Genzyme Diagnostics P.E.I. Inc.
70 Watts Avenue, Charlottetown, PE Canada C1E 2B9
Tel: 800-565-0265 902-566-1396 Fax: 902-628-6504
Email: sales@dclchem.com techserve@dclchem.com orders@dclchem.com
www.dclchem.com www.genzymediagnostics.com
Material Safety Data Sheet
1 PRODUCT IDENTIFICATION AND USE
MANUFACTURER: Genzyme Diagnostics PEI Inc.
70 Watts Avenue
Charlottetown, P.E.I.
Canada C1E-2B9
+1-902-566-1396
PRODUCT NAME: Total Bilirubin L3K?br>
CATALOGUE NUMBER: 295-10, 295-30
PRODUCT USE: For the determination of total bilirubin in serum-plasma and neo-natal are also acceptable samples.
DATE OF MSDS PREPARATION: August 20, 2008
MSDS PREPARED BY: John Gabriel
EMERGENCY TELEPHONE NO.: 1- (902) 566-1396
2 COMPOSITION, INGREDIENT INFORMATION
COMPONENT CAS REGISTRY NUMBER ACGIH TLV
Total Bilirubin L3K?Accelerator Reagent (R1)
Tetramethylene sulfone 7.6 % w/w 126-33-0 not established
Hydrogen chloride 0.68 % w/w 7647-01-1 C 2 ppm (STEL)
Total Bilirubin L3K?Diazo Reagent (R2)
Hydrogen chloride 0.5 % w/w 7647-01-1 C 2 ppm (STEL)
3 HAZARDOUS IDENTIFICATION
EMERGENCY OVERVIEW:
R1 and R2 are corrosive. Physical and health hazard information on reagent mixtures have not been fully determined.
POTENTIAL HEALTH EFFECTS:
ROUTE OF ENTRY/EXPOSURE: EYE CONTACT: [X] SKIN CONTACT: [X] INHALATION: [X] INGESTION: [X]
SKIN ABSORPTION: [X]
EFFECTS OF ACUTE EXPOSURE TO PRODUCTS:
R1 and R2:
EYES: Reagents may cause burns.
SKIN: Reagents may cause burns.
INHALATION: Reagents may cause coughing and burns to mucous membranes and upper respiratory tract.
INGESTION: Reagents may cause digestive tract burns with abdominal pains.
EFFECTS OF CHRONIC EXPOSURE TO PRODUCT:
EVIDENCE OF CARCINOGENICITY, TERATOGENICITY, REPRODUCTIVE TOXICITY, MUTAGENICITY: No constituents recognized
by IARC, ACGIH, NTP or California Proposition 65 as carcinogenic. No human data on teratogenicity, embryo toxicity or mutagenicity.
4 FIRST AID MEASURES
EYES: Flush eyes with water for at least 15 minutes and obtain medical attention.
SKIN: In case of contact, immediately flush area with plenty of water. If irritation continues seek medical attention.
INHALATION: If inhaled, remove victim to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen and
obtain medical attention.
INGESTION: If ingested, drink plenty of fluids and obtain medical attention.
5 FIRE AND EXPLOSION HAZARDS
FLAMMABLE: No
FLASH POINT: not available
FLAMMABLE LIMITS (% in Air): Lower: not available. Upper: not available
EXTINGUISHING MEDIA: As appropriate for fires in surrounding materials.
FIREFIGHTING: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
AUTOIGNITION TEMPERATURE: not available
HAZARDOUS COMBUSTION PRODUCTS: not available
EXPLOSION DATA: Sensitivity to mechanical impact: not available. Sensitivity to static discharge: not available
6 ACCIDENTAL RELEASE MEASURES
PROCEDURE TO BE FOLLOWED IN CASE OF LEAK OR SPILL: Ventilate the area. Wear appropriate personal protective equipment as
specified in Section 8. Contain and recover liquid when possible. Collect liquid in an appropriate container or absorb with an inert material and
place in waste container. Wash surrounding area. Dispose of spilled and contaminated material in accordance with federal, provincial, state, and
local regulations.
7 HANDLING AND STORAGE
HANDLING PROCEDURES AND EQUIPMENT: Avoid contact. Do not get in eyes, on skin, or clothing. Wash thoroughly after handling.
Wash contaminated clothing before reuse.
STORAGE REQUIREMENTS: 2-8 癈
INCOMPATIBILITIES: not available
HAZARDOUS DECOMPOSITION PRODUCTS: not available
8 EXPOSURE CONTROLS, PERSONAL PROTECTION
ENGINEERING CONTROLS: Local exhaust not required under normal circumstances.
PERSONAL PROTECTIVE CLOTHING (PPE): safety glasses with side-shields, lab coat, rubber nitrile or other impermeable gloves.
RESPIRATORY PROTECTION: none required.
EXPOSURE LIMITS: not available
9 PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE: R1 and R2 are liquids
COLOR: R1 is clear and colorless: R2 is clear with a slight peach color.
ODOR: R1 has a moderate sulfidic odor; R2 is odorless.
ODOUR THRESHOLD: not available
MELTING POINT: not available
BOILING POINT: not available
SPECIFIC GRAVITY: R1 = 1.047; R2 = 1.008
VAPOUR PRESSURE: not available
VAPOUR DENSITY: not available
WATER SOLUBILITY: soluble
EVAPORATION RATE: not available
pH at 25 癈: R1 = 1.0-1.4; R2 = 0.7-1.1
COEFFICIENT OF OIL/WATER DISTRIBUTION: not available
10 STABILITY AND REACTIVITY
STABILITY: Stable
POSSIBLE HAZARDOUS REACTIONS/CONDITIONS: not available
CONDITIONS TO AVOID: not available
MATERIALS TO AVOID: not available
HAZARDOUS DECOMPOSITION PRODUCTS: not available.
11 TOXICOLOGICAL INFORMATION
Tetramethylene sulfone:
LD50: 1540 uL/kg mg/kg, oral rat
LC50: not available
Hydrogen chloride:
LD50: 900 mg/kg, oral rabbit
LC50: 3124 ppm/1H, inhalation rat
SENSITIZATION TO PRODUCT: not available
NAME OF TOXICOLOGICALLY SYNERGISTIC PRODUCTS: not available
IRRITANCY OF PRODUCT: not available
EVIDENCE OF CARCINOGENICITY, TERATOGENICITY, REPRODUCTIVE TOXICITY, MUTAGENICITY: no data available
12 ECOLOGICAL INFORMATION
not available
13 DISPOSAL CONSIDERATIONS
RECOMMENDATION FOR DISPOSAL OF UNUSED PRODUCT: Observe all federal, provincial, state and local regulations. If solutions
containing sodium azide are drain disposed, dilute and flush with a copious amount of running water to prevent azide build-up (See Section 3).
RECOMMENDATION FOR DISPOSAL OF PACKAGING: Observe all federal, provincial, state and local regulations.
14 TRANSPORT INFORMATION
SPECIAL SHIPPING INFORMATION:
R1 and R2:
UN1789, Hydrochloric acid solution, Class 8, Packing Group II
15 REGULATORY INFORMATION
This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulation (CPR) and the MSDS contains all the
information required by the CPR.
R1 and R2:
RISK PHRASES: R20/21/22 Harmful by inhalation, in contact with skin and if swallowed
R34 Causes burns
SAFETY PHRASES: S26 In case of contact with eyes, rinse immediately with plenty of water
S35 This material and its container must be disposed of in a safe way
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection
S45 In case of accident or if you feel unwell, seek medical advice immediately
16 OTHER INFORMATION
The information provided on this Material Safety Data Sheet is provided in the interest of promoting safe handling of the material. While this
information is believed to be correct, Genzyme Diagnostics PEI Inc. makes no warranty in respect to any of the information disclosed. Observe
all federal, provincial, state and local laws concerning health and the environment.
MSDS29510-0
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