MATERIAL SAFETY DATA SHEET
Date prepared: December 6, 2002 page 1 of 5
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1. Product and Company Identification
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PRODUCT IDENTIFIERS: Borane-tetrahydrofuran complex, 1M solution in tetrahydrofuran (BTHF1M)
PRODUCT PART NUMBERS: 10001035 (bulk)
10001251 (400 liter cylinder)
10001041 (90 liter cylinder)
10001250 (18 liter cylinder)
1009447 (800 ml cylinder)
STABILIZER: <0.005M NaBH4
PRODUCT USE: Hydroboration and reduction reactions
MANUFACTURED BY: Callery Chemical Company
Division of Mine Safety Appliances Company
PO Box 429; Pittsburgh, PA 15230
Callery Customer Service: 1-412-967-4141
Callery 24-Hour Telephone: 1-412-967-4100
Transportation Emergency: 1-800-424-9300 in USA or 1-703-527-3887 outside USA
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2. Composition/Information on Ingredients
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wt% Synonym(s)
Borane-tetrahydrofuran complex (CASRN: 14044-65-6) ~9.2 BTHF, THFB
Tetrahydrofuran (CASRN: 109-99-9) ~90.8 THF
OSHA REGULATORY STATUS: Hazardous by definition of Hazard Communication Standard, 29 CFR 1910.1200.
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3. Hazards Identification
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Indications of danger (Annex II): Highly flammable and Irritant
Nature of special risk attributed to dangerous substances (Annex III): R11, R14/15, R36/37/38, R19
Safety advice concerning dangerous chemical substances (Annex IV): S2, S7/8, S16, S23, S29, S33, S43, S51
EMERGENCY OVERVIEW: Colorless liquid with tetrahydrofuran and diborane odor. Reacts violently with water, moist
air, alcohols, acids, and other incompatible materials releasing flammable hydrogen gas which can ignite explosively.
Extremely flammable liquid and vapor. Vapor may cause flash fire. Causes skin irritation. May cause eye and
respiratory tract irritation and central nervous system depression with nausea, dizziness, and headache. May be
absorbed through the skin. May cause liver and kidney effects. Evolves flammable and toxic diborane gas above 50癈.
Tetrahydrofuran can form potentially explosive peroxides upon long standing in air.
PHYSICAL HAZARDS: Reacts violently with water, moist air, alcohols, acids, and other incompatible materials releasing
flammable hydrogen gas which can ignite explosively. Extremely flammable liquid and vapor. Vapor may cause flash
fire.
Evolves flammable and toxic diborane gas above 50癈. Tetrahydrofuran can form potentially explosive peroxides upon
long standing in air.
POTENTIAL HEALTH EFFECTS: Causes skin irritation. May cause eye and respiratory tract irritation and central
nervous system depression with nausea, dizziness, and headache. May be absorbed through the skin. May cause liver
and kidney effects.
Primary Routes of Entry: Skin absorption, eye and skin contact, inhalation, ingestion
Target Organs: Eyes, skin, respiratory tract, central nervous system, kidneys, liver
Medical Conditions Generally Recognized as Aggravated by Exposure: Persons with preexisting skin,
respiratory,
liver and kidney conditions may be more susceptible to the effects of this product.
Carcinogenicity: Borane-tetrahydrofuran complex and tetrahydrofuran are not listed in the National Toxicology
Program (NTP) Annual Report on Carcinogens, not found to be potential carcinogens in the International
Agency for Research on Cancer (IARC) Monographs, and not listed as OSHA carcinogens.
Callery Chemical Company Borane-tetrahydrofuran complex, 1M solution in tetrahydrofuran
Revision: ANSIZ400.1-1998-R5-1M page 2 of 5
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POTENTIAL ENVIRONMENTAL EFFECTS: No environmental toxicity data for the product. See Section 12 for additional
information.
Callery Chemical Company Borane-tetrahydrofuran complex, 1M solution in tetrahydrofuran
Revision: ANSIZ400.1-1998-R5-1M page 3 of 5
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4. First Aid Measures
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SEND TO A PHYSICIAN IN ALL CASES.
Note: Immediately flushing with plenty of water is the appropriate eye and skin emergency first aid treatment for this
water-reactive chemical. For the eye, it is extremely important that flushing with water (with the eyelids held open) begins
within the first minute after borane-tetrahydrofuran complex has entered the eye and continues for the full 20 minutes. If
large amounts of borane-tetrahydrofuran complex are involved, flammable fumes and solutions may be produced during
the emergency first aid treatment procedure; therefore, emergency showers should be adequately ventilated and
equipped to handle flammable fumes and solutions that emergency first aid treatment may generate.
Eyes: Immediately flush eyes with plenty of water for at least 20 minutes while holding eyelids open.
Skin: Immediately flush skin with plenty of water for at least 20 minutes while removing contaminated clothing and shoes.
Dispose of contaminated clothing and shoes in compliance with all local, state, and federal laws and regulations.
Ingestion: For any accidental contamination of the mouth, gargle with water and rinse mouth thoroughly for at least 20
minutes. If swallowed, do not induce vomiting. Give demulcent such as milk, olive oil, or margarine in small amounts up
to 2 or 3 ounces. Never give anything by mouth to an unconscious person.
Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
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5. Fire Fighting Measures
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FLAMMABLE PROPERTIES: Water reactive. Extremely flammable liquid and vapor. Closed containers exposed to fire
conditions may present risk of overpressurization, rupture, explosion, or flammable and toxic diborane gas release.
Flashpoint (closed cup): -21.7癈/-5.8癋
Flammable Limits: LFL - 1.58 ?0.05%; UFL - 12.42 ?0.6%
Autoignition Temperature: 79-82癈/174-180癋
EXTINGUISHING MEDIA: Use carbon dioxide or dry chemical.
DO NOT use water, foam, or halogenated extinguishing agents.
UNUSUAL FIRE AND EXPLOSION HAZARDS: Evolves flammable and toxic diborane gas above 50癈. Reacts violently
with water, moist air, alcohols, acids and other incompatible materials liberating flammable hydrogen gas which can ignite
explosively. See also STABILITY TO AIR in Section 9. THF vapor is heavier than air and may travel along the ground to
a distant source of ignition and flashback. If THF is distilled from the reaction mixture, potentially explosive peroxides may
form in the distillate. Distillate must be inhibited or protected from air.
PROTECTION OF FIRE FIGHTERS: Wear full protective clothing, including protective gloves and boots. For respiratory
protection, wear a NIOSH approved self-contained breathing apparatus with full facepiece operated in a positive-pressure
mode.
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6. Accidental Release Measures
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PROCEDURES FOR CLEANUP: Wear recommended personal protective equipment. Be prepared to fight fire.
Eliminate ignition sources. Do not flush spill to drain. Mix with large amounts of DRY soda ash. Using non-sparking
tools, scoop solids into a DRY metal container, properly label, and cover. Take immediately to a waste handling area. If
contaminated, flammable hydrogen gas can evolve and cause fire, explosion, or pressure buildup in container. Properly
dispose of all residues immediately. Handle in compliance with all local, state, and federal laws and regulations. The
reportable quantity for tetrahydrofuran is 1000 pounds.
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7. Handling And Storage
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HYGIENIC PRACTICES: Avoid breathing vapor or mist. Use only with adequate ventilation. Keep container tightly
closed. Avoid contact with eyes, skin, and clothing. Wash thoroughly after handling.
STORAGE: To protect product purity, refrigerate at 5癈 or lower. Handle and store in a DRY closed system under DRY
nitrogen gas. Do not store residues. Properly dispose of all residues immediately.
WORK PRACTICES: Keep away heat, sparks, flame and any possible contact with water, moist air, alcohols, acids, and
other incompatible materials. Do not expose to air. Handle and store in a closed system under DRY nitrogen gas. Use
DRY nitrogen gas to inert containers, transfer lines, vessels, tanks, etc., such that the atmosphere stays below 3%
oxygen.
Use non-sparking tools when opening or closing containers. Bond and ground all systems when handling. Since empty
containers retain product residue, follow label warnings even after container is emptied.
Callery Chemical Company Borane-tetrahydrofuran complex, 1M solution in tetrahydrofuran
Revision: ANSIZ400.1-1998-R5-1M page 4 of 5
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PROTECTIVE MEASURES DURING REPAIR AND MAINTENANCE OF CONTAMINATED EQUIPMENT: See Section
8.
Callery Chemical Company Borane-tetrahydrofuran complex, 1M solution in tetrahydrofuran
Revision: ANSIZ400.1-1998-R5-1M page 5 of 5
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8. Exposure Controls/Personal Protection
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ENGINEERING CONTROLS: Maintain a leakproof system. Use packless valves, welded piping, and other leakproof
construction. Handle in a closed system under DRY nitrogen gas. Provide adequate local exhaust ventilation to maintain
worker exposure below exposure limits. Prevent electrostatic charge buildup by using common bonding and grounding
techniques. Use DRY nitrogen gas to inert containers, transfer lines, vessels, tanks, etc., such that the atmosphere stays
below 3% oxygen.
EXPOSURE CONTROLS: None established for the mixture.
For tetrahydrofuran: ACGIH TLV-TWA: 200 ppm
ACGIH TLV-STEL: 250 ppm
OSHA PEL-TWA: 200 ppm (590 mg/m3)
ACGIH has proposed a Biological Exposure Index (TLV-BEI) for tetrahydrofuran.
The IDLH for tetrahydrofuran is 2000 ppm.
Odor thresholds of 2 ppm and 7.4 ppm have been reported for tetrahydrofuran.
OSHA PEL-TWA: 0.1 ppm (0.1 mg/m3)
For diborane:
ACGIH TLV-TWA: 0.1 ppm
The IDLH for diborane is 15 ppm.
Odor threshold of 2.5 ppm has been reported for diborane.
PERSONAL PROTECTIVE EQUIPMENT:
Normal Use & Handling: When exposure to eyes and skin is possible, wear chemical protective goggles with a faceshield
and flame-retardant protective clothing. Glove permeation data does not exist for this mixture. Exposure limits have not
been established for Borane-tetrahydrofuran complex in tetrahydrofuran. When inhalation of vapor or mist is possible,
wear a NIOSH-approved self-contained breathing apparatus with full facepiece operated in a positive-pressure mode.
Eye wash and safety showers must be available and in good working order.
Emergency Handling: For firefighting, wear full protective clothing, including protective gloves and boots. For chemical
spills, wear special protective clothing (vapor-protective suit with additional chemical flash fire escape protection, as
specified in NFPA 1991). For respiratory protection, wear a NIOSH-approved self-contained breathing apparatus with full
facepiece operated in a positive-pressure mode.
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9. Physical And Chemical Properties
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APPEARANCE: Colorless liquid
ODOR: Tetrahydrofuran and diborane odor
BOILING POINT: Evolves flammable and toxic diborane gas before boiling (at temperatures as low as 112癋/50癈).
THF boils at 151癋/66癈 at 760 mm Hg.
VAPOR DENSITY: 2.5 for THF
DENSITY: 0.876g/ml @ 25癈
STABILITY TO AIR: Reacts with oxygen and moisture in air.
FORMULA WEIGHT: 85.94 g/mol
FORMULA: (CH2)4O:BH3 in (CH2)4O
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10. Stability And Reactivity
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STABILITY (CONDITIONS TO AVOID): Stable. Keep away from heat, sparks, and flame. To protect product purity,
refrigerate at 5癈 or lower.
INCOMPATIBILITY (SPECIFIC MATERIALS TO AVOID): Avoid unintended reactions with any chemical including, but
not limited to, water, moist air, alcohols, acids, acid chlorides, acid anhydrides, oxygen, oxidizers, and some precious
metal catalysts.
HAZARDOUS DECOMPOSITION PRODUCTS: Hydrogen, diborane, carbon monoxide, carbon dioxide, boron oxides,
boranes.
HAZARDOUS POLYMERIZATION: Not expected to occur.
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11. Toxicological Information
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This product is a mixture which has not been tested for health hazards. The assumption is made in the OSHA Hazard
Communication Standard that an untested mixture will present the same health hazards as do the components which
comprise one percent or more. Health hazard information for all components is therefore included as part of this MSDS.
Callery Chemical Company Borane-tetrahydrofuran complex, 1M solution in tetrahydrofuran
Revision: ANSIZ400.1-1998-R5-1M page 6 of 5
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Borane-tetrahydrofuran complex has been shown to be an in vitro mutagen. No other information found for borane-
tetrahydrofuran complex.
Tetrahydrofuran (THF) is a strong eye and respiratory irritant. Inhalation of vapors can cause central nervous system
effects such as nausea, headache, dizziness, drowsiness, narcosis, and loss of feeling. THF may cause liver and kidney
effects. THF may be absorbed through the skin.
Diborane is a gas that is toxic by inhalation, may cause eye irritation, and may cause central nervous system effects.
Diborane gas acts primarily as an irritant to the respiratory system. Symptoms of acute exposure are respiratory distress,
chest tightness, difficulty in breathing, non-productive coughing and wheezing, and sometimes nausea. Symptoms
appear within a few minutes. In cases of mild exposure, they may last less than an hour; in more severe exposures,
generally three to five days. Secondary infections were reported in some persons needing treatment. Chronic respiratory
distress was present in two persons from recurring diborane exposure; it was believed to be due to a hypersensitivity
reaction.
Exposure to low concentrations of diborane over a prolonged time period can cause lightheadedness, headache,
fatigue, drowsiness, tremors, vertigo, chills, and sometimes fever; a cough and chest tightness may be present.
Symptoms lasted from five days to three weeks.
The odor of diborane is unique and offers some warning, but potentially hazardous concentrations which cannot be
detected by smell can exist in air. The odor detection threshold is 3.2 ppm or 3.7 mg/m3. In addition, prolonged exposure
to diborane can temporarily impair the sense of smell.
TOXICITY DATA: No information found for the product.
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12. Ecological Information
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ECOLOGICAL DATA: No environmental toxicity data for the product.
If released to the atmosphere, tetrahydrofuran will exist solely in the vapor phase in the ambient atmosphere based on
a measured vapor pressure of 162 mm Hg at 25癈. Vapor-phase tetrahydrofuran is degraded in the atmosphere by
reaction with photochemically-produced hydroxyl radicals and nitrate radicals with half-lives of about 1 and 3 days,
respectively. Measured Koc values of 23 and 18 indicate that tetrahydrofuran will have very high mobility in soil.
Volatilization from moist and dry soil surfaces may occur based on a measured Henry's Law constant of 7.05X10-5 atm-
cu m/mole and tetrahydrofuran's measured vapor pressure, respectively. Tetrahydrofuran is expected to biodegrade
under aerobic conditions but may be resistant to biodegradation in anaerobic environments. In the modified MITI
screening test, tetrahydrofuran at 30 mg/l was completely biodegraded in 14 days using an activated sludge inoculum.
The EEC manometric respirometric method, tested in 22 different laboratories, gave a mean of 34% of the theoretical
BOD within 28 days. Tetrahydrofuran at 50 mg C/l was resistant to anaerobic biodegradation with a lag period of greater
than 60 days using a primary digesting sludge as an inoculum; no gas production was seen during this time.
Tetrahydrofuran is not expected to adsorb to suspended matter in the water based on its measured Koc values.
Tetrahydrofuran should volatilize from water surfaces given its Henry's Law constant. Estimated half-lives for a model
river and model lake are 13 hours and 6 days, respectively. An estimated BCF value of 1 suggests that tetrahydrofuran
will not bioconcentrate in aquatic organisms.
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13. Disposal Considerations
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WASTE DISPOSAL: Do not flush to sewer. Dispose in compliance with all local, state, and federal laws and regulations.
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14. Transport Information
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Note: The reportable quantity (RQ) for tetrahydrofuran is 1000 pounds.
To protect product purity, refrigerate at 5癈 or lower.
HAZARDOUS MATERIALS/DANGEROUS GOODS CLASSIFICATION:
Proper Shipping Name: Water-reactive liquid, n.o.s. (borane-tetrahydrofuran complex, tetrahydrofuran)
Hazard Class: 4.3 (subsidiary hazard class - 3)
Packaging Group: I
Identification Number: UN3148
Labels: Dangerous when wet, flammable liquid
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15. Regulatory Information
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TSCA: Borane-tetrahydrofuran complex and tetrahydrofuran are listed on the TSCA Public Inventory.
Callery Chemical Company Borane-tetrahydrofuran complex, 1M solution in tetrahydrofuran
Revision: ANSIZ400.1-1998-R5-1M page 7 of 5
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SARA 313 INFORMATION: Borane-tetrahydrofuran complex does not contain a toxic chemical or chemicals subject to
the reporting requirements of section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 and
40 CFR 372.
Callery Chemical Company Borane-tetrahydrofuran complex, 1M solution in tetrahydrofuran
Revision: ANSIZ400.1-1998-R5-1M page 8 of 5
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CERCLA/SUPERFUND: The reportable quantity (RQ) for tetrahydrofuran is 1000 pounds.
EINECS: 237-881-8 for borane-tetrahydrofuran complex, 203-726-8 for tetrahydrofuran
EUROPEAN LABEL INFORMATION:
Symbols: F, Xi
Indications of danger (Annex II): Highly flammable, irritant
Nature of special risk attributed to dangerous substances (Annex III):
R11 Highly flammable.
R14/15 Reacts violently with water, liberating highly flammable gases.
R36/37/38 Irritating to eyes, respiratory system, and skin.
R19 May form explosive peroxides.
Safety advice concerning dangerous chemical substances (Annex IV):
S2 Keep out of reach of children.
S7/8 Keep container tightly closed and dry.
S16 Keep away from sources of ignition.
S23 Do not breathe gas/fumes/vapour/spray.
S29 Do not empty into drains.
S33 Take precautionary measures against static discharges.
S43 In case of fire, use dry chemical or carbon dioxide. Never use water.
S51 Use only in well-ventilated areas.
CANADA: This mixture contains tetrahydrofuran, a chemical listed on the WHMIS Ingredient Disclosure List.
CALIFORNIA: This product does not contain a chemical known to the State of California to cause cancer.
NEW JERSEY: This mixture contains tetrahydrofuran, a chemical listed on the New Jersey Department of Health Hazard
Right-to-Know Program Hazardous Substance List as a special health hazard.
PENNSYLVANIA: This mixture contains tetrahydrofuran and is subject to the Pennsylvania Worker and Community
Right-to-Know Act.
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16. Other Information
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MSDS STATUS: Revised Sections 1, 2, 3, 5, 7, 8, 9, 10, 11, 14, 15, and 16.
WARNING: This is a dangerous chemical product. By following the directions and warnings provided with this product,
the dangers associated with the use of this product can be greatly reduced but never entirely eliminated. Callery
Chemical Company makes no warranties, expressed or implied, with respect to this product and EXPRESSLY
DISCLAIMS THE WARRANTY OF MERCHANTABILITY AND ANY WARRANTY OF FITNESS FOR A PARTICULAR
PURPOSE. Users assume all risks in handling, using or storing this product.
?2002, MSA
file: BTHF-MSDS-ANSI-98-R5-1M
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