Material Safety Data Sheet
Glycol Ether EE
Effective Date May 2005
Page 1 of 14
SECTION 1: IDENTIFICATION
Product Name: GLYCOL ETHER EE
Chemical Family: Glycol Ethers
CAS Number: 110-80-5
Chemical Name: 2-ethoxyethanol
Synonyms: Ethylene Glycol Monoethyl Ether, Cellosolve, Ethylene glycol ethyl ether
COMPANY: TRInternational, Inc.
1218 Third Avenue, Suite 2100
Seattle, WA 98101
206-505-3500
Emergency Contact: Infotrac 800-505-5053
SECTION 2 : COMPOSITION/INFORMATION ON INGREDIENTS
Component Name CAS # EU Inventory Concentration Wt.%*
Risk Symbol
2-Ethoxyethanol 110-80-5 203-804-1 99.0 <= 99.9 R60,
R61, T Rep2, R10,R20/21/22
1,2-Ethanediol 107-21-1 203-473-3 <= 0.5 R22
Xn
Diethylene Glycol Monoethyl 111-90-0 203-919-7 <= 0.5 None
None
Ether
Water 7732-18-5 231-791-2 <= 0.2 None
None
* Concentration of gaseous products or materials is given in Mole %
Compositions given are typical values not specifications.
SECTION 3: HAZARD IDENTIFICATION
Emergency Overview
This material is HAZARDOUS by OSHA Hazard Communication definition.
Signal Word
WARNING!
Hazards
Flammable liquid. Eye irritant. Mucous membrane irritant. Respiratory tract irritant. CNS
depressant. May cause liver
and/or kidney damage.
Physical State
Liquid.
Color
Clear
Material Safety Data Sheet
Glycol Ether EE
Effective Date May 2005
Page 2 of 14
Odor
Mild Sweetish Odor
Odor Threshold
2.7 ppm / (detectable) 6.5 ppm / (recognizable)
Potential Health Effects
Routes of Exposure
Inhalation Skin. Ingestion
Signs and Symptoms of Acute Exposure
See component summary.
?2-Ethoxyethanol 110-80-5
May be irritating to the eyes. Exposure to this material may cause respiratory irritation. This
substance may cause effects
on the central nervous system, liver and kidneys. This material may be absorbed through the
skin. Not a skin irritant. Not
expected to be a sensitizer.
?1,2-Ethanediol 107-21-1
Ingestion hazard. Ingestion may include inebriation, nausea and vomiting, metabolic acidosis,
and CNS depression.
Cardiopulmonary effects including tachycardia, hypertension, severe metabolic acidosis with
hyperventilation, hypoxia,
congestive heart failure and adult respiratory distress syndrome, as well as, renal failure are also
possible. May also
produce a local irritation effect on the digestive system, and cause pain and bleeding. Irritation of
the eyes and respiratory
system. Effects of eye irritation are reversible. High aerosol concentrations may cause respiratory
irritation. Mildly irritating
to the skin but not a skin sensitizer. Not a skin absorption hazard.
?Diethylene Glycol Monoethyl Ether 111-90-0
May be irritating to the eyes. Slight skin irritant.
Skin
May be absorbed in toxic amounts through the skin.
Inhalation
Vapor or mist is irritating to the respiratory tract.
Eye
May be irritating to the eyes.
Ingestion
May cause headache, dizziness, nausea, vomiting, gastrointestinal distress, liver and kidney
injury.
Chronic Health Effects
See component summary.
Material Safety Data Sheet
Glycol Ether EE
Effective Date May 2005
Page 3 of 14
?2-Ethoxyethanol 110-80-5
Prolonged or repeated exposure may result in CNS and gastrointestinal system disturbance, and
possible adverse
reproductive effects. Excessive oral exposure may result in changes to the liver and testes.
Repeated, prolonged,
excessive exposure may result in kidney damage.
?1,2-Ethanediol 107-21-1
Repeated or prolonged exposure may result in kidney damage. May produce symptoms of central
nervous system
depression including headache, dizziness, nausea, euphoria, loss of equilibrium, drowsiness,
visual disturbances, fatigue,
unconsciousness and respiratory arrest.
?Diethylene Glycol Monoethyl Ether 111-90-0
Repeated or prolonged skin contact may cause slight transient irritation. Skin absorption may add
significantly to the overall
toxic effect.
Conditions Aggravated by Exposure
Any pre-existing conditions affecting target organs:
SECTION 4: FIRST AID MEASURES
General
Take proper precautions to ensure your own health and safety before attempting rescue and
providing first aid. For specific
information refer to the Emergency Overview in Section 3 of this MSDS.
Skin
Immediately remove excess chemical and contaminated clothing; thoroughly wash contaminated
skin with mild soap and
water. If irritation persists after washing, seek medical attention. Thoroughly clean contaminated
clothing before reuse;
discard contaminated leather goods (gloves, shoes, belts, wallets, etc.).
Inhalation
Move the exposed person to fresh air at once. If breathing has stopped, perform artificial
respiration. When breathing is
difficult, properly trained personnel may assist the affected person by administering oxygen. Keep
the affected person
warm and at rest. Get medical attention immediately.
Eye
Flush with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.
Ingestion
NEVER GIVE ANYTHING BY MOUTH TO AN UNCONSCIOUS PERSON. Have patient drink
several glasses of water then
induce vomiting by having patient tickle back of throat with finger.
Material Safety Data Sheet
Glycol Ether EE
Effective Date May 2005
Page 4 of 14
SECTION 5: FIRE FIGHTING MEASURES
Flammable Properties
Classification
OSHA/NFPA Class II combustible liquid.
Flash Point:
43 癈 (109.4 癋) closed cup
Auto-Ignition Temperature
235 癈 (455 癋)
Lower Flammable Limit
1.8 vol%
Upper Flammable Limit
14 vol%
Extinguishing Media
Suitable: SMALL FIRE: Use dry chemicals, CO2, water spray or alcohol-resistant foam. LARGE
FIRE: Use water spray,
water fog or alcohol-resistant foam.
Unsuitable: Do not use solid water stream.
Protection of Firefighters
Protective Equipment/Clothing: Wear an approved positive pressure self-contained breathing
apparatus and firefighter
turnout gear.
Fire Fighting Guidance: Avoid sparks, heat, and open flame. Fight fire from maximum distance
or use unmanned hose
holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is
out. Withdraw
immediately in case of rising sound from venting safety devices or discoloration of tank. Always
stay away from tanks
engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is
impossible, withdraw from area
and let fire burn.
Hazardous Combustion Products: Carbon oxides (CO, CO2)
SECTION 6: ACCIDENTAL RELEASE MEASURES
Release Response
Contain spill with dike to prevent entry into sewers or waterways. For large spills, dike and pump
into properly labeled
Material Safety Data Sheet
Glycol Ether EE
Effective Date May 2005
Page 5 of 14
containers for reclamation or disposal. For small spills, soak up with absorbent material and place
in properly labeled
containers for disposal. All recovered material should be packaged, labeled, transported and
disposed of or reclaimed in
conformance with applicable laws and regulations and in conformance with good engineering
practices. Reclaim where
possible.
SECTION 7: HANDLING AND STORAGE
Handling
Containers, even those that have been emptied, will retain product residue and vapor and should
be handled as if they were
full. Do not eat, drink or smoke in areas where this material is used. After handling, always wash
hands thoroughly with
soap and water. Do not handle near heat, sparks, or flame. Avoid contact with incompatible
agents. Use only with
adequate ventilation/personal protection. Avoid contact with eyes, skin and clothing. Do not enter
storage area unless
adequately ventilated. Metal containers involved in the transfer of this material should be
grounded and bonded.
Storage
Store containers in a cool, dry, ventilated, fire resistant area away from sources of ignition and
incompatible materials. Keep
container tightly closed and properly labeled.
SECTION 8: EXPOSURE CONTROLS AND PERSONAL PROTECTION
Engineering Controls
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne
levels below
recommended exposure limits. Emergency shower and eyewash facility should be in close
proximity (ANSI Z358.1)
Personal Protection
Inhalation A respiratory protection program that meets OSHA's 29 CFR 1910.134 or ANSI Z88.2
requirements must be
followed whenever workplace conditions warrant respirator use.
Skin Wear chemical resistant gloves such as: Butyl rubber. When skin contact is possible,
protective clothing including
gloves, apron, sleeves, boots, head and face protection should be worn. The equipment must be
cleaned thoroughly after
each use.
Eye Wear chemical safety goggles plus full face shield to protect against splashing when
appropriate (ANSI Z87.1).
Material Safety Data Sheet
Glycol Ether EE
Effective Date May 2005
Page 6 of 14
Additional Remarks
Selection of appropriate personal protective equipment should be based on an evaluation of the
performance
characteristics of the protective equipment relative to the task(s) to be performed, conditions
present, duration of use, and
the hazards and/or potential hazards that may be encountered during use. Emergency eye wash
fountains and safety
showers should be available in the immediate vicinity of any potential exposure. Use good
personal hygiene practices.
Wash hands before eating, drinking, smoking, or using toilet facilities. Promptly remove soiled
clothing/wash thoroughly
before reuse. Use care in walking on spilled material.
Occupational Exposure Limits
Component Name Source / Date Value Type
2-Ethoxyethanol US (ACGIH) 18 mg/m3 8 HRS/TWA
US (OSHA) 740 mg/m3 8 HRS/TWA
1,2-Ethanediol US (ACGIH) 100 mg/m3 CEILING
Aerosol
US (OSHA) N/L
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
Appearance: Liquid. Clear
Odor: Mild Sweetish Odor
Odor Threshold: 2.7 ppm (detectable) 6.5 ppm (recognizable)
pH: Not applicable.
Boiling Point/Boiling Range: 135 癈 (275 癋)
Freezing Point/Melting Point: -90 癈 (-130 癋)
Flash Point: 43 癈 (109.4 癋) closed cup
Auto-ignition: 235 癈 (455 癋)
Flammability: OSHA/NFPA Class II combustible liquid.
Lower Flammable Limit: 1.8 vol%
Upper Flammable Limit: 14 vol%
Explosive Properties: No Data Available.
Oxidizing Properties: No Data Available.
Vapor Pressure: 3.7 mm Hg @ 20 癈 (68 癋)
Material Safety Data Sheet
Glycol Ether EE
Effective Date May 2005
Page 7 of 14
Evaporation Rate: 0.41
Relative Density: 0.931 @ 20 癈 (68 癋) (Water = 1)
Relative Vapor Density: 3.10 (Air = 1.0)
Viscosity: Not applicable.
Solubility (Water): @ 20 癈 (68 癋) 100%
Partition Coefficient (Kow): Not applicable.
Additional Physical and Chemical Properties: No additional information available.
SECTION 10: STABILITY AND REACTIVITY
Chemical Stability
The product is stable.
Conditions to Avoid
All sources of ignition.
Substances to Avoid
Oxidizers, Alkalis, Other
Decomposition Products
Carbon oxides (CO, CO2)
Hazardous Polymerization
May form peroxides in the presence of air.
Reactions with Air and Water
Does not react with air or water.
SECTION 11: TOXICOLOGICAL INFORMATION
PRODUCT INFORMATION
Product Summary
Repeated, prolonged, excessive exposure may result in kidney damage.
COMPONENT INFORMATION
?2-Ethoxyethanol 110-80-5
Material Safety Data Sheet
Glycol Ether EE
Effective Date May 2005
Page 8 of 14
Acute Toxicity - Lethal Doses
LC50 (Inhl) Guinea Pig 2000 PPM 7 HOURS
LD50 (Oral) Rat 2125 MG/KG
Rabbit 3300 MG/KG
LD50 (Skin) Rat 3.35 G/KG
?1,2-Ethanediol 107-21-1
Acute Toxicity - Lethal Doses
LD50 (Oral) Rat 5890 - 13,400 MG/KG BWT
NOAEL Rabbit > 3549 MG/KG BWT (SKIN)
Irritation
Skin May be irritating to the skin. Not expected to be a sensitizer. No significant signs or
symptoms indicative of any health
hazard are expected to occur as a result of skin absorption exposure.
Eye May cause minor eye irritation. Effects of eye irritation are reversible.
Sensitization
Not expected to be a sensitizer.
Target Organ Effects
Central nervous system effects. Blood (metabolic acidosis). Respiratory system. Cardiovascular
system. Kidneys.
Repeated Dose Toxicity
If exposures are sufficiently high to cause accumulation of calcium oxalate crystals, kidney
pathology may occur. In male
rats, crystal nephropathy has been seen after dietary administration of 500 mg/kg/day bwt for 16
weeks, whereas no effects
were seen in rats that ingested 200 mg/kg/day bwt for 2 years or in several animal species that
inhaled 12 mg/m3 for 3
months . Human exposures at occupational relevant concentrations are unlikely to cause crystal
nephropathy.
Reproductive Effects
No evidence of adverse effects on reproductive organs or fertility in rats and rabbits have
occurred from ethylene glycol
exposure. Mice exposed to doses considerably higher than those associated with developmental
effects or kidney effects in
rats exhibited reduced number of litters and smaller litters. No reproductive effects expected from
human exposures.
Developmental Effects
Doses of ethylene glycol that result in high levels of the metabolite glycolic acid induce
developmental/teratogenic effects in
rats and mice, although at doses greater than those associated with kidney effects in rats. Human
exposure is not expected to generate sufficient levels of glycolic acid; therefore, no
developmental effects are expected in humans.
Material Safety Data Sheet
Glycol Ether EE
Effective Date May 2005
Page 9 of 14
Genetic Toxicity
Negative for genotoxicity both in vitro and in vivo tests.
Carcinogenicity
Ethylene glycol was not carcinogenic in two year studies in rats and mice. This material is not
classified as a carcinogen.
Not listed by IARC, NTP, or OSHA.
Other Information
Human acute toxicity has three recognized stages: Stage 1. (0.5 to 12 hours post ingestion) may
include inebriation, nausea
and vomiting, metabolic acidosis, and CNS depression. Stage 2. (12-24 hours) cardiopulmonary
effects include
tachycardia, hypertension, severe metabolic acidosis with hyperventilation, hypoxia, congestive
heart failure and adult
respiratory distress syndrome. Stage 3. (24-72 hours) renal failure. Ethylene glycol may also
produce a local irritation effect
on the digestive system, and cause pain and bleeding.
?Diethylene Glycol Monoethyl Ether 111-90-0
Acute Toxicity - Lethal Doses
LD50 (Oral) Rat 5.5 G/KG
Mouse 6.6 G/KG
LD50 (Skin) Rabbit 9.0 G/KG
Acute Toxicity - Effects
Ingestion Rat toxicity data (5.0 g/kg/day) indicates oxalate crystals in urine, degeneration of the
liver and renal tubules, and
transient dermititis.
Repeated Dose Toxicity
In a two year drinking water study with rats and mice, no adverse effects were observed at 1%
and 5%, respectively.
Carcinogenicity
Not listed by IARC, NTP, or OSHA.
?Water 7732-18-5
Repeated Dose Toxicity
No known chronic health effects.
Material Safety Data Sheet
Glycol Ether EE
Effective Date May 2005
Page 10 of 14
SECTION 12: ECOLOGICAL INFORMATION
developmental effects are expected in humans.
PRODUCT INFORMATION
Ecotoxicity
This material is highly soluble in water. Limited toxicity tests and models indicate this material
should exhibit low toxicity to
aquatic organisms. The odor and flavor of this material may attract some wildlife and cause them
to consume spilled
material.
Environmental Fate and Pathway
This material should biodegrade after an acclimation period, and it is is not expected to be
environmentally persistant. Due
care should be taken to avoid accidental releases to aquatic or terrestrial systems.
Persistance and Degradability
Bioaccumulation: This material is highly soluble in water and should not bioaccumulate in aquatic
or terrestrial organisms.
COMPONENT INFORMATION
?2-Ethoxyethanol 110-80-5
Ecotoxicity
This material is not classified as harmful or toxic to fish.
Acute toxicity to fish
LC50 / 24 HOUR goldfish > 5,000 mg/l
LC50 / 96 HOUR bluegill. > 10,000 mg/l
Environmental Fate and Pathway
Expected to have high mobility in soils. Volatilization from dry soil surfaces is expected. Not likely
to adsorb to suspended
solids and sediment in water. This material is expected to exist solely as a vapor in the ambient
atmosphere. Vapor-phase
is degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals.
Persistance and Degradability
Biodegradation: This material is expected to be readily biodegradable.
Bioaccumulation: This material is not expected to bioaccumulate.
?1,2-Ethanediol 107-21-1
Material Safety Data Sheet
Glycol Ether EE
Effective Date May 2005
Page 11 of 14
Ecotoxicity
Terrestrial plant and avian NOEC (No Observed Effect Concentration) data are available upon
request.
Acute toxicity to fish
LC50 / 96 HOUR rainbow trout. 22,810 mg/l
LC50 / 96 HOUR fathead minnow 49,000 mg/l
Summary: This material is not classified as harmful or toxic to fish.
Acute toxicity to aquatic invertebrates
EC50 / 48 HOUR Daphnia magna. 41,000 mg/l
EC50 / 48 HOUR daphnia 10,000 mg/l
Summary: This material is not classified as harmful or toxic to invertebrates.
Toxicity to aquatic plants
Toxicity Threshold / 7 DAY blue green algae. 2,000 mg/l
Summary: This material is not classified as harmful or toxic to algae or higher aquatic plants.
Toxicity to microorganisms
Toxicity Threshold / 16 HOUR bacteria. > 10,000 mg/l
Chronic toxicity to fish
LC50 / 12 DAY rainbow trout. 20,403 mg/l
Chronic toxicity to aquatic invertebrates
LC50 / 7 DAY daphnia 30,461 mg/l
Environmental Fate and Pathway
Mobile in soil. Not expected to volatilize from surface waters or soils. Not likely to adsorb to
suspended solids and sediment
in water. Environmental half-life of 0.35 to 24 days in soil, air, surface and ground water. Not
expected to undergo
hydrolysis. Undergoes photooxidation with hydroxyl radicals in air with a half-life of 8.3 to 83
hours.
Persistance and Degradability
Biodegradation: Reported biodegradation studies show ethylene glycol with 97% biodegradation
after 20 days, and 96%
biodegradation after 28 days. Biodegradable under aerobic conditions.
Bioaccumulation: BCF = 0.21 - 0.61 (crawfish) BCF = 10.0 (fish) This material is not expected to
bioaccumulate.
?Diethylene Glycol Monoethyl Ether 111-90-0
Material Safety Data Sheet
Glycol Ether EE
Effective Date May 2005
Page 12 of 14
Ecotoxicity
This material is expected to have low toxicity to aquatic species. However, due caution should be
exercised to prevent the
accidental release of this material to the environment.
Acute toxicity to fish
LC50 / 24 HOUR goldfish > 5,000 mg/l
LC50 / 96 HOUR fathead minnow 26,500 mg/l
Environmental Fate and Pathway
Expected to have high mobility in soils. Volatilization from dry soil surfaces is expected. While this
material may evaporate
into the air from dry soil, it is unlikely to evaporate from moist soil or water. This material is
expected to exist solely as a
vapor in the ambient atmosphere. The vapor-phase of this material is degraded in the
atmosphere by reaction with
photochemically-produced hydroxyl radicals and ozone.
Persistence and Degradability
Biodegradation: Incubation of diethylene glycol monoethyl ether for 5, 10, and 20 days without an
acclimation period
resulted in theorectical BOD values or 5, 31, and 48%, respecitively. This material is expected to
be readily biodegradable.
Bioaccumulation: BCF = 0.2 This material is not expected to bioaccumulate.
?Water 7732-18-5
Ecotoxicity
Not Applicable.
Environmental Fate and Pathway
Not Applicable.
SECTION 13: DISPOSAL CONSIDERATIONS
Recycle if possible. Use only licensed transporters and permitted facilities for waste disposal.
Contaminated
product/soil/water may be U.S. Resource Conservation and Recovery Act (RCRA)/U.S.
Occupational Safety and Health
Administration (OSHA) hazardous waste. Comply with federal, state, or local regulations for
disposal.
SECTION 14: TRANSPORT INFORMATION
Special Requirements
If you reformulate or further process this material, you should consider re-evaluation of the
regulatory status of the
Material Safety Data Sheet
Glycol Ether EE
Effective Date May 2005
Page 13 of 14
components listed in the composition section of this sheet, based on final composition of your
product.
Proper Shipping Name Ethylene glycol monoethyl ether
RQ ETHYLENE GLYCOL MONOETHYL ETHER
ID No. UN1171
Hazard Class 3
PG III
SECTION 15: REGULATORY INFORMATION
Regulatory Status
Country Inventory
Australia AICS X
Canada DSL X
Canada NDSL
China IECS X
European Union EINECS X
European Union ELINCS
European Union NLP
Japan ENCS X
Korea ECL X
Philippines PICCS X
United States TSCA X
X = All components are included or are otherwise
exempt from inclusion on this inventory.
If identified components of this product are listed under the TSCA 12(b) Export Notification rule,
they will be listed below.
Export notification required.
Ethylene glycol ethyl ether - CASRN 110-80-5 TSCA section 5
SARA 302/304
This material contains a component(s) with known CAS numbers classified as hazardous
substances subject to the
reporting of CERCLA (40 CFR 302) and/or to the release reporting requirements of SARA
(Section 302) based on
reportable quantities (RQs).
Component RQ
Ethylene Glycol Monoethyl Ether / CAS# 110-80-5 1,000 lbs
Ethylene glycol / CAS# 107-21-1 5,000 lbs
Material Safety Data Sheet
Glycol Ether EE
Effective Date May 2005
Page 14 of 14
SARA 311/312
Based upon available information, this material is classified as the following health and/or
physical hazards according to
Section 311 & 312:
Immediate (Acute) Health Hazard.
Delayed (Chronic) Health Hazard.
Fire Hazard.
SARA 313
This material contains the following chemicals with known CAS numbers subject to the reporting
requirements of SARA Title
III, Section 313 and 40 CFR 372:
Component Reporting Threshold
Ethylene Glycol Monoethyl Ether / CAS# 110-80-5 1.0%
State Reporting
This product contains the following ingredients for which the state of California has found to
cause cancer, birth defects or
other reproductive harm, which would require a warning under the statute:
?Ethylene glycol monoethyl ether, Reproductive and Developmental Toxin
SECTION 16: OTHER INFORMATION
The information above is believed to be accurate and represents the best information currently
available to us. However, we make no warranty of merchantability or any other warranty, express
or implied, with respect to such information, and we assume no liability resulting from its use.
Users should make their own investigations to determine the suitability of the information for their
particular purposes. In no event shall TRInternational, Inc. be liable for any claims, losses, or
damages of any third party or for lost profits or any special, indirect, incidental, consequential or
exemplary damages, howsoever arising, even if TRInternational, Inc. has been advised of the
possibility of such damages.
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