SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 31/JUL/2005
Date Updated: 16/MAR/2004
Version 1.5
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name DIOCTYL PHTHALATE, 99%
Product Number D201154
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
BIS(2-ETHYLHEXYL) PHTHALATE 117-81-7 204-211-0 607-317-00-9
Formula C24H38O4
Molecular Weight 390.56 AMU
Synonyms 1,2-Benzenedicarboxylic acid, bis(2-ethylhexyl)
ester *
Bis(2-ethylhexyl)-1,2-benzenedicarboxylate *
Bis-(2-ethylhexyl)ester kyseliny ftalove (Czech)
* Bis(2-ethylhexyl)phthalate * Bisoflex 81 *
Bisoflex DOP * Compound 889 * DEHP *
Di(2-ethylhexyl)orthophthalate *
Di(2-ethylhexyl)phthalate * Dioctyl phthalate *
Di-sec-octyl phthalate (ACGIH:OSHA) * Ergoplast
FDO * 2-Ethylhexyl phthalate * Eviplast 80 *
Eviplast 81 * Fleximel * Flexol DOP * Flexol
Plasticizer DOP * Good-rite GP 264 * Hatcol DOP
* Hercoflex 260 * Jayflex DOP * Kodaflex DOP *
Mollan O * NCI-C52733 * Nuoplaz DOP * Octoil *
Palatinol AH * Phthalic acid dioctyl ester *
Pittsburgh PX-138 * Platinol AH * Platinol DOP *
RC Plasticizer DOP * RCRA waste number U028 *
Reomol DOP * Reomol D 79P * Sicol 150 * Staflex
DOP * Truflex DOP * Vestinol AH * Vinicizer 80 *
Witcizer 312
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May impair fertility. May cause harm to the unborn child.
Repr. Cat.2
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam. Foam and water spray are effective but may cause frothing.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
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Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 1 MG/M3
Poland NDSCh 5 MG/M3
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 3 mg/m3
Remarks: K
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 10 mg/m3
Remarks: 4
Remarks: Y
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 3 mg/m3
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 5 mg/m3
Remarks: E C
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 5 mg/m3
OEL STEL 10 mg/m3
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator in
nonventilated areas and/or for exposure above the TLV or PEL.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 384 掳C 760 mmHg
MP/MP Range -50 掳C
Flash Point 207 掳C Method: closed cup
Flammability N/A
Autoignition Temp 390 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 0.3 %
Vapor Pressure 1.2 mmHg 93 掳C
SG/Density 0.985 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density > 16 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
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Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: TI0350000
ACUTE TOXICITY
LD50
Oral
Rat
30000 mg/kg
LD50
Intraperitoneal
Rat
30700 MG/KG
LD50
Intravenous
Rat
250 MG/KG
Remarks: Lungs, Thorax, or Respiration:Other changes.
LD50
Oral
Mouse
1500 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Structural or functional change in
trachea or bronchi. Gastrointestinal:Necrotic changes.
LD50
Intraperitoneal
Mouse
14 GM/KG
Remarks: Vascular:BP lowering not charactertized in autonomic
section. Behavioral:Excitement.
LD50
Intravenous
Mouse
1060 MG/KG
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LD50
Oral
Rabbit
34000 mg/kg
LD50
Skin
Rabbit
25000 mg/kg
LD50
Oral
Guinea pig
26000 mg/kg
LD50
Skin
Guinea pig
10000 mg/kg
IRRITATION DATA
Skin
Rabbit
500 mg
24H
Remarks: Mild irritation effect
Eyes
Rabbit
500 mg
Remarks: Mild irritation effect
Eyes
Rabbit
500 mg
24H
Remarks: Mild irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause: Lung irritation. Gastrointestinal
disturbances.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Liver. G.I. System. Kidneys.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be possibly carcinogenic based on its IARC, ACGIH,
NTP, or EPA classification.
Rat
Route of Application: Oral
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Exposure Time: 2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Liver:Tumors. Endocrine:Tumors.
Mouse
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Liver:Tumors. Tumorigenic Effects: Testicular tumors.
Mouse
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
Mouse
Route of Application: Oral
Exposure Time: 24W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
Mouse
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
IARC CARCINOGEN LIST
Rating: Group 2B
CHRONIC EXPOSURE - MUTAGEN
Human
6 MG/L
Cell Type: leukocyte
Cytogenetic analysis
Human
50 UMOL/L
Cell Type: lymphocyte
Sister chromatid exchange
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Rat
500 UMOL/L
Cell Type: liver
Unscheduled DNA synthesis
Rat
670 MG/KG
Oral
Unscheduled DNA synthesis
Rat
1 PPH/60D-C
Oral
sperm
Mouse
40 MG/L (+S9)
Cell Type: lymphocyte
Mutation in microorganisms
Mouse
202 GM/KG
Oral
40W
Unscheduled DNA synthesis
Mouse
1 GM/KG
Oral
Other mutation test systems
Mouse
12780 MG/KG
Intraperitoneal
Dominant lethal test
Mouse
2970 MG/KG
Subcutaneous
10D
Dominant lethal test
Hamster
750 MG/KG
Oral
Morphological transformation.
Hamster
4 MG/L
Cell Type: Embryo
Morphological transformation.
Hamster
7500 MG/KG
Oral
Cytogenetic analysis
Hamster
25 MG/L
Cell Type: ovary
Sister chromatid exchange
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Hamster
50 MG/L
Cell Type: liver
SLN
CHRONIC EXPOSURE - TERATOGEN
Result: May cause congenital malformation in the fetus.
Species: Rat
Dose: 7140 MG/KG
Route of Application: Oral
Exposure Time: (1-21D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 10 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Other effects
to embryo. Specific Developmental Abnormalities: Hepatobiliary
system.
Species: Rat
Dose: 9766 MG/KG
Route of Application: Oral
Exposure Time: (12D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Cardiovascular
(circulatory) system. Specific Developmental Abnormalities:
Urogenital system.
Species: Rat
Dose: 5 GM/KG
Route of Application: Intraperitoneal
Exposure Time: (5-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Mouse
Dose: 50 MG/KG
Route of Application: Oral
Exposure Time: (7D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Mouse
Dose: 1 GM/KG
Route of Application: Oral
Exposure Time: (7D PREG)
Result: Effects on Embryo or Fetus: Fetal death. Specific
Developmental Abnormalities: Musculoskeletal system.
Species: Mouse
Dose: 2040 MG/KG
Route of Application: Oral
Exposure Time: (1-17D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Eye, ear. Specific
Developmental Abnormalities: Cardiovascular (circulatory) system.
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Species: Mouse
Dose: 12780 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1D MALE)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Mouse
Dose: 15 MG/KG
Route of Application: Intravenous
Exposure Time: (3-5D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: May cause reproductive disorders.
Species: Rat
Dose: 35 MG/KG
Route of Application: Oral
Exposure Time: (14D PRE)
Result: Maternal Effects: Ovaries, fallopian tubes.
Species: Rat
Dose: 6 GM/KG
Route of Application: Oral
Exposure Time: (3D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Paternal Effects: Prostate, seminal vessicle, Cowper's gland,
accessory glands.
Species: Rat
Dose: 17200 MG/KG
Route of Application: Oral
Exposure Time: (MULTIGENERATIONS)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rat
Dose: 137 ML/KG
Route of Application: Oral
Exposure Time: (1-22D PREG/21D POST)
Result: Effects on Newborn: Physical.
Species: Rat
Dose: 6 GM/KG
Route of Application: Intraperitoneal
Exposure Time: (3-9D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Rat
Dose: 10 GM/KG
Route of Application: Intraperitoneal
Exposure Time: (5-15D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Specific Developmental Abnormalities: Eye, ear. Specific
Developmental Abnormalities: Other developmental abnormalities.
Species: Rat
Dose: 1 GM/KG
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Route of Application: Intraperitoneal
Exposure Time: (10D MALE)
Result: Paternal Effects: Other effects on male.
Species: Rat
Dose: 6 GM/KG
Route of Application: Intraperitoneal
Exposure Time: (3-9D PREG)
Result: Maternal Effects: Parturition. Effects on Fertility:
Pre-implantation mortality (e.g., reduction in number of
implants per female; total number of implants per corpora lutea).
Species: Mouse
Dose: 78880 MG/KG
Route of Application: Oral
Exposure Time: (6-13D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth).
Species: Mouse
Dose: 4200 MG/KG
Route of Application: Oral
Exposure Time: (21D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Mouse
Dose: 2040 MG/KG
Route of Application: Oral
Exposure Time: (1-17D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Fertility: Litter size (e.g.; # fetuses per litter;
measured before birth). Effects on Embryo or Fetus: Fetal death.
Species: Mouse
Dose: 30 GM/KG
Route of Application: Intraperitoneal
Exposure Time: (5D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct.
Species: Mouse
Dose: 25560 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1D MALE)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Fertility: Litter size
(e.g.; # fetuses per litter; measured before birth).
Species: Mouse
Dose: 12780 UG/KG
Route of Application: Intraperitoneal
Exposure Time: (1D MALE)
Result: Effects on Fertility: Male fertility index (e.g., #
males impregnating females per # males exposed to fertile
nonpregnant females).
Species: Mouse
Dose: 24 GM/KG
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Route of Application: Intraperitoneal
Exposure Time: (7-9D PREG)
Result: Effects on Fertility: Abortion.
Species: Mouse
Dose: 2970 MG/KG
Route of Application: Subcutaneous
Exposure Time: (3D MALE)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Embryo or Fetus: Fetal
death.
Species: Mouse
Dose: 19722 MG/KG
Route of Application: Subcutaneous
Exposure Time: (3D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Effects on Fertility: Male fertility index (e.g., # males
impregnating females per # males exposed to fertile nonpregnant
females).
Species: Mouse
Dose: 1972 MG/KG
Route of Application: Subcutaneous
Exposure Time: (3D MALE)
Result: Paternal Effects: Other effects on male.
Species: Mouse
Dose: 9861 MG/KG
Route of Application: Subcutaneous
Exposure Time: (3D PRE)
Result: Maternal Effects: Other effects.
Species: Mouse
Dose: 50 MG/KG
Route of Application: Intravenous
Exposure Time: (1D PRE)
Result: Effects on Fertility: Female fertility index (e.g., #
females pregnant per # sperm positive females; # females
pregnant per # females mated ).
Species: Mouse
Dose: 350 MG/KG
Route of Application: Intravenous
Exposure Time: (7D MALE)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth).
Species: Mouse
Dose: 5 MG/KG
Route of Application: Intravenous
Exposure Time: (8D PREG)
Result: Effects on Fertility: Other measures of fertility
Species: Guinea pig
Dose: 20 GM/KG
Route of Application: Oral
Exposure Time: (10D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Mammal
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Dose: 20 GM/KG
Route of Application: Oral
Exposure Time: (10D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Mammal
Dose: 509 GM/KG
Route of Application: Oral
Exposure Time: (60W MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: > 0.67 mg/l
Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: > 0.32 mg/l
Test Type: LC50 Fish
Species: Cyprinodon variegatus (Sheepshead minnow)
Time: 96 h
Value: > 0.17 mg/l
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: > 0.2 mg/l
Test Type: LC50 Fish
Species: Daphnia magna
Time: 96 h
Value: > 0.16 mg/l
ADDITIONAL ECOLOGICAL INFORMATION
BOD5: 40 %
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
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15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 607-317-00-9
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 60 61
May impair fertility. May cause harm to the unborn child.
S-PHRASES: 53 45
Restricted to professional users. Attention - Avoid exposure -
obtain special instructions before use. In case of accident or
if you feel unwell, seek medical advice immediately (show the
label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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