SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 02/AUG/2005
Date Updated: 13/JUL/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name DL-PROPRANOLOL HCL
Product Number P0884
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
PROPRANOLOL HYDROCHLORIDE 318-98-9 206-268-7 None
Formula C16H21NO2.ClH
Molecular Weight 295.81 AMU
Synonyms Anaprilin * DL-Anapriline * Avlocardyl * AY
64043 * Berkolol * beta-NEG * Caridorol *
Deralin * Dociton * Duranol * Frekven * ICI
45520 * Inderal * Inderal LA * Indobloc *
1-(Isopropylamino)-3-(alpha-naphthoxy)-2-propanol
hydrochloride *
1-(Isopropylamino)-3-(1-naphthyloxy)propan-2-ol
hydrochloride *
1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol
hydrochloride *
1-(1-Naphthyloxy)-2-hydroxy-3-isopropylaminopropa
ne hydrochloride * Naprilin * NSC-91523 *
Obsidan * Oposim * DL-Propranolol hydrochloride
* (R,S)-Propranolol hydrochloride *
(+-)-Propranolol hydrochloride * 2-Propanol,
1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-,
hydrochloride * Propraratiopharm * Pylapron *
Rapynogen * Tesnol
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at 2-8掳C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Mechanical exhaust required. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
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PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 163 - 165 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents, Strong acids.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: UB7525000
ACUTE TOXICITY
LDLO LDLO
Intravenous Oral
Woman Woman
64 mg/kg
40 UG/KG
Remarks: Cardiac:Arrythmias (including changes it conduction).
Lungs, Thorax, or Respiration:Acute pulmonary edema.
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Behavioral:General anesthetic. Behavioral:Coma. Cardiac:EKG
changes not diagnostic of above.
LDLO LD50
Oral Oral
Man Rat
34 mg/kg 466 mg/kg
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Cardiac:Pulse rate. Vascular:BP lowering not charactertized in
autonomic section.
LDLO LD50
Intravenous Intraperitoneal
Woman Rat
40 UG/KG 76 MG/KG
Remarks: Cardiac:Arrythmias (including changes it conduction).
Lungs, Thorax, or Respiration:Acute pulmonary edema.
Behavioral:Muscle weakness. Behavioral:Irritability. Lungs,
Thorax, or Respiration:Dyspnea.
LD50 LD50
Oral Subcutaneous
Rat Rat
466 mg/kg
115 MG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Mydriasis (pupilliary dilation).
Behavioral:Convulsions or effect on seizure threshold.
Nutritional and Gross Metabolic:Changes in:Body temperature
decrease.
LD50 LD50
Intraperitoneal Intravenous
Rat Rat
76 MG/KG 21 MG/KG
Remarks: Behavioral:Muscle weakness. Behavioral:Irritability.
Lungs, Thorax, or Respiration:Dyspnea. Sense Organs and Special
Senses (Nose, Eye, Ear, and Taste):Eye:Mydriasis (pupilliary
dilation). Behavioral:Convulsions or effect on seizure
threshold. Nutritional and Gross Metabolic:Changes in:Body
temperature decrease.
LD50 LD50
Subcutaneous Oral
Rat Mouse
320 mg/kg
115 MG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Mydriasis (pupilliary dilation).
Behavioral:Convulsions or effect on seizure threshold.
Nutritional and Gross Metabolic:Changes in:Body temperature
decrease.
LD50 LD50
Intravenous Intraperitoneal
Rat Mouse
21 MG/KG 80 MG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Mydriasis (pupilliary dilation).
Behavioral:Convulsions or effect on seizure threshold.
Nutritional and Gross Metabolic:Changes in:Body temperature
decrease.
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LD50 LD50
Oral Subcutaneous
Mouse Mouse
320 mg/kg
208 MG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Mydriasis (pupilliary dilation).
Behavioral:Convulsions or effect on seizure threshold.
Nutritional and Gross Metabolic:Changes in:Body temperature
decrease.
LD50 LD50
Intraperitoneal Intravenous
Mouse Mouse
80 MG/KG 18 MG/KG
LD50 LD50
Subcutaneous Oral
Mouse Rabbit
600 mg/kg
208 MG/KG
Remarks: Sense Organs and Special Senses (Nose, Eye, Ear, and
Taste):Eye:Mydriasis (pupilliary dilation).
Behavioral:Convulsions or effect on seizure threshold.
Nutritional and Gross Metabolic:Changes in:Body temperature
decrease.
LD50 LD50
Intravenous Intravenous
Mouse Rabbit
18 MG/KG 12500 UG/KG
LD50
Oral
Rabbit
600 mg/kg
LD50
Intravenous
Rabbit
12500 UG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Cardiovascular system.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 130 MG/KG
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Route of Application: Implant
Exposure Time: (7-19D PREG)
Result: Effects on Embryo or Fetus: Other effects to embryo.
Specific Developmental Abnormalities: Respiratory system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Woman Woman
Dose: 48 MG/KG 48 MG/KG
Route of Application: Oral Oral
Exposure Time: (25-34W PREG) (25-34W PREG)
Result: Effects on Newborn: Other neonatal measures or effects.
Effects on Newborn: Biochemical and metabolic. Effects on
Newborn: Other neonatal measures or effects. Effects on Newborn:
Biochemical and metabolic.
Species: Rat Rat
Dose: 150 MG/KG 150 MG/KG
Route of Application: Oral Oral
Exposure Time: (8-18D PREG) (8-18D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain). Effects on Newborn: Growth statistics (e.g.,
reduced weight gain).
Species: Rat Rat
Dose: 60 MG/KG 60 MG/KG
Route of Application: Oral Oral
Exposure Time: (18-22D PREG) (18-22D PREG)
Result: Effects on Newborn: Behavioral. Effects on Newborn:
Behavioral.
Species: Rabbit Rabbit
Dose: 10500 UG/KG 10500 UG/KG
Route of Application: Intravenous Intravenous
Exposure Time: (7D PRE) (7D PRE)
Result: Effects on Fertility: Mating performance (e.g., # sperm
positive females per # females mated; # copulations per # estrus
cycles). Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Fertility: Other
measures of fertility Effects on Fertility: Mating performance
(e.g., # sperm positive females per # females mated; #
copulations per # estrus cycles). Effects on Fertility:
Pre-implantation mortality (e.g., reduction in number of
implants per female; total number of implants per corpora
lutea). Effects on Fertility: Other measures of fertility
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
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RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22
Harmful if swallowed.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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