SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 28/JUN/2005
Date Updated: 13/APR/2005
Version 1.6
According to 91/155/EEC
1 - Product and Company Information
Product Name DIETHYL PHTHALATE, 99.5% (EASTMAN DEP)
Product Number 524972
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
DIETHYL PHTHALATE 84-66-2 201-550-6 None
Formula C12H14O4
Molecular Weight 222.24 AMU
Synonyms Anozol * o-Benzenedicarboxylic acid diethyl
ester * 1,2-Benzenedicarboxylic acid, diethyl
ester * DEP * Diethyl 1,2-benzenedicarboxylate *
Diethylester kyseliny ftalove (Czech) * Diethyl
phthalate (ACGIH) * Diethyl o-phthalate *
DPX-F5384 * Ethyl phthalate * NCI-C60048 *
Neantine * Palatinol A * Phthalol *
Phthalsaeurediaethylester (German) * Placidol E
* RCRA waste number U088 * Solvanol * Unimoll DA
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Not hazardous according to Directive 67/548/EEC.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
ENVIRONMENTAL PRECAUTION(S)
Do not allow material to enter drains or water courses. Avoid
contaminating sewers and waterways with this material.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid inhalation. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 5 MG/M3
Poland NDSCh 15 MG/M3
Poland ACGIH TWA -
5 mg/m3
USA OSHA. PEL TWA 5 mg/m3
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 3 mg/m3
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 3 mg/m3
Remarks: NL
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EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 3 mg/m3
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level3 mg/m3
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 5 mg/m3
Remarks: E
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 5 mg/m3
OEL STEL 10 mg/m3
PERSONAL PROTECTIVE EQUIPMENT
Hand Protection: Protective gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 294 - 296 掳C
MP/MP Range -3 掳C
Flash Point 156 掳C Method: closed cup
Flammability N/A
Autoignition Temp 457 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 0.75 %
Vapor Pressure N/A
SG/Density 1.118 g/cm3
Partition Coefficient N/A
Viscosity 9.5 Pas 25 掳C
Vapor Density 7.66 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Slightly. Soluble.
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Oxidizing agents, Acids.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
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HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: TI1050000
ACUTE TOXICITY
LD50
Oral
Rat
9,000 mg/kg
LD50
Oral
Rabbit
1,000 mg/kg
LC50
Inhalation
Rat
> 4.64 mg/kg
6 HRS.
LD50
Skin
Guinea pig
> 20 mg/kg
LD50
Oral
Rat
8600 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Withdrawal. Nutritional and Gross Metabolic:Weight
loss or decreased weight gain.
LD50
Intraperitoneal
Rat
5058 UL/KG
LD50
Oral
Mouse
6172 mg/kg
LD50
Intraperitoneal
Mouse
2749 MG/KG
Remarks: Lungs, Thorax, or Respiration:Acute pulmonary edema.
Kidney, Ureter, Bladder:Changes in tubules (including acute
renal failure, acute tubular necrosis). Blood:Changes in spleen.
LD50
Oral
Rabbit
1000 mg/kg
LD50
Oral
Guinea pig
8600 mg/kg
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Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Withdrawal. Nutritional and Gross Metabolic:Weight
loss or decreased weight gain.
LD50
Subcutaneous
Guinea pig
3 GM/KG
IRRITATION DATA
Skin
Guinea pig
Remarks: Mild irritation effect
Eyes
Rabbit
Remarks: Mild irritation effect
Eyes
Rabbit
112 mg
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Mouse
Route of Application: Skin
Exposure Time: 2Y
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 25 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 101 GM/KG
Route of Application: Skin
Exposure Time: (1-17D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Rabbit
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Dose: 26 ML/KG
Route of Application: Skin
Exposure Time: (6-18D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 506 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (5-15D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Mouse
Dose: 171 GM/KG
Route of Application: Oral
Exposure Time: (7D MALE/7D PRE-21D POST)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Prostate, seminal vessicle, Cowper's gland, accessory
glands. Effects on Newborn: Live birth index (# fetuses per
litter; measured after birth).
Species: Mouse
Dose: 171 GM/KG
Route of Application: Oral
Exposure Time: (7D MALE/7D PRE-21D POST)
Result: Effects on Newborn: Physical.
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: other fish
Time: 48 h
Value: 53 - 61 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 86 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 17 mg/l
Test Type: LC50 Fish
Species: other fish
Time: 96 h
Value: 29 mg/l
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: 17 mg/l
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Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 12 mg/l
Test Type: EC50 Daphnia
Species: Selenastrum capricornutum resp.
Time: 96 h
Value: 16 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
Not hazardous according to Directive 67/548/EEC.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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