8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: N-Trifluoroacetyl-L-prolyl chloride 0.1 M in Chloroform
Code: 440001, 440002
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
SECTION 1 ..................................................... PRODUCT IDENTIFICATION ........................................................................
Name: N-Trifluoroacetyl-L-prolyl chloride 0.1 M in Chloroform
Code: 440001, 440002
SECTION 2 .................................. COMPOSITION, INFORMATION ON INGREDIENTS .....................................................
Synonyms 0.1 M TPC in Chloroform; 0.1 M N-TFA-L-prolyl chloride in Chloroform
CAS #: 36724-68-2 MF: C7H7ClF3NO3 TPC; N-TFA-L-prolyl chloride; (S)-1-(trifluoroacetyl)-2-pyrrolidinecarbonyl
chloride; (S)-(-)-N-(Trifluoroacetyl)-prolyl chloride; N-Trifluoroacetyl-(S)-(-)-prolyl chloride;
N-Trifluoroacetyl-(S)-prolyl chloride; Trifluoroacetyl-L-prolyl chloride
CAS #: 71890-93-2 MF: C7H7ClF3NO3 N-TFA-D-prolyl chloride; (R)-1-(trifluoroacetyl)-2-pyrrolidinecarbonyl chloride;
N-Trifluoroacetyl-(R)-prolyl chloride; Trifluoroacetyl-D-prolyl chloride
CAS #: 356-42-3 MF: CHCl3 Trichloroform; Trichloromethane
Ingredients Concentration (%/wt)
N-TFA-L-prolyl chloride (36724-68-2)...............................................................NLT 95% L-isomer 5%
N-TFA-D-prolyl chloride (71890-93-2) ............................................................. NMT 5% D-isomer 0.1 %
Chloroform (356-42-3) (inhibitor free) ............................................................................................. 98.4 %
SECTION 3 ..................................................... HAZARDS IDENTIFICATION ........................................................................
Precautionary Statements See Sections 8 and 11 for further details.
Toxic. Causes drowsiness and dizziness.
........................................................ Emergency Overview .......................................................
NFPA Ratings (Scale 0-4); Health = 3; Fire = 1; Reactivity = 1; W
Liquid: clear, colorless. Odor: sweet, fruity odor--ethereal odor
Toxic volatile liquid and vapor. Causes dizziness and drowsiness. Readily absorbed
through skin and lungs. Relatively potent general anesthetic--central nervous
system depressant. May produce hallucinations, distorted perceptions, and signs of
drunkenness. May be harmful or fatal if swallowed or inhaled. Alcohol exposure or
consumption can increase effects. Delayed effects possible. Keep cool.
Light sensitive--pH decreases upon prolonged exposure to light and air due to the
formation of hydrochloric acid. Contact with moist air or water may produce HCl.
The properties of this material have not been fully investigated. Use due caution in
handling and use of this material.
May cause irritation to skin, eyes, mucous membranes, and respiratory tract. May harm
unborn and newborn. Possible Cancer Hazard--based on animal data.
Emits toxic fumes under fire conditions--potential chemical or thermal decomposition products:
carbon monoxide, carbon dioxide, hydrochloric acid, chlorine, phosgene, hydrogen fluoride
Standard chemical handling precautions: Avoid ingestion or breathing mists. Avoid contact
with eyes, skin, and clothing. Wash thoroughly after handling.
Target organs: central nervous system, cardiovascular, blood, kidneys, liver, heart, GI,
reproductive system
See Sections 4, 5, 6, 8, 9, and 10.
.....................................................................................................................................................
Other Hazard Information
This compound has not fully been tested for toxicological, irritation, or similar tendencies.
Primary Route(s) of Entry: Inhalation, Ingestion, Eye, Skin--Readily absorbed through skin and lungs.
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 440001b2 Effective Date: 08/05/2008 Version #: 2.2 Page 1 of 9
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: N-Trifluoroacetyl-L-prolyl chloride 0.1 M in Chloroform
Code: 440001, 440002
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
Corrosive hydrochloric acid (strong acid) may be formed when TPC reacts with the water in the skin, eyes, and
mucous membranes. Chloroform may also contain small amounts of hydrochloric acid. Hydrochloric
acid is destructive to skin, eye, and mucous membrane tissues. TPC in chloroform may immediately
dehydrate tissues upon contact.
Eye: Can cause moderate to severe irritation with burning, itching, tearing, and redness.
Skin: Can cause mild to severe irritation with itchiness and possible dryness, cracking and dermatitis
from loss of natural skin oils. Readily absorbed through skin with systemic effects similar to
inhalation and ingestion. Can be harmful or fatal.
Inhalation: Can cause respiratory tract irritation. Can be harmful or fatal. Inhalation of high concentrations
may cause central nervous system (CNS) effects characterized by headache, nausea, vomiting,
excitement, drowsiness, dizziness, confusion, hallucinations, distorted perceptions, loss of
muscle coordination, unconsciousness, and coma. Prolonged exposure may cause heart, liver,
and kidney damage. Delayed effects possible.
Ingestion: Can be harmful or fatal. Can cause severe gastrointestinal irritation with severe burning in mouth
and throat, pain in chest, nausea, vomiting, and diarrhea. May cause nervous system depression
as described under inhalation. Chronic, or repeated exposure in low concentrations to chloroform
may cause heart, liver, and kidney damage characterized by irregular heart beat, liver
enlargement. Chloroform may pass through the placenta or be excreted in breast milk and may
cause harm to the unborn or newborn. The mean lethal dose in humans is about 1 ounce.
Acute: See above route. Use adrenergic agents such as epinephrine or pseudoepinephrine might
enhance irregular heartbeat effect.
Chronic: See above route. Chloroform may cause cancer--dependant on level and duration of exposure.
Symptoms: See specific route above. Chloroform toxicity may be increased by exposure to alcohol, steroids,
and ketones.
Pre-existing conditions that may be aggravated: pregnancy, alcoholism, liver, heart, kidney,
nerves, GI tract, Use adrenergic agents such as epinephrine or pseudoepinephrine
See Section 11 for additional toxicological data.
SECTION 4 ......................................................... FIRST AID MEASURES ............................................................................
Eye contact: Immediately flush eyes with copious amounts of water or eyewash solution for at least 15
minutes; lift eyelids occasionally. If irritation persists, consult physician.
Skin contact: Immediately remove contaminated clothing and shoes, then wash skin with soap and copious
amounts of water. If irritation persists, consult physician.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration and keep person warm and at
rest. If breathing is difficult, give oxygen; consult physician.
Ingestion: Wash out mouth with water provided person is conscious; give large amounts of water or milk
(2-4 cups). DO NOT induce vomiting without first consulting physician. If vomiting occurs, keep
head lower than hips to help prevent aspiration. Maintain airway and respiration. Treat
symptomatically and supportively.
Wash contaminated clothing before reuse. Discard contaminated footware.
Physician note: Symptomatic and supportive care. Chloroform causes cardiac sensitization to endogenous
catecholamines that may lead to heart arrhythmias. DO NOT use adrenergic agents such as
epinephrine or pseudoepinephrine. Effects may be delayed. Treatment based on physician
judgment in response to reactions of the patient.
SECTION 5 ..................................................... FIRE FIGHTING MEASURES ........................................................................
Flash Point: None Method: tcc Autoignition: NE
OSHA Flammability Class: NA Explosion Limits: upper: NE
NFPA: See Section 3 Hazards Identification Emergency Overview above. lower: NE
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 440001b2 Effective Date: 08/05/2008 Version #: 2.2 Page 2 of 9
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: N-Trifluoroacetyl-L-prolyl chloride 0.1 M in Chloroform
Code: 440001, 440002
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
Extinguishing Media
Water spray, carbon dioxide, dry chemical powder, or appropriate foam.
Special Fire Fighting Procedures
Self-contained breathing apparatus (SCBA) and protective clothing to prevent inhalation and contact with skin
and eyes should be worn in fighting large fires involving chemicals.
Standard Fire and Explosion Hazards
Avoid inhalation of material or combustion by-products.
Use any means suitable for extinguishing surrounding fire.
Unusual Fire and Explosion Hazards
Slight fire hazard when exposed to high heat, otherwise practically non-flammable.
Toxic volatile liquid and vapor. Causes dizziness and drowsiness. Readily absorbed through skin and lungs.
Relatively potent general anesthetic--central nervous system depressant. May produce hallucinations,
distorted perceptions, and signs of drunkenness.
May decompose on contact with water to produce small amounts of hydrochloric acid, that in contact with metals
may form flammable or explosive hydrogen gas.
Containers may build pressure or rupture when heated.
Water spray may be used to cool fire-exposed containers.
Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Emits toxic fumes under fire conditions.
Hazardous Combustion or Decomposition Products
carbon monoxide, carbon dioxide, hydrochloric acid, chlorine, phosgene, hydrogen fluoride
SECTION 6 ............................................. ACCIDENTAL RELEASE MEASURES ................................................................
Eliminate all ignition sources/slight fire hazard due to possible formation of small amounts of hydrochloric acid
upon contact with moist air or water, that in contact with metals may form flammable or explosive
hydrogen gas.
Use spark proof tools.
Evacuate unnecessary people from area. Isolate spilled material.
Ventilate area.
Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Vapors can cause dizziness, drowsiness, hallucinations, and distorted perceptions.
Wear NIOSH/MSHA approved respirator for organic/acid gas, dust, and mists to prevent inhalation of mists.
Wear protective clothing to prevent contact with skin and eyes (lab coat, gloves, and safety glasses). Material is
readily absorbed through the skin and lungs.
Contain and recover material when possible.
Use chemically compatible spill pillows, or similar adsorbent material.
Sweep up, seal in appropriate hazardous waste container, and hold for proper waste disposal.
Avoid raising contaminated dust.
Wash spill site after material pickup is complete.
Standard chemical precautions: Keep out of water supplies and sewers.
SECTION 7 ..................................................... HANDLING AND STORAGE.........................................................................
General Handling Measures
See Section 8 Below.
General Storage Measures
Store tightly closed in a cool, dry place with adequate ventilation, in a storage area suitable for halogenated
solvents.
Special Storage Instructions
Empty containers retain product residue, (liquid/vapor), and can be dangerous.
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 440001b2 Effective Date: 08/05/2008 Version #: 2.2 Page 3 of 9
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: N-Trifluoroacetyl-L-prolyl chloride 0.1 M in Chloroform
Code: 440001, 440002
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
Special Handling Instructions
Use appropriate precautions for handling toxic, volatile halogenated organic liquids.
Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Light and moisture sensitive--prolonged exposure decreases pH due to the formation of hydrochloric acid.
Wash thoroughly after handling. Avoid breathing vapors and mists.
Immediately remove contaminated clothing since chloroform is readily absorbed through skin and lungs.
SECTION 8 ................................. EXPOSURE CONTROLS, PERSONAL PROTECTION ....................................................
Airborne Exposure Limits TWA (8H)/VPEL STEL Ceiling Limit Ceiling (skin)
mg/m3 ppm mg/m3 ppm mg/m3 ppm mg/m3
ppm
N-TFA-L-prolyl chloride OSHA PEL NE NE NE NE NE NE NE NE
36724-68-2 ACGIH - TLV NE NE NE NE NE NE NE NE
N-TFA-D-prolyl chloride OSHA PEL/VPEL NE NE NE NE NE NE NE NE
71890-93-2 ACGIH - TLV NE NE NE NE NE NE NE NE
Chloroform OSHA PEL/VPEL 2 9.78 NE NE 50 240 NE NE
356-42-3 ACGIH - TLV 10 49 NE NE NE NE NE NE
Hydrochloric Acid* OSHA PEL NE NE NE NE 5 7 NE NE
7647-01-0 ACGIH - TLV NE NE 5 7.5 5 7.5 NE NE
*Hydrochloric acid may be formed on contact with water, moist air, or prolonged exposure to light.
Chloroform Exposure Notations
Acute
1,000-2,000 ppm may cause dizziness, headache, fatigue, salivation, and nausea;
4,000 ppm may cause vomiting, serious disorientation, and a fainting feeling;
14,000-16,000 ppm may cause anesthesia and rapid loss of consciousness;
More than 20,000 ppm may cause respiratory failure, cardiac arrhythmias, and death.
Chronic
Repeated exposure to 77-237 ppm has caused lassitude, dullness, urinary frequency, and
gastrointestinal disturbances.
17 of 68 workers exposed to 10-200 ppm for 1-4 years exhibited hepatomegaly and increased
susceptibility to viral hepatitis.
Special/Other Control Measures
Odor threshold: 85 ppm (chloroform); 1-5 ppm (hydrochloric acid)
Personal Protective Equipment (PPE)
OSHA/ANSI approved chemical safety eyewear or goggles
Compatible chemical-resistant gloves: PVC and rubber are not suitable for PPE
Wear NIOSH/MSHA approved respirator for organic/acid gas, dust, and mists to prevent inhalation.
Protective Clothing (e.g., lab coat)
Other Standard Safety Equipment and Engineering Preventive Measures
Safety shower and eye wash
Mechanical exhaust required. Hood recommended. Use adequate general and/or local exhaust ventilation to
keep airborne concentrations below the permissible exposure limits.
Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 440001b2 Effective Date: 08/05/2008 Version #: 2.2 Page 4 of 9
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: N-Trifluoroacetyl-L-prolyl chloride 0.1 M in Chloroform
Code: 440001, 440002
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
General Precautions and Handling Measures
Avoid ingestion, inhalation and contact with eyes, skin, and clothing.
Avoid prolonged or repeated exposure. Wash thoroughly after handling.
Wash contaminated clothing before reuse. Discard contaminated footware.
Chloroform is readily absorbed through skin and lungs.
SECTION 9 ......................................... PHYSICAL AND CHEMICAL PROPERTIES ............................................................
Chemical Family: Halogenated amino acid derivative Use: Derivatization Enantiomeric Purity Reagent for GC
in halogenated organic solvent
Appearance, Odor, and Other Properties
Appearance: clear, colorless liquid Odor: sweet, fruity odor--ethereal
Freeze/MP: -63.5癈 (-83癋) (CHCl3) Water Reactive: no
bp (1atm): 61-62癈 (141-143癋) (CHCl3) Water Solubility: slightly
FW: 229.59 (TPC) Specific Gravity (H20 = 1.0): 1.508
229.59 (N-TFA-D-prolyl Cl) VP (mmHg): 160mm @ 20癈 (CHCl3)
119.38 (chloroform) Vapor Density (air=1): 4.12 (CHCl3)
% Volatiles: 98% Evap. Rate (BuAc = 1.0): 11.6 (CHCl3)
Refractive Index (nD20):
pH: NE 1.4476 (CHCl3)
3.6x10-13 atm-m3/mol at 24癈 (CHCl3)
Critical Temp: 263.2癈 (506癋) (CHCl3) Henry's Law Const:
Critical Press: 54 atm (CHCl3) Octanol Water Dist. Coeff. (LKOW): 1.97 (CHCl3)
Soluble in Organic Solvents: NE
SECTION 10 .................................................. STABILITY AND REACTIVITY .......................................................................
Stability
Stable if stored tightly sealed and refrigerated--protected from light, air, and heat.
Incompatibilities
Acids, Acetone, and Strong oxidizers
Alkalies and caustics (ammonium hydroxide, sodium methoxide, potassium hydroxide, etc.)
Aluminium, magnesium
Dinitrogen tetraoxide, Disilane, Fluorine, Triisopropylphospine
Light sensitive--pH decreases upon prolonged exposure to light and air due to the formation of HCl.
Water or moist air--May decompose on contact to produce small amounts of hydrochloric acid, that in contact with
metals may form flammable or explosive hydrogen gas.
Will attack some forms of plastic, rubber, and coatings
Precautions
Avoid incompatibilities.
Protect from heat, flames, sparks, and ignition sources.
Refrigerate. Protect from light.
Keep out of water supplies and sewers.
Hazardous Combustion or Decomposition Products
carbon monoxide, carbon dioxide, hydrochloric acid, chlorine, phosgene, hydrogen fluoride
Hazardous Polymerization
None
SECTION 11 .............................................. TOXICOLOGICAL INFORMATION....................................................................
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 440001b2 Effective Date: 08/05/2008 Version #: 2.2 Page 5 of 9
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: N-Trifluoroacetyl-L-prolyl chloride 0.1 M in Chloroform
Code: 440001, 440002
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
RTECS # CAS #
not assigned N-TFA-L-prolyl chloride 36724-68-2 Only selected Registry of Toxic Effects of Chemical
not assigned N-TFA-D-prolyl chloride 71890-93-2 Substances data (RTECS) is presented here.
FS9100000 Chloroform 356-42-3 See actual entry in RTECS for complete information.
MW4025000 Hydrogen Chloride 7647-01-0
Irritation Data eye skin
N-TFA-L-prolyl chloride NDA NDA
N-TFA-D-prolyl chloride NDA NDA
Chloroform eye rbt 148 mg; skn rbt 10 mg/24H open mld;
eye rbt 20 mg/24H mod skn rbt 500 mg/24H mld
Hydrogen Chloride eye rbt 5 mg/30S rinse mld NDA
Toxicity Data oral inhalation dermal
N-TFA-L-prolyl Cl NDA NDA NDA
N-TFA-D-prolyl Cl NDA NDA NDA
Chloroform orl man LDLo 2,514 mg/kg; ihl man LCLo 25,000 ppm/5m; skn rbt LD50:>20 gm/kg;
unr man LDLo 546 mg/kg; ihl rat LC50 47,702 mg/m3/4H scu mus LD50:704 mg/kg
orl rat LD50 695 mg/kg
Hydrogen Chloride orl man LDLo 2857ug/kg ihl hmn LCLo 1300ppm/30M NDA
orl rbt 900 mg/kg ihl hmn LCLo 3000ppm/5M
unr man LDLo 81mg/kg
ihl rat LC50 3124ppm/1H
OSHA IARC NTP ACGIH NIOSH
Carcinogenicity Notes
N-TFA-L-prolyl Cl NL NL NL NL NL None
N-TFA-D-prolyl Cl NL NL NL NL NL None
may cause cancer based on animal studies;
Chloroform Y Y Y Y Y
possible cancer hazard;
ACGIH-A3-Animal Carcinogen;
California-carcinogen; initial date 10/01/1987;
NIOSH--occupational carcinogen;
NTP-Suspect carcinogen;
OSHA--Possible select carcinogen;
IARC--Group 2B carcinogen
IARC Group 3--Not classifiable as a carcinogen
Hydrogen Chloride NL NL NL NL NL
NL = Not Listed as a carcinogen;
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 440001b2 Effective Date: 08/05/2008 Version #: 2.2 Page 6 of 9
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: N-Trifluoroacetyl-L-prolyl chloride 0.1 M in Chloroform
Code: 440001, 440002
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
Lab studies indicate that chloroform causes cancer in animals and may cause cancer in humans. The risk depends on level
and duration of exposure.
Teratogenicity and Reproductive Effects
Lab studies reported in RTECS indicate that chloroform may cause adverse fetal effects, newborn harm, and
reproductive effects. RTECS also reports laboratory studies that indicate that hydrochloride acid may
cause adverse fetal effects.
Neurotoxicity
No data available.
Mutagenicity
RTECS reports mutation data on chloroform and hydrogen chloride.
Miscellaneous
No data available.
Acute and Chronic Effects
See specific route responses in Section 3 Hazards Identification above.
SECTION 12 ................................................. ECOLOGICAL INFORMATION.......................................................................
Environmental Fate
N-TFA-L-prolyl chloride and N-TFA-D-prolyl chloride: No data available.
Chloroform: When released into the soil, this material is expected to leach into groundwater where it will reside
for long periods of time. Releases to water and land will quickly evaporate. When released into the water,
this material is expected to have a half-life between 1-10 days. This material has a log octanol-water
partition coefficient of less than 3.0. This material is not expected to significantly bioaccumulate. When
released into the air it may be transported long distances and will moderately photodegrade with a half-
life of a few months. When released into the air, this material may be removed from the atmosphere to a
moderate extent by wet deposition.
Hydrochloric Acid: Rapidly hydrolyzes when exposed to water. Will exhibit extensive evaporation from soil
surfaces. Upon transport through the soil, hydrochloric acid will dissolve some of the soil materials
(especially those with carbonate bases) and the acid will neutralize to some degree.
Environmental Toxicity
Chloroform: It will not be expected to bioconcentrate into the food chain but contamination of food is likely due to
its use as an extractant and its presence in drinking water. It is not expected to be toxic to aquatic life.
The LC50/96-hour values for fish are over 100 mg/L.
N-TFA-L-prolyl chloride, N-TFA-D-prolyl chloride and Hydrochloric Acid: No data available.
Ecotoxicity Data
Chloroform:
Fish toxicity: 66,800 ug/L 96H LC50 (Mortality) Rainbow trout,donaldson trout (Oncorhynchus mykiss)
Invertebrate toxicity: 32,000 ug/L 96H NOEC (Mortality) Pink shrimp (america) (Penaeus duorarum)
Algal toxicity: >3,200,000 ug/L 48H (Population Growth) Cryptomonad (Chilomonas paramecium)
Other toxicity: 270 ug/L 7H EC50 (Teratogenesis) Spring peeper (Hylacrucifer)
N-TFA-L-prolyl chloride, N-TFA-D-prolyl chloride and Hydrochloric Acid: No data available.
Fate and Transport
Chloroform: Bioconcentration: 690 Ci/mol 6H BCF (Residue) Green algae (Selenastrum capricornutum) 13.9
Ci/mol
N-TFA-L-prolyl chloride, N-TFA-D-prolyl chloride and Hydrochloric Acid: No data available.
Standard Chemical Precautions
Keep out of air, water, and soil
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 440001b2 Effective Date: 08/05/2008 Version #: 2.2 Page 7 of 9
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: N-Trifluoroacetyl-L-prolyl chloride 0.1 M in Chloroform
Code: 440001, 440002
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
SECTION 13 ................................................. DISPOSAL CONSIDERATIONS ......................................................................
That which cannot be recovered or recycled, should be disposed of in accordance with all applicable Federal, State, and
local environmental regulations.
RCRA waste code(s): D022 RCRA Hazard Class (40CFR 261): Toxic--chloroform
SECTION 14 .................................................. TRANSPORT INFORMATION........................................................................
Ship in accordance with all applicable local, State, Federal, and International transportation regulations.
The following is a summary only. Check regulations for complete information:
U. S. Department of Transportation (49CFR171.101)
Shipping Name: Chloroform
Hazard Class or Division: 6.1, Subsidiary Class: none
ID Number: UN1888
Packing Group: III
Labeling: Toxic or Poison
SECTION 15 ................................................. REGULATORY INFORMATION ......................................................................
Reviews, Standards, and Regulations
........................................................................ N-TFA-L-prolyl . N-TFA-D-prolyl . Chloroform ..... Hydrogen
............................................................................. Chloride .............Chloride................. ..............Chloride**
CAS number ......................................................36724-68-2........ 71890-93-2 .......356-42-3.......7647-01-0
TSCA:.............................................................................NL* .....................NL* ...................Y....................Y
*This compound is sold strictly for FDA or research and development use.
**Under EPA Hydrochloric acid, aq/Hydrogen chloride, gas may be regulated differently.
EINECS: ..........................................................................NL...................... NL ....................Y....................Y
Number .............................................................................NA ........................ NA ............... 206-604-2........ 231-595-7
CERCLA [Section 103 (40 CFR 302.4)]: .......................NL...................... NL ....................Y.....................
RQ (lbs).............................................................................NA ........................ NA ..................... 10..................5,000
RCRA Waste Code ...........................................................NA ........................ NA .......... U044 [pure only].........NA
OSHA Process Safety [29 CFR 1910.119]: ...................NL...................... NL ...................NL................Y/NL
TQ (lbs).............................................................................NA ........................ NA .....................NA ..............5,000/NA
Clean Air Act
[Section 112r (40 CFR 68)]: ..............................................NL......................... NL ...................... Y...................... Y
TQ (lbs) ........................................................................NA ........................ NA ..................20,000 ........15,000/5,000
Contains Ozone Depleters (Class I or Class II)..................N........................... N ....................... N...................... N
SARA Title III Notification [40 CFR 302.4]:
Section 302/304 (EHS) Ingredient
[40 CFR 355.3]..................................................................NL......................... NL ...................... Y................... NL/Y
TPQ (lbs.......................................................................NA ........................ NA ..................10,000 ............ NA/500
RQ (lbs)........................................................................NA ........................ NA ..................10,000 ............ NA/500
Section 313 Ingredient [40 CFR 372.65] ...........................NL......................... NL ...................... Y................... NL/Y
State Lists: ......................................................................NL...................... NL ....................Y...................NL
States................................................................................NA ........................ NA .............. CA, FL, MA.............NA
............................................................................................ ............................. ................. MN, NJ, PA ..............
On CA 65 Significant Risk Level .......................................NA ........................ NA ...................... Y.....................NA
WARNING: This product contains a chemical(s) known to the State of California to cause cancer. (Chloroform)
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 440001b2 Effective Date: 08/05/2008 Version #: 2.2 Page 8 of 9
8210 N. Austin Avenue, Morton Grove, IL 60053-0519, U.S.A.
847-967-6000 800-323-8144 Emergency Contact:
(Monday - Friday: 7:30 a.m. - 4:00 p.m. CST) INFOTRAC 800-535-5053 [U.S.A.]
Name: N-Trifluoroacetyl-L-prolyl chloride 0.1 M in Chloroform
Code: 440001, 440002
................................................................... MATERIAL SAFETY DATA SHEET....................................................................
Hazard Classes
Sara Acute Chronic Fire Pressure Reactivity
Title III Y Y N N N
Health Flammability Reactivity Special Hazards
NFPA 2 1 1 light sensitive, W
HMIS 2 1 1 None
Risk Phrases:
Caution: The properties of this material have not been fully investigated.
R22...................... Harmful if swallowed
R36/37/38............ Irritating (severely) to eyes, respiratory system, and skin
R40...................... Possible risk of irreversible effects
R48/20/22............ Harmful: Danger of serious damage to health by prolonged exposure through inhalation and if
swallowed
R64...................... Vapors cause drowsiness and dizziness
Safety Phrases:
S02 ...................... Keep out of reach of children
S23/24/25 ............ Do not breath vapors. Avoid contact with skin and eyes
S26/28 ................. In case of contact with eyes or skin, rinse immediately with plenty of water and seek medical
advice
S27 ...................... Take off immediately all contaminated clothing
S36/37/39 ............ Wear suitable protective clothing, gloves, and eye/face protection
S44 ...................... If you feel unwell, seek medical advice immediately (show the label where possible)
SECTION 16 ........................................................OTHER INFORMATION .............................................................................
Miscellaneous
The health and toxicological hazards of this compound have not been fully investigated; therefore, this substance must be
handled only by, or under close supervision of those qualified in the handling and use of potentially hazardous substances.
This MSDS was revised as follows:
This is a new MSDS format. Consider all sections to contain new information.
Disclaimer
The above information is believed to be correct, but does not purport to be all-inclusive and shall be used only as a guide.
Regis Technologies, Inc., does not guarantee said information is accurate or complete, nor shall any of this information
constitute a warranty, whether expressed or implied, as to the safety of the goods, the merchantability of the goods, or the
fitness of the goods for a particular purpose. Adjustment may be required to conform to the actual conditions of usage. Regis
Technologies, Inc. shall not be held liable for any damage resulting from handling or from contact with the above product, nor
for the results obtained, or for incidental or consequential damage arising from the use of these data. No freedom from
infringement of any patent, copyright or trademark is to be inferred.
Approved of by: MBF This is the last page of this MSDS.
Reviewed and re-approved of with minor changes to the footer abbreviations, format and update the HMIS code.
by: Jon Pilli 08/05/2008
Abbreviations: NA--not applicable; NE--not established; U--unknown/not available; NL--not listed; N--no; Y--yes.; NDA-No data available.
MSDS# 440001b2 Effective Date: 08/05/2008 Version #: 2.2 Page 9 of 9
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