SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 09/JUN/2005
Date Updated: 13/MAR/2004
Version 1.4
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ISOPROPYLAMINE, 99.5+%
Product Number 471291
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ISO-PROPYLAMINE ANHYDROUS 75-31-0 200-860-9 612-007-00-1
Formula C3H9N
Molecular Weight 59.11 AMU
Synonyms 2-Amino-propaan (Dutch) * 2-Aminopropan (German)
* 2-Aminopropane * 2-Amino-propano (Italian) *
Isopropilamina (Italian) * Isopropylamine
(ACGIH:OSHA) * 1-Methylethylamine *
Monoisopropylamine * 2-Propanamine * Propane,
2-amino- * sec-Propylamine * 2-Propylamine
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Extremely flammable. Irritating to eyes, respiratory system and
skin.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Extremely flammable. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions. Forms explosive mixtures in air.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition. Use nonsparking
tools.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep container closed. Keep away from
heat, sparks, and open flame.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
GENERAL HYGIENE MEASURES
Remove and wash contaminated clothing promptly. Wash thoroughly
after handling.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 12 MG/M3
Poland NDSCh 24 MG/M3
Poland NDSP -
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EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 12 mg/m3
5 ppm
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 12 mg/m3
5 ppm
Remarks: 4
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 12 mg/m3
5 ppm
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level12 mg/m3
5 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 12 mg/m3
5 ppm
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH 13 20 掳C Concentration: 700
g/l
BP/BP Range 33 - 34 掳C 760 mmHg
MP/MP Range -101 掳C
Flash Point -18 掳C Method: closed cup
Flammability N/A
Autoignition Temp 402 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 2 %
Upper: 10.4 %
Vapor Pressure 475.64 mmHg 20 掳C
SG/Density 0.694 g/cm3
Partition Coefficient Log Kow: -0.03
Viscosity 0.36 Pas 20 掳C
Vapor Density 2.04 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
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Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
Other Solvents: MISCIBLE IN ETHANOL, ETHER
VERY SOLUBLE IN ACETONE
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide,
and nitrogen oxides.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: NT8400000
ACUTE TOXICITY
LD50
Oral
Rat
550 mg/kg
LC50
Inhalation
Rat
9,800 mg/m3
4H
LD50
Skin
Rat
> 400 mg/kg
LD50
Oral
Rat
111 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Dyspnea. Gastrointestinal:Other
changes.
LC50
Inhalation
Rat
4,000 ppm
4H
LD50
Oral
Mouse
2200 mg/kg
LD50
Oral
Rabbit
3200 mg/kg
Remarks: Gastrointestinal:Hypermotility, diarrhea. Skin and
Appendages: Other: Hair. Nutritional and Gross Metabolic:Changes
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in:Body temperature decrease.
LD50
Skin
Rabbit
380 mg/kg
LD50
Oral
Guinea pig
2700 mg/kg
LC50
Inhalation
Mammal
1,800 mg/m3
IRRITATION DATA
Skin
Rabbit
Remarks: Severe irritation effect
Skin
Rabbit
345 mg
Remarks: Open irritation test
Skin
Rabbit
10 mg
24H
Remarks: Open irritation test
Eyes
Rabbit
0.1 ml
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting. To the best of our knowledge, the chemical, physical,
and toxicological properties have not been thoroughly
investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: Harmful if absorbed through skin. Readily
absorbed through skin.
Eye Contact: Causes burns.
Inhalation: Harmful if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: Harmful if swallowed.
12 - Ecological Information
ELIMINATION
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Elimination: 70 - 80 %
ECOTOXICOLOGICAL EFFECTS
Test Type: LC50 Bacteria
Time: 17 h
Value: 99 mg/l
Test Type: EC50 Algae
Time: 72 h
Value: 4.13 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 47.4 mg/l
Test Type: LC50 Fish
Species: Salmon
Time: 96 h
Value: 40 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1221
Class: 3
PG: I
Proper Shipping Name: Isopropylamine
IMDG
UN#: 1221
Class: 3
PG: I
Subrisk: 8
Proper Shipping Name: Isopropylamine
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1221
Class: 3
PG: I
Subrisk: 8
Proper Shipping Name: Isopropylamine
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 612-007-00-1
INDICATION OF DANGER: F+ Xi
Extremely Flammable. Irritant.
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R-PHRASES: 12 36/37/38
Extremely flammable. Irritating to eyes, respiratory system and
skin.
S-PHRASES: 16 26 29
Keep away from sources of ignition - no smoking. In case of
contact with eyes, rinse immediately with plenty of water and
seek medical advice. Do not empty into drains.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2 (self-classification)
SWITZERLAND
SWISS POISON CLASS: 3
NORWAY
Labelling for organic solvents where the package is 1liter or
more.
YL-tall m3/l: 115000
YL-group: 5
Risk phrases: 20
Harmful by inhalation.
Safety phrases: 38 42 210
In case of insufficient ventilation, wear suitable respiratory
equipment. During fumigation/spraying wear suitable respiratory
equipment. Use compressed air- or fresh air line breathing
apparatus in confined spaces.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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