The MSDS format adheres to the standards and regulatory requirements
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DuPont Page 1
Material Safety Data Sheet
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FE-227
6160FR Revised 28-FEB-2008
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CHEMICAL PRODUCT/COMPANY IDENTIFICATION
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Material Identification
FE-227 is a registered trademark of DuPont.
CAS Number : 431-89-0
Formula : CF3 CHF CF3
Molecular Weight : 170.03
CAS Name : Propane, 1,1,1,2,3,3,3-Heptafluoro-
Tradenames and Synonyms
2-Hydroperfluoropropane
Propane, 1,1,1,2,3,3,3-Heptafluoro-
HFC-227eaHP
2-Hydroheptafluoropropane
Heptafluoropropane
2-H-heptafluoropropane
1,1,1,2,3,3,3-Heptafluoropropane
FM-200
R-227
R227
HFC-227ea
Company Identification
MANUFACTURER/DISTRIBUTOR
DuPont Fluoroproducts
1007 Market Street
Wilmington, DE 19898
PHONE NUMBERS
Product Information : 1-800-441-7515 (outside the U.S.
302-774-1000)
Transport Emergency : CHEMTREC 1-800-424-9300(outside U.S.
703-527-3887)
Medical Emergency : 1-800-441-3637 (outside the U.S.
302-774-1000)
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COMPOSITION/INFORMATION ON INGREDIENTS
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Components
Material CAS Number %
1,1,1,2,3,3,3-Heptafluoropropane 431-89-0 99.95
6160FR DuPont Page 2
Material Safety Data Sheet
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HAZARDS IDENTIFICATION
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# Potential Health Effects
Based on animal data, exposure to HFC-227ea by inhalation
may cause suffocation, if air is displaced by vapors, and
irregular heart beat with a strange sensation in the chest,
"heart thumping," apprehension, lightheadedness, feeling of
fainting, dizziness, weakness, sometimes progressing to loss
of consciousness and death.
HFC-227ea may cause frostbite if liquid or escaping vapor
contacts the skin.
HFC-227ea may cause "frostbite-like" effects if the liquid
or escaping vapors contact the eyes.
In one study, human volunteers were selected to inhale
HFC-227ea at a concentration of 6000 ppm but the study was
terminated due to a rise in pulse rate that was believed to
be unrelated to the chemical. In a subsequent study with
human volunteers inhaling concentrations up to 8000 ppm no
clinically significant effects were observed for any of the
measured laboratory parameters.
Individuals with preexisting diseases of the cardiovascular
system or nervous system may have increased susceptibility
from excessive exposures.
Carcinogenicity Information
None of the components present in this material at concentrations
equal to or greater than 0.1% are listed by IARC, NTP, OSHA or ACGIH
as a carcinogen.
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FIRST AID MEASURES
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First Aid
INHALATION
If inhaled, immediately remove to fresh air. If not breathing,
give artificial respiration. If breathing is difficult, give
oxygen. Call a physician.
SKIN CONTACT
Treat for frostbite if necessary by gently warming affected area.
EYE CONTACT
In case of contact, immediately flush eyes with plenty of water
for at least 15 minutes. Call a physician.
6160FR DuPont Page 3
Material Safety Data Sheet
(FIRST AID MEASURES - Continued)
INGESTION
Ingestion is not considered a potential route of exposure.
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FIRE FIGHTING MEASURES
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Flammable Properties
1,1,1,2,3,3,3-Heptafluoropropane is not flammable, however
in the presence of a flame or ignition source it may
decompose to form toxic hydrogen fluoride or carbonyl
fluoride.
Non-flammable.
Extinguishing Media
Use media appropriate for surrounding material.
Fire Fighting Instructions
Self-contained breathing apparatus (SCBA) may be required if
cylinders rupture or release under fire conditions.
Keep cylinders cool with water spray applied from a safe
distance.
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ACCIDENTAL RELEASE MEASURES
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Safeguards (Personnel)
NOTE: Review FIRE FIGHTING MEASURES and HANDLING (PERSONNEL)
sections before proceeding with clean-up. Use appropriate
PERSONAL PROTECTIVE EQUIPMENT during clean-up.
Evacuate personnel, thoroughly ventilate area, use self-contained
breathing apparatus. Keep upwind of leak - evacuate until gas has
dispersed.
Initial Containment
Use forced ventilation to disperse vapors.
6160FR DuPont Page 4
Material Safety Data Sheet
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HANDLING AND STORAGE
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Handling (Personnel)
Do not breathe gas. Avoid contact with eyes, skin, or clothing.
Wash thoroughly after handling. Wash clothing after use.
Storage
Store in a clean, dry place. Store below 52 C (126 F).
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EXPOSURE CONTROLS/PERSONAL PROTECTION
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Engineering Controls
Use only with adequate ventilation. Keep container tightly closed.
Personal Protective Equipment
EYE/FACE PROTECTION
Wear safety glasses or coverall chemical splash goggles.
RESPIRATORS
Wear NIOSH approved respiratory protection, as appropriate.
PROTECTIVE CLOTHING
Where there is potential for skin contact have available and wear
as appropriate impervious gloves, apron, pants, and jacket.
Exposure Guidelines
Exposure Limits
FE-227
AEL * (DuPont) : 1000 ppm, 8 & 12 Hr. TWA
* AEL is DuPont鈥檚 Acceptable Exposure Limit. Where governmentally
imposed occupational exposure limits which are lower than the AEL
are in effect, such limits shall take precedence.
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PHYSICAL AND CHEMICAL PROPERTIES
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Physical Data
Boiling Point : -16.4 C (2.5 F)
Melting Point : -131 C (-204 F)
Vapor Pressure : 65.7 psia @ 25 C (77 F) (453.3 kPa)
Liquid Density : 1.386 g/cm3 @ 25 C (77 F) (86.53 lb/ft3)
Critical temperature : 101.6 C (214.9 F)
Critical pressure : 424.7 psia (2930 kPa)
Odor : None.
6160FR DuPont Page 5
Material Safety Data Sheet
(PHYSICAL AND CHEMICAL PROPERTIES - Continued)
Form : Liquified Gas
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STABILITY AND REACTIVITY
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Chemical Stability
Stable at normal temperatures and storage conditions.
Avoid sources of heat or open flame.
Incompatibility with Other Materials
Incompatible with strong reducing agents such as alkali
metals (e.g., sodium, potassium), alkali-earth metals (e.g.,
magnesium, calcium), and powdered aluminum or zinc.
Decomposition
Decomposes by reaction with high temperature (open flames,
glowing metal surfaces, etc.) forming hydrofluoric acid,
carbonyl fluorides, carbon monoxide and carbon dioxide.
Polymerization
Polymerization will not occur.
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TOXICOLOGICAL INFORMATION
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# Animal Data
HFC-227ea
Inhalation 4 hour LC50: > 788,698 ppm in rats
Repeated exposure of rats by inhalation for 4 weeks at
concentrations up to 50,000 ppm revealed no toxicologically
significants effects. The NOEL for this study was 50,000
ppm. A 90-day inhalation study in rats did not find any
exposure related effects at 105,000 ppm. The NOEL for this
study was 105,000 ppm.
Cardiac sensitization, a potentially fatal disturbance of
heart rhythm associated with a heightened sensitivity to the
action of epinephrine, occurred in dogs at 105,000 ppm. The
NOAEL for cardiac sensitization was 90,000 ppm. In a
different study to evaluate cardiac sensitization in dogs,
concentrations of 90,000, 105,000, and 140,000 ppm caused a
dose-related increase in incidence and severity; at 90,000
ppm efffects were minimal or mild in nature.
Inhalation studies of HFC-227ea in rabbits and rats do not
suggest developmental toxicity at concentrations up to
6160FR DuPont Page 6
Material Safety Data Sheet
(TOXICOLOGICAL INFORMATION - Continued)
105,000 ppm. Tests have shown that HFC-227ea does not cause
genetic damage in bacterial or mammalian cell cultures.
Tests in animals for carcinogenicity or reproductive
toxicity have not been conducted.
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DISPOSAL CONSIDERATIONS
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Waste Disposal
Treatment, storage, transportation, and disposal must be in
accordance with applicable Federal, State/Provincial, and Local
regulations. Incinerate material in accordance with Federal,
State/Provincial and Local requirements.
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TRANSPORTATION INFORMATION
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Shipping Information
DOT
Proper Shipping Name : Heptafluoropropane
Hazard Class : 2.2
I.D. No. (UN/NA) : UN 3296
DOT Label(s) : Nonflammable Gas
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REGULATORY INFORMATION
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U.S. Federal Regulations
TSCA Inventory Status : Listed.
TITLE III HAZARD CLASSIFICATIONS SECTIONS 311, 312
Acute : Yes
Chronic : No
Fire : No
Reactivity : No
Pressure : No
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OTHER INFORMATION
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NFPA, NPCA-HMIS
NFPA Rating
Health :1
Flammability :0
Reactivity :1
NPCA-HMIS Rating
Health :1
Flammability :0
6160FR DuPont Page 7
Material Safety Data Sheet
(Continued)
Reactivity :0
Personal Protection rating to be supplied by user depending on use
conditions.
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The data in this Material Safety Data Sheet relates only to the
specific material designated herein and does not relate to use in
combination with any other material or in any process.
Responsibility for MSDS : MSDS Coordinator
> : DuPont Fluoroproducts
Address : Wilmington, DE 19898
Telephone : (800) 441-7515
# Indicates updated section.
This information is based upon technical information believed to be
reliable. It is subject to revision as additional knowledge and
experience is gained.
End of MSDS
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