SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 05/MAY/2005
Date Updated: 14/MAR/2004
Version 1.2
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name 2-PHENYLPHENOL, 99%
Product Number P28263
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
2-PHENYLPHENOL 90-43-7 201-993-5 604-020-00-6
Formula C12H10O
Molecular Weight 170.21 AMU
Synonyms Biphenyl, 2-hydroxy- * (1,1'-Biphenyl)-2-ol *
o-Biphenylol * o-Diphenylol * Dowicide 1 *
Dowicide 1 antimicrobial * 2-Fenylfenol (Czech)
* 2-Hydroxybifenyl (Czech) * o-Hydroxybiphenyl *
2-Hydroxybiphenyl * o-Hydroxydiphenyl *
2-Hydroxydiphenyl * Invalon OP * NCI-C50351 *
Nectryl * Orthohydroxydiphenyl *
Orthophenylphenol * Orthoxenol * Phenol,
o-phenyl- * o-Phenylphenol * 2-Phenylphenol *
Preventol O Extra * Remol TRF * Tetrosin OE *
Torsite * Tumescal OPE * USAF EK-2219 * o-Xenol
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Irritating to eyes, respiratory system and skin. Very toxic to
aquatic organisms.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Avoid contact
with eyes, skin, and clothing. Avoid prolonged or repeated
exposure.
STORAGE
Conditions of Storage: Keep tightly closed.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Solid
Color: White
Form: Fine plates
Property Value At Temperature or Pressure
ALDRICH - P28263 www.sigma-aldrich.com Page 2
pH 6.1 22.7 癈
BP/BP Range 282 癈 760 mmHg
MP/MP Range 56 癈
Flash Point 124 癈 Method: closed cup
Flammability N/A
Autoignition Temp > 520 癈
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.4 %
Upper: 9.5 %
Vapor Pressure 7 mmHg 140 癈
SG/Density 1.24 g/cm3 20 癈
Partition Coefficient Log Kow: 3.18
Viscosity 0.002 Pas 100 癈
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density 0.65 kg/l
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:0.2 mg/ml H2O
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents, Strong bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: DV5775000
ACUTE TOXICITY
LD50
Oral
Rat
2000 mg/kg
LD50
Oral
Mouse
1050 mg/kg
Remarks: Behavioral:Ataxia. Cardiac:Other changes. Lungs,
Thorax, or Respiration:Respiratory depression.
LD50
Intraperitoneal
Mouse
50 MG/KG
ALDRICH - P28263 www.sigma-aldrich.com Page 3
LD50
Oral
Cat
500 mg/kg
Remarks: Behavioral:Somnolence (general depressed activity).
Lungs, Thorax, or Respiration:Dyspnea. Blood: Hemorrhage.
IRRITATION DATA
Skin
Rabbit
250 mg
Skin
Rabbit
20 mg
24H
Remarks: Moderate irritation effect
Eyes
Rabbit
0.05 mg
24H
Remarks: Severe irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes severe eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Kidneys.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that is not
classifiable as to its carcinogenicity based on its IARC, ACGIH,
NTP, or EPA classification.
Rat
Route of Application: Oral
Exposure Time: 91W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Liver:Tumors.
Rat
Route of Application: Oral
Exposure Time: 91W
Result: Tumorigenic:Carcinogenic by RTECS criteria. Kidney,
Ureter, Bladder:Tumors.
Rat
Route of Application: Oral
Exposure Time: 26W
Result: Tumorigenic:Neoplastic by RTECS criteria. Kidney,
Ureter, Bladder:Tumors.
ALDRICH - P28263 www.sigma-aldrich.com Page 4
IARC CARCINOGEN LIST
Rating: Group 3
CHRONIC EXPOSURE - MUTAGEN
Result: Laboratory experiments have shown mutagenic effects.
Human
200 UG/L
Cell Type: fibroblast
Cytogenetic analysis
Human
20 MG/L
Cell Type: Embryo
Mutation in mammalian somatic cells.
Human
15 MG/L
Cell Type: Other cell types
Mutation in mammalian somatic cells.
Rat
336 GM/KG
Oral
4W
Unscheduled DNA synthesis
Mouse
5 MG/L (+S9)
Cell Type: lymphocyte
Mutation in microorganisms
Mouse
2 GM/KG
Oral
DNA damage
Mouse
50 MG/L
Cell Type: lymphocyte
Mutation in mammalian somatic cells.
Hamster
100 MG/L
Cell Type: ovary
Cytogenetic analysis
Hamster
29900 UG/L
Cell Type: ovary
Sister chromatid exchange
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 6 GM/KG
Route of Application: Oral
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Fetal death.
ALDRICH - P28263 www.sigma-aldrich.com Page 5
Species: Mouse
Dose: 13050 MG/KG
Route of Application: Oral
Exposure Time: (7-15D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Eye, ear. Specific
Developmental Abnormalities: Musculoskeletal system.
Species: Mouse
Dose: 13050 MG/KG
Route of Application: Oral
Exposure Time: (7-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Species: Rat
Dose: 52168 MG/KG
Route of Application: Oral
Exposure Time: (13W MALE)
Result: Paternal Effects: Testes, epididymis, sperm duct.
Paternal Effects: Prostate, seminal vessicle, Cowper's gland,
accessory glands.
Species: Rabbit
Dose: 6500 MG/KG
Route of Application: Oral
Exposure Time: (7-19D PREG)
Result: Maternal Effects: Other effects.
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Algae
Species: Scenedesmus subspicatus
Time: 72 h
Value: 0.85 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 48 h
Value: 1 - 3.17 mg/l
Test Type: LC50 Fish
Species: Lepomis macrochirus (Bluegill) Onchorhynchus
mykiss (Rainbow trout)
Time: 96 h
Value: 2.74 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 5.7 - 6.47 mg/l
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
ALDRICH - P28263 www.sigma-aldrich.com Page 6
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.
14 - Transport Information
RID/ADR
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
IMDG
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 3077
Class: 9
PG: III
Proper Shipping Name: Environmentally hazardous
substance, solid, n.o.s
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 604-020-00-6
INDICATION OF DANGER: Xi N
Irritant. Dangerous for the environment.
R-PHRASES: 36/37/38 50
Irritating to eyes, respiratory system and skin. Very toxic to
aquatic organisms.
S-PHRASES: 61 22
Avoid release to the environment. Refer to special
instructions/safety data sheets. Do not breathe dust.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 2
SWITZERLAND
SWISS POISON CLASS: 4
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
ALDRICH - P28263 www.sigma-aldrich.com Page 7
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
ALDRICH - P28263 www.sigma-aldrich.com Page 8
|