Ethyl Magnesium Bromide 1.0M solution in THF
Material Safety Data Sheet
Arkema Inc.
1 PRODUCT AND COMPANY IDENTIFICATION
EMERGENCY PHONE NUMBERS:
Functional Additives
Chemtrec: (800) 424-9300 (24hrs) or (703) 527-3887
2000 Market Street
Medical: Rocky Mountain Poison Control Center
21st Floor
(866) 767-5089 (24Hrs)
Philadelphia, PA 19103-3222
Information Telephone Numbers Phone Number Available Hrs
Customer Service Number (800) 331-7654 8:00 AM - 5:00 PM EST
Product Name Ethyl Magnesium Bromide 1.0M solution in THF
Product Synonym(s)
Chemical Family Organometallic compound
Chemical Formula NA
Chemical Name NA
EPA Reg Num NA
Product Use Grignard
2 COMPOSITION / INFORMATION ON INGREDIENTS
Ingredient Name CAS RegistryNumber Typical % OSHA
Ethyl magnesium bromide 925-90-6 < 20 Y
Tetrahydrofuran 109-99-9 > 80 Y
The substance(s) marked with a "Y" in the OSHA column, are identified as hazardous chemicals according to the
criteria of the OSHA Hazard Communication Standard (29 CFR 1910.1200)
The components of this product are all on the TSCA Inventory list.
3 HAZARDS IDENTIFICATION
Emergency Overview
Pale yellow liquid with a characteristic odor.
DANGER!
REACTS VIOLENTLY WITH WATER.
CAUSES EYE BURNS. MAY CAUSE BLINDNESS.
CAUSES SKIN IRRITATION.
CAUSES RESPIRATORY TRACT IRRITATION.
HARMFUL IF ABSORBED THROUGH SKIN.
MAY CAUSE LIVER DAMAGE
EXTREMELY FLAMMABLE LIQUID AND VAPOR.
VAPOR MAY CAUSE FLASH FIRE.
Potential Health Effects
Inhalation and skin contact are expected to be the primary routes of occupational exposure to this material. Grignard
reagents react violently with water, moist skin, mucous membranes or atmospheric moisture and may cause tissue
injury. Based on its composition, this material is anticipated to be corrosive to eyes and skin. Prolonged or repeated
contact may remove oils from the skin and may dry skin and cause irritation, redness and rash. The solvent in this
Product Code: VHQ00 Page 1
Revision: 8 Issued: 02 JAN 2007 of 7
Ethyl Magnesium Bromide 1.0M solution in THF
Material Safety Data Sheet
Arkema Inc.
material can be absorbed through the skin in toxic amounts. Inhalation of vapor may cause upper respiratory tract
irritation with nausea, dizziness, headaches and, at higher exposures, temporary nervous system effects such as
weakness, confusion, loss of coordination and loss of consciousness. Severe overexposure can cause liver damage.
4 FIRST AID MEASURES
IN CASE OF CONTACT, immediately flush with plenty of water for at least 15 minutes while removing
contaminated clothing and shoes. Get medical attention. Call a Poison Control Center. Wash clothing
before reuse. Destroy contaminated shoes.
IF INHALED, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give
oxygen. Get medical attention.
IF SWALLOWED, do NOT induce vomiting. Give water to drink. Get medical attention immediately. NEVER
GIVE ANYTHING BY MOUTH TO AN UNCONSCIOUS PERSON.
5 FIRE FIGHTING MEASURES
Fire and Explosive Properties
Auto-Ignition Temperature NE
Flash Point 1 deg F, as THF (N/A) Flash Point Method
Flammable Limits- Upper NE
NE
Lower
Extinguishing Media
dry chemical Do NOT use water.
Fire Fighting Instructions
Do NOT use water to cool containers exposed to fire. Material may form explosive mixtures with water. Fire
fighters and others who may be exposed to products of combustion should wear full fire fighting turn out gear (full
Bunker Gear) and self-contained breathing apparatus (pressure demand NIOSH approved or equivalent). Fire
fighting equipment should be thoroughly decontaminated after use.
Fire and Explosion Hazards
Do NOT use water, foam, carbon dioxide or halogenated extinguishing agents. When burned, the following
hazardous products of combustion can occur: Carbon monoxide Carbon dioxide Chloride Avoid breathing fumes
from fire exposed material. Avoid needless exposures to gas, fume or vapor. If practical, remain upwind when
approaching a fire outdoors, even when wearing a respirator.
6 ACCIDENTAL RELEASE MEASURES
In Case of Spill or Leak
Stop the leak, if possible. Ventilate the space involved. Contain, sweep up, place in container for disposal.
Shut off or remove all ignition sources. Prevent waterway contamination. Construct a dike to prevent
spreading. If waterway contamination occurs, contact appropriate authorities. Collect run-off water and
transfer to drums or tanks for later disposal. Consult a regulatory specialist to determine appropriate state or
local reporting requirements, for assistance in waste characterization and/or hazardous waste disposal and
other requirements listed in pertinent environmental permits.
Clean up procedures: Transfer to containers, preparatory for later disposal. Avoid generation of vapors.
Place in non-sparking containers for recovery or disposal. Remove from spill location. Decontaminate area.
7 HANDLING AND STORAGE
Product Code: VHQ00 Page 2
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Ethyl Magnesium Bromide 1.0M solution in THF
Material Safety Data Sheet
Arkema Inc.
7 HANDLING AND STORAGE
Handling
Do not get in eyes, on skin or on clothing. Avoid breathing vapor. Use only with adequate ventilation. Wash
thoroughly after handling. Keep away from heat, sparks and flame. CONTAINER HAZARDOUS WHEN
EMPTY. Emptied container retains vapor and product residue. Follow labeled warnings even after container
is emptied. RESIDUAL VAPORS MAY EXPLODE ON IGNITION. DO NOT CUT, DRILL GRIND OR WELD
ON OR NEAR THIS CONTAINER. Improper disposal or reuse of this container may be dangerous and/or
illegal.
Storage
Store away from excessive heat, sources of ignition, and reactive materials. Ground all metal containers
during storage. Limit indoor storage to areas equipped with a non-aqueous automatic fire suppression
system. This product is water reactive.
8 EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering Controls
Investigate engineering techniques to reduce exposures below airborne exposure limits. Provide ventilation
if necessary to control exposure levels below airborne exposure limits (see below). If practical, use local
mechanical exhaust ventilation at sources of air contamination such as open process equipment. Consult
ACGIH ventilation manual or NFPA Standard 91 for design of exhaust systems.
Eye / Face Protection
Where there is potential for eye contact, wear chemical goggles and have eye flushing equipment
immediately available.
Skin Protection
Wear appropriate chemical resistant protective clothing and chemical resistant gloves to prevent skin
contact. Consult glove manufacturer to determine appropriate type glove material for given application.
Wear chemical goggles, a face shield, and chemical resistant clothing such as a rubber apron when
splashing may occur. Rinse immediately if skin is contaminated. Remove contaminated clothing promptly
and wash before reuse. Clean protective equipment before reuse. Provide a safety shower at any location
where skin contact can occur. Wash skin thoroughly after handling.
Respiratory Protection
Avoid breathing vapor or mist. When airborne exposure limits are exceeded (see below), use NIOSH
approved respiratory protection equipment appropriate to the material and/or its components. Full facepiece
equipment is recommended and, if used, replaces need for face shield and chemical goggles. Consult
OSHA Standard (29 CFR ?1910.10 to determine required type equipment for given application. Observe
respirator use limitations specified by NIOSH or the manufacturer. For emergency and other conditions
where exposure limit may be significantly exceeded, use an approved full face positive-pressure, self-
contained breathing apparatus or positive-pressure airline with auxiliary self-contained air supply.
Respiratory protection programs must comply with 29 CFR ?1910.134.
Airborne Exposure Guidelines for Ingredients
Exposure Limit Value
Tetrahydrofuran
ACGIH Skin designator - Y
ACGIH STEL - 100 ppm
ACGIH TWA - 50 ppm
ARKEMA 12-hour TWA - 40 ppm
OSHA TWA PEL - 200 ppm (590 mg/m3)
Product Code: VHQ00 Page 3
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Ethyl Magnesium Bromide 1.0M solution in THF
Material Safety Data Sheet
Arkema Inc.
-Only those components with exposure limits are printed in this section.
-Skin contact limits designated with a "Y" above have skin contact effect. Air sampling alone is insufficient to accurately quantitate
exposure. Measures to prevent significant cutaneous absorption may be required.
-ACGIH Sensitizer designator with a value of "Y" above means that exposure to this material may cause allergic reactions.
-WEEL-AIHA Sensitizer designator with a value of "Y" above means that exposure to this material may cause allergic skin reactions.
9 PHYSICAL AND CHEMICAL PROPERTIES
Appearance/Odor
Pale yellow liquid with a characteristic odor.
pH NE
Specific Gravity NE
Vapor Pressure NE
Vapor Density NE
Melting Point NE
Freezing Point NE
Boiling Point NE
Solubility In Water Reactive
Solubility in Other Materials NE
Evaporation Rate NE
Particle Size NA
Percent Volatile NE
Molecular Weight NA
n-Octanol/Water Partition Coefficient NE
Oil/Water Partition Coefficient NE
10 STABILITY AND REACTIVITY
Stability
This material is chemically stable under normal and anticipated storage and handling conditions.
Hazardous Polymerization
Does not occur.
Incompatibility
Contact with water or moisture may result in a rapid energy release and may liberate extreemly flammable gases
(vapors)
Hazardous Decomposition Products
Hydrogen and ethane gases can be liberated at high temperatures
11 TOXICOLOGICAL INFORMATION
Toxicological Information
Data on this material and/or its components are summarized below.
Single exposure (acute) studies indicate:
Oral - Slightly Toxic to Rats & Mice (LD50 2,000-3,197 mg/kg)
Inhalation - Practically Non-toxic to Rats (3-hr LC50 21,000 ppm)
Eye Irritation - Corrosive to Rabbits
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Revision: 8 Issued: 02 JAN 2007 of 7
Ethyl Magnesium Bromide 1.0M solution in THF
Material Safety Data Sheet
Arkema Inc.
11 TOXICOLOGICAL INFORMATION
Skin Irritation - Moderately Irritating to Rabbits
Tetrahydrofuran
Occupational exposure to vapor is irritating to the eyes, skin and respiratory tract, while high concentrations
have produced signs of liver damage such as hepatitis and fatty degeneration. Acute inhalation exposure
produced effects on behavior (slow righting reflex, a pattern of decreased motor activity followed by increased
motor activity, etc.). This material rapidly penetrates the skin of rats and rabbits resulting in death. A drying
effect on the skin with no evidence of allergic skin reaction was observed in guinea pigs. Repeated inhalation
by rats and mice produced loss of coordination with evidence of transient sedation and decreases in thymus
and spleen weights. In mice, liver, forestomach, adrenal and uterine effects as well as anesthesia were
observed. Other inhalation studies in rats and mice have shown irritation to eyes, skin and the upper respiratory
tract and changes in liver function and blood chemistry. Repeated oral administration to mice produced no
significant effects. Repeated administration to rats in the drinking water produced no adverse toxic effects. An
increased incidence of kidney tumors in male rats and liver tumors in female mice were observed following long-
term inhalation exposure. Studies in rats and mice have shown developmental effects only at exposure levels
producing toxic effects in the mother. No genetic changes were observed in tests using bacteria, animal cells or
animals.
12 ECOLOGICAL INFORMATION
Ecotoxicological Information
Data on this material and/or its components are summarized below.
This material is practically non-toxic to water flea (48-hr LC50 3,485 mg/l) and fathead minnow (96-hr LC50
2,160 mg/l).
Chemical Fate Information
This material is not expected to bioconcentrate in fish or other aquatic organisms due to its low log
octanol/water partition coefficient (log Kow 0.47).
13 DISPOSAL CONSIDERATIONS
Waste Disposal
Recover, reclaim or recycle when practical. Dispose of in an approved landfill if allowed locally. Comply with
federal, state, and local regulations. Dispose of in a permitted waste management facility if incineration or
landfill is not practical.
14 TRANSPORT INFORMATION
DOT Name Organometallic Substance, Liquid, Water reactive, flammable
DOT Technical Name (ehtyl magnesium bromide, tetrahydrofuran)
DOT Hazard Class 4.3, 3
UN Number UN3399
DOT Packing Group PG I
RQ 1000 lbs. (Tetrahydrofuran)
15 REGULATORY INFORMATION
Product Code: VHQ00 Page 5
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Ethyl Magnesium Bromide 1.0M solution in THF
Material Safety Data Sheet
Arkema Inc.
Hazard Categories Under Criteria of SARA Title III Rules (40 CFR Part 370)
Immediate (Acute) Health Y Fire Y
Delayed (Chronic) Health N Reactive Y
Sudden Release of Pressure N
The components of this product are all on the TSCA Inventory list.
Ingredient Related Regulatory Information:
CERCLA RQ SARA TPQ
SARA Reportable Quantities
Ethyl magnesium bromide NE
Tetrahydrofuran 1000 LBS
Massachusetts Right to Know
This product does contain the following chemicals(s), as indicated below, currently on the Massachusetts Right to Know Substance
List.
Tetrahydrofuran
New Jersey Right to Know
This product does contain the following chemical(s), as indicated below, currently on the New Jersey Right-to-Know Substances List.
Tetrahydrofuran
Pennsylvania Environmental Hazard
This product does contain the following chemical(s), as indicated below, currently on the Pennsylvania Environmental Hazard List.
Tetrahydrofuran
Pennsylvania Right to Know
This product does contain the following chemical(s), as indicated below, currently on the Pennsylvania Hazardous Substance List.
Tetrahydrofuran
16 OTHER INFORMATION
Revision Information
Revision Number 8
02 JAN 2007
Revision Date
Supercedes Revision Dated 07-DEC-2005
Revision Summary
The name of this business group has changed to Functional Additives.
Key
NE= Not Established NA= Not Applicable (R) = Registered Trademark
Product Code: VHQ00 Page 6
Revision: 8 Issued: 02 JAN 2007 of 7
Ethyl Magnesium Bromide 1.0M solution in THF
Material Safety Data Sheet
Arkema Inc.
Arkema Inc. believes that the information and recommendations contained herein (including data and
statements) are accurate as of the date hereof. NO WARRANTY OF FITNESS FOR ANY PARTICULAR
PURPOSE, WARRANTY OF MERCHANTABILITY, OR ANY OTHER WARRANTY, EXPRESSED OR
IMPLIED, IS MADE CONCERNING THE INFORMATION PROVIDED HEREIN. The information provided
herein relates only to the specific product designated and may not be valid where such product is used in
combination with any other materials or in any process. Further, since the conditions and methods of use are
beyond the control of Arkema Inc., Arkema Inc. expressly disclaims any and all liability as to any results
obtained or arising from any use of the product or reliance on such information.
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