dimethylaminoethanol *
2-(Dimethylamino)ethanol *
beta-Dimethylaminoethyl alcohol *
N,N-Dimethylethanolamine *
N,N-Dimethyl-N-(2-hydroxyethyl)amine *
N,N-Dimethyl-2-hydroxyethylamine * DMAE *
2-Dwumetyloaminoetanolu (Polish) *
beta-Hydroxyethyldimethylamine * Kalpur P *
Liparon * Norcholine * Propamine A * Texacat DME
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Flammable. Harmful by inhalation, in contact with skin and if
swallowed. Causes burns.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician. Do not induce vomiting.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat
and open flame. Store in a cool dry place.
SPECIAL REQUIREMENTS: Handle and store under inert gas.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
ALDRICH - 471453 www.sigma-aldrich.com Page 2
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 7.4 mg/m3
2 ppm
OEL STEL 22 mg/m3
6 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
Special Protective Measures: Faceshield (8-inch minimum).
9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Very faintly yellow
Odor: Fishy
Property Value At Temperature or Pressure
pH 10.5 - 11 20 掳C Concentration: 100
g/l
BP/BP Range 134 - 136 掳C
MP/MP Range -70 掳C
Flash Point 39 掳C Method: closed cup
Flammability N/A
Autoignition Temp 245 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.4 %
Upper: 12.2 %
Vapor Pressure 6.12 mmHg 20 掳C
SG/Density 0.886 g/cm3
Partition Coefficient Log Kow: 0.55
Viscosity N/A
Vapor Density 3.1 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Oxidizing agents Copper, Copper alloys, Zinc,
Galvanized iron Avoid contact with acid.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
ALDRICH - 471453 www.sigma-aldrich.com Page 3
11 - Toxicological Information
RTECS NUMBER: KK6125000
ACUTE TOXICITY
LD50
Oral
Rat
2000 mg/kg
LC50
Inhalation
Rat
1,641 ppm
4H
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Lacrimation. Behavioral:Ataxia. Lungs, Thorax, or
Respiration:Dyspnea.
LD50
Intraperitoneal
Rat
1080 MG/KG
Remarks: Biochemical:Enzyme inhibition, induction, or change in
blood or tissue levelsTrue cholinesterase.
LC50
Inhalation
Mouse
3,250 mg/m3
Remarks: Brain and Coverings:Recordings from specific areas of
CNS. Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Conjunctive irritation. Behavioral:Convulsions or
effect on seizure threshold.
LD50
Intraperitoneal
Mouse
234 MG/KG
Remarks: Behavioral:Ataxia.
LD50
Subcutaneous
Mouse
961 MG/KG
Remarks: Behavioral:Tremor. Behavioral:Coma. Lungs, Thorax, or
Respiration:Other changes.
LD50
Skin
Rabbit
1370 UL/KG
IRRITATION DATA
Skin
Rabbit
Remarks: Severe irritation effect
Skin
Rabbit
ALDRICH - 471453 www.sigma-aldrich.com Page 4
445 mg
Remarks: Open irritation test
Eyes
Rabbit
0.005 ml
Remarks: Severe irritation effect
SENSITIZATION
Skin: May cause allergic skin reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: Harmful if absorbed through skin.
Eye Contact: Causes burns. Lachrymator.
Inhalation: Material is extremely destructive to the tissue of
the mucous membranes and upper respiratory tract. Harmful if
inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Central nervous system.
12 - Ecological Information
ELIMINATION
Elimination: > 60 %
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 96 h
Value: > 100 - 220 mg/l
Test Type: EC50 Daphnia
Species: Daphnia
Time: 48 h
Value: 98.37 mg/l
Test Type: EC50 Algae
Time: 72 h
Value: 35 mg/l
Test Type: LC50 Bacteria
Time: 17 h
Value: > 8,000 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
ALDRICH - 471453 www.sigma-aldrich.com Page 5
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2051
Class: 8
PG: II
Proper Shipping Name: 2-Dimethylaminoethanol
IMDG
UN#: 2051
Class: 8
PG: II
Subrisk: 3
Proper Shipping Name: 2-Dimethylaminoethanol
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 2051
Class: 8
PG: II
Subrisk: 3
Proper Shipping Name: 2-Dimethylaminoethanol
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 603-047-00-0
INDICATION OF DANGER: C
Corrosive.
R-PHRASES: 10 20/21/22 34
Flammable. Harmful by inhalation, in contact with skin and if
swallowed. Causes burns.
S-PHRASES: 25 26 36/37/39 45
Avoid contact with eyes. In case of contact with eyes, rinse
immediately with plenty of water and seek medical advice. Wear
suitable protective clothing, gloves, and eye/face protection.
In case of accident or if you feel unwell, seek medical advice
immediately (show the label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
ALDRICH - 471453 www.sigma-aldrich.com Page 6
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
ALDRICH - 471453 www.sigma-aldrich.com Page 7
|