SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 02/27/2007
Date Updated: 02/16/2007
Version 1.12
Section 1 - Product and Company Information
Product Name 4-METHYL-2-PENTANONE, CHROMASOLV? FOR
HPLC, >=99.5%
Product Number 293261
Brand ALDRICH
Company Sigma-Aldrich
Address 3050 Spruce Street
SAINT LOUIS MO 63103 US
Technical Phone: 800-325-5832
Fax: 800-325-5052
Emergency Phone: 314-776-6555
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
4-METHYL-2-PENTANONE 108-10-1 Yes
Formula C6H12O
Synonyms Hexon (Czech) * Hexone (OSHA) *
Isobutyl-methylketon (Czech) * Isobutyl methyl
ketone * Isopropylacetone * Ketone, isobutyl
methyl * Methyl-isobutyl-cetone (French) *
Methylisobutylketon (Dutch, German) * Methyl
isobutyl ketone (ACGIH:OSHA) *
Metyloizobutyloketon (Polish) *
4-Methyl-pentan-2-on (Dutch, German) *
2-Methyl-4-pentanone * 4-Methyl-2-pentanon
(Czech) * 4-Methyl-2-pentanone *
Metilisobutilchetone (Italian) *
4-Metilpentan-2-one (Italian) * MIBK * MIK * RCRA
waste number U161 * Shell MIBK
RTECS Number: SA9275000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Flammable (USA) Highly Flammable (EU). Harmful.
Harmful by inhalation. Irritating to eyes and respiratory system.
Repeated exposure may cause skin dryness or cracking.
Target organ(s): Nerves. May form explosive peroxides.
HMIS RATING
HEALTH: 2*
FLAMMABILITY: 3
REACTIVITY: 1
NFPA RATING
HEALTH: 2
FLAMMABILITY: 3
REACTIVITY: 1
*additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious
amounts of water.
EYE EXPOSURE
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
Section 5 - Fire Fighting Measures
FLAMMABLE HAZARDS
Flammable Hazards: Yes
EXPLOSION HAZARDS
Vapor may travel considerable distance to source of ignition and
flash back. Container explosion may occur under fire conditions.
Forms explosive mixtures in air.
FLASH POINT
57.2 癋 14 癈 Method: closed cup
EXPLOSION LIMITS
Lower: 1.2 % Upper: 8 %
AUTOIGNITION TEMP
459 癈
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: For small (incipient) fires, use media such as
"alcohol" foam, dry chemical, or carbon dioxide. For large
fires, apply water from as far as possible. Use very large
quantities (flooding) of water applied as a mist or spray; solid
streams of water may be ineffective. Cool all affected
containers with flooding quantities of water.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Flammable liquid. Emits toxic fumes under
fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
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PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Avoid breathing vapor. Avoid contact with eyes,
skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep container closed. Keep away from heat, sparks,
and open flame.
Unsuitable: May form peroxides on contact with air.
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved
under appropriate government standards such as NIOSH (US) or CEN
(EU). Where risk assessment shows air-purifying respirators are
appropriate use a full-face respirator with multi-purpose
combination (US) or type ABEK (EN 14387) respirator cartridges as
a backup to engineering controls. If the respirator is the sole
means of protection, use a full-face supplied air respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
EXPOSURE LIMITS, RTECS
Country Source Type Value
USA ACGIH STEL 75 PPM
USA ACGIH TWA 50 PPM
USA MSHA Standard-air TWA 100 PPM (410 MG/M3)
USA OSHA. PEL 8H TWA 100 PPM (410 MG/M3)
USA NIOSH TWA 50 PPM
STEL 75 PPM
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 83
Poland NDSCh 200
Poland NDSP -
Section 9 - Physical/Chemical Properties
Appearance Physical State: Liquid
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Property Value At Temperature or Pressure
Molecular Weight 100.16 AMU
pH N/A
BP/BP Range N/A
MP/MP Range - 80.0 癈
Freezing Point N/A
Vapor Pressure 15 mmHg 20 癈
Vapor Density 3.5 g/l
Saturated Vapor Conc. N/A
SG/Density 0.8 g/cm3
Bulk Density N/A
Odor Threshold 0.1 ppm
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension 23.6 mN/m 20 癈
Partition Coefficient Log Kow: 1.31
Decomposition Temp. N/A
Flash Point 57.2 癋 14 癈 Method: closed cup
Explosion Limits Lower: 1.2 %
Upper: 8 %
Flammability N/A
Autoignition Temp 459 癈
Refractive Index 1.396
Optical Rotation N/A
Miscellaneous Data N/A
Solubility Solubility in Water:20 mg/ml H2O
Other Solvents: ACETONE, BENZENE
CHLOROFORM. MISCIBLEWITH MOST
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Conditions to Avoid: May form peroxides on contact with air.
Materials to Avoid: Oxidizing agents, Strong bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract. Harmful if inhaled.
Ingestion: May be harmful if swallowed.
SENSITIZATION
Sensitization: Will not occur
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TARGET ORGAN(S) OR SYSTEM(S)
Nerves.
SIGNS AND SYMPTOMS OF EXPOSURE
Contact with eyes can cause redness, tearing, and blurred
vision. Prolonged or repeated contact with skin can cause
defatting and dermatitis. To the best of our knowledge, the
chemical, physical, and toxicological properties have not been
thoroughly investigated.
TOXICITY DATA
Skin
Rabbit
> 16,000 mg/kg
LD50
4H
Inhalation
Rat
8.2 - 16.4 mg/m3
LC50
Oral
Rat
2080 mg/kg
LD50
Inhalation
Rat
100,000 mg/m3
LC50
Intraperitoneal
Rat
400 MG/KG
LD50
Oral
Mouse
1900 mg/kg
LD50
Inhalation
Mouse
23,300 mg/m3
LC50
Intraperitoneal
Mouse
268 MG/KG
LD50
Oral
Guinea pig
1600 mg/kg
LD50
Intraperitoneal
Guinea pig
800 MG/KG
LD50
IRRITATION DATA
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Skin
Rabbit
Remarks: Moderate irritation effect
Eyes
Rabbit
Remarks: No irritation effect
Eyes
Human
200 ppm
15M
Skin
Rabbit
500 mg
24H
Remarks: Mild irritation effect
Eyes
Rabbit
40 mg
Remarks: Severe irritation effect
Eyes
Rabbit
0.1 ml
24H
Remarks: Moderate irritation effect
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 300 PPM/6H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Musculoskeletal
system. Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Mouse
Dose: 3000 PPM/6H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Fetal death.
Species: Mouse
Dose: 3000 PPM/6H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
Section 12 - Ecological Information
ACUTE ECOTOXICITY TESTS
Test Type: EC50 Algae
Species: Scenedesmus subspicatus
Time: 48 h
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Value: 980.0 - 2,000.0 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 1,550.0 - 3,623.0 mg/l
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 48 h
Value: 672.0 - 744.0 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 496.0 - 593.0 mg/l
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Methyl isobutyl ketone
UN#: 1245
Class: 3
Packing Group: Packing Group II
Hazard Label: Flammable liquid
PIH: Not PIH
IATA
Proper Shipping Name: Methyl isobutyl ketone
IATA UN Number: 1245
Hazard Class: 3
Packing Group: II
Section 15 - Regulatory Information
EU DIRECTIVES CLASSIFICATION
Symbol of Danger: F-Xn
Indication of Danger: Highly Flammable. Harmful.
R: 11-20-36/37-66
Risk Statements: Highly flammable. Harmful by inhalation.
Irritating to eyes and respiratory system. Repeated exposure may
cause skin dryness or cracking.
S: 9-16-29
Safety Statements: Keep container in a well-ventilated place.
Keep away from sources of ignition - no smoking. Do not empty
into drains.
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Flammable (USA) Highly Flammable (EU).
Harmful.
Risk Statements: Harmful by inhalation. Irritating to eyes and
respiratory system. Repeated exposure may cause skin dryness or
cracking.
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Safety Statements: Keep away from sources of ignition - no
smoking. Do not empty into drains. Keep container in a
well-ventilated place.
US Statements: Target organ(s): Nerves. May form explosive
peroxides.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: Yes
DEMINIMIS: 1 %
NOTES: This product is subject to SARA section 313 reporting
requirements.
TSCA INVENTORY ITEM: Yes
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: Yes
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2007 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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