SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 23/NOV/2005
Date Updated: 19/MAR/2004
Version 1.3
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name PROSTAGLANDIN E1
Product Number P5515
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ALPROSTADIL 745-65-3 212-017-2 None
Formula C20H34O5
Molecular Weight 354.49 AMU
Synonyms Alprostadil *
3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopenta
neheptanoic acid *
l-3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopen
taneheptanoic acid * PGE-1 * l-PGE1 *
Prostaglandin E1 * (-)-Protaglandin E1 *
l-Protaglandin E1 * Prost-13-en-1-oic acid,
11,15-dihydroxy-9-oxo-, (11-alpha,13E,15S)-
(9CI) *
3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopenta
neheptanoic acid * Prostaglandin E1,
(-)-Protaglandin E1, Alprostadil, l-PGE1,
l-Protaglandin E1, PGE-1 *
l-3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopen
taneheptanoic acid * Prost-13-en-1-oic acid,
11,15-dihydroxy-9-oxo-, (11-alpha,13E,15S)- (9CI)
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
Explosion Hazards: May form explosive mixtures with air
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at -20藲C
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
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Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
pH N/A
BP/BP Range N/A
MP/MP Range 113.0 - 116.0 藲C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solvent: 10 mg/ml acetone clear, colorless
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: Light. Heat. Moisture.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: GY4569800
ACUTE TOXICITY
LD50
Oral
Rat
228 mg/kg
LD50
Intraperitoneal
Rat
24900 UG/KG
LD50
Subcutaneous
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Rat
18600 UG/KG
LD50
Intravenous
Rat
19200 UG/KG
LD50
Intraarterial
Rat
21 MG/KG
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Lungs, Thorax, or Respiration:Dyspnea.
Gastrointestinal:Hypermotility, diarrhea.
LD50
Oral
Mouse
186 mg/kg
LD50
Intraperitoneal
Mouse
19800 UG/KG
LD50
Subcutaneous
Mouse
26400 UG/KG
LD50
Intravenous
Mouse
21 MG/KG
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Smooth muscle. Heart.
CHRONIC EXPOSURE - MUTAGEN
Rat
200 UG/KG
Subcutaneous
Other mutation test systems
Mouse
1 UMOL/L
Cell Type: Other cell types
DNA inhibition
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Mouse
100 NMOL/L
Cell Type: Other cell types
Other mutation test systems
Mouse
19 MG/L
Cell Type: Other cell types
Cytogenetic analysis
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 20 MG/KG
Route of Application: Subcutaneous
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Eye, ear. Specific
Developmental Abnormalities: Homeostasis
Species: Mouse
Dose: 5 MG/KG
Route of Application: Subcutaneous
Exposure Time: (16D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Woman
Dose: 64 UG/KG
Route of Application: Intravenous
Exposure Time: (20W PREG)
Result: Effects on Fertility: Abortion.
Species: Woman
Dose: 360 NG/KG
Route of Application: Intravenous
Exposure Time: (20W PREG)
Result: Maternal Effects: Uterus, cervix, vagina.
Species: Rat
Dose: 500 UG/KG
Route of Application: Intraperitoneal
Exposure Time: (7D POST)
Result: Maternal Effects: Postpartum.
Species: Rat
Dose: 2 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (2D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Rat
Dose: 10 MG/KG
Route of Application: Subcutaneous
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth). Effects on Embryo or Fetus:
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Fetotoxicity (except death, e.g., stunted fetus).
Species: Rat
Dose: 5 MG/KG
Route of Application: Subcutaneous
Exposure Time: (13D PREG)
Result: Effects on Fertility: Other measures of fertility
Effects on Fertility: Post-implantation mortality (e.g., dead
and/or resorbed implants per total number of implants). Maternal
Effects: Ovaries, fallopian tubes.
Species: Rat
Dose: 15 MG/KG
Route of Application: Subcutaneous
Exposure Time: (30D MALE)
Result: Paternal Effects: Prostate, seminal vessicle, Cowper's
gland, accessory glands. Paternal Effects: Spermatogenesis
(including genetic material, sperm morphology,motility, and
count). Paternal Effects: Testes, epididymis, sperm duct.
Species: Rat
Dose: 15 MG/KG
Route of Application: Subcutaneous
Exposure Time: (21D PREG)
Result: Effects on Newborn: Biochemical and metabolic.
Species: Rat
Dose: 9 MG/KG
Route of Application: Intravenous
Exposure Time: (90D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Paternal Effects: Prostate, seminal vessicle, Cowper's gland,
accessory glands.
Species: Mouse
Dose: 1 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (19D PREG)
Result: Maternal Effects: Parturition.
Species: Mouse
Dose: 45 MG/KG
Route of Application: Subcutaneous
Exposure Time: (15D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
Species: Mouse
Dose: 30 MG/KG
Route of Application: Subcutaneous
Exposure Time: (15D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Prostate, seminal vessicle, Cowper's gland, accessory
glands.
Species: Mouse
Dose: 10 MG/KG
Route of Application: Subcutaneous
Exposure Time: (16D PREG)
Result: Effects on Fertility: Abortion.
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Species: Rabbit
Dose: 2500 UG/KG
Route of Application: Subcutaneous
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rabbit
Dose: 2 MG/KG
Route of Application: Subcutaneous
Exposure Time: (2D PREG)
Result: Effects on Fertility: Other measures of fertility
Species: Guinea pig
Dose: 1200 UG/KG
Route of Application: Subcutaneous
Exposure Time: (23-24D PREG)
Result: Effects on Fertility: Abortion.
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 22
Harmful if swallowed.
S-PHRASES: 36
Wear suitable protective clothing.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
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from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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