SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 12/MAY/2005
Date Updated: 13/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name PROCAINE HYDROCHLORIDE
Product Number P9879
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
PROCAINE HCL 51-05-8 200-077-2 None
Formula C13H20N2O2.ClH
Molecular Weight 272.78 AMU
Synonyms Allocaine * p-Aminobenzoic acid
2-diethylaminoethyl ester hydrochloride *
4-Aminobenzoic acid 2-(diethylamino)ethyl ester
hydrochloride *
p-Aminobenzoyldiethylaminoethanol hydrochloride
* Aminocaine * Anadolor * Anesthesol * Anestil *
Atoxicocaine * Benzoic acid, 4-amino-,
2-(diethylamino)ethyl ester, monohydrochloride *
Bernocaine * Cetain * Chlorocaine *
Diethylaminoethanol 4-aminobenzoate
hydrochloride * 2-Diethylaminoethyl
p-aminobenzoate hydrochloride * Ethocaine *
Eugerase * Irocaine * Isocaine-asid *
Isocaine-heisler * Jenacain * Juvocaine *
Lactocaine * Naucaine * Neocaine *
Novocain-chlorhydrat (German) * Novocaine
hydrochloride * Novocain hydrochlorid (German) *
Paracain * Planocaine * Procaine hydrochloride *
Scurocaine * Sevicaine * Syncaine * Topokain *
Westocaine
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic if swallowed. May cause sensitization by skin contact.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide. Dry chemical powder. Water spray.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing. Avoid prolonged or repeated exposure.
STORAGE
Conditions of Storage: Keep tightly closed. Store in a cool dry
place.
SPECIAL REQUIREMENTS: Air and light sensitive.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Use only in a chemical fume hood. Safety shower and eye bath.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
PERSONAL PROTECTIVE EQUIPMENT
Special Protective Measures: Wear appropriate government approved
respirator, chemical-resistant gloves, safety goggles, other
protective clothing.
9 - Physical and Chemical Properties
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Appearance Color: White
Form: Crystals
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 154 掳C
Flash Point N/A
Flammability N/A
Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Conditions of Instability: Light sensitive.
Conditions to Avoid: Air sensitive.
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide,
and nitrogen oxides, Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: DG2275000
ACUTE TOXICITY
LD50
Oral
Rat
200 mg/kg
LD50
Intraperitoneal
Rat
160 MG/KG
LD50
Subcutaneous
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Rat
597 MG/KG
LD50
Intravenous
Rat
38 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Muscle contraction or spasticity. Lungs, Thorax, or
Respiration:Other changes.
LD50
Oral
Mouse
175 mg/kg
LD50
Intraperitoneal
Mouse
165 MG/KG
LD50
Subcutaneous
Mouse
339 MG/KG
LD50
Intravenous
Mouse
33 MG/KG
LD50
Intramuscular
Mouse
500 MG/KG
LD50
Intracerebral
Mouse
33 MG/KG
LD50
Parenteral
Mouse
192 MG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Excitement. Lungs, Thorax, or Respiration:Dyspnea.
LD50
Intravenous
Dog
63 MG/KG
Remarks: Cardiac:Other changes. Vascular:BP lowering not
charactertized in autonomic section. Lungs, Thorax, or
Respiration:Respiratory depression.
LD50
Subcutaneous
Rabbit
687 MG/KG
LD50
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Intravenous
Rabbit
43 MG/KG
LD50
Intracerebral
Rabbit
4800 UG/KG
Remarks: Behavioral:Convulsions or effect on seizure threshold.
Behavioral:Ataxia. Lungs, Thorax, or Respiration:Dyspnea.
LD50
Subcutaneous
Guinea pig
407 MG/KG
LD50
Intravenous
Guinea pig
51 MG/KG
LD50
Subcutaneous
Mammal
630 MG/KG
SENSITIZATION
Skin: May cause allergic skin reaction.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract. May be harmful if inhaled.
Ingestion: Toxic if swallowed.
TARGET ORGAN INFORMATION
Nerves.
CHRONIC EXPOSURE - MUTAGEN
ZINCL
Histidine reversion (Ames)
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
regulations.
14 - Transport Information
RID/ADR
UN#: 2811
Class: 6.1
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PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
IMDG
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 25 43
Toxic if swallowed. May cause sensitization by skin contact.
S-PHRASES: 36/37/39 45
Wear suitable protective clothing, gloves, and eye/face
protection. In case of accident or if you feel unwell, seek
medical advice immediately (show the label where possible).
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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