SAFETY DATA SHEET
Isocyanate A 100
A-side
Section 1: PRODUCT & COMPANY INFORMATION
MANUFACTURER OF CHEMICAL COMPONENTS PRODUCT
Trade name: Isocyanate A 100
DEMILEC (USA) LLC
Chemical name: Diphenylmethane Diisocyanate (MDI)
2925 Galleria Dr.
Chemical family: Aromatic Isocyanate
Arlington, TX 76011
Product Use: Component of a Polyurethane System
Phone: (817) 640-4900
Fax: (817) 633-2000
e-mail: info@demilecusa.com
Emergency telephone:
1-877-DEMILEC or
CHEMTREC: (800) 424-9300 or
CANUTEC: (613) 996-6666
Section 2: HAZARDS IDENTIFICATION
Liquid / Brown / Slightly musty
Physical State / Color / Odor:
Emergency Overview / Warning:
This material is classified hazardous under OSHA Hazard Communication Standard (29
OSHA/HCS Status:
CFR 1910.1200).
Toxic gases/fumes may be released during burning or thermal decomposition. Closed
Physical /Chemical Hazards:
container may forcibly rupture under extreme heat or when contents have been
contaminated with water. Use cold water spray to cool fire exposed containers to minimize
the risk of rupture.
Harmful by inhalation. Irritating to eyes, respiratory system and skin.
Human Health Hazard:
May cause sensitization by inhalation and skin contact.
This product is respiratory irritant and potential respiratory sensitizer: repeated inhalation
of vapor or aerosol at levels above the occupational exposure limit could cause respiratory
sensitization. A hyper reactive response to even minimal concentrations of MDI may
develop in sensitized persons. The onset of the respiratory symptoms may be delayed for
several hours after exposure. Lung damage and respiratory sensitization may be permanent.
Section 3: COMPOSITION / INFORMATION ON INGREDIENTS
Ingredients CAS # %
Polymeric Diphenylmethane Diisocyanate (pMDI) 9016-87-9 50 ?60
4, 4' Diphenylmethane Diisocyanate (MDI) 101-68-8 35 ?45
2, 4' Diphenylmethane Diisocyanate (MDI) 5873-54-1 1?
Section 4: FIRST AID MEASURES
Immediately flush eyes with running water for a minimum of 15 minutes. Use lukewarm water
Eye contact:
if possible. Hold eyelids open during flushing. Obtain medical attention immediately.
In case of contact, immediately remove contaminated clothing and shoes. Immediately flush
Skin contact:
skin with plenty of soap and water. Use lukewarm water if possible. Wash contaminated
clothing and shoes thoroughly before reuse. For severe exposures, immediately get under safety
Isocyanate A 100
shower and start rinsing. If the irritation develops, obtain medical attention.
Move to an area free from further exposure. Obtain medical attention immediately. If breathing
Inhalation:
is difficult, qualified personnel should administer artificial respiration or oxygen. Asthmatic
symptoms may develop and may be immediate or delayed up to several hours. Extreme
asthmatic reactions can be life threatening.
DO NOT induce vomiting unless directed to do so by medical personnel. Never give anything
Ingestion:
by mouth to an unconscious person. If patient is conscious, wash out mouth with water. Get
immediate medical attention.
No action shall be taken involving any personal risk or without suitable training. If it is
Protection of first-aiders:
suspected that fumes are still present, the rescuer should wear an appropriate mask or self-
contained breathing apparatus. It may be dangerous to the person providing aid to give mouth-
to-mouth resuscitation.
Eyes: Stain for evidence of corneal injury. If cornea is burned, instill antibiotic/steroid
Notes to physician:
preparation as needed. Workplace vapors could produce reversible corneal epithelial edema
impairing vision.
Skin: this compound is a skin sensitizer. Treat symptomatically as for contact dermatitis or
thermal burn.
Ingestion: treat symptomatically. There is no specific antidote. Inducing vomiting is
contraindicated because of the irritating nature of compound.
Inhalation: treatment is essentially symptomatic. An individual having a dermal or pulmonary
sensitization reaction to this material should be removed from further exposure to any
diisocyanate.
Following severe exposure the patient should be kept under medical review for at least 48
hours.
Section 5: FIRE FIGHTING MEASURES
Dry chemical, Carbon Dioxide (CO2), Foam, Water Spray for large fires.
Suitable Extinguishing
Media:
Combustion products may include Carbon Monoxide, Carbon Dioxide, Nitrogen Oxides,
Hazardous Products of
Hydrocarbons and HCN.
Thermal Decomposition:
Firefighter should be equipped with self-contained breathing apparatus (SCBA) with a full face-
Special Fire Fighting
piece operated in positive pressure mode to protect against potentially toxic and irritating fumes
Procedures:
generated by thermal decomposition or combustion during a fire. They should wear appropriate
protective equipment such as PVC boots, gloves, safety helmet and protective clothing. Avoid
contact with product. Exposure to heated diisocyanate can be extremely dangerous.
Decontaminate equipment and protective clothing prior to reuse.
A hazardous pressure buildup could result due to reaction with water producing CO2 gas if
Unusual Fire / Explosion
contaminated containers are re-sealed. Containers may burst if overheated. Use cold water
Hazards:
spray to cool fire exposed containers to minimize the risk of rupture. Large fires can be
extinguished with large volumes of water applied from a safe distance, since reaction between
water and hot diisocyanate can be vigorous.
Section 6: ACCIDENTAL RELEASE MEASURES
Evacuate all non-emergency personnel. Isolate the area and prevent access. Eliminate all
Spill and Leak
sources of ignition. Notify management. Use protective equipment. Control sources of the leak.
Procedures:
Ventilate. Clean-up should be performed by trained personnel.
Environmental Precautions: Contain the spill to prevent spread into drains, sewers, water
Methods for Cleaning-up:
supplies, or soil.
Page 2 of 9
Isocyanate A 100
Major Spill or Leak: Released material may be pumped into closed, but not sealed metal
containers for disposal. Process can generate heat. People dealing with major spillage should
wear full protective clothing including respiratory protection. Use suitable protective
equipment.
Minor Spill or Leak: Cover spill area with sand, earth or any suitable absorbent material.
Saturate absorbent material with neutralization solution and mix. Wait 15 minutes. Collect
material in open-head metal containers. Repeat applications of decontamination solution, with
scrubbing, followed by absorbent until the surface is decontaminated. Check for residual
surface contamination. Swipe?test kits have been used for this purpose. Apply lid loosely and
allow containers to vent for 72hoursto let carbon dioxide to escape. Wash the spillage area with
water. Test atmosphere for MDI vapor.
a) a mixture of 75% water, 20% non-ionic surfactant (e.g. Tergitol TMN-10, Plurafac
Neutralization solutions:
SL-62) and 5% n-propanol
b) a mixture of 80% water with 20% non-ionic surfactant Tergitol TMN-10,
c) a mixture of 90% water, 3-8% ammonium hydroxide or concentrated ammonia and 2%
detergent
Section 7: HANDLING & STORAGE
50 - 100癋 (10 - 38癈)
Storage Temperature
(minimum-maximum):
6months
Storage Life:
Do not breathe vapor, mists or dusts. Avoid contact with skin and eyes. Use adequate
Handling:
ventilation to keep airborne isocyanate levels below the exposure limits. The efficiency of the
ventilation system must be monitored regularly because of the possibility of blockage. When
the product is sprayed, heated, or used in confined space, suitable respiratory protection
equipment with positive air supply is required. Keep equipment clean.
This material can produce asthmatic sensitization upon either single inhalation exposure to a
relatively high concentration or upon repeated inhalation exposures to lower concentrations.
Individuals with lung or breathing problems or prior allergic reactions to isocyanates must not
be exposed to vapors and mist. Do not breathe smoke and gases created by overheating or
burning this material. Decomposition products can be highly toxic and irritating.
Keep stocks of decontaminant readily available.
Employee education and training in the safe use and handling of this product are required under
the OSHA Hazard Communication Standard 29 CFR 1910.1200.
Store in tightly closed containers to prevent moisture contamination. Due to reaction with water
Storage:
producing CO2 gas, a hazardous build up of pressure could result if contaminated containers are
re-sealed. Do not reseal container if contamination is suspected.
Uncontaminated containers, free of moisture, may be resealed only after placing under a
nitrogen blanket.
Suitable: steel, stainless steel.
Packaging Containers:
Unsuitable: copper, copper alloys or galvanized surfaces.
Section 8: EXPOSURE CONTROL / PERSONAL PROTECTION
4,4'- Diphenylmethane Diisocyanate
Ingredient name:
Occupational exposure limits:
US. ACGIH Threshold Limit Values:
TWA: 0.005ppm
US. OSHA Table Z -1 Limits for Air Contaminants (29CFR 1910.1000):
Page 3 of 9
Isocyanate A 100
Ceiling Limit Value : 0.02ppm, 0.2mg/m?br>
US. NIOSH : Pocket Guide to Chemical Hazards :
Recommended exposure limit REL/TWA : 0.005ppm, 0.05 mg/m?(10-hour, 40 hrs/week)
Ceiling Limit Value and Time Period (if specified) : 0.020ppm, 0.2mg/m?(10min)
Environmental Controls:
Provide exhaust ventilation or other engineering controls to keep the airborne vapors
Occupational Exposure
concentrations bellow their respective occupational exposure limits.
Controls:
Standard Reference Sources regarding industrial ventilation (e.g. ACGIH Industrial Ventilation
Manual) should be used as a guide about adequate ventilation. To ensure that published
exposure limits have not been exceeded, monitoring for airborne diisocyanate should become
part of the overall employee exposure characterization program. NIOSH and OSHA have
developed sampling and analytical methods and they are available upon request.
MDI can only be smelled if the occupational exposure limit has been exceeded
considerably.
Emissions from ventilation or work process equipment should be checked to ensure they
Environmental Exposure
comply with the requirements of environmental protection legislation. In some cases, fume
Controls:
scrubbers, filters or engineering modifications to the process equipment will be necessary to
reduce emissions to acceptable levels.
Eye protection is required when directly handling liquid product.
Eye Protection:
Safety eyewear such as chemical safety goggles or 8" face shield should be used when there is a
greater risk of liquid splash.
Contact lenses should not be worn when working with this chemical.
Avoid all contact with skin. Depending on the conditions of use, cover as much of exposed skin
Skin Protection:
area as possible with appropriate clothing to prevent skin contact.
Use chemical resistant gloves such as Nitrile/butadiene rubber ("nitrile" or "NBR"), Butyl
rubber, Polyvinyl chloride ("PVC" or "vinyl"), Polychloroprene (Neoprene*).
Protective gloves should be worn when handling freshly made polyurethane products to avoid
contact with trace residual materials that may be hazardous in contact with skin.
Wash hands, forearms and face thoroughly after handling chemical products, before eating,
smoking and using the lavatory and at the end of the working period.
Appropriate techniques should be used to remove potentially contaminated clothing. Wash
contaminated clothing before reusing.
Animal tests and other research indicate that skin contact with MDI can play a role in causing
isocyanate sensitization and respiratory reaction. This data reinforces the need to prevent direct
skin contact with isocyanates.
Airborne MDI concentrations greater than the ACGIH TLV-TWA(TWA) or OSHA PEL-
Respiratory Protection:
C(PEL) can occur in inadequately ventilated environments when MDI is sprayed, aerosolized or
heated. In such cases, respiratory protection must be worn.
The type of protection selected must comply with the requirements set forth in OSHA's
Respiratory Protection Standard (29 CFR 1910.134). The type of available protection include:
1) an atmosphere-supplying respirator such as a self-contained breathing apparatus (SCBA) or a
supplied air respirator (SAR) in the positive pressure or continuous flow mode, or
2) an air purifying respirator (APR). If an APR is selected then: a) cartridge must be equipped
with an end-of-service life indicator (ESLI) certified by NIOSH, or (b) a change out of
schedule, based on objective information or data that will ensure that the cartridges are changed
out before the end of their service life, must be developed and implemented. The basis for the
change out of schedule must be described in the written respirator program. Further, if an APR
is selected, the airborne diisocyanate concentration must be no greater than 10 times the TLV or
Page 4 of 9
Isocyanate A 100
PEL. The recommended APR cartridge is an organic vapor/particulate filter combination
cartridge (OV/P100).
All applicants who are assigned to an isocyanate work area should undergo a pre-placement
Medical Surveillance:
medical evaluation. A history of asthma, bronchitis, eczema or respiratory allergies such as hay
fever, are possible reasons for medical exclusion from isocyanate areas. Once a worker has
been diagnosed as sensitized to any isocyanate, no further exposure can be permitted. The
Occupational Exposure Limits do not apply to previously sensitized individuals.
A comprehensive annual medical surveillance program should be instituted for all employees
who are potentially exposed to diisocyanates.
Ensure that eyewash stations and safety showers are close to the workstation location. Educate
Additional Protective
and train employees in the safe use and handling of this product. Follow all label instructions.
Measures:
Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Brown Liquid
Physical State:
Slightly musty
Odor:
180-220cps
Viscosity @ 77篎:
1.24
Specific Gravity @ 77篎:
1.234kg/m?br>
Bulk Density:
Not applicable
pH:
Insoluble. Reacts slowly with water to liberate CO2.
Solubility in Water:
~406篎 (208篊)
Boiling Point:
388篎 (198篊) by ASTM D 93
Flash Point:
>600篊
Auto-ignition Temperature:
<0.0001 mmHg @ 25篊 (MDI)
Vapor Pressure:
8.5 for MDI (Air=1)
Vapor Density:
Section 10: STABILITY AND REACTIVITY
Stable at room temperature. This product will react and release heat with any materials
Incompatibility:
containing active hydrogen. The reaction is accelerated and can be violent at higher
temperatures if the miscibility of the reaction partners is good or is supported by stirring or by
the presence of solvents.
MDI is insoluble with and heavier than water and sinks to the bottom, but reacts slowly at the
interface. A solid water-insoluble layer of polyurea is formed at the interface by liberating CO2.
Avoid high temperatures.
Conditions to avoid:
Water, alcohols, amines, bases, copper alloys
Materials to avoid:
May occur at elevated temperatures (350篎 (177篊)), in the presence of alkalies, tertiary amines
Hazardous
and metal compounds.
polymerization:
Isocyanate vapors and other irritating, highly toxic gases such as Carbon Dioxide, Carbon
Hazardous products of
Monoxide, Nitrogen Oxides, Hydrocarbons and HCN
decomposition:
Section 11: TOXICOLOGICAL INFORMATION
Acute Oral Toxicity, Acute Inhalation Acute Dermal Repeated Dose Toxicity: (Rat)
LD50 (Rat): Toxicity, LC50 (Rat) Toxicity, LD50
(Rabbit):
90 days, inhalation: NOAEL:
Isocyanate A 500 > 2000 mg/kg 490mg/m?(4hr) slightly irritating 1 mg/m?6hrs/day 5days/week)
Irritation to lungs & nasal cavities
90 days, inhalation: NOAEL:
4,4'- Diphenylmethane N/A 369 mg/m?(4hr) > 10,000 mg/kg 0.3 mg/m?18hrs/day 5days/week)
Irritation to lungs & nasal
Diisocyanate >2240 mg/m?(1hr)
cavities
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Isocyanate A 100
Potential acute health effects:
This product is a respiratory irritant and potential respiratory sensitizer. Repeated inhalation of
Inhalation:
vapors or aerosols at levels above the occupational exposure limit could cause respiratory
sensitization. Symptoms may include irritation to eyes, nose, throat and lungs, possibly
combined with dryness of the throat, tightness of chest and difficulty in breathing. The onset of
the respiratory symptoms may be delayed for several hours after exposure. A hyper-reactive
response to even minimal concentrations of MDI may develop in sensitized persons.
Low oral toxicity. Ingestion may cause irritation of gastrointestinal tract.
Ingestion:
Irritating to skin. May cause sensitization by skin contact.
Skin Contact:
Irritating to eyes.
Eye contact:
Potential chronic health effects:
Lungs, Upper respiratory tract, skin
Target Organs:
A study was conducted where groups of rats were exposed for 2 years to a respirable polymeric
Carcinogenic Effects:
MDI aerosol at concentrations of 0, 0.2, 1 or 6 mg/m?
No adverse effects were observed at 0.2 mg/m? At the 1 mg/m? minimal nasal and lung irritant
effects were seen. Only at the top concentration (6 mg/m? there was an increased incidence of
benign tumor of the lung. One malignant pulmonary tumor was seen in the 6mg/m?group. MDI
administration to rats in this study did not change the distribution and incidence of tumors from
those seen in control animals. The increased incidence of lung tumors is associated with
prolonged respiratory irritation and the concurrent accumulation of yellow material in the lung.
In the absence of prolonged exposure to high concentrations leading to chronic irritation and
lung damage, it is highly unlikely that tumor formation will occur.
There is no substantial evidence of mutagenic potential.
Mutagenic Effects:
No adverse reproductive effects are anticipated.
Reproductive Effects:
No birth defects were seen in two independent animal (rat) studies. Fetotoxicity was observed at
doses that were extremely toxic (including lethal) to the mother. Fetotoxicity was not observed
at doses that were not maternally toxic. The doses used in these studies were maximal
respirable concentrations well in excess of the defined occupational exposure limits.
Section 12: ECOLOGICAL INFORMATION
Aquatic Toxicity Data For Components Toxicity:
Biodegradation: 0%, not degradable (Exposure time 28days)
Bioacumulation: does not accumulate (fish: rainbow trout) (Exposure time 112days)
Acute & Prolonged Toxicity to fish:
LC50: >1,000mg/l (96hrs) (zebra fish)
Isocyanate A 500
LC50: >3,000mg/l (96hrs) (orange-red killifish)
Acute & Prolonged Toxicity to Invertebrates: EC50: >1,000mg/l (24hrs) (Daphnia magna)
Toxicity to Aquatic Plants: NOEC: 1,640 mg/l (72hrs) (Green algae)
Toxicity to Microorganisms: EC50: >100mg/l (3hrs) (Activated Sludge)
Acute & Prolonged Toxicity to fish:
4,4'- Diphenylmethane LC50: >500mg/l (24hrs) (zebra fish)
Diisocyanate Acute & Prolonged Toxicity to Invertebrates
EC50: >500mg/l (24hrs) (Daphnia magna)
By considering the production and use of substance, it is unlikely that significant environmental
Mobility:
exposure in the air or water will arise. Immiscible with water but will react with it and produce
inert and non-biodegradable solids. Conversion to soluble products, including diamino-
diphenylmethane (MDA) is very low under the optimal laboratory conditions of good
dispersion and low concentration. In air, the predominant degradation process is predicted to be
Page 6 of 9
Isocyanate A 100
relatively rapid OH radical attack, by calculation and by analogy with related diisocyanates.
By comparison with an analogous product, the following values are anticipated. The measured
Other Adverse Effects:
ecotoxicity is that of the hydrolyzed product, generally under conditions maximizing production
of soluble species. Even so, the observed ecotoxicity is low/very low. A pond study showed
gross contamination caused no significant toxic effects on a wide variety of flora in all tophic
levels (including fish), no detectable diamino-diphenylmethane (MDA), and no evidence of
bioaccumulation of MDI or MDA.
Section 11: DISPOSAL CONSIDERATION
The generation of waste should be avoided or minimized whenever possible. Disposal should
Waste Disposal Method:
be in accordance with the existing federal, state and local environmental control laws. Dispose
of surplus and non-recyclable products via licensed waste disposal contractor. Incineration is
the preferred method.
Empty containers contain residues. Do not heat or cut empty container with electric or gas torch
Empty Container
because of highly toxic vapors and gases can be formed. Do not reuse without through
Precautions:
commercial cleaning and reconditioning. If container will be disposed, ensure all product
residues are removed prior to disposal.
Section 12: TRANSPORTATION INFORMATION
Aromatic Isocyanate - Isocyanate A 100
Technical Shipping Name:
Other Regulated Substances, Liquid, N.O.S.
Land Transport / DOT Classification:
UN 3082 / Hazard Class or Division: 9 / Packaging Group III
Hazardous Label: Miscellaneous
4,4'- Diphenylmethane Diisocyanate
RSPA / DOT Regulated Components:
Reportable Quantity (RQ) for 4,4 MDI: Single containers with 5,000 lbs
Reportable Quantity (RQ) for A 500: Single containers with 11,905 lbs
Not regulated
Sea Transport / IMDG Classification
Not regulated
Air Transport / ICAO/IATA Classification:
When in individual containers of less than the product Reportable Quantity,
Additional Transport Information:
this material ships as non-regulated.
1-877-DEMILEC
Emergency telephone number:
CHEMTREC: (800) 424-9300 &
CANUTEC: (613) 996-6666
Section 15: REGULATORY INFORMATION
U.S. Federal Regulations
This material is classified as hazardous under OSHA Hazard Communication
OSHA Hazcom Standard Rating:
Standard (29 CFR 1910.1200).
Toxic / Irritant / Sensitizer
HSC Classification:
Listed on the TSCA Inventory
US. Toxic Substances Control Act / TSCA:
4,4-Methylene Diphenyl Diisocyanate (CAS 101-68-8) has a 5,000 lbs RQ.
US. EPA CERCLA Hazardous Substances
(40CFR 302): Any spill or release above the RQ must be reported to the National Response
Center (800-424-8802).
Acute Health Hazard, Chronic Health Hazard
SARA Section 311/312 Hazard Categories:
Components:
US. EPA EPCRA SARA Title III Section 302
Extremely Hazardous Substance (40 CFR 355, none
Appendix A):
Page 7 of 9
Isocyanate A 100
Components:
US. EPA EPCRA SARA Title III Section 313
Toxic Chemicals (40 CFR 372.65) - Supplier Polymeric Diphenylmethane Diisocyanate (pMDI)
Notification Required:
4,4-Methylene Diphenyl Diisocyanate
If discarded in its purchased form, this product will not be a hazardous waste either
US. EPA RCRA Composite List of Hazardous
by listing or by characteristic. However, under RCRA, it is the responsibility of the
Wastes and Appendix VIII Hazardous
product user to determine at the time of disposal, whether a material containing the
Constituents (40CFR 261):
product or derived from the product should be classified as a hazardous waste(40
CFR 261.20-24)
The following chemicals are specifically listed by individual states; other
State Regulations:
product specific health and safety data in other sections of the MSDS may
also be applicable to state requirements. For details on your regulatory
requirements you should contact appropriate agency in your state.
No ingredients listed
California prop. 65:
Components CAS # Weight, %
Massachusetts, New Jersey or Pennsylvania
Right to know Substances Lists:
Polymeric Diphenylmethane Diisocyanate (pMDI) 9016-87-9 50 ?60
4, 4' Diphenylmethane Diisocyanate (MDI) 101-68-8 35 ?45
2, 4' Diphenylmethane Diisocyanate (MDI) 5873-54-1 1?
Components CAS # Weight, %
Ney Jersey Environmental Hazardous
Substances List and/or Ney Jersey RTK Special
Polymeric Diphenylmethane Diisocyanate (pMDI) 9016-87-9 40 ?55
Hazardous Substances Lists:
4, 4' Diphenylmethane Diisocyanate (MDI) 101-68-8 35 ?45
Canada
Class D-1A Material causing immediate and serious toxic effects (very toxic)
WHMIS
Class D-2A Material causing other toxic effects (very toxic)
Class D-2B Material causing other toxic effects (toxic)
Canada Inventory: All components are listed or exempted.
CEPA (DSL)
Section 16. OTHER INFORMATION
Health 2*
HMIS Rating
0-Minimal; 1- Slight; 2- Moderate; 3-Serious; 4- Severe; Fire Hazard 1
*- Chronic Health Hazard Reactivity 1
Health Hazard: 2
NFPA Rating
Flammability Hazard: 1
0- Insignificant; 1-Slight; 2-Moderate; 3-High; 4-Extreme
Instability Hazard: 1
This product does not contain nor is it manufactured with ozone depleting substances.
Section 16: APPROVALS
Notice: The information herein is presented in good faith and believed to be accurate as of the effective date shown bellow.
However, no warranty expresses or implied is given.
Regulatory requirements are subject to change and may differ from one location to another; it is user's responsibility to
ensure that its activities comply with country, provincial and local laws.
This product may present hazards and should be used with caution. While certain hazards are described in this
publication, no guarantee is made that these are only hazards that exist.
Hazards, toxicity and behavior of the products may differ when used with other materials and are dependent upon
manufacturing circumstances or other processes. Such hazards, toxicity and behavior should be determined by the user
and made known to handlers, processors and end users.
Page 8 of 9
Isocyanate A 100
Julija Sinanovic, Polyurethane Chemist
Prepared by:
Dave Lall, General Manager
Approved by:
May, 2003
Preparation date:
February, 2010
Current issue date:
Page 9 of 9
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