SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/JUL/2005
Date Updated: 13/MAR/2004
Version 1.5
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name P-DIMETHYLAMINOAZOBENZENE CRYSTALLINE
Product Number D6760
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
4-DIMETHYLAMINOAZOBENZENE 60-11-7 200-455-7 None
Formula C14H15N3
Molecular Weight 225.3 AMU
Synonyms Atul Fast Yellow R * Azobenzene,
p-dimethylamino- * Benzenamine,
N,N-dimethyl-4-(phenylazo)- (9CI) *
Benzeneazodimethylaniline * Brilliant Fast Oil
Yellow * Brilliant Fast Spirit Yellow *
Brilliant Fast Yellow * Brilliant Oil Yellow *
Butter Yellow * Cerasine Yellow GG * C.I. 11020
* C.I. Solvent Yellow 2 * DAB (carcinogen) *
p-Dimethylaminoazobenzen (Czech) *
N,N-Dimethyl-p-aminoazobenzene *
N,N-Dimethyl-4-aminoazobenzene *
p-Dimethylaminoazobenzene *
4-(N,N-Dimethylamino)azobenzene *
4-Dimethylaminoazobenzene (OSHA) *
p-Dimethylamino-azobenzol (German) *
4-Dimethylaminoazobenzol *
4-Dimethylaminophenylazobenzene *
N,N-Dimethyl-p-azoaniline *
N,N-Dimethyl-p-phenylazoaniline *
N,N-Dimethyl-4-(phenylazo)benzamine *
N,N-Dimethyl-4-(phenylazo)benzenamine * Dimethyl
Yellow * Dimethyl Yellow Analar * Dimethyl
Yellow N,N-dimethylaniline * DMAB * Enial Yellow
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic if swallowed. Limited evidence of a carcinogenic effect.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
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GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator in
nonventilated areas and/or for exposure above the TLV or PEL.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 115 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Acids, Acid anhydrides, Oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: BX7350000
ACUTE TOXICITY
LD50
Oral
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Rat
200 mg/kg
LD50
Intraperitoneal
Rat
230 MG/KG
Remarks: Lungs, Thorax, or Respiration:Dyspnea. Lungs, Thorax,
or Respiration:Cyanosis.
LD50
Oral
Mouse
300 mg/kg
LD50
Intraperitoneal
Mouse
230 MG/KG
Remarks: Lungs, Thorax, or Respiration:Dyspnea. Lungs, Thorax,
or Respiration:Cyanosis.
SIGNS AND SYMPTOMS OF EXPOSURE
Absorption into the body leads to the formation of methemoglobin
which in sufficient concentration causes cyanosis. Onset may be
delayed 2 to 4 hours or longer.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Liver. Bladder. Blood. Kidneys.
CHRONIC EXPOSURE - CARCINOGEN
Result: OSHA carcinogen. This is or contains a component that
has been reported to be carcinogenic based on its IARC, OSHA,
ACGIH, NTP, or EPA classification.
Rat
Route of Application: Oral
Exposure Time: 17W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
Rat
Route of Application: Skin
Exposure Time: 90W
Result: Tumorigenic:Neoplastic by RTECS criteria. Skin and
Appendages: Other: Tumors.
Mouse
Route of Application: Intraperitoneal
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Mouse
Route of Application: Subcutaneous
Result: Tumorigenic:Carcinogenic by RTECS criteria. Tumorigenic
Effects: Uterine tumors. Lungs, Thorax, or Respiration:Tumors.
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Mouse
Route of Application: Multiple
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors. Tumorigenic:Tumors at site or
application.
Dog
Route of Application: Oral
Exposure Time: 69W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Kidney, Ureter, Bladder:Tumors.
Hamster
Route of Application: Oral
Exposure Time: 42W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Change in gall bladder structure or function.
Blood:Other hemolysis with or withot anemia.
Rat
Route of Application: Oral
Exposure Time: 13W
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Rat
Route of Application: Oral
Exposure Time: 53W
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Rat
Route of Application: Oral
Exposure Time: 14W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors.
Rat
Route of Application: Oral
Exposure Time: 14W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors.
Rat
Route of Application: Oral
Exposure Time: 7W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors.
Rat
Route of Application: Oral
Exposure Time: 17W
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Rat
Route of Application: Oral
Exposure Time: 33W
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Rat
Route of Application: Oral
Exposure Time: 19W
Result: Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax,
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or Respiration:Consolidation. Liver:Tumors.
Mouse
Route of Application: Intraperitoneal
Result: Tumorigenic:Neoplastic by RTECS criteria. Liver:Tumors.
Rat
Route of Application: Oral
Exposure Time: 64D
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors.
IARC CARCINOGEN LIST
Rating: Group 2B
CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.
Human
10 NMOL/L
Cell Type: HeLa cell
Unscheduled DNA synthesis
Human
4 MG/L
Cell Type: fibroblast
Unscheduled DNA synthesis
Human
100 UMOL/L
Cell Type: HeLa cell
DNA inhibition
Rat
1 UMOL/L
Cell Type: liver
Unscheduled DNA synthesis
Rat
12 MG/L
Cell Type: Embryo
Morphological transformation.
Rat
300 MG/KG
Oral
DNA
Rat
150 MG/KG
Intraperitoneal
DNA
Rat
1 UMOL/L
Cell Type: liver
Unscheduled DNA synthesis
Rat
600 MG/KG
Cell Type: S. typhimurium
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Body fluid assay
Rat
756 MG/KG
Oral
3W
Cytogenetic analysis
Mouse
6400 UG/KG
Intraperitoneal
Micronucleus test
Mouse
6250 UG/L (+S9)
Cell Type: lymphocyte
Mutation in microorganisms
Mouse
89 UMOL/L
Cell Type: Embryo
Morphological transformation.
Mouse
120 MG/KG
Intraperitoneal
DNA
Mouse
192 UMOL/KG
Skin
DNA
Mouse
500 MG/KG
Oral
DNA damage
Mouse
1 UMOL/L
Cell Type: liver
Unscheduled DNA synthesis
Mouse
20 GM/KG
Intraperitoneal
DNA inhibition
Mouse
100 MG/KG
Oral
DNA inhibition
Mouse
29 MG/KG
Intraperitoneal
Sister chromatid exchange
Mouse
89 UMOL/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
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Mouse
255 MG/KG
3H
Cell Type: S. typhimurium
Host-mediated assay
Mouse
3 GM/KG
Intraperitoneal
5D
sperm
Hamster
500 MG/KG
Intraperitoneal
Morphological transformation.
Hamster
50 UG/L
Cell Type: Embryo
Morphological transformation.
Hamster
25 MG/L
Cell Type: kidney
Morphological transformation.
Hamster
1 UMOL/L
Cell Type: liver
Unscheduled DNA synthesis
Non-mammalian
250 UG/L
Cell Type: Other cell types
Morphological transformation.
CHRONIC EXPOSURE - TERATOGEN
Result: May cause congenital malformation in the fetus.
Species: Mouse
Dose: 200 MG/KG
Route of Application: Subcutaneous
Exposure Time: (10D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Mouse
Dose: 3 GM/KG
Route of Application: Intraperitoneal
Exposure Time: (5D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
SWEDISH OE CARCINOGEN: Substances which according to 21搂, AFS
2000:3, no use allowed.
12 - Ecological Information
No data available.
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13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
IMDG
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 25 40
Toxic if swallowed. Limited evidence of a carcinogenic effect.
S-PHRASES: 36/37 45
Wear suitable protective clothing and gloves. In case of
accident or if you feel unwell, seek medical advice immediately
(show the label where possible).
SWITZERLAND
SWISS POISON CLASS: 1*
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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