SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 12/MAY/2005
Date Updated: 13/MAR/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name PROPIONALDEHYDE, REAGENT GRADE, 97%
Product Number 538124
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
PROPIONALDEHYDE 123-38-6 204-623-0 605-018-00-8
Formula C3H6O
Molecular Weight 58.08 AMU
Synonyms Aldehyde propionique (French) *
Methylacetaldehyde * NCI-C61029 * Propaldehyde *
Propanal * Propionic aldehyde * Propyl aldehyde
* Propylic aldehyde
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. Irritating to eyes, respiratory system and skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam. Water spray.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions. Forms explosive mixtures in air.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Open carefully.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame. Store under nitrogen.
Store at 2-8掳C
SPECIAL REQUIREMENTS: May develop pressure. Open carefully.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
Special Protective Measures: Faceshield (8-inch minimum).
9 - Physical and Chemical Properties
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Appearance Color: Colorless
Form: Clear liquid
Odor: Stench.
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 47 - 49 掳C
MP/MP Range -81 掳C
Flash Point -27 掳C Method: closed cup
Flammability N/A
Autoignition Temp 207 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 2.6 %
Upper: 17 %
Vapor Pressure 258 mmHg 20 掳C
SG/Density 0.798 g/cm3
Partition Coefficient Log Kow: 0.59
Viscosity 0.47 Pas 10 掳C
Vapor Density 2 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension 23.4 mN/m 20 掳C
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Complete
10 - Stability and Reactivity
STABILITY
Stable: Normally stable; however, on long term storage, materials
containing similar functional groups form peroxides of unknown
stability.
Materials to Avoid: Oxidizing agents, Strong bases, Strong
reducing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: May occur
Hazardous Polymerization Reactions: Polymerizing initiators
11 - Toxicological Information
RTECS NUMBER: UE0350000
ACUTE TOXICITY
LD50
Oral
Rat
*
LD50
Oral
Mouse
*
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LC50
Inhalation
Rat
26,000 ppm
0.5 HR
LD50
Skin
Rabbit
5 ML/KG
LD50
Skin
Guinea pig
10 - 20 ML/KG
LD50
Oral
Rat
1410 mg/kg
LD50
Intraperitoneal
Rat
200 MG/KG
Remarks: Behavioral:General anesthetic. Behavioral:Muscle
weakness.
LD50
Subcutaneous
Rat
820 MG/KG
Remarks: Behavioral:General anesthetic. Behavioral:Convulsions
or effect on seizure threshold.
LC50
Inhalation
Mouse
21,800 mg/m3
2H
LD50
Intraperitoneal
Mouse
200 MG/KG
Remarks: Behavioral:General anesthetic. Behavioral:Somnolence
(general depressed activity). Lungs, Thorax, or
Respiration:Respiratory depression.
LD50
Subcutaneous
Mouse
680 MG/KG
Remarks: Behavioral:General anesthetic. Behavioral:Convulsions
or effect on seizure threshold.
LD50
Skin
Rabbit
2460 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Convulsions or effect on seizure threshold. Lungs,
Thorax, or Respiration:Dyspnea.
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LD50
Skin
Guinea pig
10 ML/KG
Remarks: Skin and Appendages:Skin: After systemic exposure:
Dermatitis, other
LD50
Oral
Mammal
1400 mg/kg
LC50
Inhalation
Mammal
21,800 mg/m3
IRRITATION DATA
Skin
Guinea pig
Remarks: Severe irritation effect
Eyes
Rabbit
Remarks: Severe irritation effect
Skin
Rabbit
500 mg
Remarks: Open irritation test
Eyes
Rabbit
41 mg
Remarks: Severe irritation effect
Eyes
Rabbit
20 mg
24H
Remarks: Moderate irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. Exposure can cause: Nausea, dizziness, and headache.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes burns.
Inhalation: May be harmful if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Liver.
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CHRONIC EXPOSURE - MUTAGEN
Rat
30 UMOL/L
Cell Type: liver
Unscheduled DNA synthesis
Hamster
10 MMOL/L
Cell Type: lung
Mutation in mammalian somatic cells.
Mammal
100 MMOL/L
Cell Type: lymphocyte
DNA damage
12 - Ecological Information
No data available.
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill)
Time: 96 h
Value: 130 mg/l
Test Type: LC50 Fish
Species: other fish
Time: 96 h
Value: 100 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 14 mg/l
ADDITIONAL ECOLOGICAL INFORMATION
BOD: 95 %
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1275
Class: 3
PG: II
Proper Shipping Name: Propionaldehyde
IMDG
UN#: 1275
Class: 3
PG: II
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Proper Shipping Name: Propionaldehyde
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1275
Class: 3
PG: II
Proper Shipping Name: Propionaldehyde
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 605-018-00-8
INDICATION OF DANGER: F Xi
Highly Flammable. Irritant.
R-PHRASES: 11 36/37/38
Highly flammable. Irritating to eyes, respiratory system and
skin.
S-PHRASES: 9 16 29
Keep container in a well-ventilated place. Keep away from
sources of ignition - no smoking. Do not empty into drains.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1 (self-classification)
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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