Safety Data Sheet (91/155/EEC)
72755I
Revision Date: 05/14/2004
Issued: 11/02/2004
M-PYROL?br>
1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE
COMPANY/UNDERTAKING
Identification of the substance/preparation
Product Id: 72755I
Product Name: M-PYROL?br>
CAS Registry Number: 872-50-4
CAS Name: 2-Pyrrolidinone, 1-methyl
Formula: C5H9NO
Molecular Weight: 99.1
Responsible Party: International Specialty Products
4501 Attwater Ave. and State Highway
Texas City, TX 77590
Distributed By:
ISP (Great Britain) Co. Ltd.
Waterfield, Tadworth
Surrey KT20 5HQ, United Kingdom
Tel: +44 161 998 1122
Emergency Telephone Number: +32.3.575.55.55 (SGS)
Prepared By: Product Stewardship
2. COMPOSITION/INFORMATION ON INGREDIENTS
Components: Weight % EU Classification: German MAK: UK OES/MEL:
N-METHYL-2- 99.8 Xi; R36/38 Vapor. Can be Can be absorbed
PYRROLIDONE absorbed through the through the skin.
309 mg/m3 75 ppm
872-50-4 skin.
80 mg/m3 19 ppm 4 103 mg/m3 25 ppm
Vapor. If in
compliance with the
MAK and BAT
values, then there
should be no risk to
the fetus.
3. HAZARDS IDENTIFICATION
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Indication of Danger: Xi Irritant R36/38 - Irritating to eyes and skin.
Hazard Overview
Target Organs: Eyes
Primary Entry Routes: Eyes.
Acute Health Hazards: Causes moderate eye irritation.
Chronic Health Hazards: None known
Signs and Symptoms of Overexposure
Eye Contact: Causes moderate eye irritation.
Skin Contact: Not a hazard under normal use conditions.
Ingestion: Not a hazard under normal use conditions.
Inhalation: Not a hazard under normal use conditions.
4. FIRST AID MEASURES
Eye Contact: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes
and get medical attention if irritation persists.
Skin Contact: Wash with soap and water.
Ingestion: Do not induce vomiting. Slowly dilute with 1-2 glasses of water or milk and seek
medical attention. Never give anything by mouth to an unconscious person.
Inhalation: No specific treatment is necessary since material is not likely to be hazardous by
inhalation. If exposed to excessive levels of dust or fumes, remove to fresh air and
get medical attention if cough or other symptoms develop.
5. FIRE-FIGHTING MEASURES
Flash Point (癋): 194
Extinguishing Media: Water / Alcohol foam/ Dry chemical/ Carbon dioxide
Unusual Fire/Explosion Hazards: Combustible liquid. Dangerous fire hazard when exposed to heat or flame. Vapors
are heavier than air and may travel a considerable distance to a source of ignition
and flash back. Vapor-air mixtures are explosive.
Special Protective Equipment: Fire fighters should wear full protective clothing, including self-contained breathing
equipment.
6. ACCIDENTAL RELEASE MEASURES
Personal Precautionary Use appropriate protective equipment.
Measures:
Procedure for Remove ignition sources. Contain spill with sand or other inert materials. Flush
Cleaning/Absorption: area with water.
7. HANDLING AND STORAGE
Handling: Avoid contact with eyes. Wash thoroughly with soap and water after handling.
Storage: Keep containers tightly closed when not in use. Store in a cool, dry place, out of
direct sunlight.
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8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering Controls: Use in a well ventilated area.
Respiratory Protection: Use in a well ventilated area.
Hand Protection: Impervious gloves of natural latex or neoprene (Natural latex gloves AR-340 & Style#
Y-18 from Glover Latex Inc. - Anaheim, CA; Neoprene gloves " Scorpio" #8-352 from
Edmont Wilson - Coshocton, OH).
Eye Protection: Chemical goggles; also wear a face shield if splashing hazard exists.
9. PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Liquid
Color: Clear
pH: 7.20 (~10% solution)
Specific Gravity: 1.027 @25癈
Flash Point (癋): 194
Boiling Point (癋): 395.6
Melting Point/Freezing Point(癋): -11.92
Vapor Pressure: 0.27 mm Hg @20癈
Solubility: Miscible in water
10. STABILITY AND REACTIVITY
Chemical Stability: Stable under normal conditions of handling, use and transportation.
Hazardous Polymerization: Will not occur
Conditions to Avoid: Not determined.
Materials to Avoid: Strong oxidizing agents. Strong reducing agents.
Hazardous Decomposition Carbon monoxide. Oxides of nitrogen.
Products:
11. TOXICOLOGICAL INFORMATION
Toxicity Test:
Acute Oral LD50 (mg/kg): 4,200 (rat)
Acute Dermal LD50 (mg/kg): 8,000 (rat)
Acute Inhalation LC50 (mg/l): >400 ppm (rat)
Sensitization: Non-sensitizing to guinea pigs (1% v/v solution)
Non-sensitizing (Human RIPT- 15 applications)
Prolonged, repeated contact found material to be a possible fatiguing agent.
Mutagenicity: Non-mutagenic (Ames Assay, Yeast Aneuploidy Induction Test, CHO/HGPRT
Forward Mutation Assay, Mouse Lymphoma Assay, Rat Primary Hepatocyte
Unscheduled DNA Synthesis Assay, In vivo Mouse Micronucleus Test, In vivo
Dominant Lethal Test, In vivo Chinese Hamster Inhalation Test).
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Reproductive/Developmental Rat; Dermal; Developmental Toxicity; 75, 237 and 750 mg/kg; Maternal and
Toxicity: Developmental NOAEL: 237 mg/kg.
Rat; Inhalation; Developmental Toxicity; 0.1 (25 ppm) and 0.36 (89 ppm) mg/L;
Maternal and Developmental NOAEL: 0.36 (89 ppm) mg/L.
Rabbit; Oral; Developmental Toxicity; 55, 175 and 540 mg/kg/day; Maternal NOAEL:
55 mg/kg/day; Developmental NOAEL: 175 mg/kg/day.
Rat; Oral; Multi-generation; 50, 160 and 500 mg/kg/day; Parental, Reproductive and
Developmental NOAEL: 160 mg/kg/day.
Rat; Oral; Multi-generation; 50, 160 and 350 mg/kg/day; Reproductive NOAEL: 350
mg/kg/day; Parental and Developmental: 160 mg/kg/day.
Rat; Oral; Multi-generational; 50, 160 and 350 mg/kg/day; Parental and Reproductive
NOAEL: 350 mg/kg/day; Developmental NOAEL: 160 mg/kg/day.
Carcinogenicity: Rat; 2-Year; Inhalation: 0.04 (10 ppm) and 0.4 (99 ppm) mg/L/day; 6hrs/day, 5
days/week - no observed adverse (or carcinogenic) effects level (NOAEL) 0.4 (99
ppm) mg/L/day.
Rat; 2-Year; Oral: 66.4-87.8 (1,600 ppm), 207-283 (5,000 ppm), and 678-939
(15,000 ppm) mg/kg/day - no observed carcinogenic effects level 678-939 (15,000
ppm) mg/kg/day (M & F); no observed adverse effects level (NOAEL) 207-283 (5,000
ppm) mg/kg/day (M & F). The high dose males had a statistically significant increase
in severe chronic progressive nephropathy.
Mice; 18-Month; Oral: 89-115 (600 ppm), 173-221 (1,200 ppm), and 1,089-1,399
(7,200 ppm) mg/kg/day - no observed carcinogenic effects level 173-221 (1,200
ppm) mg/kg/day (M & F); no observed adverse effects level (NOAEL) 89 (600 ppm)
mg/kg/day in males and 221 (1,200 ppm) mg/kg/day in females. The high dose
males had increased hepatocellular adenomas and carcinomas, and high dose
females had hepatocellular adenomas only. The high dose males and females had
increased relative and absolute liver weights, and in mid-dose males had increased
centrilobular hepatocellular hypertrophy.
Skin Irritation: Mildly irritating to rabbit skin. (50% solution).
However, human experience has demonstrated severe dermatitis, e.g. blisters,
cracking, edema, redness upon prolonged or repeated contact.
Prolonged contact may induce defatting of skin which may result in redness and/or
cracking.
Non irritating (Human RIPT).
Eye Irritation: Moderately irritating to rabbit eye. (100%)
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Other Information: Sub-Chronic Oral Toxicity: Mice; 90-Day; Oral: 277 (1,000 ppm), 619 (2,500 ppm)
and 1,931 (7,500 ppm) mg/kg/day - no observed adverse effect level (NOAEL) 277
(1,00 ppm) mg/kg/day. The high dose animals had an increase in absolute and
relative liver weights and centrilobular hepatocellular hypertrophy, and the mid-dose
males had increased absolute and relative liver weights.
Rat; 90-Day; Oral: 69-217 (3,000 ppm), 433-565 (7,500 ppm) and 1,057-1,344
(18,000 ppm) mg/kg/day - no observed adverse effect level (NOAEL) 169-217 (3,000
ppm) mg/kg/day. The mid and high dose animals had decreased body weights and
body weight gains.
Sub-Chronic Inhalation Toxicity: Inhalation studies; Rats, guinea pigs, rabbits, cats;
No gross or histopathological abnormalities when exposed to 50 ppm M-Pyrol for 8
hrs/day for 20 days; Exposures as high as 370 ppm for 6 hrs/day for 10 days
similarly caused no effects in rats.
4-Week; Rat; Aerosol-vapor mixture of M-Pyrol at 0, 0.1 (25 ppm), 0.5 (123 ppm) and
1.0 (247 ppm) mg/L for 6 hrs/day, 5 days/week; no effects at 0.1 or 0.5 mg/L;
hemopoietic effects observed at 1.0 mg/L.
Sub-Chronic Dermal Toxicity: 20-Day; Rabbit; 0.4, 0.8 and 1.6 ml/kg/day on abraded
and intact skin; Mild local irritation; No systemic effects; 1/4 animals died at 1.6
ml/kg/day.
Neurobehavior: Rat; 90-Day; Oral: 169-217 (3,000 ppm), 433-565 (7,500 ppm) and
1,057-1,344 (18,000 ppm) mg/kg/day - no observed adverse effect level (NOAEL)
1,344 (18,000 ppm) mg/kg/day in females; 169 (3,000 ppm) mg/kg/day in males.
The mid high dose males had increased low arousal; foot splay; palpebral closure.
12. ECOLOGICAL INFORMATION
Biodegradability: Warburg Respirometry Method: Biodegradable
Aquatic Toxicity: Bluegill (Lepomis Marochirus) LC50 @22癈: 832 mg/l
Fathead Minnow (Pimephales Promelas) LC50 @22癈: 1,072 mg/l
Trout (Salmo Gairdneri) LC50 @12癈: 3,048 mg/l.
13. DISPOSAL CONSIDERATIONS
Disposal of Waste Method: Follow all applicable community, national or regional regulations regarding waste
management methods.
14. TRANSPORT INFORMATION
Land Transportation:
DOT (Non-Bulk):
DOT Shipping Name: NOT REGULATED
UN/NA Number: NONE
Hazard Class: NONE
DOT (Bulk):
DOT Shipping Name: COMBUSTIBLE LIQUID, N.O.S. (CONTAINS N-METHYL-2-PYRROLIDONE)
UN/NA Number: NA1993
Hazard Class: COMBUSTIBLE LIQUID
Packing Group: III
Air Transportation (IATA):
Proper Shipping Name: NOT REGULATED
UN Number: NONE
Hazard Classification: NONE
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Sea Transportation (IMO):
Proper Shipping Name: NOT REGULATED
UN/ID Number: NONE
Hazard Classification: NONE
ADR:
Proper Shipping Name: NOT REGULATED
15. REGULATORY INFORMATION
Classification:
R36/38 - Irritating to eyes and skin.
Safety Phrases: S41 - In case of fire and/or explosion do not breathe fumes.
TSCA Inventory List: This product and/or its components is listed on TSCA.
California Proposition 65 One or more components of this product is listed on CALPROP.
Carcinogens & Reproductive
Toxicity (CRT) List:
Canada DSL Inventory List: This product and/or its components is listed on DSL.
Canada NDSL Inventory List: This product and/or its components is not listed on NDSL.
EU EINECS List: This product and/or its components is listed on EINECS.
ELINCS: This product and/or its components is not listed on ELINCS.
Germany VCI Assigned This product and/or its components is listed on or has been reviewed by WGK.
Classification into Water
Endangering Classes (WGK) List:
Japan Inventory of Existing & This product and/or its components is listed on ENCS.
New Chemical Substances
(ENCS):
Australia Inventory of Chemical This product and/or its components is listed on AICS.
Substances (AICS) List:
16. OTHER INFORMATION
Prepared By: Product Stewardship
Legend: N.Av.= Not Available; N.Ap.= Not Applicable
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Important Note: For purposes of this MSDS, International Specialty Products, as responsible party,
provides the information herein which is intended for use by persons who have or
should obtain professional knowledge and experience in the subjects discussed.
ISP's industrial products are used as materials in the production of products by
industrial customers. ISP usually has only limited information about the products of
its customers and their composition, methods of manufacture and use. Accordingly,
ISP MAKES NO WARRANTY, EXPRESS OR IMPLIED, AS TO THE ACCURACY,
COMPLETENESS OR RELIABILITY OF INFORMATION HEREIN EXCEPT THAT
SUCH INFORMATION IS, TO THE BEST OF ISP'S KNOWLEDGE AND BELIEF,
ACCURATE AS OF THE DATE INDICATED. ISP recommends that customers
independently test and evaluate its products and their products and processes in
which ISP products are used in order to decide their safety and effectiveness.
***END OF MSDS***
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