SIGMA-ALDRICH
Material Safety Data Sheet
Date Printed: 15/NOV/2004
Date Updated: 13/MAR/2004
Version 1.1
According to 91/155/EEC
Classified as Hazardous according to the criteria of EU Annex 1 and
NOHSC.
1 - Product and Company Information
Product Name CUPFERRON, 97%, A.C.S. REAGENT
Product Number 206881
Company Sigma-Aldrich Pty, Ltd
Unit 2, 14 Anella Avenue
Castle Hill NSW 1765
Australia
Technical Phone # +61 2 9841 0555
Fax +61 2 9841 0500
Emergency Phone # +61 2 9841 0566
2 - Composition/Information on Ingredients
Product Name CAS # EC no Annex I
Index Number
CUPFERRON 135-20-6 205-183-2 None
Formula C6H6N2O2.H3N
Molecular Weight 155.16 AMU
Synonyms Ammonium N-nitrosophenylhydroxylamine * Cupferon
(Czech) * Cupferron *
N-Hydroxy-N-nitroso-benzenamine, ammonium salt *
Kupferron (Czech) * NCI-C03258 *
N-Nitrosofenylhydroxylamin amonny (Czech) *
N-Nitrosophenylhydroxylamin ammonium salz
(German * N-Nitrosophenylhydroxylamine ammonium
salt
3 - Hazards Identification
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Toxic if swallowed. Limited evidence of a carcinogenic effect.
4 - First Aid Measures
AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.
5 - Fire Fighting Measures
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.
6 - Accidental Release Measures
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.
PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves. Wear disposable coveralls and discard them after
use.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.
7 - Handling and Storage
HANDLING
Directions for Safe Handling: Do not breathe dust. Do not get in
eyes, on skin, on clothing.
STORAGE
Conditions of Storage: Keep tightly closed.
Store at 2-8癈
SPECIAL REQUIREMENTS: Hygroscopic.
8 - Exposure Controls / Personal Protection
ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.
GENERAL HYGIENE MEASURES
Wash thoroughly after handling. Wash contaminated clothing before
reuse.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Rubber gloves.
Eye Protection: Chemical safety goggles.
9 - Physical and Chemical Properties
Appearance Color: Light yellow
Form: Fine crystals
Property Value At Temperature or Pressure
pH N/A
BP/BP Range N/A
MP/MP Range 150 癈
Flash Point N/A
Flammability N/A
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Autoignition Temp N/A
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits N/A
Vapor Pressure N/A
SG/Density N/A
Partition Coefficient N/A
Viscosity N/A
Vapor Density N/A
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content N/A
Surface Tension N/A
Conductivity N/A
Miscellaneous Data N/A
Solubility N/A
10 - Stability and Reactivity
STABILITY
Conditions of Instability: Protect from moisture.
Conditions to Avoid: Protect from moisture.
Materials to Avoid: Strong oxidizing agents, Strong acids, Strong
bases.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides.
11 - Toxicological Information
RTECS NUMBER: NC4725000
ACUTE TOXICITY
LD50
Oral
Rat
199 mg/kg
Remarks: Behavioral:Muscle weakness. Lungs, Thorax, or
Respiration:Dyspnea. Skin and Appendages:Skin: After systemic
exposure: Dermatitis, other
LD50
Intravenous
Mouse
180 MG/KG
LD50
Skin
Guinea pig
> 5000 mg/kg
IRRITATION DATA
Eyes
Rabbit
20 mg
24H
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Remarks: Moderate irritation effect
SIGNS AND SYMPTOMS OF EXPOSURE
Dermatitis. To the best of our knowledge, the chemical,
physical, and toxicological properties have not been thoroughly
investigated. May cause cyanosis (blue-gray coloring of skin and
lips caused by lack of oxygen).
ROUTE OF EXPOSURE
Inhalation: Material is irritating to mucous membranes and upper
respiratory tract.
Multiple Routes: Harmful if swallowed, inhaled, or absorbed
through skin. Causes eye and skin irritation.
TARGET ORGAN INFORMATION
Blood.
CHRONIC EXPOSURE - CARCINOGEN
Result: Carcinogen.
Rat
Route of Application: Oral
Exposure Time: 78W
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Vascular:Tumors. Liver:Tumors.
Mouse
Route of Application: Oral
Exposure Time: 78W
Result: Tumorigenic:Carcinogenic by RTECS criteria.
Vascular:Tumors. Liver:Tumors.
Rat
Route of Application: Oral
Exposure Time: 65W
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS
criteria. Lungs, Thorax, or Respiration:Tumors.
CHRONIC EXPOSURE - MUTAGEN
Human
2 MMOL/L
Cell Type: HeLa cell
DNA inhibition
12 - Ecological Information
No data available.
13 - Disposal Considerations
SUBSTANCE DISPOSAL
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
regulations.
14 - Transport Information
RID/ADR
UN#: 2811
Class: 6.1
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PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
IMDG
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Marine Pollutant: No
Severe Marine Pollutant: No
Technical Name: Required
IATA
UN#: 2811
Class: 6.1
PG: III
Proper Shipping Name: Toxic solid, organic, n.o.s.
Inhalation Packing Group I: No
Technical Name: Required
15 - Regulatory Information
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: T
Toxic.
R-PHRASES: 25 40
Toxic if swallowed. Limited evidence of a carcinogenic effect.
S-PHRASES: 36/37/39 45
Wear suitable protective clothing, gloves, and eye/face
protection. In case of accident or if you feel unwell, seek
medical advice immediately (show the label where possible).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
16 - Other Information
WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2004 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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