MSDS Material Safety Data Sheet

624-64-2 626-64-2

File Name: 624-64-2_626-64.asp

0125A01 Div.03 sds 4-Hydroxypyridine                                        GHS Format


Product Name 4-Hydroxy pyridine
CAS RN 624-64-2
EC# 210-958-3.
SYNONYMS 4-Pyridinol
De : Pyridin-4-ol
Es : Piridin-4-ol
Fr : Pyridine-4-ol



Chemical CAS Purity Unit
4-Hydroxy pyridine 626-64-2 >98% w/w

PRODUCT USES: It is used as an intermediate in pharmaceutical industry

Jubilant Organosys Limited
Jubilant Organosys Limited, Plot 1-A, Sector 16-A,
Bhartiagram, Gajraula Institutional Area, Noida,
District: Jyotiba Phuley Nagar Uttar Pradesh-201301 India.
Uttar Pradesh-244223, India PHONE NO: +91-120-2516601
PHONE NO: +91-5924-252353 unto Contact department: EHS
252360 FAX NO : +91-120-2516834
Contact Department-Safety: Ext. 7424 Email:
FAX NO : 91-5924-252352

Medical and Transport Emergencies: +91-9997022412 (India)
Logistics emergencies +91-120-4365441. (India)

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Skin corrosion / irritant: Category 2.
Eye damage/eye irritant: Category 2B.

It is off white to beige Powder and chunks. The solid powder is odorless and soluble in
water. It is irritating to respiratory system.

Causes eye and skin irritation.

?Wash hands thoroughly after handling.
?Wear protective gloves as specified by the manufacturer/supplier or the competent
?Wash thoroughly after handling.


If in Eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing. If eye irritation persists, get medical
advice/attention. Wash hands after handling

If on Skin: Wash with plenty of soap and water. Take of contaminated clothing and wash
before re-use. If skin irritation occurs, seek medical advice/attention.

Store locked up

Dispose of the container as per local norms and regulations.

Section 3: Composition of ingredients

Sr. Chemical CAS # EC# Purity
1. 4-Hydroxy pyridine 626-64-2 210-958-3. >98%

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Section 4: First Aid Measures

Key symptoms.
?Acute effects:
The exposure to this chemical has causes irritation to skin, eyes and respiratory


Eyes: If substance has got into eyes rinse cautiously with water. Remove contact lenses if
easy to do so. Continue rinsing. Seek medical attention if irritation persists.
Skin: Wash thoroughly with water for at least 15 minutes. Seek immediate medical
attention if required.
Ingestion: After swallowing: make victim drink plenty of water, Call a physician.
Inhalation: Remove the person from the area into fresh air. If the person is conscious
give oxygen. If unconscious give artificial respiration. Call for medical services if

Section 5: Fire Fighting Measures

Flash Point: 2210C Non-combustible solid.

Extinguishing media
Dry chemical powder, chemical foam, and alcohol resistant foam. Do not use water jet or
fog (spray) to extinguish. Water can be effective in cooling down the fire-exposed
containers. Use water spray to knock down fire fumes if possible.

Special Protective Equipment And Precautions For Fire Fighter.
Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep
out of low area. Wear self-contained (positive pressure if available) breathing apparatus
and full protective clothing. Isolate for 1/2 mile in all directions if tank car or truck is
involved in fire (DOT 1984, Guide 29).

Section 6: Accidental Release Measures

Minor Spills
? Clean up all spills following relevant Standard Operating Procedures.
? Avoid all contact with the material.
? Wear protective clothing, boots, impervious gloves and safety glasses.
? Wipe up.

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Major Spill
? Alert Emergency Responders and tell them location and nature of hazard.
? Wear protective clothing, full boots, impervious gloves, safety glasses and
Self Contained Breathing Apparatus (SCBA), as may be deemed
? Clear area of personnel and move upwind.
? Prevent, by any means available, spillage from entering drains or water
and watercourses.
? Collect recoverable product into labeled containers for recycling, recovery
or disposal.
? Collect spillage with sand, earth or vermiculite.
? Wash up the area with water
? Inform authorities in event of contamination of any public sewers, drains
or water bodies.

Section 7: Handling & Storage

? Wear protective gloves/clothing and eye/face protection.
? Wash thoroughly after handling.
? Avoid contact with incompatible materials.
? When handling, DO NOT eat, drink or smoke.
? Launder contaminated clothing before re-use.

? Store away from incompatible materials.
? Keep closed when not in use.
? Store locked up

Section 8: Exposure Controls/Personal Protection

Exposure Limits

4-Hydroxy pyridine Not established Not established Not established

Occupational Exposure Limits:
There are no known occupational exposure limits for this chemical.

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Exposure Controls
Provide exhaust ventilation or other engineering controls to keep the relevant airborne
concentrations below their respective occupational exposure limits. Ensure that eyewash
stations and safety showers are close to the workstation location.

Personal Protection:
Protective clothing should be selected specifically for the working place, depending on
concentration and quantity of the hazardous substances handled. The resistance of the
protective clothing to chemicals should be ascertained with the respective supplier.
Hands: Wear appropriate protective gloves to prevent skin exposure.
Eyes: Safety goggles/ Chemical Safety glasses and Face shield.
Clothing: Boots and clothing to prevent contact.
Respirator: Follow the OSHA respirator regulations found in 29CFR 1910.134 or
European Standard EN 149. Always use a NIOSH or European Standard EN 149
approved respirator when necessary.

General Hygiene and general comments:
?Wash hands and face after working with substance.
?Immediately change contaminated clothing.
?Apply skin protective barrier cream.

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Section 9: Physical and Chemical Properties

Sr.No. Parameter Typical value
1 Powder and chunks, off
Appearance white to beige
2 Odor Odorless.
3 Odor Threshold Not available
141 癈
4 Melting point
5 Boiling point 230-235癈 @12 mmHg
6 Flash point 221癈
7 Evaporation rate (n-BuAc=1) Not available
8 Explosive limits Not available
9 Vapor pressure Not available
Vapor density (air=1) at 200C
10 Not available.
11 Specific gravity (water=1) Not available.
12 Soluble
Solubility in water
7.0 at 20 oC.
13 PH
14 Log Kow (octonol/water) 0.32
675 oC
15 Auto-ignition temperature
16 Decomposition temperature Not available
17 Viscosity Not available
18 95.1
Molecular Weight
19 Not available
Pka (@250C)
20 1.728
Log Koc
21 No
Flammable material
22 No
23 No
Corrosive material
24 No
Explosive material

Section 10: Stability and Reactivity

Stability: Stable at low and dry conditions.
Conditions to Avoid: Dust generation, keep away from moisture.
Incompatibilities with Other Materials: Strong oxidizing agents, strong acids, strong
bases, acid chlorides, heavy metal salts.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, irritating and
toxic fumes and gases, carbon dioxide, cyanide fumes.
Hazardous Polymerization: Has not been reported.

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Section 11: Toxicological Information

(a) Acute Toxicity
?RTECS 1 # UU7701450
?Route of Exposure Interperitonial
?Species Observed Rodent-mouse
?LD50 923 mg/kg.

(b) Skin Corrosion/Irritation;
?It is irritating to skin.

(c) Eye Damage/Irritation;
?It is irritating to eyes.

(d) Respiratory or Skin Sensitization;
?It causes respiratory irritation.

(e) Germ Cell Mutagenicity;
?No information available.

(f) Carcinogenicity;
?Not listed by NTP, IARC and OSHA.
?Not present on the EU CMR list.

(g) Reproductive Toxicity;
?At higher concentration it was significantly teratogenic2.

(h) Aspiration Hazard.
?No information available.

Section 12: Ecological Information

(A) Ecotoxicity:
?The Ecotoxicity data is not available.
?Fish ChV = 190. No toxic effects are expected for fish and aquatic

(B) Persistence and Degradability.
?It is expected to be biodegradable in aerobic and anaerobic conditions.

(C) Bioaccumulative Potential (Predicted)
? BCF = 3.2
? Log Kow = 0.32

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Based on the Log Kow and Bioconcentration factor value it is expected to have
negligible potential to concentrate in fatty tissue of fish and aquatic organisms
relative to its surroundings.

(D) Mobility (Predicted):

? Log Koc= 1.728 (estimated). Low sorption.
? Henry's Law Constant 7.39 X 10-10 atm/m3 mole at 25 degrees. It is
non volatile from aqueous bodies.
? Log Kow= 0.32 (estimated). Low potential to bioaccumulation.

(E) Environment Fate:

Based on the environmental modeling, this material has a low potential to get absorbed in
the organic matter of soil and is non-volatile from water bodies. Since this is an estimated
result it is recommended that the material should not be disposed into the environment.
The material should never be disposed into the sewage.

Section 13: Disposal Consideration

? Dispose of this material in accordance with standard practice for disposal of
potentially hazardous materials as required by applicable federal, state or local
laws. Note that disposal regulations may also apply to empty containers and
equipment rinsates.

Section 14: Transport Information

? It is considered to be Non Hazardous for Transport by Road/Rail/Sea/Air and not
regulated by ADR/RID/IMDG/IATA.

Section 15: Regulatory Information

European information
EC# 210-958-3.
Classification: Xi;R36/37/38

?R36/37 /38 Irritating to eyes, respiratory system and skin

?S 26 In case of contact with eyes, rinse immediately with plenty of water.

? S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.

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Pre-Registration Status under REACH Regulation (EC) No. 1907/2006

EC Name Submission Pre-registration Name of the Validity
Number Number Organization
Pyridin-4-ol CA242272-71 05-2114624468-43-0000 Jubilant 31/05/2018
Pharmaceuticals NV


CAS# 626-64-2 is listed on the TSCA inventory.
None of the chemicals in this product has an RQ under SARA Section 302 RQ
None of the chemicals in this product has an TPQ under SARA Section 302 TPQ
None of the chemicals in this product is reported under SARA Section 313
None of the chemicals in this product contain any class1 & class2 ozone depletors ,
neither contain any hazardous air pollutants under `Clean Air Act'
None of the chemicals in this product is listed as Hazardous substances or priority
pollutants or Toxic substances list under `Clean Water Act'

CAS# 626-64-2 is listed on Canada's NDSL List.
CAS# 626-64-2 is not listed on Canada's Ingredient Disclosure List.

Section 16: Other Information

SDS data
Chemical: 4-Hydroxypyridine.
CAS #: 626-64-2
File Name: 0125A01 Div.03 sds 4-Hydroxypyridine
Date: December 16, 2008
Revision Number: 01

1. Reference: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall,
Oxford OX3 OBW, UK) V.1- 1962- Volume (issue)/page/year: 23,815,1985

2. Reference: International Toxicologist 1995 Jul;7(1):AB# 73-P-20.

Information contained in this SDS is believed to be correct but no representation;
guarantee or warranties of any kind are made as to its accuracy, suitability for a particular
application or results to be obtained from them. This SDS shall be used as a guide only.
JUBILANT ORGANOSYS LIMITED makes no warranties expressed or implied of the

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adequacy of this document for any particular purpose.


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