SIGMA-ALDRICH
MATERIAL SAFETY DATA SHEET
Date Printed: 10/13/2005
Date Updated: 08/29/2005
Version 1.3
Section 1 - Product and Company Information
Product Name CARMUSTINE
Product Number C0400
Brand SIGMA
Company Sigma-Aldrich
Street Address 3050 Spruce Street
City, State, Zip, Country SAINT LOUIS MO 63103 US
Technical Phone: 314 771 5765
Emergency Phone: 414 273 3850 Ext. 5996
Fax: 800 325 5052
Section 2 - Composition/Information on Ingredient
Substance Name CAS # SARA 313
CARMUSTINE 154-93-8 No
Formula C5H9Cl2N3O2
Synonyms BCNU * BiCnu *
N,N'-Bis(2-chloroethyl)-N-nitrosourea *
Bis(2-chloroethyl)nitrosourea *
1,3-Bis(beta-chloroethyl)-1-nitrosourea *
1,3-Bis-(2-chloroethyl)-1-nitrosourea *
Bischloroethylnitrosourea * Carmubris * Carmustin
* Carmustine * FDA 0345 * NCI-C04773 * Nitrumon *
NSC-409962 * SK 27702 * SRI 1720 * Urea,
N,N'-bis(2-chloroethyl)-N-nitroso- (9CI)
RTECS Number: YS2625000
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Highly Toxic (USA) Very Toxic (EU).
May cause cancer. May cause heritable genetic damage. May impair
fertility. May cause harm to the unborn child. Very toxic if
swallowed.
Target organ(s): Lungs. Bone marrow.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures
ORAL EXPOSURE
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
Section 5 - Fire Fighting Measures
FLASH POINT
N/A
AUTOIGNITION TEMP
N/A
FLAMMABILITY
N/A
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
FIREFIGHTING
Protective Equipment: Wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
Section 7 - Handling and Storage
HANDLING
User Exposure: Do not breathe dust. Do not get in eyes, on skin,
on clothing. Avoid prolonged or repeated exposure.
STORAGE
Suitable: Keep tightly closed. Store in a cool dry place.
Store at -20藲C
Section 8 - Exposure Controls / PPE
ENGINEERING CONTROLS
Mechanical exhaust required. Safety shower and eye bath.
PERSONAL PROTECTIVE EQUIPMENT
Other: Wear appropriate government approved respirator,
chemical-resistant gloves, safety goggles, other protective
clothing.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Wash thoroughly after
handling.
Section 9 - Physical/Chemical Properties
Appearance Physical State: Solid
Form: Oily liquid toamorphous solid
Property Value At Temperature or Pressure
Molecular Weight 214.1 AMU
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pH N/A
BP/BP Range N/A
MP/MP Range N/A
Freezing Point N/A
Vapor Pressure N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
SG/Density N/A
Bulk Density N/A
Odor Threshold N/A
Volatile% N/A
VOC Content N/A
Water Content N/A
Solvent Content N/A
Evaporation Rate N/A
Viscosity N/A
Surface Tension N/A
Partition Coefficient N/A
Decomposition Temp. N/A
Flash Point N/A
Explosion Limits N/A
Flammability N/A
Autoignition Temp N/A
Refractive Index N/A
Optical Rotation N/A
Miscellaneous Data N/A
Solubility N/A
N/A = not available
Section 10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Acids.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Hydrogen chloride gas, Nitrogen
oxides Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
Section 11 - Toxicological Information
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: May cause eye irritation.
Inhalation: May be harmful if inhaled. Material may be
irritating to mucous membranes and upper respiratory tract.
Ingestion: May be fatal if swallowed.
TARGET ORGAN(S) OR SYSTEM(S)
Bone marrow. Lungs. Liver. Kidneys. Eyes.
SIGNS AND SYMPTOMS OF EXPOSURE
May cause liver function alteration, ataxia, dysarthria, central
nervous system depression, vomiting, nausea, flushing of skin,
conjuctiva, renal damage, pulmonary damage.
CONDITIONS AGGRAVATED BY EXPOSURE
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Immunosuppressant causes delayed and cumulative bone-marrow
depression.
TOXICITY DATA
Intravenous
Child
78 MG/KG
LDLO
Remarks: Gastrointestinal:Nausea or vomiting. Lungs, Thorax, or
Respiration:Other changes. Blood:Changes in bone marrow not
included above.
Parenteral
Woman
1566 MG/KG
LDLO
Remarks: Lungs, Thorax, or Respiration:Cyanosis. Lungs, Thorax,
or Respiration:Fibrosis (interstitial). Lungs, Thorax, or
Respiration:Dyspnea.
Oral
Rat
20 mg/kg
LD50
Intraperitoneal
Rat
17420 UG/KG
LD50
Subcutaneous
Rat
83200 UG/KG
LD50
Remarks: Nutritional and Gross Metabolic:Weight loss or
decreased weight gain. Gastrointestinal:Hypermotility, diarrhea.
Behavioral:Ataxia.
Intravenous
Rat
13800 UG/KG
LD50
Remarks: Lungs, Thorax, or Respiration:Chronic pulmonary edema.
Gastrointestinal:Ulceration or bleeding from stomach.
Blood:Changes in bone marrow not included above.
Intramuscular
Rat
79600 UG/KG
LD50
Remarks: Nutritional and Gross Metabolic:Weight loss or
decreased weight gain. Gastrointestinal:Hypermotility, diarrhea.
Behavioral:Ataxia.
Oral
Mouse
19 mg/kg
LD50
Remarks: Kidney, Ureter, Bladder:Urine volume increased.
Liver:Jaundice, other or unclassified.
Gastrointestinal:Hypermotility, diarrhea.
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Intraperitoneal
Mouse
21260 UG/KG
LD50
Subcutaneous
Mouse
24 MG/KG
LD50
Remarks: Kidney, Ureter, Bladder:Urine volume increased.
Gastrointestinal:Hypermotility, diarrhea. Liver:Jaundice, other
or unclassified.
Intravenous
Mouse
45 MG/KG
LD50
Intramuscular
Mouse
86300 UG/KG
LD50
Remarks: Nutritional and Gross Metabolic:Weight loss or
decreased weight gain. Gastrointestinal:Hypermotility, diarrhea.
Behavioral:Ataxia.
CHRONIC EXPOSURE - CARCINOGEN
Result: This product is or contains a component that has been
reported to be probably carcinogenic based on its IARC, OSHA,
ACGIH, NTP, or EPA classification.
Species: Rat
Route of Application: Intraperitoneal
Dose: 15 MG/KG
Exposure Time: 7W
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Gastrointestinal:Tumors. Lungs, Thorax, or
Respiration:Tumors.
Species: Rat
Route of Application: Intravenous
Dose: 16 MG/KG
Exposure Time: 60W
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors.
Species: Mouse
Route of Application: Skin
Dose: 276 MG/KG
Exposure Time: 23W
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Skin and Appendages: Other: Hair. Skin and Appendages:
Other: Tumors.
Species: Mouse
Route of Application: Intraperitoneal
Dose: 98 MG/KG
Exposure Time: 26W
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Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors.
Gastrointestinal:Tumors.
Species: Rat
Route of Application: Intravenous
Dose: 26 MG/KG
Exposure Time: 60W
Frequency: I
Result: Gastrointestinal:Tumors. Tumorigenic:Equivocal
tumorigenic agent by RTECS criteria.
Species: Rat
Route of Application: Intravenous
Dose: 45 MG/KG
Exposure Time: 60W
Frequency: I
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors.
Species: Rat
Route of Application: Intravenous
Dose: 51 MG/KG
Exposure Time: 24W
Frequency: I
Result: Lungs, Thorax, or Respiration:Tumors.
Tumorigenic:Equivocal tumorigenic agent by RTECS criteria.
Gastrointestinal:Tumors.
IARC CARCINOGEN LIST
Rating: Group 2A
NTP CARCINOGEN LIST
Rating: Clear evidence.
Species: Mouse
Route: Intraperitoneal
CHRONIC EXPOSURE - TERATOGEN
Result: May cause congenital malformation in the fetus.
Species: Rat
Dose: 8 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (6-9D PREG)
Result: Specific Developmental Abnormalities: Urogenital system.
Specific Developmental Abnormalities: Cardiovascular
(circulatory) system. Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Rat
Dose: 8 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (6-9D PREG)
Result: Specific Developmental Abnormalities: Body wall.
Specific Developmental Abnormalities: Eye, ear. Specific
Developmental Abnormalities: Central nervous system.
Species: Rat
Dose: 4 MG/KG
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Route of Application: Intraperitoneal
Exposure Time: (6-9D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
Species: Rabbit
Dose: 6500 UG/KG
Route of Application: Intravenous
Exposure Time: (6-18D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus).
CHRONIC EXPOSURE - MUTAGEN
Species: Human
Dose: 100 UMOL/L
Cell Type: Embryo
Mutation test: DNA damage
Species: Human
Dose: 100 UMOL/L
Cell Type: lung
Mutation test: DNA damage
Species: Human
Dose: 25 UMOL/L
Cell Type: HeLa cell
Mutation test: DNA
Species: Human
Dose: 50 UMOL/L
Cell Type: Other cell types
Mutation test: DNA damage
Species: Human
Dose: 60 MG/L
Cell Type: Other cell types
Mutation test: DNA damage
Species: Human
Dose: 10 MG/L
Cell Type: HeLa cell
Mutation test: Other mutation test systems
Species: Human
Dose: 1 UMOL/L
Cell Type: leukocyte
Mutation test: DNA inhibition
Species: Human
Dose: 100 UMOL/L
Cell Type: HeLa cell
Mutation test: DNA inhibition
Species: Human
Dose: 50 UMOL/L
Cell Type: lymphocyte
Mutation test: DNA inhibition
Species: Human
Dose: 5 UMOL/L
Cell Type: lymphocyte
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Mutation test: Sister chromatid exchange
Species: Human
Dose: 4 UMOL/L
Cell Type: Other cell types
Mutation test: Sister chromatid exchange
Species: Rat
Route: Intraperitoneal
Dose: 100 UMOL/KG
Mutation test: DNA damage
Species: Rat
Dose: 50 UMOL/L
Cell Type: Other cell types
Mutation test: DNA damage
Species: Rat
Dose: 80 MG/KG
Cell Type: S. typhimurium
Mutation test: Body fluid assay
Species: Rat
Dose: 5 MG/L
Cell Type: Other cell types
Mutation test: Cytogenetic analysis
Species: Rat
Dose: 1 UMOL/L
Cell Type: Other cell types
Mutation test: Sister chromatid exchange
Species: Mouse
Route: Intraperitoneal
Dose: 1450 UG/KG
Mutation test: Micronucleus test
Species: Mouse
Dose: 200 UG/L (+S9)
Cell Type: lymphocyte
Mutation test: Mutation in microorganisms
Species: Mouse
Route: Intraperitoneal
Dose: 150 UMOL/KG
Mutation test: DNA damage
Species: Mouse
Dose: 20 MG/L
Cell Type: leukocyte
Mutation test: DNA damage
Species: Mouse
Route: Intraperitoneal
Dose: 30 MG/KG
Mutation test: DNA inhibition
Species: Mouse
Dose: 1 MG/L
Cell Type: leukocyte
Mutation test: DNA inhibition
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Species: Mouse
Dose: 20 UMOL/L
Cell Type: Bone marrow
Mutation test: DNA inhibition
Species: Mouse
Dose: 40 UMOL/L
Cell Type: Bone marrow
Mutation test: Other mutation test systems
Species: Mouse
Dose: 1 MG/L
Cell Type: leukocyte
Mutation test: Other mutation test systems
Species: Mouse
Route: Intraperitoneal
Dose: 9050 UG/KG
Mutation test: Cytogenetic analysis
Species: Mouse
Route: Intravenous
Dose: 4400 UG/KG
Mutation test: Sister chromatid exchange
Species: Mouse
Route: Unreported
Dose: 8800 UG/KG
Mutation test: Sister chromatid exchange
Species: Mouse
Dose: 1500 UG/KG
Cell Type: lymphocyte
Mutation test: Sister chromatid exchange
Species: Mouse
Dose: 100 GM/L
Cell Type: lymphocyte
Mutation test: Sister chromatid exchange
Species: Mouse
Dose: 200 UG/L
Cell Type: lymphocyte
Mutation test: Mutation in mammalian somatic cells.
Species: Hamster
Dose: 3 MG/L
Cell Type: lung
Mutation test: Mutation in mammalian somatic cells.
Species: Mouse
Dose: 25 MG/KG
Cell Type: S. typhimurium
Mutation test: Host-mediated assay
Species: Mouse
Dose: 4 MG/KG
Cell Type: leukocyte
Mutation test: Host-mediated assay
Species: Mouse
Route: Intraperitoneal
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Dose: 33 MG/KG
Mutation test: sperm
Species: Hamster
Dose: 10 UMOL/L
Cell Type: lung
Mutation test: Micronucleus test
Species: Hamster
Dose: 8500 NMOL/L
Cell Type: lung
Mutation test: DNA damage
Species: Hamster
Route: Intraperitoneal
Dose: 15 MG/KG
Mutation test: DNA inhibition
Species: Hamster
Dose: 3200 UG/L
Cell Type: lung
Mutation test: Cytogenetic analysis
Species: Hamster
Dose: 12 UMOL/L
Cell Type: lung
Mutation test: Sister chromatid exchange
Species: Hamster
Dose: 10 UMOL/L
Cell Type: lung
Mutation test: Mutation in mammalian somatic cells.
Species: Hamster
Dose: 4 MG/L
Cell Type: ovary
Mutation test: Mutation in mammalian somatic cells.
Species: Mammal
Dose: 10 MMOL/L
Cell Type: lymphocyte
Mutation test: DNA damage
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD
Result: May cause reproductive disorders.
Species: Rat
Dose: 9 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (9W MALE)
Result: Effects on Fertility: Litter size (e.g.; # fetuses per
litter; measured before birth). Effects on Fertility:
Pre-implantation mortality (e.g., reduction in number of
implants per female; total number of implants per corpora lutea).
Species: Mouse
Dose: 11 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (1D MALE)
Result: Paternal Effects: Spermatogenesis (including genetic
material, sperm morphology,motility, and count).
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Species: Mouse
Dose: 40 MG/KG
Route of Application: Intraperitoneal
Exposure Time: (12D PREG)
Result: Effects on Newborn: Growth statistics (e.g., reduced
weight gain). Effects on Newborn: Viability index (e.g., # alive
at day 4 per # born alive). Effects on Newborn: Live birth index
(# fetuses per litter; measured after birth).
Section 12 - Ecological Information
No data available.
Section 13 - Disposal Considerations
APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
regulations.
Section 14 - Transport Information
DOT
Proper Shipping Name: Toxic solids, organic, n.o.s.
UN#: 2811
Class: 6.1
Packing Group: Packing Group II
Hazard Label: Toxic substances.
PIH: Not PIH
IATA
Proper Shipping Name: Toxic solid, organic, n.o.s.
IATA UN Number: 2811
Hazard Class: 6.1
Packing Group: II
Section 15 - Regulatory Information
EU ADDITIONAL CLASSIFICATION
Symbol of Danger: T+
Indication of Danger: Very toxic.
R: 45-46-60-61-28
Risk Statements: May cause cancer. May cause heritable genetic
damage. May impair fertility. May cause harm to the unborn
child. Very toxic if swallowed.
S: 53-22-36/37/39-45
Safety Statements: Avoid exposure - obtain special instructions
before use. Do not breathe dust. Wear suitable protective
clothing, gloves, and eye/face protection. In case of accident
or if you feel unwell, seek medical advice immediately (show the
label where possible).
US CLASSIFICATION AND LABEL TEXT
Indication of Danger: Highly Toxic (USA) Very Toxic (EU).
Risk Statements: May cause cancer. May cause heritable genetic
damage. May impair fertility. May cause harm to the unborn
child. Very toxic if swallowed.
Safety Statements: Avoid exposure - obtain special instructions
before use. Do not breathe dust. Wear suitable protective
clothing, gloves, and eye/face protection. In case of accident
or if you feel unwell, seek medical advice immediately (show the
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label where possible).
US Statements: Target organ(s): Lungs. Bone marrow.
UNITED STATES REGULATORY INFORMATION
SARA LISTED: No
UNITED STATES - STATE REGULATORY INFORMATION
CALIFORNIA PROP - 65
California Prop - 65: California Proposition 65: This product is
or contains chemical(s) known to the state of California to
cause developmental toxicity. California Proposition 65: This
product is or contains chemical(s) known to the state of
California to cause developmental toxicity.
CANADA REGULATORY INFORMATION
WHMIS Classification: This product has been classified in
accordance with the hazard criteria of the CPR, and the MSDS
contains all the information required by the CPR.
DSL: No
NDSL: No
Section 16 - Other Information
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
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