SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/JUL/2005
Date Updated: 10/FEB/2005
Version 1.7
According to 91/155/EEC
1 - Product and Company Information
Product Name DIMETHYL SULFOXIDE
Product Number D5879
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
DIMETHYL SULFOXIDE 67-68-5 200-664-3 None
Formula C2H6OS
Molecular Weight 78.13 AMU
Synonyms A 10846 * Deltan * Demeso * Demasorb * Demavet *
Demsodrox * Dermasorb * Dimethyl sulfoxide *
Dimethyl sulphoxide * Dimexide *
Dipirartril-tropico * DMS-70 * DMS-90 * DMSO *
Dolicur * Domoso * Dromisol * Durasorb * Gamasol
90 * Hyadur * Infiltrina * M 176 * Methane,
sulfinylbis- * Methylsulfinylmethane * NSC-763 *
Rimso-50 * Somipront * SQ 9453 *
Sulfinylbis(methane) * Syntexan * Topsym
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Not hazardous according to Directive 67/548/EEC.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
ENVIRONMENTAL PRECAUTION(S)
Avoid contaminating sewers and waterways with this material.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with DMSO solutions containing toxic materials or
materials with unknown toxicological properties. Dimethyl
sulfoxide is readily absorbed through skin and may carry such
materials into the body. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Store under inert gas. Keep tightly
closed. Keep away from heat and open flame. Store in a cool dry
place.
SPECIAL REQUIREMENTS: Store under inert gas. Hygroscopic.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS - GERMANY
Source Type Value
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TRGS 900 OEL 160 mg/m3
Remarks: H,CH
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level150 mg/m3
50 ppm
Remarks: H
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 160 mg/m3
50 ppm
Remarks: H
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
Skin Protection: Chemical resistant apron.
9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 189 掳C
MP/MP Range 18.4 掳C
Flash Point 87 掳C Method: closed cup
Flammability N/A
Autoignition Temp 301 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 3.5 %
Upper: 42 %
Vapor Pressure 0.42 mmHg 20 掳C
SG/Density 1.1 g/cm3
Partition Coefficient Log Kow: -2.03
Viscosity 0.002 Pas 20 掳C
Vapor Density 2.7 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. > 190 掳C
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Miscible.
Other Solvents: ALCOHOLS, ETHYL ETHERS
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Moisture.
Materials to Avoid: Acid chlorides, Phosphorus halides, Strong
acids, Strong oxidizing agents, Strong reducing agents.
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HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Sulfur oxides.
HAZARDOUS EXOTHERMIC REACTIONS
Hazardous Exothermic Reactions: Methyl sulfoxide (DMSO) undergoes
a violent exothermic reaction on mixing with copper wool and
trichloroacetic acid. On mixing with potassium permanganate it
will flash instantaneously. It reacts violently with: acid
halides, cyanuric chloride, silicon tetrachloride, phosphorus
trichloride and trioxide, thionyl chloride, magnesium perchlorate,
silver fluoride, methyl bromide, iodine pentafluoride, nitrogen
periodate, diborane, sodium hydride, and perchloric and periodic
acids. When heated above its boiling point methyl sulfoxide
degrades giving off formaldehyde, methyl mercaptan, and sulfur
dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: PV6210000
ACUTE TOXICITY
LC50
Inhalation
Rat
40,250 ppm
4 HR
LD50
Oral
Rat
3,300 mg/kg
LD50
Skin
Rabbit
> 5,000 mg/kg
LD50
Oral
Rat
14500 mg/kg
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Hemorrhage. Sense Organs and Special Senses (Nose,
Eye, Ear, and Taste):Eye:Conjunctive irritation.
LD50
Skin
Rat
40000 mg/kg
LD50
Intraperitoneal
Rat
8200 MG/KG
LD50
Subcutaneous
Rat
12 GM/KG
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Remarks: Behavioral:Change in motor activity (specific assay).
Lungs, Thorax, or Respiration:Dyspnea.
LD50
Intravenous
Rat
5360 MG/KG
Remarks: Behavioral:Tremor. Behavioral:Muscle weakness. Lungs,
Thorax, or Respiration:Dyspnea.
LD50
Oral
Mouse
7920 mg/kg
LD50
Skin
Mouse
50000 mg/kg
LD50
Intraperitoneal
Mouse
2500 MG/KG
LD50
Subcutaneous
Mouse
14 GM/KG
Remarks: Behavioral:Change in motor activity (specific assay).
Lungs, Thorax, or Respiration:Other changes. Kidney, Ureter,
Bladder:Hematuria.
LD50
Intravenous
Mouse
3100 MG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Hemorrhage. Sense Organs and Special Senses (Nose,
Eye, Ear, and Taste):Eye:Conjunctive irritation.
LD50
Oral
Dog
> 10000 mg/kg
LD50
Intravenous
Dog
2500 MG/KG
Remarks: Cardiac:Other changes. Kidney, Ureter,
Bladder:Hematuria. Kidney, Ureter, Bladder:Other changes.
LD50
Oral
Chicken
12000 mg/kg
LD50
Oral
Mammal
21400 mg/kg
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LD50
Oral
Bird (wild)
100 mg/kg
IRRITATION DATA
Skin
Rabbit
4 HOURS
Remarks: No irritation effect
Eyes
Rabbit
Remarks: Mild irritation effect
Skin
Rabbit
10 mg
24H
Remarks: Open irritation test
Skin
Rabbit
500 mg
24H
Remarks: Mild irritation effect
Eyes
Rabbit
100 mg
Eyes
Rabbit
500 mg
24H
Remarks: Mild irritation effect
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Readily absorbed through skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Eyes. Skin.
CONDITIONS AGGRAVATED BY EXPOSURE
Avoid contact with DMSO solutions containing toxic materials or
materials with unknown toxicological properties. Dimethyl
sulfoxide is readily absorbed through skin and may carry such
materials into the body.
CHRONIC EXPOSURE - CARCINOGEN
Rat
Route of Application: Oral
Exposure Time: 81W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Skin and Appendages: Other: Tumors.
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Rat
Route of Application: Subcutaneous
Exposure Time: 82W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Skin and Appendages: Other: Tumors.
Mouse
Route of Application: Oral
Exposure Time: 66W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Blood:Leukemia Skin and Appendages: Other: Tumors.
Mouse
Route of Application: Subcutaneous
Exposure Time: 66W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors. Skin and
Appendages: Other: Tumors.
CHRONIC EXPOSURE - MUTAGEN
Human
140 MMOL/L
Cell Type: lymphocyte
Other mutation test systems
Rat
25 GM/KG
Intraperitoneal
5D
Cytogenetic analysis
Mouse
75 MMOL/KG
Intraperitoneal
DNA damage
Mouse
93 GM/L
Cell Type: lymphocyte
Cytogenetic analysis
Mouse
1 MOL/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
19 PPH
Cell Type: ovary
Cytogenetic analysis
Hamster
1 PPH
Cell Type: lung
Cytogenetic analysis
CHRONIC EXPOSURE - TERATOGEN
Species: Mouse
Dose: 210 GM/KG
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Route of Application: Intraperitoneal
Exposure Time: (6-12D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Mouse
Dose: 5500 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (10D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Hamster
Dose: 11 GM/KG
Route of Application: Oral
Exposure Time: (7D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Musculoskeletal
system.
Species: Hamster
Dose: 5500 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (8D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
Species: Hamster
Dose: 4400 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (8D PREG)
Result: Effects on Embryo or Fetus: Fetal death. Specific
Developmental Abnormalities: Central nervous system.
Species: Hamster
Dose: 2500 MG/KG
Route of Application: Intravenous
Exposure Time: (8D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Craniofacial
(including nose and tongue). Specific Developmental
Abnormalities: Musculoskeletal system.
Species: Hamster
Dose: 2500 MG/KG
Route of Application: Intravenous
Exposure Time: (8D PREG)
Result: Specific Developmental Abnormalities: Other
developmental abnormalities.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 56 GM/KG
Route of Application: Intraperitoneal
Exposure Time: (6-12D PREG)
Result: Effects on Fertility: Abortion.
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Species: Rat
Dose: 6600 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (7-15D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rat
Dose: 30750 MG/KG
Route of Application: Subcutaneous
Exposure Time: (8-10D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Litter size (e.g.; # fetuses per litter;
measured before birth).
Species: Mouse
Dose: 16 MG/KG
Route of Application: Oral
Exposure Time: (5-9D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Embryo or Fetus:
Fetotoxicity (except death, e.g., stunted fetus). Specific
Developmental Abnormalities: Musculoskeletal system.
Species: Mouse
Dose: 8250 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (10D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Mouse
Dose: 240 GM/KG
Route of Application: Intravenous
Exposure Time: (1-20D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 35,000 mg/l
Test Type: EC50 Daphnia
Species: Daphnia pulex
Value: 27,500 mg/l
Test Type: EC50 Algae
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: > 400,000 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 34,000 mg/l
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13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. This combustible material may be burned in a
chemical incinerator equipped with an afterburner and scrubber.
Observe all federal, state, and local environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
Not hazardous according to Directive 67/548/EEC.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: FREI
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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