SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 28/JUN/2005
Date Updated: 12/MAR/2004
Version 1.8
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name DI(ETHYLENE GLYCOL), REAGENTPLUS(TM),
99%
Product Number H26456
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
DI(ETHYLENE GLYCOL) 111-46-6 203-872-2 603-140-00-6
Formula C4H10O3
Molecular Weight 106.12 AMU
Synonyms Bis(2-hydroxyethyl) ether * Brecolane ndg *
Deactivator E * DEG * Dicol * Diethylenglykol
(Czech) * Diglycol * Dihydroxydiethyl ether *
beta,beta'-Dihydroxydiethyl ether *
2,2'-Dihydroxyethyl ether * Dissolvant APV *
Ethanol, 2,2'-oxydi- * Ethylene diglycol *
3-Oxapentane-1,5-diol * 3-Oxa-1,5-pentanediol *
2,2'-Oxybisethanol * 2,2'-Oxydiethanol *
2,2'-Oxyethanol * TL4N
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam. Water spray.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid prolonged or repeated
exposure. Do not breathe vapor. Avoid contact with eyes, skin,
and clothing.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Hygroscopic.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 10 MG/M3
Poland NDSCh -
Poland NDSP -
EXPOSURE LIMITS - DENMARK
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Source Type Value
OEL TWA 11 mg/m3
2.5 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 44 mg/m3
10 ppm
Remarks: 4
Remarks: Y
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level90 mg/m3
10 ppm
Remarks: H
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 44 mg/m3
10 ppm
Remarks: C
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 101 mg/m3
23 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH 5-8 20 掳C Concentration: 500
g/l
BP/BP Range 125 - 126 掳C 11 mmHg
MP/MP Range -10 掳C
Flash Point 123 掳C Method: closed cup
Flammability N/A
Autoignition Temp 228 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 2 %
Upper: 12.3 %
Vapor Pressure 0.03 mmHg
SG/Density 1.114 g/cm3
Partition Coefficient N/A
Viscosity 38 Pas 20 掳C
Vapor Density 2.14 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content < 0.05 %
Surface Tension 48.5 mN/m 25 掳C
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Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Moisture.
Materials to Avoid: Strong oxidizing agents, Strong acids.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: ID5950000
ACUTE TOXICITY
LDLO
Oral
Human
1000 mg/kg
LD50
Oral
Rat
12565 mg/kg
LD50
Intraperitoneal
Rat
7700 MG/KG
LD50
Subcutaneous
Rat
18800 MG/KG
LD50
Intravenous
Rat
6565 MG/KG
LD50
Oral
Mouse
23700 mg/kg
Remarks: Behavioral:General anesthetic. Behavioral:Muscle
weakness. Liver:Other changes.
LD50
Intraperitoneal
Mouse
9719 MG/KG
Remarks: Lungs, Thorax, or Respiration:Chronic pulmonary edema.
Kidney, Ureter, Bladder:Changes in both tubules and glomeruli.
Blood:Changes in spleen.
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LD50
Oral
Dog
9000 mg/kg
LD50
Oral
Cat
3300 mg/kg
LD50
Oral
Rabbit
4400 mg/kg
Remarks: Behavioral:Coma. Lungs, Thorax, or Respiration:Dyspnea.
Nutritional and Gross Metabolic:Changes in:Body temperature
decrease.
LD50
Skin
Rabbit
11890 mg/kg
LD50
Oral
Guinea pig
7800 mg/kg
Remarks: Behavioral:General anesthetic. Behavioral:Muscle
weakness. Liver:Other changes.
IRRITATION DATA
Skin
Human
112 mg
3D
I
Remarks: Mild irritation effect
Skin
Rabbit
500 mg
Remarks: Mild irritation effect
Eyes
Rabbit
50 mg
Remarks: Mild irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Prolonged exposure can cause: Nausea, headache, and vomiting.
Weakness. Confusion. Dizziness. Damage to the kidneys.
Unconsciousness. Convulsions. Pulmonary edema. Effects may be
delayed.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
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Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Kidneys. Liver. Central nervous system.
CHRONIC EXPOSURE - CARCINOGEN
Rat
Route of Application: Oral
Exposure Time: 53W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Kidney,
Ureter, Bladder:Tumors. Kidney, Ureter, Bladder:Changes in both
tubules and glomeruli.
Rat
Route of Application: Subcutaneous
Exposure Time: 82W
Result: Tumorigenic:Neoplastic by RTECS criteria. Blood:Tumors.
Mouse
Route of Application: Oral
Exposure Time: 22W
Result: Tumorigenic:Neoplastic by RTECS criteria. Blood:Tumors.
Mouse
Route of Application: Inhalation
Exposure Time: 2H/30W-
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Blood:Lymphomas including Hodgkin's disease. Skin and
Appendages: Other: Tumors.
Mouse
Route of Application: Subcutaneous
Exposure Time: 66W
Result: Tumorigenic:Neoplastic by RTECS criteria. Blood:Tumors.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Kidney, Ureter, Bladder:Tumors.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Kidney, Ureter, Bladder:Tumors.
Rat
Route of Application: Oral
Exposure Time: 81W
Result: Tumorigenic:Neoplastic by RTECS criteria. Blood:Tumors.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 50 GM/KG
Route of Application: Oral
Exposure Time: (1-20D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
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Species: Rat
Dose: 76420 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 38212 MG/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 100 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Mouse
Dose: 343 GM/KG
Route of Application: Oral
Exposure Time: (MULTIGENERATION)
Result: Maternal Effects: Parturition. Effects on Embryo or
Fetus: Fetal death. Effects on Newborn: Sex ratio.
Species: Mouse
Dose: 343 GM/KG
Route of Application: Oral
Exposure Time: (MULTIGENERATION)
Result: Effects on Fertility: Female fertility index (e.g., #
females pregnant per # sperm positive females; # females
pregnant per # females mated ). Effects on Newborn: Other
postnatal measures or effects.
Species: Mouse
Dose: 50 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Maternal Effects: Other effects.
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: > 10,000 mg/l
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 48 h
Value: > 1,000 mg/l
Test Type: LC50 Fish
Species: Carassius auratus (Goldfish)
Time: 24 h
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Value: 5,000 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 603-140-00-6
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22
Harmful if swallowed.
S-PHRASES: 46
If swallowed, seek medical advice immediately and show this
container or label.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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