The MSDS format adheres to the standards and regulatory requirements
of the United States and may not meet regulatory requirements
in other countries.
DuPont Page 1
Material Safety Data Sheet
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"DuPont" "MANEX" FUNGICIDE
M0000546 Revised 23-MAY-2005
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CHEMICAL PRODUCT/COMPANY IDENTIFICATION
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Tradenames and Synonyms
"MANEX"
"MANEB"
Tradenames and Synonyms (Remarks)
"MANEX" is a registered trademark of E. I. du Pont
de Nemours and Company and its affiliates.
Company Identification
MANUFACTURER/DISTRIBUTOR
DuPont
1007 Market Street
Wilmington, DE 19898
PHONE NUMBERS
Product Information : 1-800-441-7515 (outside the U.S.
302-774-1000)
Transport Emergency : CHEMTREC 1-800-424-9300(outside U.S.
703-527-3887)
Medical Emergency : 1-800-441-3637 (outside the U.S.
302-774-1000)
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COMPOSITION/INFORMATION ON INGREDIENTS
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# Components
Material CAS Number %
*MANEB* 12427-38-2 37
(Manganese Ethylenebisdithiocarbamate)
(Total manganese as metallic 7.6%)
INERT INGREDIENTS 63
* Disclosure as a toxic chemical is required under Section 313 of
Title III of the Superfund Amendments and Reauthorization Act of 1986
and 40 CFR part 372.
Components (Remarks)
4 Pounds of Maneb Per Gallon
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Material Safety Data Sheet
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HAZARDS IDENTIFICATION
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# Emergency Overview
CAUTION! Harmful if absorbed through skin or inhaled.
Avoid contact with skin, eyes or clothing. Avoid breathing
vapor or spray mist. Remove contaminated clothing and
wash clothing before reuse.
Potential Health Effects
Inhalation: May cause irritation to the nose and throat.
Eye Contact: May cause irritation to the eyes.
Skin Contact: May cause irritation to the skin.
Skin Sensitization: May cause dermal sensitization.
Ingestion: Irritation to the digestive system may cause
diarrhea and vomiting.
CHRONIC:
Maneb at high levels has caused birth defects in test
animals, hind leg paralysis and an increased incidence of
retinal atrophy related to old age. It has caused thyroid
tumors in test animals, resulting from ethylene thiourea
(ETU) formation. ETU, a trace contaminant and breakdown
product of Manex (Maneb) Fungicide, primarily affects the
thyroid. It has also caused other endocrine, liver and
blood effects, tumors and birth defects in test animals.
Rats fed 2 years on a diet containing 250 ppm suffered no
ill effects. In long term feeding studies on rodents, some
dithocarbamates, including maneb, have induced
carcinogenicity and birth defects at high dietary intake
levels.
Carcinogenicity Information
None of the components present in this material at concentrations
equal to or greater than 0.1% are listed by IARC, NTP, OSHA or ACGIH
as a carcinogen.
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FIRST AID MEASURES
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# First Aid
IF INHALED: Move person to fresh air. If person is not
breathing, call 911 or an ambulance, then give artificial
respiration, preferably mouth-to-mouth, if possible. Call a
poison control center or doctor for further treatment
advice.
IF ON SKIN OR CLOTHING: Take off contaminated clothing.
M0000546 DuPont Page 3
Material Safety Data Sheet
(FIRST AID MEASURES - Continued)
Rinse skin immediately with plenty of water for 15-20
minutes. Call a poison control center or doctor for
treatment advice.
IF IN EYES: Hold eye open and rinse slowly and gently
with water for 15-20 minutes. Remove contact lenses, if
present, after the first 5 minutes, then continue rinsing
eye. Call a poison control center or doctor for treatment
advice.
IF SWALLOWED: Call a poison control center or doctor
immediately for treatment advice. Have person sip a glass
of water if able to swallow. Do not induce vomiting unless
told to do so by the poison control center or doctor. Do
not give anything by mouth to an unconscious person.
Have the product container or label with you when calling
a poison control center or doctor, or going for treatment.
For medical emergencies involving this product, call toll
free 1-800-441-3637. See Label for Additional Precautions
and Directions for Use.
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FIRE FIGHTING MEASURES
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Flammable Properties
Flash Point & Method : Not determined
Flammable Limits : Not determined
Autoignition Temperature : Not determined
FIRE FIGHTING HAZARDS & PROCEDURES
General Hazard : Prevent human exposure to fire,
smoke, fumes or products of
combustion. Large masses of
dried product residue may ignite
spontaneously.
Extinguishing Media : Use dry chemical, carbon
dioxide, water spray or foam.
Fire Fighting Equipment : Wear protective clothing and
self-contained breathing
apparatus.
Hazardous Combustion
Products : Combustion generates toxic fumes
of the following: hydrogen
sulfide, carbon disulfide,
sulfur oxides, nitrogen oxides,
and carbon oxides.
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Material Safety Data Sheet
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ACCIDENTAL RELEASE MEASURES
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Safeguards (Personnel)
NOTE: Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL)
sections before proceeding with clean-up. Use appropriate
PERSONAL PROTECTIVE EQUIPMENT during clean-up.
Spill Clean Up
Cover spill with absorbent material such as sweeping
compound or lime. Sweep up and place in suitable
(fiberboard) containers for later disposal.
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HANDLING AND STORAGE
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Handling (Personnel)
USERS SHOULD: Wash hands before eating, drinking, chewing
gum, using tobacco or using the toilet. Remove clothing
immediately if pesticide gets inside. Then wash thoroughly
and put on clean clothing. Remove PPE immediately after
handling this product. Wash the outside of gloves before
removing. As soon as possible, wash thoroughly and change
into clean clothing.
# Handling (Physical Aspects)
Keep away from fire and sparks. Store in a cool dry place.
# Storage
Do not contaminate water, food or feed by storage.
Store in a cool, dry place.
Do not store near feed, food or within the reach of
children.
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EXPOSURE CONTROLS/PERSONAL PROTECTION
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# Engineering Controls
When handlers use closed systems, enclosed cabs, or aircraft
in a manner that meets the requirements listed in the Worker
Protection Standard (WPS) for agricultural pesticides
[40 CFR 170.240 (d)(4-6)], the handler PPE requirements may
be reduced or modified as specified in the WPS.
IMPORTANT: When reduced PPE is worn because a closed system
is being used, handlers must be provided all PPE specified
above for "applicators and other handlers" and have such PPE
immediately available for use in an emergency, such as a
spill or equipment break-down.
M0000546 DuPont Page 5
Material Safety Data Sheet
(EXPOSURE CONTROLS/PERSONAL PROTECTION - Continued)
Human flaggers must be in enclosed cabs.
# Personal Protective Equipment
Some materials that are chemical resistant to this product
are listed below. If you want more options, follow the
instructions for Category A on an EPA chemical resistance
selection chart.
Applicators and other handlers (other than mixers and
loaders) must wear:
- Coveralls over long-sleeved shirt and long pants.
- Chemical resistant gloves made of any waterproof
material, such as nitrile, latex, or barrier laminate.
- Shoes plus socks.
Mixers and Loaders must wear:
- Coveralls over long-sleeved shirt and long pants.
- Chemical resistant gloves made of any waterproof
material, such as nitrile, latex, or barrier laminate.
- Shoes plus socks.
- Protective eyewear.
- Chemical-resistant apron when mixing and loading.
Follow the manufacturer's instructions for cleaning/-
maintaining PPE. If no such instructions for washables,
use detergent and hot water. Keep and wash PPE separately
from other laundry.
PPE required for early entry to treated areas that is
permitted under the Worker Protection Standard and that
involves contact with anything that has been
treated, such as plants, soil, or water, is:
- Coveralls over long-sleeved shirt and long pants.
- Chemical resistant gloves made of any waterproof
material, such as nitrile, latex, or barrier laminate.
- Shoes plus socks.
Exposure Guidelines
Applicable Exposure Limits
MANEB*
PEL (OSHA) : None Established
TLV (ACGIH) : None Established
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Material Safety Data Sheet
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PHYSICAL AND CHEMICAL PROPERTIES
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Physical Data
Vapor Pressure : Not determined
Density : 1.3 g/ml
Solubility in Water : Disperses to form a suspension.
pH : 7.8
Boiling Point : Decomposes
Freezing Point : Not determined
Odor : Characteristic odor
Color : Yellowish
Physical State : Liquid
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STABILITY AND REACTIVITY
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Chemical Stability
General : This material is stable under
normal conditions.
Incompatible Materials : Oxidizing agents and acids.
Conditions to Avoid : Avoid temperatures above 49癈.
Hazardous Decomposition : Thermal decomposition may yield
the following: carbon disulfide,
hydrogen sulfide, NOx, and SOx.
Hazardous Polymerization : Material is not known to
polymerize.
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TOXICOLOGICAL INFORMATION
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Animal Data
ACUTE
Inhalation : Acute inhalation
LC50 >5 mg/L (rat - 4 hour).
Eye Contact : Moderate irritation. Conjunctival redness
and discharge, chemosis and ocular
irritation were observed in the unwashed
eyes of rabbits but cleared by day 7.
Conjunctival redness and discharge and
ocular irritation were observed in the
washed eyes of rabbits but cleared by
day 4.
Skin Contact : Primary Irritation Index=0.25.
Slight irritation.
Skin Absorption: Acute dermal LD50 > 2,000 mg/kg.
Ingestion : Oral LD50 >5,000 mg/kg.
Sensitization : Possible skin sensitization.
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Material Safety Data Sheet
(TOXICOLOGICAL INFORMATION - Continued)
CHRONIC:
A three-month feeding study in rats indicated hind leg
paralysis after a two-week exposure, at a high dose level of
5000 ppm, which also caused significant systemic toxicity
and 40% mortality. A two-year feeding study in rats
indicated an increased incidence of old age-related
retinopathy at a dose level of 750 ppm.
Carcinogenicity:
No evidence of carcinogenicity was observed in long-term
studies with mice.
Two-year feeding studies of ETU indicated thyroid and
pituitary tumors in rats at dietary concentrations of
83 ppm or higher and also thyroid, pituitary and liver
tumors in mice at dietary concentrations of 330 ppm or
higher.
Carcinogenic effects are considered to be secondary to
inhibition of thyroid synthesis and disruption of hormonal
balance.
Tests have shown that ETU causes developmental toxicity but
does not affect reproductive performance in animals. Tests
in some animals indicate that Maneb may have developmental
toxicity but only at levels also producing maternal
toxicity. Tests in animals demonstrate that Maneb does not
produce reproductive toxicity.
Mutagenicity:
Ames mutagenicity: Negative
Mouse Host Mediated Bacterial Gene Mutation Test: Negative
In vitro rat hepatocyte Unscheduled DNA Synthesis: Negative
Mammalian cell gene-mutation assay in Chinese hamster ovary
cells (CHO): Negative
In vivo cytogenetic assay (mouse): Negative
Sex-linked recessive lethal assay (Drosophila): Negative
Sister Chromatid Exchange: Positive without metabolic
activation; negative with metabolic activation Cell
Transformation in 10T 1/2 Cells: Negative
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Material Safety Data Sheet
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ECOLOGICAL INFORMATION
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Ecotoxicological Information
Ecotox:
Maneb: 96-hour LC50 = 0.53 mg/L in the harlequin fish
Wildlife Tox:
Maneb: 5-day dietary LC50 > 10,000 ppm in mallard ducks
Maneb: 5-day dietary LC50 > 10,000 ppm in bobwhite quail
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DISPOSAL CONSIDERATIONS
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# Waste Disposal
Do not contaminate water, food or feed by disposal.
Wastes resulting from the use of this product may be
disposed of on site or at an approved waste disposal
facility.
ENVIRONMENTAL HAZARDS:
This product is toxic to fish. Drift or runoff from treated
areas may be hazardous to aquatic organisms in neighboring
areas. Do not apply directly to water, to areas where
surface water is present or to intertidal areas below the
mean high water mark. Cover or incorporate spilled treated
seed. Do not contaminate water when disposing of equipment
washwaters.
# Container Disposal
Triple rinse (or equivalent). Then offer for recycling or
reconditioning, or puncture and dispose of in a sanitary
landfill, or by incineration, or, if allowed by State and
local authorities by burning. If burned, stay out of smoke.
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TRANSPORTATION INFORMATION
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Shipping Information
DOT:
Proper Shipping Name : Not Regulated by DOT unless shipped
in bulk. Package or by water. See
IMO/IMDG description.
IMO/IMDG:
Proper Shipping Name : Environmentally Hazardous
Substances, Liquid, n.o.s.,
(maneb 37% aqueous suspension)
Hazard Class :9
UN/NA Number : UN 3082
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Material Safety Data Sheet
(TRANSPORTATION INFORMATION - Continued)
Packaging Group : III
Marine Pollutant : Yes
Reportable Quantity : Yes - add RQ if 5,000 or more pounds
maneb. In a single package.
IATA/ICAO : Not Regulated.
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REGULATORY INFORMATION
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U.S. Federal Regulations
OSHA:
This product is considered hazardous under the OSHA
Hazardous Communication Standard (29 CFR ?910.1200).
TSCA:
All product components are on the TSCA Chemical Inventory.
CERCLA:
Releases of this material to air, land, or water are not
reportable to the National Response Center under the
Comprehensive Environmental Response, Compensation, and
Liability Act (CERCLA) or to the state and local emergency
planning committees under the Superfund Amendments and
Reauthorization Act (SARA) Title III Section 304.
RCRA:
Wastes of this commercial chemical product are classified as
hazardous by 40 CFR 261.33 being a listed waste U114.
SARA TITLE III
311/312 Hazard Categories: This product has been reviewed
according to the EPA "Hazard
Categories" and is categorized
as an acute health hazard
(40 CFR ?70.41).
313 Reportable Ingredients: This product contains a material
(CAS # 12427-38-2) listed in
Section 313 of the Superfund
Amendment and Reauthorization
Act of 1986 and 40 CFR Part 372.
STATE REGULATIONS
CALIFORNIA PROPOSITION 65
This product contains Maneb and ETU, chemicals known to the
State of California to cause cancer in laboratory animals.
ETU is also known to the State of California to cause birth
defects or other reproductive harm in laboratory animals.
EPA Reg. No. 352-655
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Material Safety Data Sheet
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OTHER INFORMATION
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NFPA, NPCA-HMIS
HAZARDS CLASSIFICATION:
(0-minimal, 1-slight, 2-moderate, 3-serious, 4-severe)
HMIS: HEALTH-0 FIRE-1 REACTIVITY-0
NFPA: HEALTH-1 FIRE-1 REACTIVITY-0
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The data in this Material Safety Data Sheet relates only to the
specific material designated herein and does not relate to use in
combination with any other material or in any process.
Responsibility for MSDS: DuPont Crop Protection
Address : Wilmington, DE 19898
Telephone : 1-888-638-7668
# Indicates updated section.
This information is based upon technical information believed to be
reliable. It is subject to revision as additional knowledge and
experience is gained.
End of MSDS
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