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Biomolecules for research                              MATERIAL SAFETY DATA SHEET







Section 1 : Substance Identification



                2-Methoxyestradiol

     Name:                                                     CAS Number:         362-07-2



     Catalog Number:       S-540                               Chemical Formula:       C19H26O3



     Chemical Name:       2-Methoxy-3,17-dihydroxyestra-1,3,5(10)triene



     Chemical Class:     Steroid



     Company Identification:       BIOMOL Research Labs., Inc.

                                    5100 Campus Dr.

                                    Plymouth Meeting PA 19462-1123 USA

                                    (610) 941-0430 (9am-5pm ET)









Section 2 : Health Hazard Data



     Acute Health Effects:     May be harmful by ingestion, inhalation, or absorption through the skin. The

            toxicological properties of this compound have not been fully investigated. Exercise appropriate

            precautions to prevent opportunities for inhalation, and to prevent direct contact with skin and eyes.

            All uncharacterized chemicals should be treated as suspected toxins.

     Chronic Health Effects: NOTE: To the best of our knowledge the toxicological properties of 2-

            methoxyestradiol have not been fully investigated. The following information applies to

            ESTRADIOL, the parent compound. There is limited evidence that Estradiol is teratogenic and

            tumorigenic in laboratory animals. There is also limited evidence that Estradiol is mutagenic in

            laboratory cell cultures. Until further testing has been done, this product should be treated as a

            possible teratogen, mutagen, and tumorigen in humans.







Section 3 : First Aid Measures



     Eye Contact: Check for and remove contact lenses. Flush eyes with running water for at least 15

            minutes separating eyelids. Seek medical attention immediately

     Skin Contact: Wash with soap and water for 15 minutes. Remove contaminated clothing and shoes.

            Seek medical attention immediately.

      Inhalation: Remove from exposure. If breathing is difficult, administer oxygen. If breathing stops,

              administer artificial respiration. Seek medical attention immediately. Provide chemical label and

              MSDS if possible.

      Ingestion: Remove dentures and clear mouth. Call physician or poison control immediately.

              Provide chemical label and MSDS information if possible.









Section 4 : Fire and Explosion Data





      Flammability: Not Available

      Flash Point: Not Available

      Combustion Products: Carbon monoxide, Carbon dioxide.

      Extinguishing Media: Carbon Dioxide, Dry chemical powder, polymer foam, water spray

      Special Firefighting Procedures: Use self-contained breathing apparatus and protective clothing to

              prevent contact with skin and eyes.

      Unusual Fire/Explosion Hazards: May emit toxic gases upon thermal decomposition.







 Section 5 : Spill or Leak Procedures



      Cleanup Procedures: EVACUATE AREA Wearing appropriate protective gear as outlined under

               "Protective equipment" wipe up spill and place in sealed container and hold for disposal. Avoid

      raising dust. Ventilate the area and wash spill site after material has been removed.

      Waste Disposal Method:         Observe all Federal, State and Local regulations concerning the disposal of

               this product.









 Section 6 : Storage and Handling Precautions



      Protective Equipment: For spill clean up, wear suitable protective clothing, chemical resistant rubber

              gloves, rubber boots, and chemical safety goggles. Self contained breathing apparatus or

              NIOSH/MSHA approved respirator is required. This product should only be handled in a chemical

              fume hood with adequate ventilation.

      Storage and Handling: This product should be stored at room temperature. It should be kept in a tightly

              closed container. This product should be handled only by qualified experienced professionals. Wash

              thoroughly after handling this material









Section 7 : Physical Data



      Appearance: White solid                                           Odor: Not Available

      Molecular Weight: 302.4                                           Taste: Not Available

      Boiling Point: Not Available                                      Melting Point: Not Available

      Solubility: DMSO                                                  Vapor Density: Not Available

      Specific Gravity: Not Available                                   Vapor Pressure: Not Available

      Volatility: Not Available

Section 8 : Stability and Reactivity Data



         Stability: This material is stable if stored as directed

         Conditions to Avoid: Not Available

         Incompatibles: Not available







Section 9 : Toxicity Data



         NOTE: To the best of our knowledge, the toxicological properties of 2-Methoxyestradiol have not

         been thoroughly investigated. The following information pertains to the parent compound

         ESTRADIOL.



         RTECS#:         KG2975000 (Estradiol)



         Refer to the Registry of Toxic Effects of Chemical Substances for information concerning the

         Reproductive, Genetic, and Tumorigenic effects of estradiol.









Section 10 : Ecological Data



         Ecotoxicological Information: None Available







The above information is believed to be correct but does not purport to be complete and should be used only as a guide. The burden of

safe use of this material rests entirely with the user.





Emergency Contact:



BIOMOL Research Laboratories, Inc.

5100 Campus Dr., Suite 200

Plymouth Meeting, PA 19462 USA



(610) 941-0430







Last Revised : 12/18/98