SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 17/JUN/2005
Date Updated: 25/MAY/2004
Version 1.6
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name 4-METHYL-2-PENTANONE, REAGENTPLUS(TM),
>=99%
Product Number 537713
Company Sigma-Aldrich Pty. Ltd.
12 Anella Avenue
Castle Hill NSW 2154
Australia
Technical Phone # +61 2 9841 0555 (1800 800 097)
Fax +61 2 9841 0500 (1800 800 096)
Emergency Phone # +44 8701906777 (1800 448 465)
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
4-METHYL-2-PENTANONE 108-10-1 203-550-1 606-004-00-4
Formula C6H12O
Molecular Weight 100.16 AMU
Synonyms Hexon (Czech) * Hexone (OSHA) *
Isobutyl-methylketon (Czech) * Isobutyl methyl
ketone * Isopropylacetone * Ketone, isobutyl
methyl * Methyl-isobutyl-cetone (French) *
Methylisobutylketon (Dutch, German) * Methyl
isobutyl ketone (ACGIH:OSHA) *
Metyloizobutyloketon (Polish) *
4-Methyl-pentan-2-on (Dutch, German) *
2-Methyl-4-pentanone * 4-Methyl-2-pentanon
(Czech) * 4-Methyl-2-pentanone *
Metilisobutilchetone (Italian) *
4-Metilpentan-2-one (Italian) * MIBK * MIK *
RCRA waste number U161 * Shell MIBK
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Highly flammable. Harmful by inhalation. Irritating to eyes and
respiratory system. Repeated exposure may cause skin dryness or
cracking.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.
Unsuitable: Carbon Dioxide, dry chemical powder, or appropriate
foam. Water can be applied as a spray or fog and if properly
applied is capable of extinguishing the fire by sweeping the
flames off the surface of the burning liquid.
SPECIAL RISKS
Specific Hazard(s): Vapor may travel considerable distance to
source of ignition and flash back. Emits toxic fumes under fire
conditions.
Explosion Hazards: Vapor may travel considerable distance to
source of ignition and flash back. Container explosion may occur
under fire conditions. Forms explosive mixtures in air.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
SPECIFIC METHOD(S) OF FIRE FIGHTING
Use water spray to cool fire-exposed containers.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area. Shut off all sources of ignition.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Cover with dry-lime, sand, or soda ash. Place in covered
containers using non-sparking tools and transport outdoors.
Ventilate area and wash spill site after material pickup is
complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Avoid breathing vapor. Avoid
contact with eyes, skin, and clothing. Avoid prolonged or
repeated exposure.
STORAGE
Conditions of Storage: Keep container closed. Keep away from
heat, sparks, and open flame.
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8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use nonsparking tools. Mechanical
exhaust required.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
EXPOSURE LIMITS
Country Source Type Value
Poland NDS 83
Poland NDSCh 200
Poland NDSP -
EXPOSURE LIMITS - EUROPEAN UNION
Source Type Value
OEL OEL 83 mg/m3
20 ppm
EXPOSURE LIMITS - DENMARK
Source Type Value
OEL TWA 100 mg/m3
25 ppm
Remarks: H
EXPOSURE LIMITS - GERMANY
Source Type Value
TRGS 900 OEL 83 mg/m3
20 ppm
Remarks: =1=
Remarks: H,Y
EXPOSURE LIMITS - NORWAY
Source Type Value
OEL 105 mg/m3
25 ppm
Remarks: H
EXPOSURE LIMITS - SWEDEN
Source Type Value
LLV (Level100 mg/m3
25 ppm
EXPOSURE LIMITS - SWITZERLAND
Source Type Value
OEL OEL 82 mg/m3
20 ppm
Remarks: M H C
EXPOSURE LIMITS - UNITED KINGDOM
Source Type Value
OEL OEL 208 mg/m3
50 ppm
OEL STEL 416 mg/m3
100 ppm
Remarks: Skin Biological Monitoring Guidance value
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
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Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Physical State: Liquid
Property Value At Temperature or Pressure
pH N/A
BP/BP Range 115 - 117 癈
MP/MP Range -80 癈
Flash Point 14 癈 Method: closed cup
Flammability N/A
Autoignition Temp 459 癈
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 1.2 %
Upper: 8 %
Vapor Pressure 15 mmHg 20 癈
SG/Density 0.8 g/cm3
Partition Coefficient N/A Log Kow: 1.31
Viscosity N/A
Vapor Density 3.5 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension 23.6 mN/m 20 癈
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:20 mg/ml H2O
Other Solvents: SOLUBLE IN ALCOHOL, ETHER
ACETONE, BENZENE CHLOR
10 - Stability and Reactivity
STABILITY
Stable: Stable.
Materials to Avoid: Oxidizing agents, Strong bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur
11 - Toxicological Information
RTECS NUMBER: SA9275000
ACUTE TOXICITY
LD50
Oral
Rat
2080 mg/kg
LC50
Inhalation
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Rat
100,000 mg/m3
LD50
Intraperitoneal
Rat
400 MG/KG
LD50
Oral
Mouse
1900 mg/kg
LC50
Inhalation
Mouse
23,300 mg/m3
LD50
Intraperitoneal
Mouse
268 MG/KG
LD50
Oral
Guinea pig
1600 mg/kg
LD50
Intraperitoneal
Guinea pig
800 MG/KG
IRRITATION DATA
Eyes
Human
200 ppm
15M
Skin
Rabbit
500 mg
24H
Remarks: Mild irritation effect
Eyes
Rabbit
40 mg
Remarks: Severe irritation effect
Eyes
Rabbit
0.1 ml
24H
Remarks: Moderate irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Contact with eyes can cause redness, tearing, and blurred
vision. Prolonged or repeated contact with skin can cause
defatting and dermatitis. To the best of our knowledge, the
chemical, physical, and toxicological properties have not been
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thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: May be harmful if inhaled. Material is irritating to
mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed.
TARGET ORGAN INFORMATION
Nerves.
CHRONIC EXPOSURE - TERATOGEN
Species: Rat
Dose: 300 PPM/6H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Specific Developmental Abnormalities:
Musculoskeletal system.
Species: Mouse
Dose: 3000 PPM/6H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Effects on Embryo or Fetus: Fetotoxicity (except death,
e.g., stunted fetus). Effects on Embryo or Fetus: Fetal death.
Species: Mouse
Dose: 3000 PPM/6H
Route of Application: Inhalation
Exposure Time: (6-15D PREG)
Result: Specific Developmental Abnormalities: Central nervous
system. Specific Developmental Abnormalities: Musculoskeletal
system. Specific Developmental Abnormalities: Cardiovascular
(circulatory) system.
12 - Ecological Information
ECOTOXICOLOGICAL EFFECTS
Test Type: EC50 Algae
Species: Scenedesmus subspicatus
Time: 48 h
Value: 980 - 2,000 mg/l
Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 1,550 - 3,623 mg/l
Test Type: LC50 Fish
Species: Leuciscus idus
Time: 48 h
Value: 672 - 744 mg/l
Test Type: LC50 Fish
Species: Pimephales promelas (Fathead minnow)
Time: 96 h
Value: 496 - 593 mg/l
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13 - Disposal Considerations
SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Burn in a chemical incinerator equipped with an
afterburner and scrubber but exert extra care in igniting as this
material is highly flammable. Observe all federal, state, and
local environmental regulations.
14 - Transport Information
RID/ADR
UN#: 1245
Class: 3
PG: II
Proper Shipping Name: Methyl isobutyl ketone
IMDG
UN#: 1245
Class: 3
PG: II
Proper Shipping Name: Methyl isobutyl ketone
Marine Pollutant: No
Severe Marine Pollutant: No
IATA
UN#: 1245
Class: 3
PG: II
Proper Shipping Name: Methyl isobutyl ketone
Inhalation Packing Group I: No
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 606-004-00-4
INDICATION OF DANGER: F Xn
Highly Flammable. Harmful.
R-PHRASES: 11 20 36/37 66
Highly flammable. Harmful by inhalation. Irritating to eyes and
respiratory system. Repeated exposure may cause skin dryness or
cracking.
S-PHRASES: 9 16 29
Keep container in a well-ventilated place. Keep away from
sources of ignition - no smoking. Do not empty into drains.
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 1
SWITZERLAND
SWISS POISON CLASS: 4
NORWAY
Labelling for organic solvents where the package is 1liter or
more.
YL-tall m3/l: 7619
YL-group: 5
Safety phrases: 38 42 210
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In case of insufficient ventilation, wear suitable respiratory
equipment. During fumigation/spraying wear suitable respiratory
equipment. Use compressed air- or fresh air line breathing
apparatus in confined spaces.
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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