TOKU-E COMPANY
MATERIAL SAFETY DATA SHEET
EMERGENCY PHONE (USA only): +1-800-535-5053 INF.: +86-21-5206 9530
. Substance identification
Griseofulvin
. Composition/ information on ingredients
CAS No.: 126-07-8
FW: C17H17ClO6
. Hazard identification
Label precautionary statements
Toxic.
May cause harm to the unborn child. May impair fertility. May cause sensitization
by skin contact. Limited evidence of a carcinogenic effect.
Calif. Prop. 65 carcinogen. Photosensitizer.
Target organ(s): Liver. Blood.
In case of accident or if you feel unwell, seek medical advice immediately (show
label when possible). Wear suitable protective clothing, gloves and eye/ face
protection.
. First-aid measures
In case of contact, immediately flush eyes or skin with copious amounts of water
at least 15minutes while removing contaminated clothing and shoes. Assure
adequate flushing of eyes by separating eyelids with fingers. If inhaled, remove
to fresh air. If breathing is difficult, call a physician. If swallowed, wash out mouth
with water (provided person is conscious). Call a physician immediately. Wash
all contaminated clothing before reuse.
. Fire extinguishing measures.
Extinguishing media: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
Wear self-contained breathing apparatus and protective clothing to prevent
contact with eyes and skin.
Unusual fire and explosion hazards:
Emits toxic fumes under fire conditions.
. Accidental release measures
Evacuate area. Wear self-contained breathing apparatus, rubber boots, and
heavy rubber gloves. Wear disposable coveralls and discard them after use.
Sweep up; avoid raising dust, place in a bag and hold for waste disposal.
Ventilate area and wash spill site after material pickup is complete.
MSDS Griseofulvin 1/4
. Handling and storage
Wear appropriate Government approved respirator, chemical resistant gloves,
safety goggles, and all other protective clothing. Mechanical exhaust required.
Safety shower and bath.
Do not breathe dust. Avoid contact with eyes, skin, and clothing. Avoid
prolonged or repeated exposure. Wash thoroughly after handling.
Keep tightly closed. Store at 2-8癈. Store in a cool dry place.
. Physical properties
Appearance: White powder.
PH: N/A
Melting point: 216癈
Solubility: N/A
. Stability and reactivity
Stable. Avoid strong oxidizing agents.
Hazardous combustion or decomposition products thermal decomposition may
produce carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen chloride
gas.
Hazardous polymerization will not occur.
. Toxicological information
May cause skin irritation. May be harmful if absorbed through the skin. May
cause eye irritation. May be harmful if inhaled. Material may be irritating to
mucous membranes and upper respiratory tract. May be harmful if swallowed.
Signs and symptoms of exposure: May induce lupus erythematosus. Can cause
anorexia, diarrhea, nausea, vomiting. Common adverse reactions are those of
hypersensitivity such as skin rashes, urticaria and angioneurotic edema rarely
occurring. Reactions of the nervous system include headache, peripheral neuritis,
lethargy, mental confusion, fatigue, syncope, vertigo, blurred vision, transient
macular edema and impairment of routine task performance. Hematological
effects that can occur are leukopenia, neutropenia, monocytosis and punctate
basophilia. Other side effects that can occur ocasionally are nausea, vomiting,
oral thrush, diarrhea, epigastric distress, paresthesias of the hands and feet,
gastrointestinal bleeding, menstrual irregularities, and hepatotoxicity. Exposure
to and/ or consumption of alcohol may increase toxic effects. To the best of our
knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Sensitization: Causes photosensitivity. Exposure to light can result in allergic
reactions resulting in dermatologic lesions, which can vary from sunburnlike
responses to edematous, vesiculated lesions, or bullae Shows cross-
allergenicity with penicillin.
Skin: May cause allergic skin reaction.
Target organ(s): Liver. Blood.
Toxicity data:
MSDS Griseofulvin 2/4
Oral Rat LD50: > 10000 MG/KG
Intraperitoneal Rat LD50: >5 GM/KG
Intravenous Rat LD50: 400 MG/KG.
Oral Mouse LD50: > 50000 MG/KG
Intraperitoneal Mouse LD50:200 MG/KG
Subcutaneous Mouse LD50: >12 GM/KG
Intravenous Mouse LD50: 280 MG/KG
Chronic exposure: Carcinogen. Teratogen. Mutagen. Reproductive hazard.
IARC carcinogen list: Rating Group 2B
Only selected registry of toxic effects of chemical substances (RTECS) data is
presented here. See actual entry in trees for complete information.
.Ecological information: Data not yet available.
. Disposal considerations
Contact a licensed professional waste disposal service to dispose of this material.
Dissolve or mix the material with a combustible solvent and burn in a chemical
incinerator equipped with an afterburner and scrubber. Observe all federal, state
and local environmental regulations.
. Transport information:
This substance is considered to be non-hazardous for transport.
Non-hazardous for air transport.
. Regulatory information
US information
Toxic.
May cause harm to the unborn child. May impair fertility. May cause sensitization
by skin contact. Limited evidence of a carcinogenic effect.
In case of accident or if you feel unwell, seek medical advice immediately (show
the label where possible).
Wear suitable protective clothing, gloves, and eye/ face protection. Do not
breathe dust.
Calif. Prop. 65 carcinogen. Photosensitizer.
Target organ(s): Liver. Blood.
SARA list: No.
California Prop - 65: California Proposition 65: This product is or contains
chemical(s) known to the state of California to cause cancer. California
Proposition 65: This product is or contains chemical(s) known to the state of
California to cause
cancer.
EU information:
Toxic.
R: 61 60 43 40
MSDS Griseofulvin 3/4
May cause harm to the unborn child. May impair fertility. May cause sensitization
by skin contact. Limited evidence of a carcinogenic effect.
S: 45 36/37/39 22
In case of accident or if you feel unwell, seek medical advice immediately (show
the label where possible). Wear suitable protective clothing, gloves, and eye/
face
protection. Do not breathe dust.
Canada information
This product has been classified in accordance with the hazard criteria of the
CPR, and the MSDS contains all the information required by the CPR.
DSL: No.
NDSL: No
. Other Information
The information and recommendations set forth herein are believed to be
completed and faithful. However, it is the user's responsibility to determine the
suitability for his/ her purpose prior to use. Toku-E Company assumes no
additional liability and responsibility resulting from use and/ or reliance on this
information.
MSDS Griseofulvin 4/4
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