SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 08/JUN/2005
Date Updated: 04/APR/2005
Version 1.5
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name ISOAMYL NITRITE, 96%
Product Number 150495
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
ISO-AMYL NITRITE 110-46-3 203-770-8 007-020-00-9
Formula C5H11NO2
Molecular Weight 117.15 AMU
Synonyms Amyl nitrite * Aspiral * Isoamyl nitrite *
Isopentyl nitrite * 3-Methylbutanol nitrite *
3-Methylbutyl nitrite * Nitramyl * Nitrous acid,
3-methylbutyl ester * Vaporole
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. Harmful by inhalation and if swallowed.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
SPECIAL RISKS
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion can occur
under fire conditions. In advanced or massive fires the area
should be evacuated and the fire should be fought from a remote
explosion-resistant location.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep container closed. Keep away from
heat, sparks, and open flame.
Store at 2-8掳C
SPECIAL REQUIREMENTS: Air, light, and moisture sensitive. Handle
and store under inert gas.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
PERSONAL PROTECTIVE EQUIPMENT
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Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Color: Deep yellow-green
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 95 - 100 掳C
MP/MP Range N/A
Flash Point -20 掳C Method: closed cup
Flammability N/A
Autoignition Temp 210 掳C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density 0.876 g/cm3
Partition Coefficient N/A
Viscosity N/A
Vapor Density 4 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions of Instability: May decompose on exposure to light.
Conditions to Avoid: Air, light, and moisture sensitive.
Materials to Avoid: Oxidizing agents, Alcohols.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Nitrites.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: NT0187500
ACUTE TOXICITY
LD50
Oral
Rat
505 mg/kg
Remarks: Behavioral:General anesthetic.
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LC50
Inhalation
Rat
716 ppm
4H
Remarks: Behavioral:Altered sleep time (including change in
righting reflex). Behavioral:Excitement. Lungs, Thorax, or
Respiration:Cyanosis.
LC50
Inhalation
Mouse
1,430 ppm
30M
Remarks: Behavioral:Change in motor activity (specific assay).
LD50
Intraperitoneal
Mouse
130 MG/KG
LD50
Intravenous
Mouse
51 MG/KG
SENSITIZATION
Skin: May cause allergic skin reaction.
SIGNS AND SYMPTOMS OF EXPOSURE
Inhalation of vapors may cause a sharp decrease in blood
pressure with resulting loss of consciousness. Absorption into
the body leads to the formation of methemoglobin which in
sufficient concentration causes cyanosis. Onset may be delayed 2
to 4 hours or longer. To the best of our knowledge, the
chemical, physical, and toxicological properties have not been
thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Harmful if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract.
Ingestion: Harmful if swallowed.
TARGET ORGAN INFORMATION
Blood. Smooth muscle.
CHRONIC EXPOSURE - MUTAGEN
Mouse
3740 NMOL/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
160 MG/L
Cell Type: ovary
Cytogenetic analysis
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Hamster
16 MG/L
Cell Type: ovary
Sister chromatid exchange
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1113
Class: 3
PG: II
Proper Shipping Name: Amyl nitrite
IMDG
UN#: 1113
Class: 3
PG: II
Proper Shipping Name: Amyl nitrite
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1113
Class: 3
PG: II
Proper Shipping Name: Amyl nitrite
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 007-020-00-9
INDICATION OF DANGER: F Xn
Highly Flammable. Harmful.
R-PHRASES: 11 20/22
Highly flammable. Harmful by inhalation and if swallowed.
S-PHRASES: 16 24 46
Keep away from sources of ignition - no smoking. Avoid contact
with skin. If swallowed, seek medical advice immediately and
show this container or label.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2 (self-classification)
SWITZERLAND
SWISS POISON CLASS: 2
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16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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