OXIS International, Inc.
MATERIAL SAFETY DATA SHEET (page 1 of 6)
SECTION I - MANUFACTURER AND PRODUCT IDENTITY
Manufacturer's Name: OXIS International, Inc.
6040 N. Cutter Circle, Suite 317
Portland, OR 97217-3935
Telephone Number: In Oregon (503) 283-3911
Toll Free (800) 547-3686
Facsimile (503) 283-4058
BIOXYTECH?LPO-586 Assay
Common Name/Trade Name:
Catalog Number(s): 21012
Date: 06 June 2004
SECTION II - HAZARDOUS COMPONENTS IDENTITY
Hazards identified with this product are associated with the following Assay Kit component(s):
Component: Hazardous Content:
R1 Name: Acetonitrile
CAS#: 75-05-8
MF: C2H3N
Name: N-Methyl-2-Phenylindole
CAS#: 3558-24-5
MF: C15H13N
R2 Name: Methanesulfonic Acid
CAS#: 75-75-2
MF: CH4SO3
MDA Standard Name: 1,1,3,3-Tetramethoxypropane
CAS#: 102-52-3
MF: C7H16O4
Name: Tris-Hydrochloride
CAS#: 1185-53-1
MF: C4H11NO3
Diluent Name: Methanol
CAS#: 67-56-1
MF: CH4O
Name: Ferric Chloride Hexahydrate
CAS#: 10025-77-1
MF: FeCl3.6H2O
SECTION III - PHYSICAL AND CHEMICAL CHARACTERISTICS
(All values are approximate)
Acetonitrile:
Boiling point: 81-82癈 Flash point: 5癈/42癋
Specific gravity: 0.786 Flammable limits: N/A
Vapor pressure: 72.8mm @ 20癈 Extinguisher media: Dry chemical, CO2.
Vapor density: 1.41 Auto-ignition temperature: 522癈/973癋
Water solubility: N/A Lower explosion limit: 4.4%
Reactivity in water N/A Upper explosion limit: 16%
Appearance: Colorless liquid
Odor: Negligible odor
Msds21012 LPO-586 Assay.doc
OXIS International, Inc.
MATERIAL SAFETY DATA SHEET (page 2 of 6)
Ferric Chloride Hexahydrate:
o
Boiling point: 280 ?285 C Flash point: N/A
Specific gravity: N/A Flammable limits: N/A
Vapor pressure: N/A Extinguisher media: Dry chemical, CO2.
Vapor density: N/A Auto-ignition temperature: N/A
Water solubility: N/A
Reactivity in water N/A
Appearance: Yellow powder and chunks
Odor: Negligible odor
Methanesulfonic Acid:
o
Boiling point: 167癈 @ 10mm Flash point: 170 C
Specific gravity: 1.481 Flammable limits: N/A
Vapor pressure: 1mm @20癈 Extinguisher media: Dry chemical, CO2.
Vapor density: 3.3 g/L Auto-ignition temperature: N/A
Water solubility: N/A
Reactivity in water N/A
Appearance: Viscous colorless liquid
Odor: Negligible odor
Methanol:
o o
Boiling point: 64.6 ?64.7 C @ 760 mm Flash point: 11 C
Specific gravity: 0.791 Explosion limits: Lower: 6%
Vapor pressure: 97.68 mmHg @20癈 Upper: 36%
Vapor density: 1.1 g/L Extinguisher media: Dry chemical, CO2
o
Water solubility: soluble Auto-ignition temperature: 385 C
Reactivity in water N/A
Appearance: Colorless liquid
Odor: Negligible odor
N-Methyl-2-phenylindole:
o
Melting point: 98 - 100 C Flash point: N/A
Specific gravity: N/A Explosion limits: Lower: N/A
Vapor pressure: N/A Upper: N/A
Vapor density: N/A Extinguisher media: Dry chemical, CO2
Water solubility: soluble Auto-ignition temperature: N/A
Reactivity in water N/A
Appearance: Powder
Odor: Negligible odor
1,1,3,3-Tetramethoxypropane:
70 ?75 癈 @ 15 mm Hg
o
Boiling point: Flash point: 57 C
Specific gravity: N/A Flammable limits: N/A
Vapor pressure: N/A Extinguisher media: Dry chemical, CO2.
Vapor density: N/A Auto-ignition temperature: N/A
Water solubility: N/A
Reactivity in water N/A
Appearance: White crystals
Odor: None
Tris-Hydrochloride:
150 - 152 癈
Melting point: Flash point: N/A
Specific gravity: N/A Flammable limits: N/A
Vapor pressure: N/A Extinguisher media: Dry chemical, CO2.
Vapor density: N/A Auto-ignition temperature: N/A
Water solubility: N/A
Reactivity in water N/A
Appearance: White crystals
Odor: None
Msds21012 LPO-586 Assay.doc
OXIS International, Inc.
MATERIAL SAFETY DATA SHEET (page 3 of 6)
SECTION IV - REACTIVITY DATA AND STORAGE CONDITIONS
Acetonitrile:
Stability: Reactive, corrosive, flammable.
Incompatibilities: Acids, bases,oxidizing or reducing agents, alkali metals.
Storage conditions: Store reagents tightly capped in the dark at refrigerator
temperatures (2-8癈).
Hazardous decomposition products: Hydrogen cyanide, nitrogen oxides, carbon monoxide,
carbon dioxide.
Hazardous polymerization: N/A
Ferric Chloride Hexahydrate:
Stability: Stable.
Incompatibilities: Strong oxidizing agents, Sodium metal, Potassium metal.
Storage conditions: Protect from moisture.
Hazardous decomposition products: Hydrogen Chloride gas.
Hazardous polymerization: N/A
Methanesulfonic Acid:
Stability: Corrosive, reactive.
Incompatibilities: Bases, amines, strong reducing agents.
Storage conditions: Store tightly capped.
Hazardous decomposition products: Carbon dioxide, carbon monoxide, sulfur oxides.
Hazardous polymerization: N/A
Methanol:
Stability: Stable.
Incompatibilities: Acids, Acid chlorides, Acid anhydrides, Oxidizing agents,
Alkali metals, Reducing agents.
Storage conditions: Store tightly capped.
Hazardous decomposition products: Carbon dioxide, carbon monoxide.
Hazardous polymerization: N/A
N-Methyl-2-phenylindole:
Stability: Stable.
Incompatibilities: Strong oxidizing agents.
Storage conditions: Store tightly capped.
Hazardous decomposition products: Carbon dioxide, carbon monoxide, nitrogen oxides.
Hazardous polymerization: N/A
1,1,3,3-Tetramethoxypropane:
Stability: Stable.
Incompatibilities: Avoid strong oxidizing agents and strong acids. Moisture
sensitive.
Storage conditions: Store tightly sealed in cool dry place; protect from moisture
Hazardous decomposition products: Carbon monoxide, carbon dioxide
Hazardous polymerization: N/A
Tris-hydrochloride:
Stability: Stable.
Incompatibilities: Bases, Oxidizing agents.
Storage conditions: Store tightly capped.
Hazardous decomposition products: Carbon dioxide, carbon monoxide, hydrogen chloride gas,
nitrogen oxides.
Hazardous polymerization: N/A
Msds21012 LPO-586 Assay.doc
OXIS International, Inc.
MATERIAL SAFETY DATA SHEET (page 4 of 6)
SECTION V - HEALTH HAZARD
Acetonitrile:
Threshold limit value: None established.
Toxicity data: Toxic.
Health hazards: Toxic by inhalation, ingestion, or skin absorption.
Destructive to eyes, respiratory system and skin. Irritant.
First aid procedures: Inhalation: Remove to fresh air. If not breathing give
artificial respiration. If breathing difficult, give oxygen if
qualified operator is available. Seek medical attention.
Ingestion: If conscious, wash out mouth with water. Seek
immediate medical attention.
Skin: Remove any contaminated clothing. Wash with
soap/mild detergent/water for at least 15 minutes. If irritation
develops/persists, seek medical attention.
Eyes: Flush with plenty of water for at least 15 minutes,
lifting eyelids. Get medical attention
Ferric Chloride Hexahydrate:
3
Threshold limit value: ACGIH TLV ?TWA 1 mg (Fe)/m .
Toxicity data: IPR-MUS LD50: 260 mg/kg. Target organs: liver, kidneys,
eyes.
Health hazards: Acute exposure: Irritation and possibly burns to
skin/eyes/lungs/mucous membranes/GI tract. Nausea.
Chronic exposure: Systemic metal poisoning hazard,
liver/kidney damage.
First aid procedures: Inhalation: Remove to fresh air. If not breathing give
artificial respiration. If breathing difficult, give oxygen if
qualified operator is available. Seek medical attention.
Ingestion: If conscious, immediately induce vomiting by
having patient drink 2 to 4 glasses of water and touching
back of throat with fingers. Seek immediate medical
attention.
Skin: Remove any contaminated clothing. Wash with
soap/mild detergent/water for at least 15 minutes. If irritation
develops/persists, seek medical attention.
Eyes: Flush with plenty of water for at least 15 minutes,
lifting eyelids. Get medical attention.
Methanesulfonic Acid:
Threshold limit value: None established.
Toxicity data: Toxic, 2 ppm carcinogen. ORL-RAT LD50: 200 mg/kg.
SKIN-GUINEA PIG LD50: >2,000 mg/kg
Health hazards: Corrosive, causes burns. Harmful by inhalation, ingestion, or
skin absorption. Destructive to eyes, respiratory system and
skin. Inhalation may be fatal. Extremely destructive to the
tissue of the mucous membranes, upper respiratory tract,
eyes and skin. Toxic if swallowed. Inhalation may result in
spasms, inflammation and edema of the larynx and bronchi,
chemical pneumonitus and pulmonary edema. Symptoms of
exposure include burning sensation, coughing, wheezing,
laryngitis, shortness of breath, headache, nausea and
vomiting.
First aid procedures: Inhalation: Remove to fresh air. If not breathing give
artificial respiration. If breathing difficult, give oxygen if
qualified operator is available. Seek medical attention.
Ingestion: If conscious, wash out mouth with water. Seek
immediate medical attention.
Skin: Remove any contaminated clothing. Wash with
soap/mild detergent/water for at least 15 minutes. If irritation
develops/persists, seek medical attention.
Eyes: Flush with plenty of water for at least 15 minutes,
lifting eyelids. Get medical attention
Msds21012 LPO-586 Assay.doc
OXIS International, Inc.
MATERIAL SAFETY DATA SHEET (page 5 of 6)
Methanol:
3
Threshold limit value: ACGIH/TLV: 328 mg/m (250 ppm) skin; OSHA/STEL: 250
ppm.
Toxicity data: Toxic via inhalation, ingestion, absorption through skin.
Teratogen, mutagen, reproductive hazard. Cannot be made
non-toxic.
Target organs: eyes, kidneys, pancreas, liver, heart.
RTECS#: PC1400000
Health hazards: Exposure can cause gastointestinal disorders. May cause
convulsions, nausea and vomiting.
Inhalation: May cause headache, dizziness, weakness,
gastrointestinal or visual disturbance (e.g., pupils dilate,
react poorly to light.) May be irritating to mucous
membranes and upper respiratory tract.
Ingestion: Causes inebriation, drowsiness, severe
abdominal pain, visual disturbanes, possible blindness or
death. Oral-rat LD50: 5628 mg/kg. Oral-human LDLO: 340
mg/kg.
Skin: Liquid is a mild irritant to skin and is readily absorbed
through skin. Repeated exposures may cause dermatitis
due to defatting action. Toxic absorption: LD50 (Rabbit):
20,000 mg/kg.
Eyes: Vapor is a mild irritant to eyes if treated promptly.
Direct liquid contact can cause inflammation and transient
corneal opacity.
First aid procedures: Inhalation: Remove to fresh air. If not breathing, give
artificial respiration. If breathing is difficult, give oxygen if
qualified operator is available.
Ingestion: If conscious, immediately induce vomiting by
having patient drink 2 to 4 glasses of water and touching
back of throat with fingers. Seek immediate medical
attention.
Skin: Flush with plenty of water. Remove contaminated
clothing and shoes. Wash clothing before re-use.
Eyes: Flush with plenty of for a minimum of 15 minutes.
Repeat procedure if irritation persists. See a physician.
N-Methyl-2-phenylindole:
Threshold limit value: N/A
Toxicity data: The toxicological properties of this material have not been
fully investigated.
Health hazards: May be harmful by inhalation, ingestion or skin absorption.
Acute exposure:May cause skin/eye irritation.
Chronic exposure: N/A.
First aid procedures: Inhalation: Remove to fresh air. If not breathing give
artificial respiration. If breathing difficult, give oxygen if
qualified operator is available. Seek medical attention.
Ingestion: If conscious,wash out mouth with water. Seek
immediate medical attention.
Skin: Remove any contaminated clothing. Wash with
soap/mild detergent/water for at least 15 minutes. If irritation
develops/persists, seek medical attention.
Eyes: Flush with plenty of water for at least 15 minutes,
lifting eyelids. Get medical attention.
Msds21012 LPO-586 Assay.doc
OXIS International, Inc.
MATERIAL SAFETY DATA SHEET (page 6 of 6)
1,1,3,3-Tetramethoxypropane:
Threshold limit value: N/A
Toxicity data: ORL-RAT LD50: 2440 mg/kg.
Health hazards: Acute exposure: May cause skin irritaion. May be harmful if
absorbed through the skin. May cause eye irritation. May
cause irritation to mucous membranes and upper respiratory
tract. May be harmful if inhaled. May be harmful if
swallowed.
Chronic exposure: N/A
First aid procedures: Inhalation: Remove to fresh air. If not breathing give
artificial respiration. If breathing difficult, give oxygen if
qualified operator is available. Seek medical attention.
Ingestion: If conscious, wash out mouth with water. Seek
immediate medical attention.
Skin: Remove any contaminated clothing. Wash with
soap/mild detergent/water for at least 15 minutes. If irritation
develops/persists, seek medical attention.
Eyes: Flush with plenty of water for at least 15 minutes,
lifting eyelids. Get medical attention.
Tris-hydrochloride:
Threshold limit value: N/A
Toxicity data: N/A
Health hazards: Acute exposure: May be harmful by inhalation, ingestion or
skin absorption. Causes eye and skin irritation. Irritating to
mucous membranes and upper respiratory tract.
Chronic exposure: N/A
First aid procedures: Inhalation: Remove to fresh air. If not breathing give
artificial respiration. If breathing difficult, give oxygen if
qualified operator is available. Seek medical attention.
Ingestion: If conscious, wash out mouth with water. Seek
immediate medical attention.
Skin: Remove any contaminated clothing. Wash with
soap/mild detergent/water for at least 15 minutes. If irritation
develops/persists, seek medical attention.
Eyes: Flush with plenty of water for at least 15 minutes,
lifting eyelids. Get medical attention.
SECTION VI - SPECIAL PROTECTION INFORMATION
Respiratory protection: Do not breath vapor.
Ventilation: Required.
Mechanical: As required.
Local Exhaust: Suggested.
Other protective clothing or equipment: Laboratory coats, gloves and eye protection required.
SECTION VII - SPECIAL PRECAUTIONS AND SPILL/LEAK PROCEDURES
Steps to be taken in case material is released or
spilled: Wear protective clothing (laboratory coats, gloves and eye
protection), wipe up spill with absorbant material and dispose
in appropriate container.
Clean up of spill site: Wash the spill site with an excess of water.
Waste disposal methods: Dispose of waste in accordance with all Federal, State and
local regulations.
The information contained in this MSDS is believed to be correct to the best of our knowledge. However, we make no warranty,
expressed or implied, with respect to such information. The information may not be all inclusive, the user should make an
independent determination of the suitability of the information based on all sources available and adopt appropriate safety
precautions. OXIS International, Inc. shall not be held liable for any damage resulting from contact or handling of this product.
Msds21012 LPO-586 Assay.doc
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