SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/JUL/2005
Date Updated: 27/MAY/2004
Version 1.5
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name DIETHYLENE GLYCOL DIMETHYL ETHER,
ANHYDROUS, 99.5%
Product Number 281662
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
DIETHYLENE GLYCOL DIMETHYL ETHER 111-96-6 203-924-4 603-139-00-0
Formula C6H14O3
Molecular Weight 134.18 AMU
Synonyms Bis(2-methoxyethyl)ether * Diethylene glycol
dimethyl ether * Diethyl glycol dimethyl ether *
Diglyme * Ethane, 1,1'-oxybis(2-methoxy- (9CI) *
Glyme 2 * Methyldiglyme *
1,1'-Oxybis(2-methoxyethane) * Poly-Solv *
2,5,8-Trioxanonane
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May impair fertility. May cause harm to the unborn child.
Flammable. May form explosive peroxides.
Repr. Cat.2
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not
breathe mist. Do not get in eyes, on skin, on clothing. Avoid
prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat
and open flame. Store in a cool dry place. Store under nitrogen.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 27 mg/m3
5 ppm
Remarks: 4
Remarks: H,
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EXPOSURE LIMITS - NORWAY
Source Type Value
Remarks: R
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 27 mg/m3
5 ppm
Remarks: HB
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 162 掳C 760 mmHg
MP/MP Range -64 掳C
Flash Point 57 掳C Method: closed cup
Flammability N/A
Autoignition Temp 188 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.5 %
Upper: 17.4 %
Vapor Pressure 3 mmHg 20 掳C
SG/Density 0.943 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 4.6 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Unstable.
Materials to Avoid: Strong oxidizing agents, Strong acids, Strong
bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
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RTECS NUMBER: KN3339000
ACUTE TOXICITY
LD50
Oral
Rat
5400 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Ataxia. Lungs, Thorax, or Respiration:Respiratory
depression.
LD50
Oral
Mouse
6000 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Ataxia. Lungs, Thorax, or Respiration:Respiratory
depression.
SIGNS AND SYMPTOMS OF EXPOSURE
In laboratory studies with this material, birth defects,
fetotoxicity, embryolethality, anemia, bone marrow damage,
hemolysis, immunosuppression, and damage to the male
reproductive tissues have been observed. To the best of our
knowledge, the chemical, physical, and toxicological properties
have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Female reproductive system. Male reproductive system.
CHRONIC EXPOSURE - MUTAGEN
Rat
1000 PPM
Inhalation
5D
Dominant lethal test
Mouse
1000 PPM
Inhalation
5D
sperm
CHRONIC EXPOSURE - TERATOGEN
Result: Laboratory experiments have shown teratogenic effects.
Species: Rat
Dose: 500 MG/KG
Route of Application: Oral
Exposure Time: (11D PREG)
Result: Effects on Embryo or Fetus: Maternal-fetal exchange.
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Species: Mouse
Dose: 537 MG/KG
Route of Application: Oral
Exposure Time: (11D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 2500 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Cardiovascular
(circulatory) system. Specific Developmental Abnormalities:
Urogenital system.
Species: Mouse
Dose: 1250 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Rat
Dose: 13680 MG/KG
Route of Application: Oral
Exposure Time: (20D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct. Paternal Effects: Other
effects on male.
Species: Rat
Dose: 1100 PPM/6H
Route of Application: Inhalation
Exposure Time: (2W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct.
Species: Mouse
Dose: 2500 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Mouse
Dose: 5 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth).
Species: Rabbit
Dose: 1400 MG/KG
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Route of Application: Oral
Exposure Time: (6-19D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetal death. Specific Developmental
Abnormalities: Musculoskeletal system.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 3271
Class: 3
PG: III
Proper Shipping Name: Ethers, n.o.s.
IMDG
UN#: 3271
Class: 3
PG: III
Proper Shipping Name: Ethers, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 3271
Class: 3
PG: III
Proper Shipping Name: Ethers, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 603-139-00-0
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 60 61 10 19
May impair fertility. May cause harm to the unborn child.
Flammable. May form explosive peroxides.
S-PHRASES: 53 45
Restricted to professional users. Attention - Avoid exposure -
obtain special instructions before use. In case of accident or
if you feel unwell, seek medical advice immediately (show the
label where possible).
COUNTRY SPECIFIC INFORMATION
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Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 3
NORWAY
Declaration Number: 67077
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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