MATERIAL SAFETY DATA SHEET (MSDS)
Date of Preparation or Revision: March 4, 1998
IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND COMPANY:
Catalog Number: 29110
Product Name: Actinomycin D, Streptomyces sp.
Supplier: OXIS International Inc.
6040 N. Cutter Circle, Suite 317
Portland, OR 97217-3935 USA
Telephone: 503-283-3911
800-547-3686
Fax: 503-283-4058
COMPOSITION/INFORMATION ON INGREDIENTS:
Chemical Name: Actinomycin D
Synonyms: Dactinomycin; Dilactone Actinomycindioic D Acid
Hazardous Ingredient: Actinomycin D
CAS Registry Number: 50-76-0
Molecular Weight: 1255.5
Molecular Formula: C62H86N12O16
HAZARDS IDENTIFICATION:
T+, Very Toxic
Acute Effects: May be harmful by ingestion, inhalation or absorption through skin.
Exposure to material may cause the following: malaise, fatigue, lethargy, nausea,
vomiting, muscle pain, and fever. Material may cause serious local tissue damage,
including phlebitis and cellulitis.
Chronic Effects: Prolonged exposure may cause bone marrow depression. Long-term
exposure may also cause kidney and liver abnormalities. There is limited evidence that
Actinomycin D is teratogenic and tumorigenic in laboratory animals. There is also limited
evidence that Actinomycin D is mutagenic in laboratory cell cultures. Until further testing
has been done, it should be treated as a possible teratogen, tumorigen, and mutagen in
humans.
FIRST AID MEASURES:
In cases of skin contact, wash immediately with copious amounts of water for at least 15
minutes. Remove contaminated clothing and shoes and wash before wearing. Consult a
physician.
In cases of eye contact, flush immediately with copious amounts of water for at least 15
minutes. Assure adequate flushing by separating the eyelids with fingers. Consult a
physician.
In cases of inhalation, remove to fresh air and monitor breathing. If breathing becomes
difficult, give oxygen and consult a physician. If breathing stops, give artificial respiration
and consult a physician.
In cases of ingestion, wash mouth out with water and consult the local poison center and
a physician.
FIRE-FIGHTING MEASURES:
Extinguishing Media: Dry chemical powder, carbon dioxide, water spray, alcohol or
polymer foam.
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Special Fire Fighting Procedures: Wear self-contained breathing apparatus and full
protective clothing to prevent contact with skin and eyes.
Unusual Fire and Explosive Hazards: Upon thermal decomposition, it may EMIT
TOXIC GASES.
ACCIDENTAL RELEASE MEASURES:
Steps to be Taken if Material is Released or Spilled: Evacuate area. Wear a self-
contained breathing apparatus, rubber boots, and heavy rubber gloves. Sweep up and
place in a suitable container. Avoid raising dust. Hold for appropriate disposal. Wash
spill site and ventilate area after material pickup is complete.
HANDLING AND STORAGE:
Store in a tightly closed container at 2-8掳C. Protect from light and moisture. Material is
toxic. Possible teratogen, mutagen, and tumorigen. Avoid contact with material. Avoid
prolonged or repeated exposure. Lab should be equipped with a safety shower and an
eye wash station. Wash thoroughly after handling material.
EXPOSURE CONTROLS/ PERSONAL PROTECTION:
Protective Equipment: Wear suitable protective clothing, such as chemical resistant
gloves and chemical safety goggles.
Respiratory Protection and Ventilation: Use a NIOSH/MSHA approved respirator.
Handle in a chemical fume hood with adequate ventilation.
PHYSICAL AND CHEMICAL PROPERTIES:
Appearance: Lyophilized solid.
Solubility: Soluble in methanol.
STABILITY AND REACTIVITY:
Stability: Stable under normal handling procedures.
Incompatibilities and Conditions to Avoid: Avoid contact with strong oxidizing agents,
strong acids, and strong bases.
Hazardous Combustion or Decomposition Products: Upon thermal decomposition, may
emit toxic gases including carbon monoxide, carbon dioxide, and nitrogen oxides.
TOXICOLOGICAL INFORMATION:
RTECS Number: AU1575000
Toxicity Data and References:
Orl; rat; LD50: 7200 碌g/kg Hypermotility and diarrhea
ANYAA9 89:348, 1960
Orl; mus; LD50: 13 mg/kg Hypermotility and diarrhea
ANYAA9 89:348, 1960
Ipr; rat; LD50: 100 碌g/kg AOGLAR 23:219, 1976
Ipr; mus; LD50: 750 碌g/kg Changes in bone marrow and decreased immune
response CTRRDO 61:103, 1977
Scu; rat; LD50: 800 碌g/kg Hypermotility and diarrhea
ANYAA9 89:348, 1960
Ivn; hmn; TDLo: 40 碌g/kg/4D-I Dermatitis NEJMAG 281:1094, 1969
Unr; rbt; LD50: 150 碌g/kg ARZNAD 30:236, 1980
Irritation Data References:
Skn; rbt; Dose: 5 mg/24H Reaction not reported
TXCYAC 14:117, 1979
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Reproductive Effects and References:
Orl; mus; Dose: 20 mg/kg TCMUD8 6:361, 1986
Ipr; rat; Dose: 70 ng/kg Musculoskeletal system developmental abnormalities
AOGLAR 23:219, 1976
Ipr; rat; Dose: 150 碌g/kg Central nervous system and craniofacial
developmental abnormalities SEIJBO 11:5, 1971
Ipr; mus; Dose: 100 碌g/kg Musculoskeletal system developmental abnormalities
DABBBA 39:1624, 1978
Ipr; mus; Dose: 214 碌g/kg Body wall developmental abnormalities
APJAAG 18:267, 1968
Scu; rat; Dose: 200 碌g/kg Fetal death and musculoskeletal system
developmental abnormalities PSEBAA 157:553, 1978
Par; rbt; Dose: 13 mg/kg Fetal death ARZNAD 30:236, 1980
Genetic Data and References:
Oth; rat; Dose: 500 nmol/L DNA damage CBINA8 77:25, 1991
Leu; mus; Dose: 1500 碌g/L DNA damage BBACAQ 654:129, 1981
Lvr; rat; Dose: 50 nmol/L Unscheduled DNA synthesis
MUREAV 221:263, 1989
Oth; hmn; Dose: 300 pmol/L DNA inhibition CNREA8 44:2421, 1984
Fbr; hmn; Dose: 1 mg/L Mutations in mammalian somatic cells
CNJGA8 21:435, 1979
Lym; mus; Dose: 4 碌g/L Mutations in mammalian somatic cells
MUREAV 192:151, 1987
Ovr; ham; Dose: 40 碌g/L Mutations in mammalian somatic cells
MUREAV 94:449, 1982
Lng; ham; Dose: 20 碌g/L Cytogenetic analysis GMCRDC 27:95, 1981
Ovr; ham; Dose: 100 碌g/L Cytogenetic analysis ENMUDM 2:455, 1980
Lym; hmn; Dose: 1 nmol/L Sister chromatid exchange
MUREAV 241:109, 1990
Tumorigenic Data and References:
Ipr; rat; Dose: 2600 碌g/kg/17W-I Tumors at the site of application
CNREA8 30:2271, 1970
Ipr; rat; Dose: 1700 碌g/kg/26W-I Tumors at the site of application
RRCRBU 52:1, 1975
Scu; mus; Dose: 280 碌g/kg/18W-I Tumors at the site of application
APJAAG 17:495, 1967
Reviews:
IARC Cancer Review: Animal Limited Evidence Reference
IMSUDL 7:80, 1987
IARC Cancer Review: Human Inadequate Evidence Reference
IMSUDL 7:80, 1987
IARC Cancer Review: Group 3 Reference IMSUDL 7:80, 1987
Toxicology Review Reference CLPTAT 5:480, 1964
Toxicology Review Reference: "Teratology" 32XPAD -:49, 1975
Toxicology Review Reference JPETAB 144:429, 1964
Toxicology Review Reference ARVPAX 5:447, 1965
Toxicology Review Reference ADVPA3 4:263, 1966
Toxicology Review Reference DMCNAW 7:353, 1965
Toxicology Review Reference CRTXB2 2:159, 1973
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Refer to the Registry of Toxic Effects of Chemical Substances (RTECS) for a definition of
abbreviations used in the above text and for additional information. This report contains
only selected information from the RTECS.
ECOLOGICAL INFORMATION:
No information available.
DISPOSAL CONSIDERATIONS:
Country, federal, state, and local regulations are varied and change frequently. For this
reason, we recommend that you contact your local Department of Health Services for
information on the disposal of this product or arrange for disposal by a licensed disposal
company.
TRANSPORT INFORMATION:
UN Number: UN3172
Proper Shipping Name: Toxins, extracted from living sources, solid, n.o.s.
IATA Class: 6.1
IATA Packing Group: II
REGULATORY INFORMATION:
Risks:
R26/27/28: Very toxic by inhalation, in contact with skin and if swallowed
R38: Irritating to skin
S45: May cause cancer
S46: May cause heritable genetic damage
S47: May cause birth defects
S48: Danger of serious damage to health by prolonged exposure
Safety:
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice
immediately
S53: Avoid exposure-obtain special instructions before use
EINECS Number: N/A
OTHER INFORMATION:
The information contained in this MSDS is believed to be correct to the best of our knowledge.
However, we make no warranty, expressed or implied, with respect to such information. The
information may not be all inclusive, the user should make an independent determination of the
suitability of the information based on all sources available and adopt appropriate safety
precautions. OXIS International Inc. shall not be liable for any damage resulting from contact or
handling of this product.
.
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