SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 12/MAY/2005
Date Updated: 26/MAY/2004
Version 1.5
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name PROPARGYL ALCOHOL, 99%
Product Number P50803
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
PROPARGYL ALCOHOL 107-19-7 203-471-2 603-078-00-X
Formula C3H4O
Molecular Weight 56.06 AMU
Synonyms Acetylene carbinol * Agrisynth PA *
Ethynylcarbinol * Methanol, ethynyl- * Propargyl
alcohol (ACGIH:OSHA) * 1-Propyne-3-ol *
2-Propynyl alcohol * RCRA waste number P102
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Flammable. Toxic by inhalation, in contact with skin and if
swallowed. Causes burns. Toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Water may be effective for cooling, but may not
effect extinguishment.
SPECIAL RISKS
Specific Hazard(s): Vapor may travel considerable distance to
source of ignition and flash back. Flammable liquid.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions. Forms explosive mixtures in air.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
SPECIFIC METHOD(S) OF FIRE FIGHTING
Use water spray to cool fire-exposed containers.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Absorb on sand or vermiculite and place in closed containers for
disposal. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame.
Store at 2-8掳C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath. Use
nonsparking tools.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
EXPOSURE LIMITS
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Country Source Type Value
Poland NDS 3 mg/m3
Poland NDSCh -
Poland NDSP
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 2.5 mg/m3
1 ppm
Remarks: H
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 5 mg/m3
2 ppm
Remarks: H
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 2.5 mg/m3
1 ppm
Remarks: H
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 2 mg/m3
1 ppm
Remarks: H
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 2.3 mg/m3
1 ppm
OEL STEL 7 mg/m3
3 ppm
Remarks: Skin
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Color: Very faintly yellow-green
Form: Clear liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 113 - 115 掳C
MP/MP Range -53 掳C
Flash Point 33 掳C Method: closed cup
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density 0.949 g/cm3
Partition Coefficient N/A
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Viscosity N/A
Vapor Density 1.93 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: Heat sensitive.
Conditions to Avoid: UV light
Materials to Avoid: Oxidizing agents, Strong acids, Strong bases,
Amines, Phosphorous pentoxide, Isocyanate vapor.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: May occur Product may explode if
polymerization is initiated in closed containers
11 - Toxicological Information
RTECS NUMBER: UK5075000
ACUTE TOXICITY
LD50
Oral
Rat
20 mg/kg
LC50
Inhalation
Rat
873 ppm
2H
LD50
Oral
Mouse
50 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Dyspnea. Blood: Hemorrhage.
LC50
Inhalation
Mouse
2,000 mg/m3
2H
Remarks: Behavioral:Somnolence (general depressed activity).
Behavioral:Excitement. Lungs, Thorax, or Respiration:Dyspnea.
LD50
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Skin
Rabbit
16 mg/kg
Remarks: Skin and Appendages:Skin: After systemic exposure:
Dermatitis, other
LD50
Oral
Guinea pig
60 mg/kg
LD50
Oral
Mammal
50 mg/kg
LC50
Inhalation
Mammal
3,000 mg/m3
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly
investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: May be fatal if absorbed through skin. Readily
absorbed through skin.
Eye Contact: Causes burns. Lachrymator.
Inhalation: May be fatal if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: May be fatal if swallowed.
TARGET ORGAN INFORMATION
Kidneys. Liver.
CHRONIC EXPOSURE - MUTAGEN
Hamster
400 UMOL/L
Cell Type: ovary
Cytogenetic analysis
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Burn in a chemical incinerator equipped with an afterburner and
scrubber but exert extra care in igniting as this material is
highly flammable. Observe all federal, state, and local
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environmental regulations.
14 - Transport Information
RID/ADR
UN#: 2929
Class: 6.1
PG: I
Proper Shipping Name: Toxic liquid, flammable,
organic, n.o.s.
IMDG
UN#: 2929
Class: 6.1
PG: I
Subrisk: 3
Proper Shipping Name: TOXIC LIQUID, FLAMMABLE,
ORGANIC, N.O.S.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2929
Class: 6.1
PG: I
Subrisk: 3
Proper Shipping Name: Toxic liquid, flammable,
organic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 603-078-00-X
INDICATION OF DANGER: T N
Toxic. Dangerous for the environment.
R-PHRASES: 10 23/24/25 34 51/53
Flammable. Toxic by inhalation, in contact with skin and if
swallowed. Causes burns. Toxic to aquatic organisms, may cause
long-term adverse effects in the aquatic environment.
S-PHRASES: 26 28 36 45 61
In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice. After contact with skin, wash
immediately with plenty of soap-suds. Wear suitable protective
clothing. In case of accident or if you feel unwell, seek
medical advice immediately (show the label where possible).
Avoid release to the environment. Refer to special
instructions/safety data sheets.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 3
NORWAY
Labelling for organic solvents where the package is 1liter or
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more.
YL-tall m3/l: 190000
YL-group: 5
Safety phrases: 38 42 210
In case of insufficient ventilation, wear suitable respiratory
equipment. During fumigation/spraying wear suitable respiratory
equipment. Use compressed air- or fresh air line breathing
apparatus in confined spaces.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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