MATERIAL SAFETY
DATA SHEET
Prepared to U.S. OSHA, CMA, ANSI and Canadian WHMIS Standards
1. PRODUCT IDENTIFICATION
CHEMICAL NAME; CLASS: FLAMMABLE, TOXIC GAS MIXTURE
Containing Phosphine (> 0.4%) and Hydrogen (Balance)
SYNONYMS: Not Applicable
CHEMICAL FAMILY: Not Applicable
FORMULA: Not Applicable
Document Number: 60006
PRODUCT USE: For use in manufacture of electronic devices.
MANUFACTURED/SUPPLIED FOR: AIR LIQUIDE
ADDRESS: 19 Steel Road West
Morrisville, PA 19067
EMERGENCY PHONE: CHEMTREC: 1-800-424-9300
BUSINESS PHONE:
General MSDS Information 1-972-301-5200
Fax on Demand: 1-800/231-1366
2. COMPOSITION and INFORMATION ON INGREDIENTS
CHEMICAL NAME CAS # mole % EXPOSURE LIMITS IN AIR
ACGIH OSHA NIOSH OTHER
TLV STEL PEL STEL IDLH
ppm ppm ppm ppm ppm ppm
Phosphine 7803-51-2 > 0.4 % 0.3 1 0.3 1 (Vacated 50 NIOSH REL: 0.3 ppm
1989 PEL) TWA; 1 ppm STEL
DFG MAK: 0.1 ppm
Carcinogenicity: EPA-D
Hydrogen 1333-74-0 Balance There are no specific exposure limits for Hydrogen. Hydrogen is a simple asphyxiant
(SA). Oxygen levels should be maintained above 19.5%.
NE = Not Established C = Ceiling Limit See Section 16 for Definitions of Terms Used.
NOTE: all WHMIS required information is included. It is located in appropriate sections based on the ANSI Z400.1-1993 format.
FLAMMABLE, TOXIC GAS MIXTURE (60006) MSDS EFFECTIVE DATE: JANUARY 1, 2005
PAGE 1 OF 9
3. HAZARD IDENTIFICATION
EMERGENCY OVERVIEW: This gas mixture is a colorless, flammable, toxic gas mixture with a distinct fishy odor
(due to the presence of Phosphine). This gas mixture may cause significant, adverse health effects, because of
the Phosphine content, which exceeds exposure limits at the percentage in this mixture. Phosphine is an irritant
and general systemic poison. Exposure to even very small quantities can result in adverse health effects (such as
pulmonary edema) and may be fatal. Phosphine has a fishy odor and a low odor threshold; the odor of this
product provides a good warning of a release of this gas mixture. This gas mixture can form flammable mixtures
in air and presents an extreme fire hazard when accidentally released. As pure Phosphine is a strong reducing
agent and can react vigorously with mild to strong oxidizing agents, this gas mixture can present the same hazard
when Phosphine reaches the higher level possible in the mixture. Persons responding to releases of this gas
mixture must protect themselves appropriately.
SYMPTOMS OF OVER-EXPOSURE BY ROUTE OF
HAZARDOUS MATERIAL INFORMATION
EXPOSURE: The most significant routes of over-exposure for this
SYSTEM
gas are by inhalation, skin or eye contact. Symptoms of exposure
by all routes of exposure may be delayed.
HEALTH 4
(BLUE)
INHALATION: This gas mixture can cause serious health effects,
due to the presence of Phosphine, which is extremely toxic at very
low levels. Both chronic and acute over-exposures to this gas
mixture are dangerous. Minor exposures may result in the
FLAMMABILITY (RED)
4
following symptoms: lacrimation (watery eyes), substernal chest
pain, chest tightness, shortness of breath, a slight cough, and
cyanosis. Such exposures can cause gastrointestinal tract
irritation and central nervous system effects. Abdominal symptoms
REACTIVITY (YELLOW)
include nausea, vomiting, severe epigastric pain, and diarrhea. 3
Neurologic symptoms include vertigo, headache, restlessness,
involuntary tremors, lack of muscular coordination, double vision,
drowsiness, and a decreased sensation in the extremities. Death
PROTECTIVE EQUIPMENT X
can occur in humans after exposure as low as 8 ppm for 1-2 hours.
In severe over-exposures, this gas mixture can cause death (due EYES HANDS BODY
RESPIRATORY
to the presence of Phosphine, from pulmonary edema (a
dangerous condition of fluid accumulation in the lungs), or from
See Section 8
tissue anoxia secondary to interference with tissue respiration.
The symptoms of pulmonary edema can be delayed. In addition,
acute overexposure to this gas mixture can cause an oxygen- For routine industrial applications
deficient atmosphere. Symptoms of oxygen deficiency include
ringing in ears, headaches, shortness of breath, wheezing, dizziness, indigestion, and nausea.
CONTACT WITH SKIN or EYES: Contact of this gas mixture with the skin can cause injury. Contact with the skin
in the presence of moisture can cause burns, due to the formation of phosphoric acid. Contact with the eyes (1-2
ppm), even briefly, will cause irritation. Contact of longer duration and concentration can cause serious injury to the
eyes, possibly blindness, due to the formation of phosphoric acid.
HEALTH EFFECTS OR RISKS FROM EXPOSURE: An Explanation in Lay Terms. Over-exposure to this gas
mixture may cause the following health effects:
ACUTE: This gas mixture may cause moderate to severe irritation to the respiratory system, skin and eyes,
depending of the duration of exposure. Severe over-exposure to this gas may cause the extremely dangerous
condition of pulmonary edema (an accumulation of fluid in the lungs) and may be fatal. Severe overexposure may
also cause damaging effects to the central nervous system, lung damage, adverse effects on the heart, and
congestion of blood in the visceral organs. In addition, acute overexposure to this gas mixture can cause an oxygen-
deficient atmosphere. Symptoms of oxygen deficiency include ringing in ears, headaches, shortness of breath,
wheezing, dizziness, indigestion, and nausea.
CHRONIC: Persistent irritation may result from repeated exposure to this gas mixture. Effects of chronic low level
exposures can result in anemia, bronchitis, gastrointestinal disorders, and visual, speech, and motor disturbances,
due to the presence of phosphine. Refer to Section 11 (Toxicology Information) for additional data.
TARGET ORGANS: Respiratory system, skin, eyes, cardiac and central nervous systems.
FLAMMABLE, TOXIC GAS MIXTURE (60006) MSDS EFFECTIVE DATE: JANUARY 1, 2005
PAGE 2 OF 9
4. FIRST-AID MEASURES
RESCUERS SHOULD NOT ATTEMPT TO RETRIEVE VICTIMS OF EXPOSURE TO THIS PRODUCT
WITHOUT ADEQUATE PERSONAL PROTECTIVE EQUIPMENT. At a minimum, Self-Contained
Breathing Apparatus and Chemically-Resistant Personal Protective equipment should be worn.
INHALATION EXPOSURE: Remove victim(s) to fresh air, as quickly as possible. If adverse effects occur after
overexposure, only trained personnel should administer supplemental oxygen and/or cardio-pulmonary resuscitation,
if necessary. In the event of severe, immediate effects or delayed symptoms which develops after exposure, victim
must seek appropriate medical attention.
SKIN EXPOSURE: If this gas mixture contaminates the skin, immediately begin decontamination with running
water. Minimum flushing is for 15 minutes. Remove exposed or contaminated clothing, taking care not to
contaminate eyes. If adverse effects occur after exposure to the skin, victim must seek immediate medical attention.
EYE EXPOSURE: If vapors or fumes of this gas mixture contaminate the eyes, or if irritation of the eye develops
after exposure to the gas, open victim's eyes while under gentle running water. Use sufficient force to open eyelids.
Have victim "roll" eyes. Minimum flushing is for 15 minutes. If adverse effects occur after exposure to the eyes, victim
must seek immediate medical attention.
Victim(s) must be taken for medical attention. Rescuers should be taken for medical attention, if necessary. Take
copy of label and MSDS to physician or other health professional with victim(s).
5. FIRE-FIGHTING MEASURES
FLASH POINT: Not determined.
NFPA RATING
AUTOIGNITION TEMPERATURE:
FLAMMABILITY
For Phosphine: 100癈 (212癋)
For Hydrogen: 565.5癈 (1050癋)
4
FLAMMABLE LIMITS (in air by volume, %) [for Phosphine and
Hydrogen]: 3
4
HEALTH REACTIVITY
For Phosphine: Lower (LEL): 1.6%
For Hydrogen: Lower (LEL): 4.0%
For Phosphine: Upper (UEL): 98.0%
For Hydrogen: Upper (UEL): 75.0% OTHER
FIRE EXTINGUISHING MATERIALS: An extreme explosion hazard exists
in areas in which the gas has been released, but the material has not yet
ignited. Hydrogen burns with an almost invisible blue flame. When
this gas mixture contains a high level of Hydrogen, fire-fighters must be aware of this.
Extinguish fires of this gas mixture by shutting-off the source of the gas. Use a flooding quantity of water as a spray.
Do not use halogenated extinguishing agents. Cool fire-exposed cylinders with water spray, from the maximum
distance possible. Carbon Dioxide and dry chemical can also be used to extinguish Phosphine fires.
UNUSUAL FIRE AND EXPLOSION HAZARDS: This gas mixture will form dangerous explosive mixtures in air.
Phosphine is toxic to humans in relatively low concentrations and so this gas mixture poses an extreme health
hazards to fire-fighters. When involved in a fire, the decomposition products are phosphoric acid and hydrogen.
Phosphine readily undergoes violent chemical change at normal or elevated temperatures.
DANGER! Fires impinging (direct flame) on the outside surface of unprotected cylinders of this product can be very
dangerous. Direct flame exposure on the cylinder wall can cause an explosion. The resulting fire and explosion can
result in severe equipment damage and personnel injury or death over a large area around the cylinder. For
massive fires in large areas, use unmanned hose holder or monitor nozzles; if this is not possible, withdraw from
area and allow fire to burn.
Explosion Sensitivity to Mechanical Impact: Not sensitive.
Explosion Sensitivity to Static Discharge: This gas mixture would be sensitive to static discharge.
SPECIAL FIRE-FIGHTING PROCEDURES: Structural fire-fighters must wear Self-Contained Breathing Apparatus
and full protective equipment. Appropriate chemically-protective clothing may be necessary. Keep away from low-
lying areas. Stay upwind. Evacuation of non-emergency personnel is essential. If water is not available for cooling
or protection of cylinder exposures, evacuate the area. Follow the guidelines of the North American Emergency
Response Guidebook (Guide #119).
FLAMMABLE, TOXIC GAS MIXTURE (60006) MSDS EFFECTIVE DATE: JANUARY 1, 2005
PAGE 3 OF 9
6. ACCIDENTAL RELEASE MEASURES
LEAK RESPONSE: Uncontrolled releases should be responded to by trained personnel using pre-planned
procedures. Proper protective equipment should be used. In case of a large release, clear the affected area, protect
people, and respond with trained personnel.
Minimum Personal Protective Equipment should be Level A: triple-gloves (rubber gloves and nitrile gloves, over
latex gloves), fully-encapsulating chemically resistant suit and boots, hard-hat, and Self Contained
Breathing Apparatus. Small releases of Phosphine leaks can be detected by means of an atomizer or squeeze
bottle filled with aqueous ammonia. A white cloud will show the location of the leak. Monitor the surrounding area
for Phosphine, Hydrogen and oxygen levels.
Locate and seal the source of the leaking gas. Protect personnel attempting the shut-off with water-spray. Allow the
gas to dissipate, if it can be done to an area in which there are no personnel. Combustible gas concentration must
be below 10% of the LEL (LEL for Phosphine = 1.6%; LEL for Hydrogen = 4.0%) prior to entry. Monitor the
surrounding area for toxic Phosphine levels as well as combustible gas levels and oxygen level. The atmosphere
must be below 50% of the TLV (TLV = 0.3 ppm) of Phosphine before personnel can be allowed in the area without
Self-Contained Breathing Apparatus and fully encapsulating, chemically-resistant suit. Attempt to close the main
source valve prior to entering the area. If this does not stop the release (or if it is not possible to reach the valve),
allow the gas to release in-place or remove it to a safe area and allow the gas to be released there. NOTE: A
colorimetric tube is available for Phosphine.
THIS IS A TOXIC, HIGHLY FLAMMABLE GAS: Protection of all personnel and the area must be maintained. All
responders must be adequately protected from exposure.
7. HANDLING and USE
WORK PRACTICES AND HYGIENE PRACTICES: Be aware of any signs of dizziness or fatigue; exposures to
fatal concentrations of this gas mixture could occur without any significant warning symptoms, due to oxygen
deficiency. All areas where gas mixtures that include Phosphine are used should be monitored with very sensitive
gas detection instruments. Detection of concentrations above 50% of the PEL (PEL = 0.3 ppm) should trigger
immediate response and corrective action. Detection of higher levels should initiate an alarm calling for evacuation
of all personnel with the potential to be exposed.
Avoid all contact with this gas. All employees who handle this material should be trained to handle it safely. Working
alone with this mixture should be avoided when possible. All work operations should be monitored in such a way
that emergency personnel can be immediately contacted in the event of a release. Avoid breathing gas mixture.
Wash hands after handling chemicals. Do not eat or drink while handling chemicals. All work practices should
minimize the release of this gas mixture.
STORAGE AND HANDLING PRACTICES: Cylinders should be stored upright (with valve-protection cap in place)
and firmly secured to prevent falling or being knocked over. Cylinders can be stored in the open, but in such cases,
should be protected against extremes of weather and from the dampness of the ground to prevent rusting. Cylinders
should be stored in dry, well-ventilated areas away from sources of heat, ignition and direct sunlight. Keep storage
area clear of materials which can burn. Do not allow area where cylinders are stored to exceed 52 癈 (125 癋).
Store containers away from heavily trafficked areas and emergency exits. Store away from process and production
areas, away from elevators, building and room exits or main aisles leading to exits. Protect cylinders against
physical damage.
Cylinders should be separated from oxygen cylinders, or other oxidizers, by a minimum distance of 20 ft., or by a
barrier of non-combustible material at least 5 ft. high, having a fire-resistance rating of at least 0.5 hours. Isolate
from other incompatible chemicals (refer to Section 10, Stability and Reactivity).
Storage areas must meet national electrical codes for Class 1 Hazardous Areas. Post "No Smoking or Open
Flames" signs in storage or use areas. Consider installation of leak detection and alarm for storage and use areas.
Have appropriate extinguishing equipment in the storage area (i.e. sprinkler system, portable fire extinguishers).
Keep the smallest amount on-site as is necessary. Full and empty cylinders should be segregated. Use a first-in,
first-out inventory system to prevent full containers from being stored for long periods of time.
Use non-sparking ventilation systems, approved explosion-proof equipment, and appropriate electrical systems.
Electrical equipment used in gas-handling operations, or located in storage areas, should be non-sparking or
explosion proof. Use a check valve in the discharge line to prevent hazardous backflow. Never tamper with
pressure relief devices in valves and cylinders.
SPECIAL PRECAUTIONS FOR HANDLING GAS CYLINDERS: Compressed gases can present significant safety
hazards. The following rules are applicable to work situations in which cylinders are being used.
FLAMMABLE, TOXIC GAS MIXTURE (60006) MSDS EFFECTIVE DATE: JANUARY 1, 2005
PAGE 4 OF 9
7. HANDLING and USE (Continued)
Before Use: Move cylinders with a suitable hand-truck. Do not drag, slide or roll cylinders. Do not drop cylinders or
permit them to strike each other. Secure cylinders firmly. Leave the valve protection cap (where provided) in-place
until cylinder is ready for use.
During Use: This gas should be used in a gas cabinet (see Section 8, Engineering Controls and Personal
Protection). Use designated CGA fittings and other support equipment. Do not use adapters. Use piping and
equipment adequately designed to withstand pressures to be encountered. Do not heat cylinder by any means to
increase the discharge rate of the product from the cylinder. Do not use oils or grease on gas-handling fittings or
equipment. Leak check system with leak detection solution, never with flame. Immediately contact the supplier if
there are any difficulties associated with the operating cylinder valve. Never insert an object (e.g. wrench,
screwdriver, pry bar, etc.) into valve cap openings. Doing so may damage valve, casing a leak to occur. Use an
adjustable strap wrench to remove over-tight or rusted caps. Never strike an arc on a compressed gas cylinder or
make a cylinder part of an electric circuit.
After Use: Close main cylinder valve. Valves should be closed tightly. Reinstall gas-tight dust cap on the cylinder
outlet. Replace valve protection cap. Mark empty cylinders "EMPTY".
NOTE: Use only DOT or ASME code containers designed for corrosive storage. Close valve after each use and
when empty.
STANDARD VALVE CONNECTIONS FOR U.S. AND CANADA: Use the proper CGA connections, DO NOT
USE ADAPTERS:
THREADED: CGA 350
PIN-INDEXED YOKE: Not applicable.
ULTRA HIGH INTEGRITY: 632
PROTECTIVE PRACTICES DURING MAINTENANCE OF CONTAMINATED EQUIPMENT: Follow practices
indicated in Section 6 (Accidental Release Measures). Make certain application equipment is locked and tagged-out
safely. Purge gas handling equipment with inert gas (i.e. nitrogen) before attempting repairs. Always use product in
areas where adequate ventilation is provided.
8. EXPOSURE CONTROLS - PERSONAL PROTECTION
VENTILATION AND ENGINEERING CONTROLS: Use with adequate ventilation. Due to the extreme toxicity of
Phosphine, cylinders of this product should always be placed in a properly designed and constructed gas cabinet.
Install automatic monitoring equipment to detect the level of Phosphine. Provide explosion-proof ventilation
adequate to ensure Phosphine does not reach its lower flammability limit of 1.6% or Hydrogen's limit of 4.0%.
Double wall piping should be used to deliver gas to the point of use. Exhaust from the cabinet and from the annular
space of the tubing should be monitored.
RESPIRATORY PROTECTION: Maintain exposure levels of Phosphine below the levels listed in Section 2
(Composition and Information on Ingredients) and oxygen levels above 19.5% in the workplace. Use supplied air
respiratory protection if Phosphine levels exceed exposure limits or during emergency response to a release of this
product. If respiratory protection is required, follow the requirements of the Federal OSHA Respiratory Protection
Standard (29 CFR 1910.134), or equivalent State standards. The following NIOSH respiratory protection
recommendations are for Phosphine.
CONCENTRATION RESPIRATORY EQUIPMENT
Up to 3 ppm: Supplied Air Respirator (SAR)
Up to 7.5 ppm: Supplied Air Respirator (SAR) operated in a continuous-flow mode.
Up to 15 ppm: Gas mask with canister to protect against Phosphine, or full-facepiece SCBA or full-
facepiece Supplied Air Respirator (SAR).
EMERGENCY OR PLANNED ENTRY INTO UNKNOWN CONCENTRATIONS OR IDLH CONDITIONS: Positive
pressure, full-facepiece SCBA, or positive pressure, full-facepiece Supplied Air Respirator
(SAR).
ESCAPE: Gas mask with canister to protect against Phosphine or escape-type SCBA.
NOTE: The IDLH for Phosphine is 50 ppm.
EYE PROTECTION: Safety glasses.
HAND PROTECTION: Wear leather gloves when handling cylinders of this product. Wear chemically resistant
gloves appropriate for use with mixtures containing Phosphine for industrial use. Use triple gloves for leak response
(see Section 6, Accidental Release Measures).
BODY PROTECTION: Use body protection appropriate for task; operations using Phosphine may require the use of
chemically-resistant and fire retardant clothing. For emergency response operations, clothing resistant to the toxic
effects of Phosphine is required.
FLAMMABLE, TOXIC GAS MIXTURE (60006) MSDS EFFECTIVE DATE: JANUARY 1, 2005
PAGE 5 OF 9
9. PHYSICAL and CHEMICAL PROPERTIES
The following information is for the Hydrogen component of this gas mixture.
GAS DENSITY @ 21.1癈 (70癋) and 1 atm: 0.00521 lb/ft3 (0.08342 kg/m3)
BOILING POINT @ 1 atm: -253.0癈 (-423.0癋)
FREEZING/MELTING POINT @ 1 atm: -259癈 (-434.6癋)
SPECIFIC GRAVITY (air = 1) @ 21.1癈 (70癋): 0.069 pH: Not applicable.
SOLUBILITY IN WATER Vol/Vol @ 15.6癈 (60癋): 0.019 MOLECULAR WEIGHT: 2.016
EVAPORATION RATE (nBuAc = 1): Not applicable. EXPANSION RATIO: Not applicable.
SPECIFIC VOLUME (ft3/lb): 192
ODOR THRESHOLD: Not applicable
VAPOR PRESSURE @ 21.1癈 (70癋) psig: Not applicable.
COEFFICIENT WATER/OIL DISTRIBUTION: Not applicable.
The following information is for the Phosphine component of this gas mixture.
GAS DENSITY @ 21.1癈 (70癋) and 1 atm: 0.0877 lb/ft3 (1.405 kg/m3)
LIQUID DENSITY @ 15癈 (59癋): 45.2 lb/ft3 (581 kg/m3)
BOILING POINT @ 1 atm: -87.7癈 (-125.9癋)
FREEZING/MELTING POINT @ 10 psig: -133癈 (-207.4癋)
SPECIFIC GRAVITY (air = 1) @ 25癈 (77癋) and 1 atm: 1.184 pH: Not applicable.
EVAPORATION RATE (nBuAc = 1): Not applicable. MOLECULAR WEIGHT: 33.998
VAPOR PRESSURE @ 21.1癈 (70癋) psig: 583 EXPANSION RATIO: Not applicable.
SPECIFIC VOLUME (ft3/lb): 11.4
ODOR THRESHOLD: 0.14 ppm (recognition)
SOLUBILITY IN WATER vol gas/vol water @ 17癈 (62.6癋): 0.26
COEFFICIENT WATER/OIL DISTRIBUTION: Not applicable.
The following information is for this gas mixture.
APPEARANCE AND COLOR: Colorless gas with a fishy odor (due to the presence of Phosphine).
HOW TO DETECT THIS SUBSTANCE (warning properties): The odor and potential irritation of the eyes caused
by the presence of Phosphine can be a distinctive warning property associated with this product. Monitoring
systems must be used for detection of this gas.
10. STABILITY and REACTIVITY
STABILITY: Hydrogen is stable. Pure Phosphine reacts violently with a broad range of materials, including air.
DECOMPOSITION PRODUCTS: Decomposition products of this gas mixture would include oxygen, phosphorous
oxides and phosphoric acid.
MATERIALS WITH WHICH SUBSTANCE IS INCOMPATIBLE: Phosphine combines violently with halogens and
oxidizers such as oxygen, chlorine, fluorine and nitric oxide. Phosphine reacts with mercury(II) nitrate to form an
explosive product. In air, Phosphine will ignite or react violently; also with boron trichloride, aqueous halogen
solutions, iodine, metal nitrates and oxidants. The organic derivatives of phosphine react violently with halogens.
Hydrogen is incompatible with strong oxidizers (i.e. chlorine, bromine, pentafluoride, oxygen, oxygen difluoride, and
nitrogen trifluoride).
HAZARDOUS POLYMERIZATION: Will not occur.
CONDITIONS TO AVOID: Contact with incompatible materials and exposure to moisture. Cylinders exposed to
high temperatures or direct flame can rupture or burst.
11. TOXICOLOGICAL INFORMATION
TOXICITY DATA: Hydrogen is inert. The following data are available for Phosphine.
Inhalation-Human LCLo: 1000 ppm Inhalation-rat TCLo: 10 ppm/4 hours/4 days- Inhalation-mouse TCLo: 10 ppm/4 hours/4 days-
Inhalation-Rat LC50: 11 ppm/4 hours intermittent: Related to Chronic Data: intermittent: Kidney, Urethra, Bladder -
3
Inhalation-rat TCLo: 200 礸/m /24 hours/6 death changes in tubules (including acute renal
3
Inhalation-Mouse LCLo: 380 mg/m /2 hours failure, acute tubular necrosis); Blood: changes
weeks-continuous: Brain and
Inhalation-rat TCLo: 5 ppm/4 hours/2 weeks- in leukocyte (WBC) count; Biochemical:
Coverings: recordings from specific
intermittent: Cardiac: changes in heart Enzyme inhibition, induction, or change in
areas of CNS; Blood: pigmented or
weight; Lungs, Thorax, or Respiration: blood or tissue levels: transaminases
nucleated red blood cells, changes in
changes in lung weight; Liver: changes Inhalation-mouse Micronucleus test: 5 ppm/6
serum composition (e.g. TP, bilirubin,
in liver weight hours/13 weeks-intermittent
cholesterol)
3
Inhalation-mouse TCLo: 5 ppm/4 hours/2 Inhalation-Cat, adult LCLo: 70 mg/m /2 hours
Inhalation-rat TCLo: 3100 ppb/6 hours/13
weeks-intermittent: Cardiac: changes in Inhalation-Rabbit, adult LCLo: 2500 ppm/20
weeks-intermittent: Blood: pigmented
heart weight; Lungs, Thorax, or minutes
or nucleated red blood cells, changes
3
Respiration: changes in lung weight; Inhalation-Guinea Pig, adult LCLo: 140 mg/m /4
in erythrocyte (RBC) count, changes
Blood: changes in serum composition hours
in platelet count
(e.g. TP, bilirubin, cholesterol)
FLAMMABLE, TOXIC GAS MIXTURE (60006) MSDS EFFECTIVE DATE: JANUARY 1, 2005
PAGE 6 OF 9
11. TOXICOLOGICAL INFORMATION (Continued)
TOXICITY DATA (continued):
Inhalation-Mammal LCLo: 1000 ppm/5 minutes
Cytogenetic analysis-Human Lymphocyte: 1400 ng/L
SUSPECTED CANCER AGENT: Phosphine is listed by the EPA as an EPA-D substance (Not Classifiable as to
Human Carcinogenicity). Phosphine and the other components of this mixture are not found on the following lists:
FEDERAL OSHA Z LIST, IARC, NTP, CAL/OSHA, and therefore is not considered to be, nor suspected to be a
cancer-causing agent by these agencies.
IRRITANCY OF PRODUCT: This gas mixture may mildly to severely irritating to contaminated tissue, depending on
the duration of contact. Phosphine reacts with water or moisture, slowly producing corrosive phosphoric acid;
therefore, this gas can be severely irritating and corrosive to the skin, the eyes, and mucous membranes
SENSITIZATION TO THE PRODUCT: The components of this gas mixture are not known to be sensitizers to
humans upon prolonged or repeated contact.
REPRODUCTIVE TOXICITY INFORMATION: Listed below is information concerning the effects of this gas mixture
on the human reproductive system.
Mutagenicity: This gas mixture is not expected to cause mutagenic effects in humans.
Embryotoxcity: This gas mixture is not expected to cause embryotoxic effects in humans.
Teratogenicity: This gas mixture is not expected to cause teratogenic effects in humans.
Reproductive Toxicity: This gas mixture is not expected to cause adverse reproductive effects in humans.
A mutagen is a chemical which causes permanent changes to genetic material (DNA) such that the changes will propagate
through generation lines. An embryotoxin is a chemical which causes damage to a developing embryo (i.e. within the first
eight weeks of pregnancy in humans), but the damage does not propagate across generational lines. A teratogen is a
chemical which causes damage to a developing fetus, but the damage does not propagate across generational lines. A
reproductive toxin is any substance which interferes in any way with the reproductive process.
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: Due to the presence of Phosphine, consideration
should be taken as to the possible aggravation of respiratory disorders, heart conditions, or central nervous system
conditions. Additionally, skin and eye conditions may be aggravated by this gas mixture.
RECOMMENDATIONS TO PHYSICIANS: Administer oxygen. Victims of exposure to Phosphine must be
monitored closely for delayed pulmonary edema. There is no specific antidote to Phosphine poisoning; therefore,
treatment is symptomatic and supportive. The usual treatments for pulmonary edema (such as digitalis, diuretics,
and phlebotomy) may be necessary. Pressor agents such as aramine and massive doses of steroids may be
necessary to support blood pressure. A central venous pressure catheter is highly recommended for determining
rates of infusion and following the course of the pulmonary edema. The use of mannitol diuresis may be used to
prevent early renal shutdown. If oliguria supervenes, extracorporeal hemodialysis must be available for survival.
Cerebral edema should be treated by usual methods with agents such as decadron. Also, appropriate sedation and
anti-epileptic drugs are employed as indicated. Frequent electrolyte determinations should be performed for early
detection of hyperkalemia with ensuing renal failure, which is treated by ion exchange resins, such as polystyrene
sulfonate (kayexalate). Cardiac monitoring is essential for arrhythmia problems which might ensue.
BIOLOGICAL EXPOSURE INDICES (BEIs): Currently, Biological Exposure Indices (BEIs) are not applicable for
the components of this gas mixture.
12. ECOLOGICAL INFORMATION
ENVIRONMENTAL STABILITY:. This gas will be dissipated rapidly in well-ventilated areas. Phosphine is a strong
reducing agent and will react with a wide variety of oxidizing materials.
EFFECT OF MATERIAL ON PLANTS or ANIMALS: Depending on the duration of exposure, this gas mixture may
have detrimental effects on plant and animal life.
EFFECT OF CHEMICAL ON AQUATIC LIFE: This gas mixture is not expected to have harmful effects on aquatic
life if released. The following aquatic toxicity data are currently available for component of this gas mixture:
PHOSPHINE: EC50: Bacillus subtilis growth inhibition = 2.7 mg/L
13. DISPOSAL CONSIDERATIONS
PREPARING WASTES FOR DISPOSAL: Waste disposal must be in accordance with appropriate Federal, State,
and local regulations. Return cylinders with any residual product to Air Liquide. Do not dispose of locally.
FLAMMABLE, TOXIC GAS MIXTURE (60006) MSDS EFFECTIVE DATE: JANUARY 1, 2005
PAGE 7 OF 9
14. TRANSPORTATION INFORMATION
THIS MATERIAL IS HAZARDOUS AS DEFINED BY 49 CFR 172.101 BY THE U.S. DEPARTMENT OF
TRANSPORTATION.
PROPER SHIPPING NAME: Compressed gas, toxic, flammable n.o.s.
(Phosphine, Hydrogen)
HAZARD CLASS NUMBER and DESCRIPTION: 2.3 (Toxic Gas) primary hazard;
2.1 (Flammable Gas) secondary hazard
UN IDENTIFICATION NUMBER: UN 1953
PACKING GROUP: Not applicable.
DOT LABEL(S) REQUIRED: Toxic Gas, Flammable gas
NORTH AMERICAN EMERGENCY RESPONSE GUIDEBOOK NUMBER (1996): 119
MARINE POLLUTANT: Phosphine is not classified by the DOT as a Marine Pollutant (as defined by 49 CFR
172.101, Appendix B).
SPECIAL PROVISION: Shipments must be described as "Poison Inhalation Hazard - ZONE D", for mixtures which
contain Phosphine from 0.40% to less than 0.67%. Shipments must be described as "Poison Inhalation Hazard -
ZONE C", for mixtures which contain Phosphine at 0.67% to less than 2.0%. Shipments must be described as
"Poison Inhalation Hazard - ZONE B", for mixtures which contain Phosphine at 2.0% to less than 10.0%. Shipments
must be described as "Poison Inhalation Hazard - ZONE A", for mixtures which contain Phosphine at 10.0% or
above
SPECIAL SHIPPING INFORMATION: Cylinders should be transported in a secure position, in a well-ventilated
vehicle. The transportation of compressed gas cylinders in automobiles or in closed-body vehicles present serious
safety hazards and should be discouraged.
NOTE: Shipment of compressed gas cylinders which have not been filled with the owners consent is a violation of
Federal law (49 CFR, Part 173.301 (b).
TRANSPORT CANADA TRANSPORTATION OF DANGEROUS GOODS REGULATIONS: THIS MATERIAL IS
CONSIDERED AS DANGEROUS GOODS. Refer to the following information for Canadian Shipments. NOTE: 102
(Poison-Inhalation Hazard).
15. REGULATORY INFORMATION
U.S. REGULATIONS:
U.S. SARA REPORTING REQUIREMENTS: Components of this gas mixture are subject to the reporting
requirements of Sections 302, 304 and 313 of Title III of the Superfund Amendments and Reauthorization Act., as
follows:
COMPOUND SARA 302 SARA 304 SARA 313
(40 CFR 355, Appendix A) (40 CFR Table 302.4) (40 CFR 372.65)
Phosphine YES YES YES
U.S. SARA THRESHOLD PLANNING QUANTITY: Hydrogen - not applicable. Phosphine = 500 pounds (225 kg)
U.S. TSCA INVENTORY STATUS: The components of this gas mixture are listed on the TSCA Inventory.
U.S. CERCLA REPORTABLE QUANTITY (RQ): Hydrogen - not applicable. Phosphine = 100 pounds (45 kg)
OTHER U.S. FEDERAL REGULATIONS: The components of this gas mixture have requirements under other U.S.
Federal regulations, as follows:
?Phosphine and Hydrogen are subject to the reporting requirements of Section 112(r) of the Clean Air Act.
Threshold Quantity: Phosphine = 5,000 lbs (2,250 kg). Hydrogen: 10,000 pounds (4,554 kg).
?This gas mixture does not contain any Class I or Class II ozone depleting chemicals (40 CFR part 82).
?Phosphine is subject to requirements of CFR 29 1910.1000. Phosphine is listed in Table Z.1.
?Phosphine is listed in 40 CFR, Part 68 (Risk Management for Chemical Release Prevention), Table 1, as an
extremely hazardous substance. The threshold quantity for Phosphine under this regulation is 5,000 lbs (2,250
kg). Hydrogen is listed as a Regulated Substance in quantities of 10,000 lbs (4,553 kg) or greater, per 40 CFR,
Part 68, of the Risk Management for Chemical Accidental Release.
?Depending on specific operations involving the use of this product, the regulations of the Process Safety
Management of Highly Hazardous Chemicals may be applicable (29 CFR 1910.119). Under this regulation
Phosphine is listed in Appendix A. The threshold quantity for Phosphine, under this regulation is 100 pounds
(45.53 kg). Under this regulation Hydrogen is not listed in Appendix A, however, any process that involves a
flammable gas on-site, in one location, in quantities of 10,000 lbs (4,554 kg) or greater is covered under this
regulation unless it is used as a fuel.
FLAMMABLE, TOXIC GAS MIXTURE (60006) MSDS EFFECTIVE DATE: JANUARY 1, 2005
PAGE 8 OF 9
15. REGULATORY INFORMATION (Continued)
U.S. STATE REGULATORY INFORMATION: The components of this gas mixture are covered under specific State
regulations, as denoted below:
Alaska - Designated Toxic and Hazardous Michigan - Critical Materials Register: Pennsylvania - Hazardous Substance List:
Phosphine. Phosphine, Hydrogen.
Substances: Phosphine, Hydrogen.
Minnesota - List of Hazardous Substances: Rhode Island - Hazardous Substance List:
California - Permissible Exposure Limits
Phosphine, Hydrogen.
Phosphine, Hydrogen.
for Chemical Contaminants:
Texas - Hazardous Substance List:
Phosphine, Hydrogen. Missouri - Employer Information/Toxic
Phosphine.
Florida - Substance List: Phosphine, Substance List: Phosphine, Hydrogen.
West Virginia - Hazardous Substance List:
Hydrogen. New Jersey - Right to Know Hazardous
Phosphine.
Illinois - Toxic Substance List: Phosphine, Substance List: Phosphine, Hydrogen.
Wisconsin - Toxic and Hazardous
Hydrogen. North Dakota - List of Hazardous
Substances: Phosphine.
Kansas - Section 302/313 List: Phosphine, Chemicals, Reportable Quantities:
Massachusetts - Substance List: Phosphine.
Phosphine, Hydrogen.
CALIFORNIA PROPOSITION 65: The components of this gas mixture are not on the California Proposition 65 lists.
CANADIAN REGULATIONS:
CANADIAN WHMIS REGULATIONS: This mixture would be categorized as a Controlled Product, Hazard Classes
A, B1, D1A, and D2A,, as per the Controlled Product Regulations.
CANADIAN DSL/NDSL INVENTORY STATUS: The components of this mixture are listed on the Canadian DSL
Inventory.
CANADIAN ENVIRONMENTAL PROTECTION ACT (CEPA) PRIORITIES SUBSTANCES LISTS: The
components of this gas mixture are not on the CEPA Priorities Substances Lists.
16. OTHER INFORMATION
MIXTURES: When two or more gases or liquefied gases are mixed, their hazardous properties may combine to
create additional, unexpected hazards. Obtain and evaluate the safety information for each component before
you produce the mixture. Consult an Industrial Hygienist or other trained person when you make your safety
evaluation of the end product. Remember, gases and liquids have properties which can cause serious injury or
death.
Further information can be found in the following pamphlets published by: Compressed Gas Association Inc.
(CGA), 4221 Walney Road 5th floor, Chantilly, VA 20151-2923. Telephone: (703) 788-2700.
P-1 "Safe Handling of Compressed Gases in Containers"
AV-1 "Safe Handling and Storage of Compressed Gases"
"Handbook of Compressed Gases"
PREPARED BY: CHEMICAL SAFETY ASSOCIATES, Inc.
9163 Chesapeake Drive, San Diego, CA 92123-1002
619/565-0302
Fax on Demand: 1-800/231-1366
This Material Safety Data Sheet is offered pursuant to OSHA's Hazard Communication Standard, 29 CFR, 1910.1200. Other government
regulations must be reviewed for applicability to this product. To the best of Air Liquide's knowledge, the information contained
herein is reliable and accurate as of this date; however, accuracy, suitability or completeness are not guaranteed and no warranties of any
type, either express or implied, are provided. The information contained herein relates only to this specific product. If this product is
combined with other materials, all component properties must be considered. Data may be changed from time to time. Be sure to consult
the latest edition.
FLAMMABLE, TOXIC GAS MIXTURE (60006) MSDS EFFECTIVE DATE: JANUARY 1, 2005
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