SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 09/JUN/2005
Date Updated: 07/APR/2004
Version 2.0
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name 2-PROPANOL, REAGENTPLUSTM, >=99%
Product Number 320471
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
2-PROPANOL 67-63-0 200-661-7 603-117-00-0
Formula C3H8O
Molecular Weight 60.1 AMU
Synonyms Alcool isopropilico (Italian) * Alcool
isopropylique (French) * Alcojel * Alcosolve *
Avantin * Avantine * Combi-schutz *
Dimethylcarbinol * Hartosol * 2-Hydroxypropane *
Imsol A * Isohol * Isopropanol * Isopropyl
alcohol (ACGIH:OSHA) * Iso-propylalkohol
(German) * IPS 1 (alcohol) * Lutosol *
1-Methylethanol * 1-Methylethyl alcohol *
Petrohol * PRO * 2-Propanol * i-Propanol
(German) * n-Propan-2-ol * sec-Propyl alcohol *
2-Propyl alcohol * i-Propylalkohol (German) *
Spectrar * Sterisol hand disinfectant *
Takineocol * Virahol * isopropanol
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. Irritating to eyes. Vapors may cause drowsiness
and dizziness.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
SPECIFIC METHOD(S) OF FIRE FIGHTING
Use water spray to cool fire-exposed containers.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat,
sparks, and open flame. Store in a cool dry place. Handle and
store under nitrogen.
SPECIAL REQUIREMENTS: Handle and store under inert gas.
Hygroscopic.
8 - Exposure Controls / Personal Protection
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ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
GENERAL HYGIENE MEASURES
Remove and wash contaminated clothing promptly. Wash thoroughly
after handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 900 MG/M3
Poland NDSCh 1200 MG/M3
Poland NDSP -
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 490 mg/m3
200 ppm
Remarks: H
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 500 mg/m3
Remarks: 4
Remarks: Y
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 245 mg/m3
100 ppm
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level350 mg/m3
150 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 490 mg/m3
200 ppm
Remarks: C M
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 999 mg/m3
40 ppm
OEL STEL 1,250 mg/m3
500 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Color: Colorless
Property Value At Temperature or Pressure
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pH N/A
BP/BP Range 81 - 83 掳C
MP/MP Range -89.5 掳C
Flash Point 12 掳C Method: closed cup
Flammability N/A
Autoignition Temp 399 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 2.5 %
Upper: 12 %
Vapor Pressure 33 mmHg 20 掳C
SG/Density 0.785 g/cm3
Partition Coefficient Log Kow: 0.05
Viscosity 0.003 Pas 20 掳C
Vapor Density 2.1 g/l
Saturated Vapor Conc. N/A
Evaporation Rate 3
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content 0.003 %
Surface Tension 20,800 mN/m 25 掳C
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Complete
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May form peroxides of unknown stability.
Materials to Avoid: Oxidizing agents, Acids, Acid anhydrides,
Halogens, Aluminum.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: NT8050000
ACUTE TOXICITY
LDLO
Oral
Man
5272 mg/kg
Remarks: Behavioral:Coma. Vascular:BP lowering not
charactertized in autonomic section. Lungs, Thorax, or
Respiration:Chronic pulmonary edema.
LDLO
Oral
Human
3570 mg/kg
Remarks: Behavioral:Coma. Lungs, Thorax, or
Respiration:Respiratory depression. Gastrointestinal:Nausea or
vomiting.
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LD50
Oral
Rat
5045 mg/kg
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Somnolence (general depressed
activity).
LC50
Inhalation
Rat
16,000 ppm
8H
LD50
Intraperitoneal
Rat
2735 MG/KG
LD50
Intravenous
Rat
1088 MG/KG
LD50
Oral
Mouse
3600 mg/kg
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Somnolence (general depressed
activity).
LD50
Intraperitoneal
Mouse
4477 MG/KG
LD50
Intravenous
Mouse
1509 MG/KG
LD50
Oral
Rabbit
6410 mg/kg
LD50
Skin
Rabbit
12800 mg/kg
LD50
Intraperitoneal
Rabbit
667 MG/KG
LD50
Intravenous
Rabbit
1184 MG/KG
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LD50
Intraperitoneal
Guinea pig
2560 MG/KG
LD50
Intraperitoneal
Hamster
3444 MG/KG
IRRITATION DATA
Skin
Rabbit
500 mg
Remarks: Mild irritation effect
Eyes
Rabbit
100 mg
Remarks: Severe irritation effect
Eyes
Rabbit
10 mg
Remarks: Moderate irritation effect
Eyes
Rabbit
100 mg
24H
Remarks: Moderate irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Can cause CNS depression. Prolonged exposure can cause: Nausea,
headache, and vomiting. Narcotic effect. Drowsiness. To the best
of our knowledge, the chemical, physical, and toxicological
properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Nerves. Kidneys. Cardiovascular system. G.I. System.
Overexposure may cause mild, reversible liver effects.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
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Rat
1030 UG/M3/16W-I
Inhalation
Cytogenetic analysis
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 8 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 32400 UG/KG
Route of Application: Oral
Exposure Time: (26W PRE)
Result: Effects on Embryo or Fetus: Fetal death.
Species: Rat
Dose: 3500 PPM/7H
Route of Application: Inhalation
Exposure Time: (1-19D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rat
Dose: 7000 PPM/7H
Route of Application: Inhalation
Exposure Time: (1-19D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system.
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 11340 MG/KG
Route of Application: Oral
Exposure Time: (45D PRE)
Result: Maternal Effects: Menstrual cycle changes or disorders.
Species: Rat
Dose: 5040 MG/KG
Route of Application: Oral
Exposure Time: (1-20D PREG)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth).
Species: Rat
Dose: 3500 GM/KG
Route of Application: Oral
Exposure Time: (MULTIGENERATION)
Result: Effects on Fertility: Mating performance (e.g., # sperm
positive females per # females mated; # copulations per # estrus
cycles).
Species: Rat
Dose: 10000 PPM/7H
Route of Application: Inhalation
Exposure Time: (1-19D PREG)
Result: Effects on Fertility: Pre-implantation mortality (e.g.,
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reduction in number of implants per female; total number of
implants per corpora lutea). Effects on Fertility:
Post-implantation mortality (e.g., dead and/or resorbed implants
per total number of implants). Effects on Embryo or Fetus: Fetal
death.
Species: Rabbit
Dose: 6240 MG/KG
Route of Application: Oral
Exposure Time: (6-18D PREG)
Result: Maternal Effects: Other effects.
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 9,640 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 5,102 mg/l
Test Type: EC50 Algae
Species: Scenedesmus subspicatus
Time: 72 h
Value: > 2,000 mg/l
Test Type: EC50 Algae
Time: 24 h
Value: > 1,000 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1219
Class: 3
PG: II
Proper Shipping Name: Isopropanol
IMDG
UN#: 1219
Class: 3
PG: II
Proper Shipping Name: Isopropanol
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1219
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Class: 3
PG: II
Proper Shipping Name: Isopropanol
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 603-117-00-0
NOTA: C
INDICATION OF DANGER: F Xi
Highly Flammable. Irritant.
R-PHRASES: 11 36 67
Highly flammable. Irritating to eyes. Vapors may cause
drowsiness and dizziness.
S-PHRASES: 7 16 24/25 26
Keep container tightly closed. Keep away from sources of
ignition - no smoking. Avoid contact with skin and eyes. In
case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: FREI
NORWAY
Labelling for organic solvents where the package is 1liter or
more.
YL-tall m3/l: 4514
YL-group: 5
Risk phrases: 20
Harmful by inhalation.
Safety phrases: 38 42 210
In case of insufficient ventilation, wear suitable respiratory
equipment. During fumigation/spraying wear suitable respiratory
equipment. Use compressed air- or fresh air line breathing
apparatus in confined spaces.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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