PF PRO PART B
Chemwatch Material Safety Data Sheet
Issue Date: 19-Nov-2008 CHEMWATCH 18-3724
NC317ECP Version No:2.0
CD 2008/3 Page 1 of 15
Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
PRODUCT NAME
PF PRO PART B
PROPER SHIPPING NAME
AMINES, SOLID, CORROSIVE, N.O.S. or POLYAMINES, SOLID, CORROSIVE, N.O.S.
(contains isophorone diamine)
PRODUCT USE
Part B of a 2-ppart epoxy system. Compound mortar.
SUPPLIER
Company: Powers Fasteners Australasia Pty Ltd
Address:
Factory 3, 205 Abbotts Road
Dandenong South
VIC, 3175
AUS
Telephone: +61 3 8787 5888
Telephone: +1 800 677 872 (freecall)
Fax: +61 3 9878 5899
Section 2 - HAZARDS IDENTIFICATION
STATEMENT OF HAZARDOUS NATURE
HAZARDOUS SUBSTANCE. DANGEROUS GOODS. According to the Criteria of NOHSC,
and the ADG Code.
POISONS SCHEDULE
S5
RISK SAFETY
?Harmful by inhalation in contact with skin ?Keep locked up.
and if swallowed.
?Causes burns. ?Avoid contact with eyes.
?Risk of serious damage to eyes. ?Wear suitable protective clothing.
?May cause SENSITISATION by skin contact. ?Use only in well ventilated areas.
?Harmful to aquatic organisms may cause ?Keep container in a well ventilated place.
long- term adverse effects in the aquatic
environment.
?Possible risk of irreversible effects. ?To clean the floor and all objects contaminated by
this material use water and detergent.
?Take off immediately all contaminated clothing.
?In case of accident or if you feel unwell
IMMEDIATELY contact Doctor or Poisons Information
Centre (show label if possible).
?This material and its container must be disposed
of as hazardous waste.
continued...
PF PRO PART B
Chemwatch Material Safety Data Sheet
Issue Date: 19-Nov-2008 CHEMWATCH 18-3724
NC317ECP Version No:2.0
CD 2008/3 Page 2 of 15
Section 3 - COMPOSITION / INFORMATION ON INGREDIENTS
NAME CAS RN %
isophorone diamine 2855-13-2 10-24
benzyl alcohol 100-51-6 1-9
2, 4, 6- tris[(dimethylamino)methyl]phenol 90-72-2 1-9
phenol 108-95-2 3-4
benzene- 1, 3- dimethanamine 1477-55-0 1-4^
diethylenetriamine 111-40-0 1-4^
Section 4 - FIRST AID MEASURES
SWALLOWED
?For advice, contact a Poisons Information Centre or a doctor at once.
?Urgent hospital treatment is likely to be needed.
?If swallowed do NOT induce vomiting.
?If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain open
airway and prevent aspiration.
?Observe the patient carefully.
?Never give liquid to a person showing signs of being sleepy or with reduced awareness; i.e. becoming unconscious.
?Give water to rinse out mouth, then provide liquid slowly and as much as casualty can comfortably drink.
?Transport to hospital or doctor without delay.
EYE
?If this product comes in contact with the eyes:
?Immediately hold eyelids apart and flush the eye continuously with running water.
?Ensure complete irrigation of the eye by keeping eyelids apart and away from eye and moving the eyelids by
occasionally lifting the upper and lower lids.
?Continue flushing until advised to stop by the Poisons Information Centre or a doctor, or for at least 15 minutes.
?Transport to hospital or doctor without delay.
?Removal of contact lenses after an eye injury should only be undertaken by skilled personnel.
SKIN
?If skin or hair contact occurs:
?Immediately flush body and clothes with large amounts of water, using safety shower if available.
?Quickly remove all contaminated clothing, including footwear.
?Wash skin and hair with running water. Continue flushing with water until advised to stop by the Poisons
Information Centre.
?Transport to hospital, or doctor.
INHALED
?If fumes or combustion products are inhaled remove from contaminated area.
?Lay patient down. Keep warm and rested.
?Prostheses such as false teeth, which may block airway, should be removed, where possible, prior to initiating
first aid procedures.
?Apply artificial respiration if not breathing, preferably with a demand valve resuscitator, bag-valve mask device,
or pocket mask as trained. Perform CPR if necessary.
?Transport to hospital, or doctor.
NOTES TO PHYSICIAN
?For acute or short-term repeated exposures to highly alkaline materials:
?Respiratory stress is uncommon but present occasionally because of soft tissue edema.
?Unless endotracheal intubation can be accomplished under direct vision, cricothyroidotomy or
tracheotomy may be necessary.
?Oxygen is given as indicated.
?The presence of shock suggests perforation and mandates an intravenous line and fluid
administration.
continued...
PF PRO PART B
Chemwatch Material Safety Data Sheet
Issue Date: 19-Nov-2008 CHEMWATCH 18-3724
NC317ECP Version No:2.0
CD 2008/3 Page 3 of 15
Section 4 - FIRST AID MEASURES
?Damage due to alkaline corrosives occurs by liquefaction necrosis whereby the saponification of
fats and solubilisation of proteins allow deep penetration into the tissue.
Alkalis continue to cause damage after exposure.
INGESTION:
?Milk and water are the preferred diluents
No more than 2 glasses of water should be given to an adult.
?Neutralising agents should never be given since exothermic heat reaction may compound injury.
* Catharsis and emesis are absolutely contra-indicated.
* Activated charcoal does not absorb alkali.
* Gastric lavage should not be used.
Supportive care involves the following:
?Withhold oral feedings initially.
?If endoscopy confirms transmucosal injury start steroids only within the first 48 hours.
?Carefully evaluate the amount of tissue necrosis before assessing the need for surgical
intervention.
?Patients should be instructed to seek medical attention whenever they develop difficulty in
swallowing (dysphagia).
SKIN AND EYE:
?Injury should be irrigated for 20-30 minutes.
Eye injuries require saline. [Ellenhorn & Barceloux: Medical Toxicology].
Section 5 - FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
?Foam.
?Dry chemical powder.
?BCF (where regulations permit).
?Carbon dioxide.
?Water spray or fog - Large fires only.
FIRE FIGHTING
?Alert Fire Brigade and tell them location and nature of hazard.
?Wear full body protective clothing with breathing apparatus.
?Prevent, by any means available, spillage from entering drains or water course.
?Use fire fighting procedures suitable for surrounding area.
?Do not approach containers suspected to be hot.
?Cool fire exposed containers with water spray from a protected location.
?If safe to do so, remove containers from path of fire.
?Equipment should be thoroughly decontaminated after use.
When any large container (including road and rail tankers) is involved in a fire,
consider evacuation by 800 metres in all directions.
FIRE/EXPLOSION HAZARD
?Combustible. Will burn if ignited.
Combustion products include: carbon monoxide (CO), carbon dioxide (CO2), nitrogen oxides (NOx),
products typical of burning organic material.
May emit corrosive fumes.
May emit poisonous fumes.
FIRE INCOMPATIBILITY
?Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine bleaches, pool chlorine etc. as
ignition may result.
HAZCHEM: 2X
continued...
PF PRO PART B
Chemwatch Material Safety Data Sheet
Issue Date: 19-Nov-2008 CHEMWATCH 18-3724
NC317ECP Version No:2.0
CD 2008/3 Page 4 of 15
Section 5 - FIRE FIGHTING MEASURES
Personal Protective Equipment
Gas tight chemical resistant suit.
Section 6 - ACCIDENTAL RELEASE MEASURES
EMERGENCY PROCEDURES
MINOR SPILLS
?Clean up all spills immediately.
?Avoid breathing vapours/ aerosols/ or dusts and avoid contact with skin and eyes.
?Control personal contact by using protective equipment.
?Contain and absorb spill with sand, earth, inert material or vermiculite.
?Place in a suitable labelled container for waste disposal.
MAJOR SPILLS
?Clear area of personnel and move upwind.
?Alert Fire Brigade and tell them location and nature of hazard.
?Wear full body protective clothing with breathing apparatus.
?Prevent, by any means available, spillage from entering drains or water course.
?Consider evacuation (or protect in place).
?Stop leak if safe to do so.
?Contain spill with sand, earth or vermiculite.
?Collect recoverable product into labelled containers for recycling.
?Neutralise/decontaminate residue.
?Collect solid residues and seal in labelled drums for disposal.
?Wash area and prevent runoff into drains.
?After clean up operations, decontaminate and launder all protective clothing and
equipment before storing and re-using.
?If contamination of drains or waterways occurs, advise emergency services.
EMERGENCY RESPONSE PLANNING GUIDELINES (ERPG)
The maximum airborne concentration below which it is believed that nearly all individuals could be exposed
for up to one hour WITHOUT experiencing or developing
life-threatening health effects is:
phenol 200ppm
irreversible or other serious effects or symptoms which could impair an individual's ability to take
protective action is:
phenol 50ppm
other than mild, transient adverse effects without perceiving a clearly defined odour is:
phenol 10ppm
American Industrial Hygiene Association (AIHA)
Ingredients considered according to the following cutoffs
Very Toxic (T+) >= 0.1% Toxic (T) >= 3.0%
R50 >= 0.25% Corrosive (C) >= 5.0%
R51 >= 2.5%
else >= 10%
where percentage is percentage of ingredient found in the mixture
Personal Protective Equipment advice is contained in Section 8 of the MSDS.
continued...
PF PRO PART B
Chemwatch Material Safety Data Sheet
Issue Date: 19-Nov-2008 CHEMWATCH 18-3724
NC317ECP Version No:2.0
CD 2008/3 Page 5 of 15
Section 7 - HANDLING AND STORAGE
PROCEDURE FOR HANDLING
?Avoid all personal contact, including inhalation.
?Wear protective clothing when risk of exposure occurs.
?Use in a well-ventilated area.
?Avoid contact with moisture.
?Avoid contact with incompatible materials.
?When handling, DO NOT eat, drink or smoke.
?Keep containers securely sealed when not in use.
?Avoid physical damage to containers.
?Always wash hands with soap and water after handling.
?Work clothes should be laundered separately. Launder contaminated clothing before re-use.
?Use good occupational work practice.
?Observe manufacturer's storing and handling recommendations.
?Atmosphere should be regularly checked against established exposure standards to ensure safe working conditions
are maintained.
Refer also to protective measures for the other component used with the product. Read both MSDS before using; store
and attach MSDS together.
SUITABLE CONTAINER
?DO NOT use aluminium or galvanised containers.
For low viscosity materials
?Drums and jerricans must be of the non-removable head type.
?Where a can is to be used as an inner package, the can must have a screwed enclosure.
For materials with a viscosity of at least 2680 cSt. (23 deg. C) and solids (between 15 C deg. and 40 deg C.):
?Removable head packaging;
?Cans with friction closures and
?low pressure tubes and cartridges
may be used.
-
Where combination packages are used, and the inner packages are of glass, porcelain or stoneware, there must be
sufficient inert cushioning material in contact with inner and outer packages unless the outer packaging is a close
fitting moulded plastic box and the substances are not incompatible with the plastic.
STORAGE INCOMPATIBILITY
?Reacts with mild steel, galvanised steel / zinc producing hydrogen gas which may form an explosive mixture with
air.
?Avoid strong acids, acid chlorides and acid anhydrides..
?Avoid contact with copper, aluminium and their alloys.
?Avoid reaction with oxidising agents.
STORAGE REQUIREMENTS
?Store in original containers.
?Keep containers securely sealed.
?Store in a cool, dry, well-ventilated area.
?Store away from incompatible materials and foodstuff containers.
?Protect containers against physical damage and check regularly for leaks.
?Observe manufacturer's storing and handling recommendations.
?DO NOT store near acids, or oxidising agents.
?No smoking, naked lights, heat or ignition sources.
continued...
PF PRO PART B
Chemwatch Material Safety Data Sheet
Issue Date: 19-Nov-2008 CHEMWATCH 18-3724
NC317ECP Version No:2.0
CD 2008/3 Page 6 of 15
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
EXPOSURE CONTROLS
Source Material TWA ppm TWA mg/m? Peak mg/m?br>
__________________ __________________ _______ _______ _______
Australia Exposure Standards phenol (Phenol) 1 4
Australia Exposure Standards benzene- 1, 3- dimethanamine 0.1
(m- Xylene- a, a' - diamine)
Australia Exposure Standards diethylenetriamine (Diethylene 1 4.2
triamine)
The following materials had no OELs on our records
?isophorone diamine: CAS:2855- 13- 2
?benzyl alcohol: CAS:100- 51- 6
?2, 4, 6- tris[(dimethylamino)methyl]phenol: CAS:90- 72- 2
EMERGENCY EXPOSURE LIMITS
Material Revised IDLH Value (mg/m3) Revised IDLH Value (ppm)
phenol 250 [Unch]
MATERIAL DATA
?Odour Threshold Value for phenol: 0.060 ppm (detection)
NOTE: Detector tubes for phenol, measuring in excess of 1 ppm, are commercially available.
Systemic absorption by all routes may induce convulsions with damage to the lungs and central nervous system.
Exposure at or below the recommended TLV-TWA is thought to protect the worker from respiratory, cardiovascular,
hepatic, renal and neurological toxicity. Workers or volunteers exposed at or below 5.2 ppm phenol have experienced
no ill-effects. Because phenol as a vapour, liquid or solid can penetrate the skin causing systemic effects, a skin
notation is considered necessary. Although ACGIH has not recommended a STEL it is felt that ACGIH excursion limits
(15 ppm limited to a total duration of 30
minutes with brief excursions limited to no more than 25 ppm) and NIOSH Ceiling values are sufficiently similar so
as to provide the same margin of safety.
Odour Safety Factor(OSF)
OSF=25 (PHENOL).
INGREDIENT DATA
2,4,6-TRIS[(DIMETHYLAMINO)METHYL]PHENOL:
BENZYL ALCOHOL:
?Exposure limits with "skin" notation indicate that vapour and liquid may be absorbed through intact skin.
Absorption by skin may readily exceed vapour inhalation exposure. Symptoms for skin absorption are the same as for
inhalation. Contact with eyes and mucous membranes may also contribute to overall exposure and may also invalidate
the exposure standard.
2,4,6-TRIS[(DIMETHYLAMINO)METHYL]PHENOL:
BENZYL ALCOHOL:
?Sensory irritants are chemicals that produce temporary and undesirable side-effects on the eyes, nose or
throat. Historically occupational exposure standards for these irritants have been based on observation of workers'
responses to various airborne concentrations. Present day expectations require that nearly every individual should
be protected against even minor sensory irritation and exposure standards are established using uncertainty factors
or safety factors of 5 to 10 or more. On occasion animal no-observable-effect-levels (NOEL) are used to determine
these limits where human results are unavailable. An additional approach, typically used by the TLV committee (USA)
in determining respiratory standards for this group of chemicals, has been to assign ceiling values (TLV C) to
rapidly acting irritants and to assign short-term exposure limits (TLV STELs) when the weight of evidence from
irritation, bioaccumulation and other endpoints combine to warrant such a limit. In contrast the MAK Commission
(Germany) uses a five-category system based on intensive odour, local irritation, and elimination half-life. However
this system is being replaced to be consistent with the European Union (EU) Scientific Committee for Occupational
Exposure Limits (SCOEL); this is more closely allied to that of the USA.
continued...
PF PRO PART B
Chemwatch Material Safety Data Sheet
Issue Date: 19-Nov-2008 CHEMWATCH 18-3724
NC317ECP Version No:2.0
CD 2008/3 Page 7 of 15
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
OSHA (USA) concluded that exposure to sensory irritants can:
?cause inflammation
?cause increased susceptibility to other irritants and infectious agents
?lead to permanent injury or dysfunction
?permit greater absorption of hazardous substances and
?acclimate the worker to the irritant warning properties of these substances thus increasing the risk of
overexposure.
ISOPHORONE DIAMINE:
?No exposure limits set by NOHSC or ACGIH.
BENZYL ALCOHOL:
OEL STEL (Russia): 5 mg/m3 Skin
Odour Threshold: 5.5 ppm
2,4,6-TRIS[(DIMETHYLAMINO)METHYL]PHENOL:
CEL TWA: 5 ppm, 54 mg/m3 SKIN [Rohm & Haas]
PERSONAL PROTECTION
EYE
?Chemical goggles.
?Full face shield may be required for supplementary but never for primary protection of
eyes
?Contact lenses may pose a special hazard; soft contact lenses may absorb and
concentrate irritants. A written policy document, describing the wearing of lens or
restrictions on use, should be created for each workplace or task. This should include a
review of lens absorption and adsorption for the class of chemicals in use and an account
of injury experience. Medical and first-aid personnel should be trained in their removal
and suitable equipment should be readily available. In the event of chemical exposure,
begin eye irrigation immediately and remove contact lens as soon as practicable. Lens
should be removed at the first signs of eye redness or irritation - lens should be
removed in a clean environment only after workers have washed hands thoroughly. [CDC
NIOSH Current Intelligence Bulletin 59].
HANDS/FEET
?Wear chemical protective gloves, eg. PVC.
?Wear safety footwear or safety gumboots, eg. Rubber.
NOTE:
?The material may produce skin sensitisation in predisposed individuals. Care must be
taken, when removing gloves and other protective equipment, to avoid all possible skin
contact.
?Contaminated leather items, such as shoes, belts and watch-bands should be removed and
destroyed.
OTHER
?Overalls.
?PVC Apron.
?PVC protective suit may be required if exposure severe.
?Eyewash unit.
?Ensure there is ready access to a safety shower.
RESPIRATOR
?Respiratory protection is required when ANY "Worst Case" vapour-phase concentration is
exceeded (see Computer Prediction in "Exposure Standards").
continued...
PF PRO PART B
Chemwatch Material Safety Data Sheet
Issue Date: 19-Nov-2008 CHEMWATCH 18-3724
NC317ECP Version No:2.0
CD 2008/3 Page 8 of 15
Section 8 - EXPOSURE CONTROLS / PERSONAL PROTECTION
Protection Factor (Min) Half- Face Respirator
Full- Face Respirator 10 x ES AK- P- - AUS
-
AK- P- - PAPR- AUS -
50 x ES -
AK- P- - AUS -
AK- P- - PAPR- AUS 100 x ES
- AK- P- - 2
-
^ - Full-face.
The local concentration of material, quantity and conditions of use determine the type of
personal protective equipment required. For further information consult site specific
CHEMWATCH data (if available), or your Occupational Health and Safety Advisor.
ENGINEERING CONTROLS
?General exhaust is adequate under normal operating conditions. Local exhaust
ventilation may be required in special circumstances. If risk of overexposure exists,
wear approved respirator. Supplied-air type respirator may be required in special
circumstances. Correct fit is essential to ensure adequate protection. Provide adequate
ventilation in warehouses and enclosed storage areas.
Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
APPEARANCE
Black paste with an amine-like odour; partly mixes with water.
PHYSICAL PROPERTIES
Corrosive.
Alkaline.
Molecular Weight: Not Applicable Boiling Range (?Not Available
C):
Melting Range (?Not Available
C): Specific Gravity (water= 1): Not Available
Solubility in water (g/L): Partly Miscible pH (as supplied): Not Applicable
pH (1% solution): Not Available Vapour Pressure (kPa): Not Available
Volatile Component (%vol): Not Available Evaporation Rate: Not Available
Relative Vapour Density (air=1): Not Available Flash Point (?Not Available
C):
Lower Explosive Limit (%): 1.0 Upper Explosive Limit (%): 13.0
Autoignition Temp (?Not Available
C): Decomposition Temp ( ?Not Available
C):
State: Non Slump Paste Viscosity: Not Available
Section 10 - CHEMICAL STABILITY AND REACTIVITY INFORMATION
CONDITIONS CONTRIBUTING TO INSTABILITY
?Presence of incompatible materials.
?Product is considered stable.
?Hazardous polymerisation will not occur.
For incompatible materials - refer to Section 7 - Handling and Storage.
continued...
PF PRO PART B
Chemwatch Material Safety Data Sheet
Issue Date: 19-Nov-2008 CHEMWATCH 18-3724
NC317ECP Version No:2.0
CD 2008/3 Page 9 of 15
Section 11 - TOXICOLOGICAL INFORMATION
POTENTIAL HEALTH EFFECTS
ACUTE HEALTH EFFECTS
SWALLOWED
?Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion
of less than 150 gram may be fatal or may produce serious damage to the health of the individual.
The material can produce chemical burns within the oral cavity and gastrointestinal tract
following ingestion.
Strong evidence exists that this substance may cause irreversible mutations (though not lethal)
even following a single exposure.
Amines without benzene rings when swallowed are absorbed throughout the gut. Corrosive action may
cause damage throughout the gastrointestinal tract. They are removed through the liver, kidney and
intestinal mucosa by enzyme breakdown.
EYE
?The material can produce chemical burns to the eye following direct contact. Vapours or mists
may be extremely irritating.
If applied to the eyes, this material causes severe eye damage.
Vapours of volatile amines irritate the eyes, causing excessive secretion of tears, inflammation
of the conjunctiva and slight swelling of the cornea, resulting in "halos" around lights. This
effect is temporary, lasting only for a few hours. However this condition can reduce the
efficiency of undertaking skilled tasks, such as driving a car. Direct eye contact with liquid
volatile amines may produce eye damage, permanent for the lighter species.
SKIN
?Skin contact with the material may be harmful; systemic effects may result following absorption.
The material can produce chemical burns following direct contactwith the skin.
Volatile amine vapours produce irritation and inflammation of the skin. Direct contact can cause
burns. They may be absorbed through the skin and cause similar effects to swallowing, leading to
death. The skin may exhibit whiteness, redness and wheals.
Open cuts, abraded or irritated skin should not be exposed to this material.
Amine epoxy-curing agents (hardeners) may produce primary skin irritation and sensitisation
dermatitis in predisposed individuals. Cutaneous reactions include erythema, intolerable itching
and severe facial swelling. Blistering, with weeping of serous fluid, and crusting and scaling may
also occur. Individuals exhibiting "amine dermatitis" may experience a dramatic reaction upon re-
exposure to minute quantities. Highly sensitive persons may even react to cured resins containing
trace amounts of unreacted amine hardener. Minute quantities of air-borne amine may precipitate
intense dermatological symptoms in sensitive individuals. Prolonged or repeated exposure may
produce tissue necrosis.
INHALED
?Inhalation of amine vapours may cause irritation of the mucous membrane of the nose and throat,
and lung irritation with respiratory distress and cough. Swelling and inflammation of the
respiratory tract is seen in serious cases; with headache, nausea, faintness and anxiety. There
may also be wheezing.
Inhalation of epoxy resin amine hardeners (including polyamines and amine adducts) may produce
bronchospasm and coughing episodes lasting several days after cessation of the exposure. Even
faint traces of these vapours may trigger an intense reaction in individuals showing "amine
asthma". The literature records several instances of systemic intoxications following the use of
amines in epoxy resin systems.
CHRONIC HEALTH EFFECTS
?Repeated or prolonged exposure to corrosives may result in the erosion of teeth, inflammatory
and ulcerative changes in the mouth and necrosis (rarely) of the jaw. Bronchial irritation, with
cough, and frequent attacks of bronchial pneumonia may ensue. Gastrointestinal disturbances may
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PF PRO PART B
Chemwatch Material Safety Data Sheet
Issue Date: 19-Nov-2008 CHEMWATCH 18-3724
NC317ECP Version No:2.0
CD 2008/3 Page 10 of 15
Section 11 - TOXICOLOGICAL INFORMATION
also occur. Chronic exposures may result in dermatitis and/or conjunctivitis.
Skin contact with the material is more likely to cause a sensitisation reaction in some persons
compared to the general population.
Laboratory (in vitro) and animal studies show, exposure to the material may result in a possible
risk of irreversible effects, with the possibility of producing mutation.
There is some evidence that inhaling this product is more likely to cause a sensitisation reaction
in some persons compared to the general population.
Sensitisation may give severe responses to very low levels of exposure, i.e. hypersensitivity.
Sensitised persons should not be allowed to work in situations where exposure may occur.
TOXICITY AND IRRITATION
?unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
?Contact allergies quickly manifest themselves as contact eczema, more rarely as urticaria or Quincke's
oedema. The pathogenesis of contact eczema involves a cell-mediated (T lymphocytes) immune reaction of the
delayed type. Other allergic skin reactions, e.g. contact urticaria, involve antibody-mediated immune
reactions. The significance of the contact allergen is not simply determined by its sensitisation potential:
the distribution of the substance and the opportunities for contact with it are equally important. A weakly
sensitising substance which is widely distributed can be a more important allergen than one with stronger
sensitising potential with which few individuals come into contact. From a clinical point of view,
substances are noteworthy if they produce an allergic test reaction in more than 1% of the persons tested.
Asthma-like symptoms may continue for months or even years after exposure to the material ceases. This may
be due to a non-allergenic condition known as reactive airways dysfunction syndrome (RADS) which can occur
following exposure to high levels of highly irritating compound. Key criteria for the diagnosis of RADS
include the absence of preceding respiratory disease, in a non-atopic individual, with abrupt onset of
persistent asthma-like symptoms within minutes to hours of a documented exposure to the irritant. A
reversible airflow pattern, on spirometry, with the presence of moderate to severe bronchial
hyperreactivity on methacholine challenge testing and the lack of minimal lymphocytic inflammation, without
eosinophilia, have also been included in the criteria for diagnosis of RADS. RADS (or asthma) following an
irritating inhalation is an infrequent disorder with rates related to the concentration of and duration of
exposure to the irritating substance. Industrial bronchitis, on the other hand, is a disorder that occurs
as result of exposure due to high concentrations of irritating substance (often particulate in nature) and
is completely reversible after exposure ceases. The disorder is characterised by dyspnea, cough and mucus
production.
ISOPHORONE DIAMINE:
?unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Oral (rat) LD50: 1030 mg/kg [Manufacturer HUE]
?Contact allergies quickly manifest themselves as contact eczema, more rarely as urticaria or Quincke's
oedema. The pathogenesis of contact eczema involves a cell-mediated (T lymphocytes) immune reaction of the
delayed type. Other allergic skin reactions, e.g. contact urticaria, involve antibody-mediated immune
reactions. The significance of the contact allergen is not simply determined by its sensitisation potential:
the distribution of the substance and the opportunities for contact with it are equally important. A weakly
sensitising substance which is widely distributed can be a more important allergen than one with stronger
sensitising potential with which few individuals come into contact. From a clinical point of view,
substances are noteworthy if they produce an allergic test reaction in more than 1% of the persons tested.
The material may be irritating to the eye, with prolonged contact causing inflammation. Repeated or
prolonged exposure to irritants may produce conjunctivitis.
Asthma-like symptoms may continue for months or even years after exposure to the material ceases. This may
be due to a non-allergenic condition known as reactive airways dysfunction syndrome (RADS) which can occur
following exposure to high levels of highly irritating compound. Key criteria for the diagnosis of RADS
include the absence of preceding respiratory disease, in a non-atopic individual, with abrupt onset of
persistent asthma-like symptoms within minutes to hours of a documented exposure to the irritant. A
reversible airflow pattern, on spirometry, with the presence of moderate to severe bronchial
hyperreactivity on methacholine challenge testing and the lack of minimal lymphocytic inflammation, without
eosinophilia, have also been included in the criteria for diagnosis of RADS. RADS (or asthma) following an
irritating inhalation is an infrequent disorder with rates related to the concentration of and duration of
continued...
PF PRO PART B
Chemwatch Material Safety Data Sheet
Issue Date: 19-Nov-2008 CHEMWATCH 18-3724
NC317ECP Version No:2.0
CD 2008/3 Page 11 of 15
Section 11 - TOXICOLOGICAL INFORMATION
exposure to the irritating substance. Industrial bronchitis, on the other hand, is a disorder that occurs
as result of exposure due to high concentrations of irritating substance (often particulate in nature) and
is completely reversible after exposure ceases. The disorder is characterised by dyspnea, cough and mucus
production.
The material may produce respiratory tract irritation, and result in damage to the lung including reduced
lung function.
The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin
redness, swelling, the production of vesicles, scaling and thickening of the skin.
BENZYL ALCOHOL:
?unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Oral (rat) LD50: 1230 mg/kg Skin (man): 16 mg/48h- Mild
Inhalation (rat) LCLo: 2000 ppm/4h Skin (rabbit):10 mg/24h open- Mild
Inhalation (rat) LC50: 1000 ppm/8h Eye (rabbit): 0.75 mg Open SEVERE
Inhalation (rat) LC50: >4178 mg/m?4h
Dermal (rabbit) LD50: 2000 mg/kg
?The material may cause skin irritation after prolonged or repeated exposure and may produce on contact
skin redness, swelling, the production of vesicles, scaling and thickening of the skin.
For benzyl alkyl alcohols:
Unlike benzylic alcohols, the beta-hydroxyl group of the members of this cluster is unlikely to undergo
phase II metabolic activation. Instead, the beta-hydroxyl group is expected to contribute to detoxification
via oxidation to hydrophilic acid. Despite structural similarity to carcinogenic ethyl benzene, only a
marginal concern has been assigned to phenethyl alcohol due to limited mechanistic analogy.
(aerosol)
2,4,6-TRIS[(DIMETHYLAMINO)METHYL]PHENOL:
?unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Oral (rat) LD50: 1200 mg/kg Skin (rabbit): 2 mg/24h - SEVERE
Oral (rat) LD50: 2500 mg/kg * Eye (rabbit): 0.05 mg/24h - SEVERE
Dermal (rabbit) LD50: 1280 mg/kg [Rohm & Haas, Henkel]*
Inhalation (rat) LC50: >0.5 mg/l/1 hr. [Ciba]
?The material may produce severe irritation to the eye causing pronounced inflammation. Repeated or
prolonged exposure to irritants may produce conjunctivitis.
The material may cause severe skin irritation after prolonged or repeated exposure and may produce on
contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin. Repeated
exposures may produce severe ulceration.
Asthma-like symptoms may continue for months or even years after exposure to the material ceases. This may
be due to a non-allergenic condition known as reactive airways dysfunction syndrome (RADS) which can occur
following exposure to high levels of highly irritating compound. Key criteria for the diagnosis of RADS
include the absence of preceding respiratory disease, in a non-atopic individual, with abrupt onset of
persistent asthma-like symptoms within minutes to hours of a documented exposure to the irritant. A
reversible airflow pattern, on spirometry, with the presence of moderate to severe bronchial
hyperreactivity on methacholine challenge testing and the lack of minimal lymphocytic inflammation, without
eosinophilia, have also been included in the criteria for diagnosis of RADS. RADS (or asthma) following an
irritating inhalation is an infrequent disorder with rates related to the concentration of and duration of
exposure to the irritating substance. Industrial bronchitis, on the other hand, is a disorder that occurs
as result of exposure due to high concentrations of irritating substance (often particulate in nature) and
is completely reversible after exposure ceases. The disorder is characterised by dyspnea, cough and mucus
production.
PHENOL:
?unless otherwise specified data extracted from RTECS - Register of Toxic Effects of Chemical Substances.
TOXICITY IRRITATION
Oral (rat) LD50: 317 mg/kg Skin(rabbit): 500 mg/24hr - SEVERE
continued...
PF PRO PART B
Chemwatch Material Safety Data Sheet
Issue Date: 19-Nov-2008 CHEMWATCH 18-3724
NC317ECP Version No:2.0
CD 2008/3 Page 12 of 15
Section 11 - TOXICOLOGICAL INFORMATION
Oral (human) LDLo: 140 mg/kg Skin(rabbit): 500 mg Open - SEVERE
Inhalation (rat) LC50: 316 mg/m? Eye(rabbit): 5 mg - SEVERE
Dermal (rabbit) LD50: 850 mg/kg Eye(rabbit): 100 mg rinse - Mild
?The material may produce severe irritation to the eye causing pronounced inflammation. Repeated or
prolonged exposure to irritants may produce conjunctivitis.
The material may cause severe skin irritation after prolonged or repeated exposure and may produce on
contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin. Repeated
exposures may produce severe ulceration.
Asthma-like symptoms may continue for months or even years after exposure to the material ceases. This may
be due to a non-allergenic condition known as reactive airways dysfunction syndrome (RADS) which can occur
following exposure to high levels of highly irritating compound. Key criteria for the diagnosis of RADS
include the absence of preceding respiratory disease, in a non-atopic individual, with abrupt onset of
persistent asthma-like symptoms within minutes to hours of a documented exposure to the irritant. A
reversible airflow pattern, on spirometry, with the presence of moderate to severe bronchial
hyperreactivity on methacholine challenge testing and the lack of minimal lymphocytic inflammation, without
eosinophilia, have also been included in the criteria for diagnosis of RADS. RADS (or asthma) following an
irritating inhalation is an infrequent disorder with rates related to the concentration of and duration of
exposure to the irritating substance. Industrial bronchitis, on the other hand, is a disorder that occurs
as result of exposure due to high concentrations of irritating substance (often particulate in nature) and
is completely reversible after exposure ceases. The disorder is characterised by dyspnea, cough and mucus
production.
The substance is classified by IARC as Group 3:
NOT classifiable as to its carcinogenicity to humans.
Evidence of carcinogenicity may be inadequate or limited in animal testing.
CARCINOGEN
phenol International Agency for Research on Cancer Group 3
(IARC) Carcinogens
SKIN
phenol Australia Exposure Standards - Skin Notes Sk
Section 12 - ECOLOGICAL INFORMATION
Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic
environment.
This material and its container must be disposed of as hazardous waste.
Section 13 - DISPOSAL CONSIDERATIONS
?Recycle wherever possible.
?Consult manufacturer for recycling options or consult local or regional waste
management authority for disposal if no suitable treatment or disposal facility can be
identified.
?Treat and neutralise at an approved treatment plant. Treatment should involve: Mixing
or slurrying in water; Neutralisation followed by: Burial in a licenced land-fill or
Incineration in a licenced apparatus (after admixture with suitable combustible material)
?Decontaminate empty containers. Observe all label safeguards until containers are
cleaned and destroyed.
continued...
PF PRO PART B
Chemwatch Material Safety Data Sheet
Issue Date: 19-Nov-2008 CHEMWATCH 18-3724
NC317ECP Version No:2.0
CD 2008/3 Page 13 of 15
Section 14 - TRANSPORTATION INFORMATION
Labels Required: CORROSIVE
HAZCHEM: 2X (ADG7)
UNDG:
Dangerous Goods Class: 8 Subrisk: None
UN Number: 3259 Packing Group: III
Shipping Name:AMINES, SOLID, CORROSIVE, N.O.S. or POLYAMINES, SOLID,
CORROSIVE, N.O.S.
(contains isophorone diamine)
Air Transport IATA:
ICAO/IATA Class: 8 ICAO/IATA Subrisk: None
UN/ID Number: 3259 Packing Group: III
Special provisions: A3
Shipping Name: AMINES, SOLID, CORROSIVE, N.O.S. *
Maritime Transport IMDG:
IMDG Class: 8 IMDG Subrisk: None
UN Number: 3259 Packing Group: III
EMS Number: F- A, S- B Special provisions: 223 274 944
Limited Quantities: 5 kg Marine Pollutant: Not Determined
Shipping Name: AMINES, SOLID, CORROSIVE, N.O.S. or
POLYAMINES, SOLID, CORROSIVE, N.O.S.
Section 15 - REGULATORY INFORMATION
POISONS SCHEDULE: S5
REGULATIONS
PF PRO Part B (CAS: None):
No regulations applicable
isophorone diamine (CAS: 2855-13-2) is found on the following regulatory lists;
Australia Hazardous Substances
Australia Inventory of Chemical Substances (AICS)
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 5
GESAMP/EHS Composite List of Hazard Profiles - Hazard evaluation of substances transported by ships
IMO IBC Code Chapter 17: Summary of minimum requirements
IMO MARPOL 73/78 (Annex II) - List of Noxious Liquid Substances Carried in Bulk
International Council of Chemical Associations (ICCA) - High Production Volume List
OECD Representative List of High Production Volume (HPV) Chemicals
benzyl alcohol (CAS: 100-51-6) is found on the following regulatory lists;
Australia - Victoria Occupational Health and Safety Regulations - Schedule 9: Materials at Major Hazard
Facilities (And Their Threshold Quantity) Table 2
Australia Hazardous Substances
Australia Inventory of Chemical Substances (AICS)
GESAMP/EHS Composite List of Hazard Profiles - Hazard evaluation of substances transported by ships
IMO IBC Code Chapter 17: Summary of minimum requirements
IMO MARPOL 73/78 (Annex II) - List of Noxious Liquid Substances Carried in Bulk
International Council of Chemical Associations (ICCA) - High Production Volume List
OECD Representative List of High Production Volume (HPV) Chemicals
2,4,6-tris[(dimethylamino)methyl]phenol (CAS: 90-72-2) is found on the following regulatory lists;
continued...
PF PRO PART B
Chemwatch Material Safety Data Sheet
Issue Date: 19-Nov-2008 CHEMWATCH 18-3724
NC317ECP Version No:2.0
CD 2008/3 Page 14 of 15
Section 15 - REGULATORY INFORMATION
Australia Hazardous Substances
Australia Inventory of Chemical Substances (AICS)
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Appendix F (Part 3)
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 5
International Council of Chemical Associations (ICCA) - High Production Volume List
OECD Representative List of High Production Volume (HPV) Chemicals
phenol (CAS: 108-95-2) is found on the following regulatory lists;
Australia - Australian Capital Territory - Environment Protection Regulation: Pollutants entering
waterways taken to cause environmental harm (Aquatic habitat)
Australia - Australian Capital Territory Environment Protection Regulation Ecosystem maintenance -
Organic chemicals - Non-pesticide anthropogenic organics
Australia - Victoria Occupational Health and Safety Regulations - Schedule 9: Materials at Major Hazard
Facilities (And Their Threshold Quantity) Table 2
Australia Exposure Standards
Australia Hazardous Substances
Australia High Volume Industrial Chemical List (HVICL)
Australia Inventory of Chemical Substances (AICS)
Australia National Pollutant Inventory
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Appendix E (Part 2)
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Appendix F (Part 3)
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 2
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 4
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 5
Australia Standard for the Uniform Scheduling of Drugs and Poisons (SUSDP) - Schedule 6
GESAMP/EHS Composite List of Hazard Profiles - Hazard evaluation of substances transported by ships
IMO IBC Code Chapter 17: Summary of minimum requirements
IMO MARPOL 73/78 (Annex II) - List of Noxious Liquid Substances Carried in Bulk
IMO Provisional Categorization of Liquid Substances - List 1: Pure or technically pure products
International Agency for Research on Cancer (IARC) Carcinogens
OECD Representative List of High Production Volume (HPV) Chemicals
Section 16 - OTHER INFORMATION
REPRODUCTIVE HEALTH GUIDELINES
?Established occupational exposure limits frequently do not take into consideration
reproductive end points that are clearly below the thresholds for other toxic effects.
Occupational reproductive guidelines (ORGs) have been suggested as an additional
standard. These have been established after a literature search for reproductive no-
observed-adverse effect-level (NOAEL) and the lowest-observed-adverse-effect-level
(LOAEL). In addition the US EPA's procedures for risk assessment for hazard
identification and dose-response assessment as applied by NIOSH were used in the creation
of such limits. Uncertainty factors (UFs) have also been incorporated.
Ingredient ORG UF Endpoint CR Adeq
TLV
phenol 3.6 mg/m3 100 D NA -
?These exposure guidelines have been derived from a screening level of risk assessment
and should not be construed as unequivocally safe limits. ORGS represent an 8-hour time-
weighted average unless specified otherwise.
CR = Cancer Risk/10000; UF = Uncertainty factor:
TLV believed to be adequate to protect reproductive health:
LOD: Limit of detection
Toxic endpoints have also been identified as:
D = Developmental; R = Reproductive; TC = Transplacental carcinogen
Jankovic J., Drake F.: A Screening Method for Occupational Reproductive
American Industrial Hygiene Association Journal 57: 641-649 (1996).
EXPOSURE STANDARD FOR MIXTURES
?"Worst Case" computer-aided prediction of vapour components/concentrations:
?Composite Exposure Standard for Mixture (TWA) (mg/m3): 54 mg/m?br>
?If the breathing zone concentration of ANY of the components listed below is exceeded,
"Worst Case" considerations deem the individual to be overexposed.
Component Breathing Zone ppm Breathing Zone mg/m3 Mixture Conc: (%).
Component Breathing zone (ppm) Breathing zone (mg/m3) Mixture Conc (%)
continued...
PF PRO PART B
Chemwatch Material Safety Data Sheet
Issue Date: 19-Nov-2008 CHEMWATCH 18-3724
NC317ECP Version No:2.0
CD 2008/3 Page 15 of 15
Section 16 - OTHER INFORMATION
2, 4, 6- 5.00 54.0000 9.0
tris[(dimethylamino)met
hyl]phenol
?Classification of the preparation and its individual components has drawn on official
and authoritative sources as well as independent review by the Chemwatch Classification
committee using available literature references.
A list of reference resources used to assist the committee may be found at:
www.chemwatch.net/references.
?The (M)SDS is a Hazard Communication tool and should be used to assist in the Risk
Assessment. Many factors determine whether the reported Hazards are Risks in the
workplace or other settings. Risks may be determined by reference to Exposures Scenarios.
Scale of use, frequency of use and current or available engineering controls must be
considered.
This document is copyright. Apart from any fair dealing for the purposes of private study, research, review or
criticism, as permitted under the Copyright Act, no part may be reproduced by any process without written permission
from CHEMWATCH. TEL (+61 3) 9572 4700.
Issue Date: 19-Nov-2008
Print Date: 20-Nov-2008
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