SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 12/MAY/2005
Date Updated: 02/DEC/2004
Version 1.5
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name (卤)-PROPYLENE OXIDE, REAGENTPLUSTM,
>=99%
Product Number 240397
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
PROPYLENE OXIDE 75-56-9 200-879-2 603-055-00-4
Formula C3H6O
Molecular Weight 58.08 AMU
Synonyms AD 6 (suspending agent) * Epoxypropane *
1,2-Epoxypropane * 1,2-Epoxypropane (ACGIH:OSHA)
* 2,3-Epoxypropane * Ethylene oxide, methyl- *
Methyl ethylene oxide * Methyloxacyclopropane *
Methyl oxirane * NCI-C50099 * Oxirane, methyl- *
Oxyde de propylene (French) * Propane, epoxy- *
Propene oxide * Propylene epoxide * Propylene
oxide * 1,2-Propylene oxide * Propylene oxide
(DOT:OSHA)
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
May cause cancer. May cause heritable genetic damage. Extremely
flammable. Harmful by inhalation, in contact with skin and if
swallowed. Irritating to eyes, respiratory system and skin.
Carc. Cat.2 Muta. Cat.2
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
CONDITIONS OF FLAMMABILITY
Under fire conditions, material may decompose to form flammable
and/or explosive mixtures in air.
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Water may be effective for cooling, but may not
effect extinguishment.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Vapor may travel
considerable distance to source of ignition and flash back.
Emits toxic fumes under fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep container closed. Keep away from
heat, sparks, and open flame.
SPECIAL REQUIREMENTS: May develop pressure. Open carefully. Heat
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sensitive. Cool to 0掳C before opening.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Use only in a
chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 12 mg/m3
5 ppm
Remarks: HK
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 6 mg/m3
2.5 ppm
Remarks: 4
Remarks: H,TRK,TRGS 901-19
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 2 mg/m3
1 ppm
Remarks: HAK
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level5 mg/m3
2 ppm
Remarks: K
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 6 mg/m3
2.5 ppm
Remarks: K
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 12 mg/m3
5 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Clear liquid
Color: Colorless
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 34 - 35 掳C
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MP/MP Range -112 掳C
Flash Point -37 掳C Method: closed cup
Flammability N/A
Autoignition Temp 748 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 2.1 %
Upper: 37 %
Vapor Pressure 444.103 mmHg 20 掳C
SG/Density 0.829 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 2 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content < 0.1 %
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Heat.
Materials to Avoid: Oxidizing agents Copper, Copper alloys, Strong
acids, Strong bases, Peroxides, Alkali, Amines.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: May occur Product may explode if
polymerization is initiated in closed containers
11 - Toxicological Information
RTECS NUMBER: TZ2975000
ACUTE TOXICITY
LD50
Oral
Rat
380 mg/kg
Remarks: Behavioral:Excitement. Behavioral:Ataxia. Lungs,
Thorax, or Respiration:Respiratory stimulation.
LC50
Inhalation
Rat
4,000 ppm
4H
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Olfaction:Other changes. Sense Organs and Special Senses
(Nose, Eye, Ear, and Taste):Eye:Lacrimation. Lungs, Thorax, or
Respiration:Dyspnea.
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LD50
Intraperitoneal
Rat
150 MG/KG
LD50
Oral
Mouse
440 mg/kg
Remarks: Behavioral:Excitement. Behavioral:Ataxia. Lungs,
Thorax, or Respiration:Respiratory stimulation.
LC50
Inhalation
Mouse
1,740 ppm
4H
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Olfaction:Other changes. Lungs, Thorax, or
Respiration:Dyspnea. Gastrointestinal:Changes in structure or
function of salivary glands.
LD50
Intraperitoneal
Mouse
175 MG/KG
LD50
Skin
Rabbit
1500 UL/KG
LD50
Oral
Guinea pig
660 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Liver:Other changes. Kidney, Ureter, Bladder:Other changes.
LD50
Oral
Mammal
440 mg/kg
IRRITATION DATA
Skin
Rabbit
415 mg
Remarks: Open irritation test
Skin
Rabbit
50 mg
6M
Remarks: Severe irritation effect
Eyes
Rabbit
20 mg
Remarks: Severe irritation effect
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Eyes
Rabbit
20 mg
24H
Remarks: Moderate irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Can cause CNS depression.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: Harmful if absorbed through skin. Readily
absorbed through skin.
Eye Contact: Causes burns.
Inhalation: Harmful if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Central nervous system.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be probably carcinogenic based on its IARC, OSHA,
ACGIH, NTP, or EPA classification.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Gastrointestinal:Tumors.
Mouse
Route of Application: Inhalation
Exposure Time: 6H/2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs
and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors.
Rat
Route of Application: Inhalation
Exposure Time: 7H/2Y
Result: Tumorigenic:Neoplastic by RTECS criteria.
Endocrine:Tumors.
Rat
Route of Application: Subcutaneous
Exposure Time: 46W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Tumorigenic:Facilitates action of known carcinogens.
Mouse
Route of Application: Inhalation
Exposure Time: 6H/2Y
Result: Tumorigenic:Carcinogenic by RTECS criteria. Sense Organs
and Special Senses (Nose, Eye, Ear, and Taste):Olfaction:Tumors.
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Mouse
Route of Application: Subcutaneous
Exposure Time: 95W
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Blood:Lymphomas including Hodgkin's disease. Tumorigenic:Tumors
at site or application.
Mouse
Route of Application: Subcutaneous
Exposure Time: 91W
Result: Tumorigenic:Neoplastic by RTECS criteria.
Blood:Lymphomas including Hodgkin's disease. Tumorigenic:Tumors
at site or application.
Mouse
Route of Application: Subcutaneous
Exposure Time: 95W
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Blood:Lymphomas including Hodgkin's disease. Tumorigenic:Tumors
at site or application.
Mouse
Route of Application: Subcutaneous
Exposure Time: 95W
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Blood:Lymphomas including Hodgkin's disease. Tumorigenic:Tumors
at site or application.
Mouse
Route of Application: Subcutaneous
Exposure Time: 95W
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Blood:Lymphomas including Hodgkin's disease. Tumorigenic:Tumors
at site or application.
Rat
Route of Application: Oral
Exposure Time: 2Y
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Gastrointestinal:Tumors.
Rat
Route of Application: Inhalation
Exposure Time: 6H/2Y
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Olfaction:Tumors.
Rat
Route of Application: Inhalation
Exposure Time: 6H/2.3Y
Result: Tumorigenic:Neoplastic by RTECS criteria. Skin and
Appendages: Other: Tumors.
IARC CARCINOGEN LIST
Rating: Group 2B
CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.
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Human
1850 UG/L
Cell Type: lymphocyte
Cytogenetic analysis
Human
25000 PPM
Cell Type: lymphocyte
Sister chromatid exchange
Rat
30 UMOL/L
Cell Type: liver
DNA damage
Rat
25 UG/L
Cell Type: liver
Cytogenetic analysis
Rat
300 PPM
Inhalation
5D
Dominant lethal test
Mouse
600 MG/KG
Intraperitoneal
24H
Micronucleus test
Mouse
160 PPM
48H
Cell Type: lymphocyte
specific locus test
Mouse
200 MG/KG
Intraperitoneal
DNA damage
Mouse
349 MG/KG
Intraperitoneal
Cytogenetic analysis
Mouse
232 MG/KG
Intraperitoneal
Sister chromatid exchange
Mouse
400 UG/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
160 MG/L
Cell Type: ovary
Cytogenetic analysis
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Hamster
5 MG/L
Cell Type: ovary
Sister chromatid exchange
Hamster
2500 UMOL/L
Cell Type: lung
Sister chromatid exchange
Mammal
75 MMOL/L
Cell Type: lymphocyte
DNA damage
Mammal
100 MMOL/TUBE
Cell Type: lymphocyte
DNA
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 500 PPM/7H
Route of Application: Inhalation
Exposure Time: (7-16D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Rat
Dose: 500 PPM/7H
Route of Application: Inhalation
Exposure Time: (1-16D PREG)
Result: Specific Developmental Abnormalities: Craniofacial
(including nose and tongue).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 500 PPM/7H
Route of Application: Inhalation
Exposure Time: (15D PRE/1-16D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Fertility: Litter size
(e.g.; # fetuses per litter; measured before birth). Effects on
Fertility: Other measures of fertility
Species: Rat
Dose: 47 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Rat
Dose: 1860 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (6W MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
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material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct.
Species: Monkey
Dose: 100 PPM/7H
Route of Application: Inhalation
Exposure Time: (2Y MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
CMR CAT.: Carc. Cat.2
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1280
Class: 3
PG: I
Proper Shipping Name: Propylene oxide
IMDG
UN#: 1280
Class: 3
PG: I
Proper Shipping Name: Propylene oxide
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1280
Class: 3
PG: I
Proper Shipping Name: Propylene oxide
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 603-055-00-4
NOTA: E
INDICATION OF DANGER: F+ T
Extremely Flammable. Toxic.
R-PHRASES: 45 46 12 20/21/22 36/37/38
May cause cancer. May cause heritable genetic damage. Extremely
flammable. Harmful by inhalation, in contact with skin and if
swallowed. Irritating to eyes, respiratory system and skin.
S-PHRASES: 53 45
Restricted to professional users. Attention - Avoid exposure -
obtain special instructions before use. In case of accident or
if you feel unwell, seek medical advice immediately (show the
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label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2 (self-classification)
SWITZERLAND
SWISS POISON CLASS: 1*
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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