SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 23/JUN/2005
Date Updated: 16/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name DILTIAZEM HYDROCHLORIDE
Product Number D2521
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
DILTIAZEM HYDROCHLORIDE 33286-22-5 251-443-3 None
Formula C22H26N2O4S.ClH
Molecular Weight 451 AMU
Synonyms Altiazem * Anginyl * Angizem * Britiazim *
Bruzem * Calcicard * Cardizem * CRD-401 *
Dilpral * Diltiazem chloridrate * Diltiazem
hydrochloride * Dilzem * Herbesser * Masdil *
Tildiem
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at 2-8藲C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Color: White
Form: Powder
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
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MP/MP Range 212 藲C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:50 mg/ml H2O clear,
very faintly yellow
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: Light.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Sulfur oxides, Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: DL0310000
ACUTE TOXICITY
LDLO
Oral
Man
21 mg/kg
Remarks: Cardiac:Cardiomyopathy including infarction.
Cardiac:Pulse rate. Vascular:BP lowering not charactertized in
autonomic section.
LDLO
Oral
Woman
120 mg/kg
Remarks: Cardiac:Cardiomyopathy including infarction.
LD50
Oral
Rat
560 mg/kg
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Remarks: Behavioral:Antipsychotic.
LD50
Subcutaneous
Rat
520 MG/KG
Remarks: Behavioral:Antipsychotic.
LD50
Intravenous
Rat
38 MG/KG
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Somnolence (general depressed
activity). Behavioral:Tetany.
LD50
Oral
Mouse
508 mg/kg
LD50
Intraperitoneal
Mouse
177 MG/KG
LD50
Subcutaneous
Mouse
260 MG/KG
Remarks: Behavioral:Antipsychotic.
LD50
Intravenous
Mouse
58 MG/KG
Remarks: Behavioral:Antipsychotic.
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Gastrointestinal disturbances. Other
symptoms include orthostatic hypotension and bradycardia.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Cardiovascular system. Liver.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 60 MG/KG
Route of Application: Oral
Exposure Time: (9-14D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Effects on Newborn: Live birth index (# fetuses per
litter; measured after birth).
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Species: Rat
Dose: 600 MG/KG
Route of Application: Oral
Exposure Time: (11D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 480 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (9-14D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Other developmental abnormalities.
Species: Mouse
Dose: 25 MG/KG
Route of Application: Oral
Exposure Time: (9D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Mouse
Dose: 25 MG/KG
Route of Application: Oral
Exposure Time: (10D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Mouse
Dose: 25 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (9D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 50 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (9D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Mouse
Dose: 50 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (13D PREG)
Result: Specific Developmental Abnormalities: Other
developmental abnormalities.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 1200 MG/KG
Route of Application: Oral
Exposure Time: (9-14D PREG)
Result: Maternal Effects: Parturition. Effects on Embryo or
Fetus: Fetal death.
Species: Rat
Dose: 700 MG/KG
Route of Application: Oral
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Exposure Time: (15-21D PREG)
Result: Effects on Newborn: Stillbirth. Effects on Newborn:
Growth statistics (e.g., reduced weight gain).
Species: Rat
Dose: 80 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (13D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Musculoskeletal system.
Species: Rat
Dose: 130 MG/KG
Route of Application: Intravenous
Exposure Time: (17-21D PREG/21D POST)
Result: Effects on Newborn: Stillbirth. Effects on Newborn:
Growth statistics (e.g., reduced weight gain).
Species: Rat
Dose: 378 MG/KG
Route of Application: Intravenous
Exposure Time: (14D PRE/1-7D PREG)
Result: Effects on Fertility: Other measures of fertility
Species: Mouse
Dose: 60 MG/KG
Route of Application: Oral
Exposure Time: (7-12D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth). Effects on Embryo or Fetus:
Fetal death. Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Mouse
Dose: 100 MG/KG
Route of Application: Oral
Exposure Time: (9D PREG)
Result: Effects on Newborn: Sex ratio.
Species: Mouse
Dose: 12500 UG/KG
Route of Application: Intraperitoneal
Exposure Time: (11D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rabbit
Dose: 125 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (7-16D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Musculoskeletal system.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
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Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22
Harmful if swallowed.
S-PHRASES: 36
Wear suitable protective clothing.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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