SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 12/MAY/2005
Date Updated: 29/MAR/2004
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name PROGESTERONE, 98%
Product Number 850454
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
PROGESTERONE 57-83-0 200-350-6 None
Formula C21H30O2
Molecular Weight 314.47 AMU
Synonyms Agolutin * Bio-luton * Corlutin * Corlutina *
Corluvite * Corporin * Corpus luteum hormone *
delta(sup 4)-Pregnene-3,20-dione * Flavolutan *
Fologenon * Gesterol 100 * Gestone * Gestormone
* Glanducorpin * Gynlutin * Gynoluton *
Hormoflaveine * Hormoluton * Lingusorbs *
Lipo-lutin * Lucorteum Sol * Luteal hormone *
Luteinique * Luteodyn * Luteogan * Luteohormone
* Luteol * Luteosan * Luteostab * Luteovis *
Lutex * Lutidon * Lutocyclin * Lutocyclin M *
Lutocylin * Lutoform * Lutogyl * Lutren *
Lutromone * Nalutron * NSC-9704 * Percutacrine
Luteinique * Piaponon * Pregn-4-ene-3,20-dione
(9CI) * 4-Pregnene-3,20-dione * Primolut *
Progekan * Progestasert * Progesterol *
beta-Progesterone * Progesteronum * Progestin *
Progestone * Prolidon * Prolutone * Syngesterone
* Syngestrets * Synovex S * Syntolutan
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Limited evidence of a carcinogenic effect.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician immediately.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
ENVIRONMENTAL PRECAUTION(S)
Do not allow material to enter drains or water courses. Avoid
contaminating sewers and waterways with this material.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
SPECIAL REQUIREMENTS: Light sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
ALDRICH - 850454 www.sigma-aldrich.com Page 2
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 128 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Insoluble.
Solvent: Soluble.
Other Solvents: ALCOHOL, ACETONE, DIOXANE
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: Light sensitive.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: TW0175000
ACUTE TOXICITY
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LD50
Oral
Rat
5,000 mg/kg
LD50
Intraperitoneal
Rat
327 MG/KG
SENSITIZATION
Sensitization: Causes photosensitivity. Exposure to light can
result in allergic reactions resulting in dermatologic lesions,
which can vary from sunburnlike responses to edematous,
vesiculated lesions, or bullae
SIGNS AND SYMPTOMS OF EXPOSURE
Causes anabolic and androgenic effects. Exposure can cause liver
disturbances, jaundice, nausea, vomiting, chills, diarrhea,
abdominal fullness, excitation, insomnia, confusion, acne, blood
lipid changes, increased serum cholesterol, retention of sodium,
chloride, water, potassium, phosphates, calcium and nitrogen,
oedema, increased vascularity of the skin, and growth of the
bones. In women, exposure can result in the suppression of
ovarian activity and menstruation. Continued exposure can
produce hirsutism, hoarseness or deepening of the voice, and
atrophy of the breasts and endometrial tissue. In men, exposure
may suppress spermatogenesis. To the best of our knowledge, the
chemical, physical, and toxicological properties have not been
thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Female reproductive system. Male reproductive system. Central
nervous system. Liver.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be possibly carcinogenic based on its IARC, ACGIH,
NTP, or EPA classification.
Mouse
Route of Application: Subcutaneous
Result: Tumorigenic:Neoplastic by RTECS criteria. Skin and
Appendages: Other: Tumors.
Mouse
Route of Application: Parenteral
Exposure Time: 78W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Tumorigenic Effects: 0varian tumors. Tumorigenic
Effects: Uterine tumors
Mouse
Route of Application: Implant
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Exposure Time: 77W
Result: Tumorigenic:Neoplastic by RTECS criteria.
Tumorigenic:Increased incidence of tumors in susceptible strains.
Dog
Route of Application: Intramuscular
Exposure Time: 4Y
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Skin and Appendages: Other: Tumors.
Dog
Route of Application: Implant
Exposure Time: 78W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Liver:Tumors.
Mouse
Route of Application: Subcutaneous
Exposure Time: 19W
Result: Tumorigenic:Neoplastic by RTECS criteria. Skin and
Appendages: Other: Tumors.
Mouse
Route of Application: Subcutaneous
Exposure Time: 5W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Blood:Leukemia
Mouse
Route of Application: Implant
Exposure Time: 78W
Result: Tumorigenic:Neoplastic by RTECS criteria. Tumorigenic
Effects: 0varian tumors.
Mouse
Route of Application: Implant
Exposure Time: 77W
Result: Tumorigenic:Neoplastic by RTECS criteria.
Tumorigenic:Increased incidence of tumors in susceptible strains.
Mouse
Route of Application: Implant
Exposure Time: 77W
Result: Tumorigenic:Neoplastic by RTECS criteria.
Tumorigenic:Increased incidence of tumors in susceptible strains.
Mouse
Route of Application: Implant
Exposure Time: 77W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Tumorigenic:Increased incidence of tumors in
susceptible strains.
Mouse
Route of Application: Implant
Exposure Time: 77W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Tumorigenic:Increased incidence of tumors in
susceptible strains.
Mouse
Route of Application: Implant
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Exposure Time: 77W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Tumorigenic:Increased incidence of tumors in
susceptible strains.
IARC CARCINOGEN LIST
Rating: Group 2B Group 2B
CHRONIC EXPOSURE - MUTAGEN
Human
5 UMOL/L
Cell Type: lymphocyte
DNA inhibition
Human
100 UG/L
Cell Type: kidney
DNA inhibition
Human
100 UG/L
Cell Type: kidney
Cytogenetic analysis
Human
20 MG/L
Cell Type: lymphocyte
Sister chromatid exchange
Rat
100 MG/KG
Oral
Micronucleus test
Rat
2600 UG/L
Cell Type: Embryo
Morphological transformation.
Mouse
80 UG/L
Cell Type: fibroblast
Morphological transformation.
Mouse
1060 MG/KG
Oral
DNA damage
Mouse
200 MG/KG
Subcutaneous
Unscheduled DNA synthesis
Mouse
200 MG/KG
Subcutaneous
DNA inhibition
Mouse
1 MG/L
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Cell Type: Embryo
Cytogenetic analysis
Hamster
30 MG/L
Cell Type: Embryo
Morphological transformation.
Rabbit
100 UG/KG
Intravenous
DNA damage
Dog
100 UG/KG
Intraarterial
Cytogenetic analysis
CHRONIC EXPOSURE - TERATOGEN
Result: Laboratory experiments have shown teratogenic effects.
Species: Woman
Dose: 113 MG/KG
Route of Application: Oral
Exposure Time: (6-32W PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Species: Woman
Dose: 600 UG/KG
Route of Application: Parenteral
Exposure Time: (67-71D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Species: Woman
Dose: 386 MG/KG
Route of Application: Unreported
Exposure Time: (18-34W PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Species: Rat
Dose: 420 MG/KG
Route of Application: Subcutaneous
Exposure Time: (15-17D PREG)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Rat
Dose: 9 MG/KG
Route of Application: Subcutaneous
Exposure Time: (15-20D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Species: Rat
Dose: 4 MG/KG
Route of Application: Subcutaneous
Exposure Time: (9D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system.
Species: Rat
Dose: 30 MG/KG
Route of Application: Intramuscular
Exposure Time: (1-6D PREG)
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Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 35 MG/KG
Route of Application: Intramuscular
Exposure Time: (14-20D PREG)
Result: Effects on Embryo or Fetus: Extra embryonic structures
(e.g., placenta, umbilical cord).
Species: Rat
Dose: 36300 UG/KG
Route of Application: Parenteral
Exposure Time: (7-17D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Effects on Newborn: Biochemical and metabolic.
Species: Rat
Dose: 60 UG/KG
Route of Application: Parenteral
Exposure Time: (16-19D PREG)
Result: Specific Developmental Abnormalities: Blood and
lymphatic system (including spleen and marrow).
Species: Pig
Dose: 18333 UG/KG
Route of Application: Intramuscular
Exposure Time: (15-25D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Species: Guinea pig
Dose: 86 MG/KG
Route of Application: Subcutaneous
Exposure Time: (18-60D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: Overexposure may cause reproductive disorder(s) based on
tests with laboratory animals.
Species: Woman
Dose: 200 MG/KG
Route of Application: Oral
Exposure Time: (20D PRE)
Result: Maternal Effects: Uterus, cervix, vagina.
Species: Woman
Dose: 120 MG/KG
Route of Application: Oral
Exposure Time: (20D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Woman
Dose: 100 MG/KG
Route of Application: Oral
Exposure Time: (20D PRE)
Result: Maternal Effects: Uterus, cervix, vagina.
Species: Woman
Dose: 120 MG/KG
Route of Application: Oral
Exposure Time: (20D PRE)
ALDRICH - 850454 www.sigma-aldrich.com Page 8
Result: Maternal Effects: Menstrual cycle changes or disorders.
Effects on Fertility: Female fertility index (e.g., # females
pregnant per # sperm positive females; # females pregnant per #
females mated ). Effects on Fertility: Other measures of
fertility
Species: Man
Dose: 50 MG/KG
Route of Application: Intramuscular
Exposure Time: (70D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Breast development.
Species: Man
Dose: 15 MG/KG
Route of Application: Intramuscular
Exposure Time: (21D MALE)
Result: Paternal Effects: Impotence.
Species: Woman
Dose: 32 MG/KG
Route of Application: Parenteral
Exposure Time: (3W PRE)
Result: Maternal Effects: Menstrual cycle changes or disorders.
Species: Woman
Dose: 210 MG/KG
Route of Application: Intravaginal
Exposure Time: (3W PRE)
Result: Maternal Effects: Menstrual cycle changes or disorders.
Species: Woman
Dose: 475 UG/KG
Route of Application: Intravaginal
Exposure Time: (1Y PRE)
Result: Maternal Effects: Menstrual cycle changes or disorders.
Species: Rat
Dose: 25 MG/KG
Route of Application: Oral
Exposure Time: (1D PRE)
Result: Effects on Fertility: Mating performance (e.g., # sperm
positive females per # females mated; # copulations per # estrus
cycles).
Species: Rat
Dose: 180 MG/KG
Route of Application: Oral
Exposure Time: (9D MALE)
Result: Paternal Effects: Prostate, seminal vessicle, Cowper's
gland, accessory glands.
Species: Rat
Dose: 50 MG/KG
Route of Application: Oral
Exposure Time: (1D PRE)
Result: Effects on Fertility: Mating performance (e.g., # sperm
positive females per # females mated; # copulations per # estrus
cycles).
Species: Rat
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Dose: 700 MG/KG
Route of Application: Oral
Exposure Time: (14D PRE)
Result: Maternal Effects: Uterus, cervix, vagina.
Species: Rat
Dose: 240 MG/KG
Route of Application: Skin
Exposure Time: (30D MALE)
Result: Paternal Effects: Prostate, seminal vessicle, Cowper's
gland, accessory glands.
Species: Rat
Dose: 7 MG/KG
Route of Application: Subcutaneous
Exposure Time: (10-16D PREG)
Result: Effects on Fertility: Abortion.
Species: Rat
Dose: 188 MG/KG
Route of Application: Subcutaneous
Exposure Time: (30D PRE)
Result: Maternal Effects: Menstrual cycle changes or disorders.
Species: Rat
Dose: 1 MG/KG
Route of Application: Subcutaneous
Exposure Time: (9D PREG)
Result: Effects on Newborn: Behavioral.
Species: Rat
Dose: 500 UG/KG
Route of Application: Subcutaneous
Exposure Time: (2D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rat
Dose: 20 MG/KG
Route of Application: Subcutaneous
Exposure Time: (23D PREG)
Result: Maternal Effects: Parturition. Maternal Effects:
Postpartum. Effects on Newborn: Growth statistics (e.g., reduced
weight gain).
Species: Rat
Dose: 110 MG/KG
Route of Application: Intramuscular
Exposure Time: (1-22D PREG)
Result: Effects on Newborn: Delayed effects.
Species: Rat
Dose: 900 UG/KG
Route of Application: Intramuscular
Exposure Time: (6-14D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Rat
Dose: 200 MG/KG
Route of Application: Intramuscular
Exposure Time: (48D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
ALDRICH - 850454 www.sigma-aldrich.com Page 10
Paternal Effects: Prostate, seminal vessicle, Cowper's gland,
accessory glands. Paternal Effects: Other effects on male.
Species: Rat
Dose: 250 UG/KG
Route of Application: Intracerebral
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rat
Dose: 8750 UG/KG
Route of Application: Parenteral
Exposure Time: (7D PRE)
Result: Maternal Effects: Uterus, cervix, vagina.
Species: Rat
Dose: 250 UG/KG
Route of Application: Implant
Exposure Time: (2D POST)
Result: Maternal Effects: Postpartum.
Species: Rat
Dose: 30 MG/KG
Route of Application: Implant
Exposure Time: (24D PRE)
Result: Maternal Effects: Ovaries, fallopian tubes.
Species: Rat
Dose: 100 MG/KG
Route of Application: Unreported
Exposure Time: (20-24D PREG)
Result: Maternal Effects: Parturition.
Species: Mouse
Dose: 240 MG/KG
Route of Application: Subcutaneous
Exposure Time: (14-16D PREG)
Result: Effects on Newborn: Biochemical and metabolic. Effects
on Newborn: Delayed effects.
Species: Mouse
Dose: 100 MG/KG
Route of Application: Subcutaneous
Exposure Time: (1D PREG)
Result: Effects on Fertility: Other measures of fertility
Species: Mouse
Dose: 20 MG/KG
Route of Application: Subcutaneous
Exposure Time: (6-9D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g.,
stunted fetus).
Species: Mouse
Dose: 1500 UG/KG
Route of Application: Subcutaneous
Exposure Time: (3D PRE)
Result: Maternal Effects: Uterus, cervix, vagina.
Species: Mouse
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Dose: 2400 MG/KG
Route of Application: Subcutaneous
Exposure Time: (20D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Species: Mouse
Dose: 3 GM/KG
Route of Application: Implant
Exposure Time: (5D PRE)
Result: Maternal Effects: Uterus, cervix, vagina.
Species: Mouse
Dose: 10 MG/KG
Route of Application: Unreported
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Dog
Dose: 16 MG/KG
Route of Application: Subcutaneous
Exposure Time: (5D PRE)
Result: Maternal Effects: Uterus, cervix, vagina.
Species: Dog
Dose: 360 MG/KG
Route of Application: Implant
Exposure Time: (34W PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Dog
Dose: 600 MG/KG
Route of Application: Implant
Exposure Time: (60W PRE)
Result: Maternal Effects: Breasts, lactation (prior to or during
pregnancy).
Species: Monkey
Dose: 30 UG/KG/30M
Route of Application: Inhalation
Exposure Time: (60D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Testes, epididymis, sperm duct.
Species: Monkey
Dose: 4 UG/KG
Route of Application: Inhalation
Exposure Time: (10D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Monkey
Dose: 900 UG/KG
Route of Application: Subcutaneous
Exposure Time: (9D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Monkey
Dose: 12 MG/KG
Route of Application: Intramuscular
Exposure Time: (8D PRE)
Result: Effects on Fertility: Other measures of fertility
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Species: Monkey
Dose: 85410 UG/KG
Route of Application: Intravaginal
Exposure Time: (52W PRE)
Result: Maternal Effects: Uterus, cervix, vagina. Effects on
Fertility: Other measures of fertility
Species: Monkey
Dose: 17155 UG/KG
Route of Application: Intravaginal
Exposure Time: (52W PRE)
Result: Maternal Effects: Ovaries, fallopian tubes.
Species: Rabbit
Dose: 1 MG/KG
Route of Application: Oral
Exposure Time: (1D PRE/1D PREG)
Result: Effects on Fertility: Other measures of fertility
Species: Rabbit
Dose: 100 MG/KG
Route of Application: Oral
Exposure Time: (1D PRE)
Result: Effects on Fertility: Mating performance (e.g., # sperm
positive females per # females mated; # copulations per # estrus
cycles). Effects on Fertility: Other measures of fertility
Species: Rabbit
Dose: 500 UG/KG
Route of Application: Skin
Exposure Time: (1D PRE)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Rabbit
Dose: 1 MG/KG
Route of Application: Skin
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rabbit
Dose: 50 UG/KG
Route of Application: Subcutaneous
Exposure Time: (5D PRE)
Result: Maternal Effects: Uterus, cervix, vagina.
Species: Rabbit
Dose: 50 UG/KG
Route of Application: Subcutaneous
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Rabbit
Dose: 70 MG/KG
Route of Application: Subcutaneous
Exposure Time: (14D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Other effects on male.
Species: Rabbit
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Dose: 300 UG/KG
Route of Application: Subcutaneous
Exposure Time: (2D PRE/1D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Rabbit
Dose: 100 UG/KG
Route of Application: Subcutaneous
Exposure Time: (1D PRE)
Result: Maternal Effects: Ovaries, fallopian tubes.
Species: Rabbit
Dose: 150 UG/KG
Route of Application: Subcutaneous
Exposure Time: (1D PRE)
Result: Effects on Fertility: Mating performance (e.g., # sperm
positive females per # females mated; # copulations per # estrus
cycles).
Species: Rabbit
Dose: 8 MG/KG
Route of Application: Intramuscular
Exposure Time: (2-9D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
Species: Rabbit
Dose: 8 MG/KG
Route of Application: Intramuscular
Exposure Time: (25-32D PREG)
Result: Maternal Effects: Postpartum.
Species: Rabbit
Dose: 2500 MG/KG
Route of Application: Intramuscular
Exposure Time: (2D PRE)
Result: Effects on Fertility: Female fertility index (e.g., #
females pregnant per # sperm positive females; # females
pregnant per # females mated ). Effects on Fertility:
Pre-implantation mortality (e.g., reduction in number of
implants per female; total number of implants per corpora
lutea). Specific Developmental Abnormalities: Other
developmental abnormalities.
Species: Rabbit
Dose: 120 UG/KG
Route of Application: Unreported
Exposure Time: (6-29D PREG)
Result: Effects on Newborn: Weaning or lactation index (e.g., #
alive at weaning per # alive at day 4).
Species: Rabbit
Dose: 684 UG/KG
Route of Application: Intrauterine
Exposure Time: (14D PRE/1-10D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
reduction in number of implants per female; total number of
implants per corpora lutea).
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Species: Rabbit
Dose: 105 UG/KG
Route of Application: Intrauterine
Exposure Time: (21D PRE)
Result: Effects on Fertility: Female fertility index (e.g., #
females pregnant per # sperm positive females; # females
pregnant per # females mated ).
Species: Rabbit
Dose: 260 UG/KG
Route of Application: Intrauterine
Exposure Time: (21D PRE/1-31D PREG)
Result: Effects on Fertility: Post-implantation mortality (e.g.,
dead and/or resorbed implants per total number of implants).
Species: Pig
Dose: 2250 UG/KG
Route of Application: Subcutaneous
Exposure Time: (1-5D PREG)
Result: Effects on Fertility: Other measures of fertility
Species: Pig
Dose: 40 MG/KG
Route of Application: Subcutaneous
Exposure Time: (16D PRE)
Result: Maternal Effects: Ovaries, fallopian tubes.
Species: Pig
Dose: 1667 UG/KG
Route of Application: Subcutaneous
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Pig
Dose: 5833 UG/KG
Route of Application: Parenteral
Exposure Time: (14D PRE)
Result: Maternal Effects: Menstrual cycle changes or disorders.
Species: Guinea pig
Dose: 1480 MG/KG
Route of Application: Intramuscular
Exposure Time: (70D MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Effects on Fertility: Mating performance (e.g., # sperm positive
females per # females mated; # copulations per # estrus cycles).
Species: Hamster
Dose: 240 UG/KG
Route of Application: Subcutaneous
Exposure Time: (1D PRE)
Result: Effects on Fertility: Other measures of fertility
Species: Hamster
Dose: 2 MG/KG
Route of Application: Subcutaneous
Exposure Time: (1D PRE)
Result: Maternal Effects: Uterus, cervix, vagina.
Species: Hamster
Dose: 80 MG/KG
Route of Application: Subcutaneous
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Exposure Time: (1D PREG)
Result: Maternal Effects: Parturition. Effects on Newborn: Live
birth index (# fetuses per litter; measured after birth).
Species: Hamster
Dose: 32 MG/KG
Route of Application: Subcutaneous
Exposure Time: (1D PRE)
Result: Effects on Fertility: Female fertility index (e.g., #
females pregnant per # sperm positive females; # females
pregnant per # females mated ).
Species: Hamster
Dose: 2400 UG/KG
Route of Application: Parenteral
Exposure Time: (3D PRE)
Result: Effects on Fertility: Mating performance (e.g., # sperm
positive females per # females mated; # copulations per # estrus
cycles).
Species: Cattle, Horse
Dose: 3 MG/KG
Route of Application: Subcutaneous
Exposure Time: (30D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count). Paternal
Effects: Other effects on male.
Species: Domestic Animals
Dose: 1273 UG/KG
Route of Application: Subcutaneous
Exposure Time: (14D PRE)
Result: Maternal Effects: Menstrual cycle changes or disorders.
Effects on Fertility: Other measures of fertility
Species: Domestic Animals
Dose: 2545 UG/KG
Route of Application: Intramuscular
Exposure Time: (7D PRE)
Result: Maternal Effects: Menstrual cycle changes or disorders.
Effects on Fertility: Female fertility index (e.g., # females
pregnant per # sperm positive females; # females pregnant per #
females mated ).
Species: Cattle, Horse
Dose: 1700 UG/KG
Route of Application: Intramuscular
Exposure Time: (39-41W PREG)
Result: Maternal Effects: Parturition.
Species: Horse, donkey
Dose: 16667 UG/KG
Route of Application: Parenteral
Exposure Time: (45-47W PREG)
Result: Maternal Effects: Parturition.
12 - Ecological Information
No data available.
13 - Disposal Considerations
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SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 40
Limited evidence of a carcinogenic effect.
S-PHRASES: 36/37
Wear suitable protective clothing and gloves.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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