University of Texas at Tyler
Hazardous Material Usage Protocol
_____________________________________________________________________
David H. O'Keeffe, Provost and Vice President for Academic Affairs Date
_____________________________________________________________________
Jim Ferguson, Vice President for Business Affairs Date
_____________________________________________________________________
Barbara N. O'Keeffe, Director Environmental Health & Safety Date
_____________________________________________________________________
Don Killebrew, Chair University Safety Committee Date
Table of Contents
Purpose:.........................................................................................................................................3
Hazardous Material Categories: ................................................................................................3
Responsibility................................................................................................................................3
Hazardous Material Purchasing Policy .....................................................................................3
Application for the Use of a Highly Toxic Chemical................................................................5
Memorandum of Understanding and Agreement ....................................................................7
Use of Hazardous Materials .......................................................................................................7
Mandatory Chemical Protocol Review List...............................................................................9
A. Highly Toxic Chemicals ......................................................................................................9
B. Carcinogens .........................................................................................................................9
C. Reproductive Toxins .........................................................................................................13
D . Select Agents....................................................................................................................15
Health & Human Services (HHS) Select Agents ...........................................................15
United States Department of Agriculture (USDA)-HHS Overlap Agents...................15
USDA High Consequence Livestock Pathogens and Toxins ......................................15
E. Pesticides ...........................................................................................................................16
Purpose:
In order to assure that highly hazardous materials used on the campus of UT Tyler are
properly stored, used and disposed of in accordance with all applicable laws and
standard laboratory procedures, prior notification to, and approval from, the Department
of Environmental Health & Safety (EH&S) is required. The following materials have
been deemed to pose a significant health risk to personnel if not used properly.
Hazardous Material Categories:
1. Radioactive Materials
2. Chemical Agents
a. Highly toxic chemicals
b. Carcinogens
c. Reproductive toxins
d. Select Agents
e. Pesticides
3. Biological Materials
a. (BSL-2 classification and greater)
b. recombinant DNA
Responsibility
The faculty member/department chair is responsible for obtaining approval for use of
the specified materials prior to the initiation of any procedure and purchase of any
materials. All protocols utilizing a hazardous material listed on the Mandatory
Chemical Protocol Review List are evaluated to determine if chemicals require
committee approval.
Hazardous Material Purchasing Policy
1. Determine if the use of this hazardous material mandates EH&S approval.
The faculty member/department chair should first review the referenced list to determine
if the material they would like to acquire requires protocol review. If use of the chemical
does not require protocol review, faculty member/department chair will send MSDS of
new chemical to EH&S.
2. If use of the material requires protocol review, then the Faculty Member/Department
Chair should:
A. Complete the "Application for the Use of Hazardous Materials." If the use of
the hazardous material requires review, then an "Application for the Use of
Highly Hazardous Materials" should be completed and submitted to the
EH&S office. This form can be completed electronically or the EH&S staff
can complete it for you in conjunction with a 25-30 minute consultation.
B. Submit "Application for the Use of Highly Hazardous Materials" to the EH&S
for approval. Once the appropriate forms are completed and submitted, the
EH&S evaluates the protocol, and if all conditions are met, grants approval. If
approval can not be granted because of usage or storage protocols, the
EH&S director will work with the department chair and faculty member to find
appropriate methods of storage and usage procedures or alternatives for the
research. A summary of the status of all applications is submitted to the
appropriate committee for review.
3. Complete a "Memorandum of Understanding for the Use of Hazardous Materials"
Once EH&S preliminary approval is granted, a "Memorandum of Understanding for The
Use of Highly Hazardous Materials" is completed.
Application for the Use of a Highly Toxic Chemical
Protocol Number:
(to be completed by EH&S)
Section 1 - Applicant Data
Date:
Project Name:
Principal Investigator: Department:
Bldg/Room Number: Office Phone:
Section 2 - Personnel Involved in Experiments / Years of experience working with
agent
1)
2)
3)
Section 3 - Location where work is to be conducted
Building : Room Number :
Section 4 - Identification of Hazardous Material
Agent (s):
Use Quantity:
Number of Procedures:
Storage Quantity :
Section 4a . Chemical/ Industrial Hygiene Related Information
( to be completed by EH&S)
Description:
Classification:
Toxicology:
Routes of Exposure:
Exposure Limits:
Other Precautions
:
Section 5 - Experimental Description (attach page if necessary)
Section 5a ?Non-Routine operations
______________________________________________________________________
Section 6. Hazard Controls (identify engineering controls/personal protective
equipment)
Section 7. Identify Occupational Monitoring Required (if any)
______________________________________________________________________
Section 8. Storage
Section 9. Waste Disposal
Classification:
Identify any mixed waste generated:
Identify method of waste disposal:
Has source substitution been
investigated?
Can chemical be neutralized/rendered less
toxic during experiment?
Section 10. Fulfillment of UTT Chemical Hygiene Plan Requirements
(completed by EH&S)
Memorandum of Understanding and Agreement
Use of Hazardous Materials
Faculty member/department chair:
Department:
Lab Room No(s): Phone:
Hazardous Agent:
The UTT policy entitled "Hazardous Material Protocol Review" has been evaluated and
the referenced materials are found to meet the following classification.
The proposed experiments utilize one of the following hazardous materials and requires
EH&S review:
________ Radioactive Material
________ Biological Agent with CDC classification > BSL-2
________ Chemical listed on the "Mandatory Protocol Review Chemical List"
________ Chemical that is highly toxic because of its toxicological properties.
I agree to comply with current regulations and university policies pertaining to the use,
storage, transfer and shipment of chemical agents. I will also abide by all of the
provisions of UT-Tyler Chemical Hygiene Plan and any recommendations of the
University Safety Committee.
___________________________________________ __________________________
Faculty member/department chair Signature Date
The University of Texas - Tyler Department of Environmental Health and Safety has
reviewed the above proposal and has verified the classification indicated by the Faculty
Member/Department Chair, and that proper usage controls are in place.
______________________________________________________________________
EH&S Representative Date
The University Safety Committee has been provided a summary of this memorandum of
understanding and agreement and concurs with the information provided above. The
activities described in this protocol will be reviewed annually.
___________________________________________ __________________________
Chair, University Safety Committee Date
Mandatory Chemical Protocol Review List
A. Highly Toxic Chemicals
Any chemical that meets the Hazard Data criteria and usage criteria are mandated to be
reviewed by the University Safety Committee.
Hazard Data Toxicity Rating Usage/ Storage
LD-50 LC-50
< 3 mg/kg <10 ppm Class I (Super Toxic) >90 mg / > 500 mg
Class II (Extremely Toxic) >1 g / >10 g
4 ?50 mg/kg 10 ?100 ppm
B. Carcinogens
Agent is classified as "carcinogenic to humans", or "probably carcinogenic to humans by the
International Agency for Research on Cancer (IARC)", or is a "Known Carcinogen" by the
National Toxicology Program (NTP).
Chemical Chemical
Abstract Abstract
Chemical Chemical
Number Number
(CAS) (CAS)
Acetaldehyde 75-07-0 Acetylaminofluorene, 2 53-96-3
Acrylamide 79-06-1 Acrylonitrile 107-13-1
Actinomycin D 50-76-0 Adriamycin 23214-92-8
Aldrin 309-00-2 Amino-2-methylanthraquinone, 1 82-28-0
Aminoanthraquinone, 2 117-79-3 Aminoazotoluene 975-63-6
Aminobiphenyl, 4 92-67-1 Amitrole 618-25-1
Ammonium dichromate (VI) 7789-09-5 Analgesic mixtures (Contain 62-44-2
phenacetin)
Anisidine 90-04-0 Anisidine Hydrochloride 134-29-2
Antimony oxide (Antimony trioxide) 1309-64-4 Arsenic acid 7440-38-2
Arsenic pentoxide 1303-28-2 Arsenic trioxide 1327-53-3
Arsenic/Certain Arsenic Compounds 7440-42-1 Arsenious acid
Asbestos 1332-21-4 Auramine 492-80-8
Azacitidine 320-67-2 Azathioprine 446-86-6
Barium chromate (VI) 10294-40-3 Benz[a]anthracene 56-55-3
Benzene 71-43-2 Benzidine 92-87-5
Benzo[a]pyrene 50-32-8 Benzo[b]fluoranthene 205-99-2
Benzo[j]fluoranthene 205-82-3 Benzo[k]fluoranthene 207-08-9
Benzotrichloride 96-07-7 Beryllium and Certain Beryllium 7440-41-7
Compounds
Bis(2-chloroethyl)-2-naphthylamine, 494-03-1 Bischloroethyl Nitrourea(BCNU) 154-93-8
N, N
Bis-chloromethyl Ether(BCME) 542-88-1 Bromodichloromethane 75-27-4
Butadiene,1,3 106-99-0 Butanediol Dimethane sulphonate 55-98-1
(Myleran), 1,4
Butanone 5407-91-0 Butanone, 4-(N-Nitroso methyl
amino)-1-(3-pyridyl)-1-(NNK)
Butylamine, N-Nitrosodi-n- Butylated hydroaxyanixole 25013-16-5
C.I. Basic red 9 Cadmium and Certain Cadmium 7440-43-9
Compounds
Cadmium chloride 10108-64-2 Cadmium fume
Cadmium sulfate 10124-36-4 Cadmium sulfide 1306-23-6
Calcium chromate (VI) 13765-19-0 Carbon tetrachloride 56-23-5
Chlorambucil 305-3-3 Chlordecone 143-50-0
Chlorendic acid 115-28-6 Chlorinated paraffins (C12 43%
Chlorine)
Chlorinated paraffins (C12 60% 108171-26- Chloro-2-methyl propene,3 ,3 563-47-3
Chlorine) 2
Chloroethyl nitrosourea, bis- 13010-47-4 Chloroform 67-66-3
chloroethyl)-3-cyclohexyl-1-
nitrosourea(CCNU), 1 2-
Chloromethyl ether, bis Chloromethyl methyl ether 107-30-2
Chlorophenols 95-57-8 Chloroprene, inhibited 126-99-8
Chloropropane 540-54-5 Chloropropane, 1,2-Dibromo-3- 96-12-8
(DBCP)
Chlorozotocin 54749-90-5 Chromic acid, disodium salt
Chromic acid, lead (2+) salt (1:1) Chromium (VI) compounds 7440-47-3
Chromium phosphate 7789-04-0 Chromium triacetate
Ciclosporin Cisplatin 15663-27-1
Cobalt alloy, Co, Cr 7440-48-4 Conestoral
Conjugated estrogens Cresidine 120-71-8
Cupferron 135-20-6 Cycasin 14901-08-7
Cyclophosphamide 50-18-0 Cyclosprin A
Dacarbazine 4342-03-4 DDT 50-29-3
Di(2,3-epoxypropyl) ether (DGE) Di(2-ethylhexyl)phthalate 117-61-7
Diaminoanisole and its salts,2,4 615-05-4 Diaminoanisole sulfate,2,4 39156-41-7
Diaminodiphenyl ether (4,4'. 101-80-4 Diaminotoluene,2,4 95-80-7
Oxydianiline)
Dibenz[a,h] acridine 226-36-8 Dibenz[a,h]anthracene 53-70-3
Dibenz[a,j] acridine 224-42-0 Dibenzo[a,e]pyrene 192-65-4
Dibenzo[a,h]pyrene 189-64-0
Dibenzo[a,j]pyrene 191-30-0 Dibenzo[a,l]pyrene 189-55-9
Dibenzo[cg]carbazole, 7-H 194-59-2 Dibromo-3- 96-12-8
chloropropane(DBCP),1,2
Dibromoethane,1,2 Dichlorobenzene, p 106-46-7
Dichlorobenzidine dihydrochloride, Dichlorobenzidine,3,3 91-94-1
3,3'
Dichloroethane,1,2 Dichloromethane (Methylene 75-09-2
Chloride)
Dichloropropene,1,3 542-75-6 Dichlorvos (DDVP) 62-73-7
Dichromic acid, diammonium salt Dieldrin 60-57-1
Dienestrol 84-17-3 Diepoxybutane
Diepoxybutane 1464-53-5 Diethyl Sulfate 64-67-5
Diethylstilbestrol(DES) 56-53-1 Diglycidyl resorcinol ether
Dimethoxybenzidine, 3,3-(ortho- ) 119-90-4 Dimethyl carbamoyl chloride 79-44-7
Dianisidine
Dimethyl sulfate 77-78-1 Dimethylaminoazobenzene, 4 60-11-7
Dimethylbenzidine, 3,3'-(o-Tolidine) 119-93-7 Dimethylhydrazine,1,1 57-14-7
Dioxane,1,4 123-91-1 Direct black 38
Direct blue 6 Dichlorobenzene,p- 106-46-7
Epichlorohydrin 106-89-8 Erionite 12510-42-8
Estra-1,2,5(10),7-tetraene-17-one,3- Estrogens
(sulfooxy)-;sodium salt
Ethyl acrylate 140-88-5 Ethyl Methanesulfonate 62-50-0
Ethylene dibromide(EDB) 106-93-4 Ethylene dichloride(EDC) 107-06-2
Ethylene oxide 75-21-8 Ethylene Thiourea 96-45-7
Ethyleneimine, inhibited 151-56-4 Formaldehyde (gas) 50-00-0
Fowlers solution 10124-50-2 Glycidol 556-52-5
Gyromitrin Hexachlorobenzene 118-74-1
Hexachlorobenzene, gamma Hexachlorobutadiene 87-68-3
Hexachlorocyclohexanes Hexachloroethane 67-72-1
Hexamethylphosphoramide 680-31-9 Hydrazine 302-01-2
Hydrazine Sulfate 10034-93-2 Hydrazobenzene 122-66-7
Indeno[1,2,3-cd]pyrene 193-39-5 Inorganic acid mists containing 7664-93-9
sulfuric acid
IQ(2-Amino-3methylimidazo(4,5- Iron-dextran complex 9004-66-4
f)quinoline)
Kepone (Chlordecone) 143-50-0 Lead (II) phosphate 7446-27-7
Lead acetate 301-04-2 Lead acetate (II), trihydrate 6080-56-4
Lead chromate (VI) oxide 18454-12-1 Lindane, alpha 58-89-9
Lindane, beta Melphalan 148-82-3
Mestranol 72-33-3 Methoxsalen 298-81-7
Methoxypsoralen, 5 484-20-8 Methyl Bromide 74-83-9
Methyl Chloride 74-87-3 Methyl Hydrazine 302-15-8
Methyl Iodide 74-88-4 Methyl Methanesulfonate 66-27-3
Methylaziridine 75-55-8 Methylaziridine, 2-(ployeneimine)
Methylchrysene, 5 3697-24-3 Methylene bis (N-N-
dimethylbenzenamine),4,4
Methylene bis(2-chloroaniline) 101-14-4 Methylene bis(n,n- 101-61-1
(MOCA), 4, 4 dimethyl)benzenamine, 4, 4
Methylenedianiline, 4,4 101-77-9 Methylpropene, 1-Chloro-2- 513-37-1
Methylpropene, 3-Chloro-2- 563-47-3 Methyl-N'-nitro-N-nitroso-guanidine, 70-25-7
N
Metronidazole 443-48-1 Michler's Ketone 90-94-8
Mirex 2385-85-5 Mitomycin C 50-07-7
Molybdate orange MOPP and other combined
chemotherapy including alkylating
Mustard gas 505-60-2 Naphthylamine, 2 91-59-8
Naphthylamine, alpha 134-32-7 Naphthylamine, beta 91-89-6
Nickel (II) acetate 373-02-4 Nickel (II)carbonate 12607-70-4
Nickel (II) hydroxide 12054-48-7 Nickel (II) oxide
Nickel (III) hydroxide Nickel compounds
Nickel carbonyl 13463-39-3 Nickel sulfide
Nickel metallic 7440-02-0 Nitrilotriacetic acid 139-13-9
Nitrobiphenyl, 4 92-93-3 Nitrofen 1836-75-5
Nitrogen mustard 51-75-5 Nitro-n-ethylurea, N 759-73-9
Nitro-n-methylurea, N 684-93-5 Nitro-o-anisidine, 5 99-59-2
Nitropropane, 2 79-46-9 Nitrosodiethanolamine, N 1116-54-7
Nitrosodiethylamine, N 55-18-5 Nitrosodiethylamine, N 55-18-5
Nitrosodimethylamine, N 62-75-9 Nitrosodi-n-butylamine, N 924-16-3
Nitrosodiphenylamine, P 156-10-5 Nitrosomethylvinylamine, N 4549-40-0
Nitrosomorpholine, N 59-89-2 Nitrosonornicotine, N 16543-55-8
Nitrosopiperidine, N 100-75-4 Nitrosopyrrolidine, N 930-55-2
Nitrososarcosine, N 13256-22-9 Norethisterone, N 68-22-4
Ochratoxin A 303-47-9 Oestrogen
Oxymetholone 434-07-1 Pentachlorbiphenyl
Phenacetin 62-44-2 Phenoxybenzamine hydrochloride 59-96-1
Phenazopyridine 94-76-0 Phenazopyridine hydrochloride 136-40-3
Phenlyenediamine, 4-chloro-o- Phenyl-beta-naphthylamine - N 135-88-6
Phenytoin 63-93-3 Phosphate, Tris-(2,3-
dibromopropyl)
Phtalate, Di-(2-ethylhexyl) Polybrominated Biphenyls(PBBs) 36355-01-8
Polychlorinated Biphenyls(PCBs) 1336-36-3 Potassium chromate VI 7789-00-6
Potassium dichromate VI 7778-50-9 Procarbazine 671-16-9
Procarbazine Hydrochloride 366-70-1 Progesterone 57-83-0
Propane sultone,1,3 1120-71-4 Propiolactone, beta 57-57-8
Propylamine, N, Nitrosodi-n 107-10-8 Propylene oxide 75-56-9
Propylthiouracil 51-52-5 Saccharin, 81-07-2
Saccharin, calcium Saccharin, sodium salt 128-44-9
Safrole 94-59-7 Silica, Crystalline 14808-60-7
Silicic acid, beryllium salt 7699-41-4 Sodium dichromate (VI) 10588-01-9
Staphylococcal enterotoxins Streptozotocin 18883-66-4
Strontium chromate 7789-06-2 Styrene ?,8-oxide
Sulfallate 95-06-7 Sulfur trioxide 7446-11-9
Tetrachlorodibenzo-para-dioxin Tetrachlorodibenzo-p- 1746-01-6
dioxin(TCDD), 2,3,7,8
Tetrachloroethane 79-34-5 Tetrachloroethane,1,1,2,2 79-34-5
Tetrachloroethylene 127-18-4 Tetranitromethane 509-14-8
Thioacetamide 62-55-5 Thiotepa 52-24-4
Thiourea 62-56-6 Thorium Dioxide 1314-20-1
Toluene diisocyanate 26471-62-5 Toluidine Hydrochloride, o- 636-21-5
Toluidine, o- 95-53-4 Toluidine, p- 106-49-0
Toluidine, p Chloro-o- Toxaphene 8001-35-2
Trenimone 010 Treosulphan 299-75-2
Trichloroethylene 79-01-6 Trichlorophenol,2,4,6 88-06-2
Trichloropropane, 1,2,3- Triethylenemelamine 51-18-3
Tris(1-aziridinyl)phosphine Sulphide 52-24-4 Tris(2,3-dibromopropyl) phosphate 126-72-7
Tris(aziridinyl)-para-benzoquinone 68-76-8 Uracil Mustard 66-75-1
(Triziquone)
Urethane 51-79-6 Vinyl bromide 593-60-2
Vinyl chloride 75-01-4 Vinyl Cylohexene Dioxide 106-87-6
Vinyl Fluoride 75-02-5 Vinylidene Fluoride Monomer 75-38-7
Zinc Chromate 13530-65-9
C. Reproductive Toxins
Agents known to cause either male and female reproductive toxicity by the State of
California.
Chemical CAS Chemical CAS
Acetihydroxamic Acid 546-88-3 Actinomycin D 50-76-0
All-trans retinoic Acid 302-79-4 Alprazolam 28981-97-7
Amikacin Sulfate 39831-55-5 Aminoglutethimide 125-84-8
Amonoglycosides Aminopterin 54-62-6
Amiodarone hydrochloride 19774-82-4 Amoxapine 14028-44-5
Angiotensin converting enzyme 1407-47-2 Anisindione 117-37-3
inhibitors
Arsenic 7440-42-1 Aspirin 50-78-2
Atenolol 29122-68-7 Azathioprine 446-86-6
Barbituates Beclomethasone dipropionate 5534-09-8
Benomyl 17804-35-2 Benzene 71-43-2
Benzphetamine hydrochloride 5411-22-3 Benzodiazepines
Bischloroethyl nitrosurea (BCNU) 154-93-8 Bromoxynil 1689-84-5
Butabarbital sodium 143-81-7 Butanediol dimethylsulfonate, 1,4' 55-98-1
Cadmium 7440-43-9 Carbon Disulfide 75-15-0
Carbon Monoxide 630-08-0 Carboplatin 41575-94-4
Chenodiol 474-25-9 Chinomethionat 2439-01-2
Chlorambucil 305-03-3 Chlorcyclizine hydrochloride 1620-21-9
Chlordecone 143-50-0 Chlodiazepoxide 58-25-3
Chlodiazepoxide hydrochloride 438-41-5 CCNU 13010-47-4
Cladribine 4291-63-8 Clarithromycin 81103-11-9
Clobetasol propionate 25122-46-7 Clomiphene citrate 50-41-9
Clorazepate dipotassium 57109-90-7 Cocaine 50-36-2
Codeine phosphate 52-28-8 Colchicine 64-86-8
Cojugated estrogens ---------- Cyanazine 21725-46-2
Cycloheximide 66-81-9 Cyclophosphamide (anhydrous) 50-18-0
Cyclophosphamide (hydrated) 6055-19-2 Cyhexatin 13121-70-5
Cytarabine 147-94-4 Danazol 17230-88-5
Daunorubicin hydrochloride 23541-50-6 DDT, o,p- 789-02-6
DDT, p,p- 50-29-3 Demeclocycline Hydrochloride 64-73-3
Diazepam 439-14-5 Dicumarol 66-76-2
Diethylstillbestrol (DES) 56-53-1 Dihydroergotamine mesylate 6190-39-2
Dinocap 39300-45-3 Dinoseb 88-85-7
Diphenylhydantoin (Phenytion) 57-41-0 Doxycycline (internal) 564-25-0
Doxycycline calcium (internal) 94088-85-4 Doxycycline hyclate (internal) 24390-14-5
Doxycycline monohyrdate (internal) 17086-28-1 Endrin 72-20-8
Ergotamine tartrate 379-79-3 Estropripate 7280-37-7
Ethionamide 536-33-4 Ethylene dibromide 106-93-4
Ethylene glycol monoethyl ether 110-80-5 Ethylene glycol monomethyl ether 109-86-4
Ethylene glycol monoethyl ether 111-15-9 Ethylene glycol monomethyl ether 110-49-6
acetate acetate
Ethylene thiourea 96-45-7 Etoposide 33419-42-0
Etretinate 54350-48-0 Fluazifop butyl 69806-50-4
Flunisolide 3385-03-3 Fluoruracil 51-12-8
Fluoxymesterone 76-43-7 Flurazepam hydrochloride 1172-18-5
Flutamide 13311-84-7 Fluticasone propionate 80474-14-2
Fluvalinate 69409-94-5 Ganciclovir sodium 82410-32-0
Goserelin acetate 65807-02-5 Halazepam 23092-17-3
Halothane 151-67-7 Hexachlorobenzene 118-74-1
Histrelin acetate Hydroxyurea 127-07-0
Ifosfamide 3778-73-2 Iodine 131 10043-66-0
Isotretinoin 4759-48-2 Lead 7439-92-1
Leuprolide acetate 74381-53-6 Lithium carbonate 554-13-2
Lithium citrate 919-16-4 Lorazepan 846-49-1
Lovastatin 75330-75-5 Medroxyprogesterone acetate 71-58-9
Megestrol acetate 595-33-5 Melphalan 148-82-3
Menotropins 9002-68-0 Meprobamate 57-53-4
Mercaptopurine 6112-76-1 Mercury compounds 7439-97-6
Methacycline hydrochloride 3963-95-9 Metham sodium 137-42-8
Methim azole 60-56-0 Methotrexate 59-05-2
Methotrexate sodium 15475-56-6 Methyl bromide as structural 74-83-9
fumigant
Methyl Mercury 593-74-8 Methyltestosterone 58-18-4
Midazolam hydrochloride 59467-96-8 Minocycline hydrochloride 13614-98-7
Misoprostol 5 9122-46-2 Mitoxantrone hydrochloride 0476-82-3
Nafarelin acetate 86220-42-0 Neomycin sulfate 1405-10-3
Netilmicin sulfate 5 6391-57-2 Nickel carbonyl 13463-39-3
Nicotine 54-11-5 Nitrogen Mustard 51-75-2
Nitrogen Mustard hydrochloride 55-86-7 Norethisterone 68-22-4
Norethisterone acetate 51-98-9 Norethisterone/Ethinyl estradiol 68-22-
4/57-63-6
Norethisterone Mestranol 68-22-4/72- Noroestrel 6533-00-2
33-3
Oxadiazon 19666-30-9 Oxazepam 604-75-1
Oxymetholone 434-07-0 Oxytetracycline 79-57-2
Oxytetracycline hydrochloride 2058-46-0 Paclitaxel 33069-62-4
Paramethadione 115-67-3 Penicillamine 52-67-5
Pentobarbitol sodium 57-33-0 Pentostatin 53910-25-1
Phenacemide 63-98-9 Phenprocoumon 435-97-2
Pipobroman 54-91-1 Plicamycin 18378-89-7
Polybrominated Biphenyls 36355-01-8 Polychlorinated Biphenyls 1336-36-3
Procarbazine hydrochloride 366-70-1 Propylthiouracil 51-52-5
Quazepam 36735-22-5 Resmethrin 10453-86-8
Retinol/retinyl esters Ribavirin 36791-04-5
Secobarbitol sodium 309-43-3 Streptomycin sulfate 3810-74-0
Tamoxifen citrate 54965-24-1 Temazepan 846-50-4
Teniposide 29767-20-2 Testostereone cypionate 58-20-8
Testosterone enantahate 315-37-7 TCDD 1746-01-6
Tetracycline (internal) 60-54-8 Tetracycline hydrochloride (internal) 64-75-5
Thalidomide 50-35-1 Thiguanine 154-42-7
Tobramycin Sulfate 49842-07-1 Triazolam 28911-01-5
Trilostane 13647-35-3 Trimethadione 127-48-0
Trimetrexate glucuronate 82952-64-5 Uracil Mustard 66-75-1
Urethane 51-79-6 Urofollitropin 26995-91-5
Valproate (Valproic acid) 99-66-1 Vinblastine sulfate 143-67-9
Vinclozin 50471-44-8 Vincristine sulfate 2068-78-2
Warfarin 81-81-2
D . Select Agents
Health & Human Services (HHS) Select Agents
q CRIMEAN-CONGO HAEMORRHAGIC FEVER VIRUS
q EBOLA VIRUSES
q LASSA FEVER VIRUS
q MARBURG VIRUS
q RICKETTSIA PROWAZEKII
q RICKETTSIA RICKETTSII
q SOUTH AMERICAN HAEMORRHAGIC FEVER VIRUSES
q TICK -BORNE ENCEPHALITIS COMPLEX VIRUSES
q VARIOLA MAJOR VIRUS (SMALLPOX VIRUS)
q VIRUSES CAUSING HANTAVIRUS PULMONARY SYNDROME
q YELLOW FEVER VIRUS
q YERSINIA PESTIS
q ABRIN
q CONOTOXINS
q DIACETOXYSCIRPENOL
q RICIN
q SAXITOXIN
q TETRODOTOXIN
United States Department of Agriculture (USDA)-HHS Overlap Agents
q BACILLUS ANTHRACIS
q BRUCELLA ABORTUS
q BRUCELLA MELITENSIS
q BRUCELLA SUIS
q BURKHOLDERIA (PSEUDOMONAS) MALLEI
q BURKHOLDERIA (PSEUDOMONAS) PSEUDOMALLEI
q CLOSTRIDIUM BOTULINUM
q COCCIDIOIDES IMMITIS
q COXIELLA BURNETII
q EASTERN EQUINE ENCEPHALITIS VIRUS
q EQUINE MORBILLIVIRUS (HENDRA VIRUS)
q FRANCISELLA TULARENSIS
q RIFT VALLEY FEVER VIRUS
q VENEZUELAN EQUINE ENCEPHALITIS VIRUS
q AFLATOXINS
q BOTULINUM TOXINS
q CLOSTRIDIUM PERFRINGENS EPSILON TOXIN
q SHIGATOXIN
q STAPHYLOCOCCAL ENTEROTOXIN
q T-2 TOXIN
USDA High Consequence Livestock Pathogens and Toxins
q AFRICAN HORSE SICKNESS VIRUS
q AFRICAN SWINE FEVER VIRUS
q AKABANE VIRUS
q AVIAN INFLUENZA VIRUS (HIGHLY PATHOGENIC)
q BLUE TONGUE VIRUS (EXOTIC)
q BOVINE SPONGIFORM ENCEPHALOPATHY AGENT
q CAMEL POX VIRUS
q CLASSICAL SWINE FEVER VIRUS
q COWDRIA RUMINANTIUM (HEARTWATER)
q FOOT AND MOUTH DISEASE VIRUS
q GOAT POX VIRUS
q JAPANESE ENCEPHALITIS VIRUS
q LUMPY SKIN DISEASE VIRUS
q MALIGNANT CATARRHAL FEVER VIRUS
q MENANGLE VIRUS
q MYCOPLASMA CAPRICOLUM/M.F 38/M.MYCOIDES CAPRI (CONTAGIOUS CAPRINE
PLEUROPNEUMONIA AGENT)
q MYCOPLASMA MYCOIDES MYCOIDES (CONTAGIOUS BOVINE PLEUROPNEUMONIA AGENT)
q NEWCASTLE DISEASE VIRUS (EXOTIC)
q NIPAH VIRUS
q PESTE DES PETITS RUMINANTS VIRUS
q RINDERPEST VIRUS
q SHEEP POX VIRUS
q SWINE VESICULAR DISEASE VIRUS
q VESICULAR STOMATITIS VIRUS
Exemptions: Toxins for medical use, inactivated for use as vaccines, or toxin preparations for
biomedical research use at an LD 5O for vertebrates of more than 100 nanograms per kilogram
body weight are exempt. National standard toxins required for biologic potency testing as
described in 9 CFR Part 113 are exempt.
Recombinant organisms/molecules
Genetically modified microorganisms or genetic elements from organisms on Appendix A,
shown to produce or encode for a factor associated with a disease. Genetically modified
microorganisms or genetic elements that contain nucleic acid sequences coding for any of the
toxins listed in this Appendix, or their toxic subunits.
Other restrictions
The deliberate transfer of a drug resistance trait to microorganisms listed in this appendix that
are not known to acquire the trait naturally is prohibited by NIH "Guidelines for Research
Involving Recombinant DNA Molecules," if such acquisition could compromise the use of the
drug to control these disease agents in humans or veterinary medicine.
E. Pesticides
Agents classified as a "pesticide" by the EPA under the Federal Insecticide, Rodenticide Act,
(FIFRA)- Title 7, United States Code, Chapter 125, Section 2
Chemical CAS Chemical CAS
Azinphos methyl 86-50-0 Demeton 8065-48-3
Disulfoton 298-04-4 Fensulfoton 115-90-2
Mevinphos 7786-34-7 Nemaphos 2 97-97-2
Parathion 56-38-2 Parathion methyl 298-00-2
Phorate 2 98-02-2 TEPP 107-79-3
DDT 50-29-3 DDE 72-55-9
DDD(Rothane) 72-54-8 Aldrin 309-00-2
Endrin 72-20-8 Endosulfan 115-29-7
Isobenzan(telodrin) 297-78-9 Chlordane 57-74-9
Heptachlor 76-44-8 Hexachlorocyclohexane 319-84-6
Lindane 58-89-9 Chlordecone(Kepone) 143-50-0
Kelevan 050 Mirex(Dechlorane) 2385-85-5
DicofIol(Kelthane) 115-32-2 Methoxychlor(Marlate) 72-43-5
Toxaphene 8001-35-2
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