Material Safety Data Sheet
Product Name: MESOMARK
Reference Number: 801-900
Version: 0 Revision Date: 03/2005
1 鈥? Product and Company Identity
Product Name: MESOMARK鈩? Kit
Supplier:
Name: CIS Bio International
Address: BP 32
91192 Gif-sur-Yvette Cedex 鈥? France
Phone Number: 33 (0) 1. 69.85.70.70
Fax Number: 33 (0) 1. 69.85.75.18
2 鈥? Composition / Information on Ingredients
Preparation
Chemical Ingredients:
KIT PRESENTATION AND REAGENT COMPONENTS
1. WASH BUFFER - 1 Bottle (50 mL). Wash Buffer (20X concentrated). 0.002M
Imidazole buffered saline, containing 0.02% Tween 20.
2. SUBSTRATE - 1 Bottle (12 mL). Substrate. <0.1% Tetramethylbenzidine
(TMB) in an acidic buffer.
3. STOP SOLUTION - 1 Bottle (12 mL). Stop Solution. 1% Hydrochloric Acid
Solution containing 鈮? 3.0% Diethylene Glycol
4. COATED PLATE - 1 Plate (96 wells). Plastic microtiter wells coated with 4H3
murine monoclonal antibody in foil pouch with desiccant.
5. CONJUGATE - 1 Bottle (12 mL). Conjugate. 569 murine monoclonal antibody
conjugated to horseradish peroxidase enzyme with protein (bovine) stabilizer.
Contains Proclin 300/Gentamicin as preservatives (< 1.0 %).
Material Safety Data Sheet
Product Name: MESOMARK
Reference Number: 801-900
Version: 0 Revision Date: 03/2005
6. CALIBRATOR/DILUENT - 1 Bottle (100 mL). Calibrator A/Assay Diluent.
PBS buffer with protein (bovine) stabilizer. Contains Proclin 300/Gentamicin as
preservatives (< 1.0 %).
7. CALIBRATORS - 1 Bottle each (1.0 mL each). Calibrators B to F contain 569
reactive antigen (recombinant) prepared in PBS buffer with protein (bovine)
stabilizer. Contains Proclin 300/Gentamicin as preservatives (< 1.0 %).
8. CONTROLS - 1 Bottle each (1.0 mL each). Controls contain 569 reactive
antigen (recombinant) prepared in PBS buffer with protein (bovine) stabilizer.
Contains Proclin 300/Gentamicin as preservatives (< 1.0 %).
3 鈥? Hazard Identification
Main Hazards
Reagent #3
The Stop Solution contains Diethylene Glycol and is classified per applicable
European Community (EC) Directives as: Irritant (Xi). The following are the
appropriate Risk (R) and Safety (S) phrases.
R36: Irritating to eyes.
R38: Irritating to skin.
S24: Avoid contact with skin.
S25: Avoid contact with eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S36/39: Wear suitable protective clothing and eye/face protection.
Reagents #5, 6, 7, 8
The Conjugate, Calibrators, Controls and Calibrator A/Assay Diluent contain a
mixture of: 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-
3-one (3:1), which is a component of Proclin 300, and are classified per
applicable European Community (EC) Directives as: Irritant (Xi). The following
are the appropriate Risk (R) and Safety (S) phrases.
Material Safety Data Sheet
Product Name: MESOMARK
Reference Number: 801-900
Version: 0 Revision Date: 03/2005
R43: May cause sensitization by skin contact
S24: Avoid contact with skin.
S35: This material and its container must be disposed of in a safe way.
S37: Wear suitable gloves.
S46: If swallowed, seek medical advice immediately and show this container or
label.
4 鈥? First Aid Measures
Eye Contact: Flush with copious amounts of water for at least 15 minutes.
Consult a Physician if irritation persists
Skin Contact: Flush with copious amounts of water. Wash contaminated clothing
before reuse. Consult a Physician if irritation persists
Inhalation: Remove subject to fresh air. Seek medical attention if needed
Ingestion: Seek medical attention
5 鈥? Fire-Fighting Measures
Extinguishing Media: Foam, Alcohol Foam, CO2, Dry Chemical and Water/Fog
Unusual Fire and Explosion Hazards: May emit toxic fumes under fire
Conditions. Wear self-contained breathing apparatus. Wear protective clothing to
prevent contact with skin, eyes and clothing.
6 - Accidental Release Measures
Contain Spill and clean contaminated surfaces with copious amounts of water.
Dispose of materials in accordance with applicable laws and regulations
Material Safety Data Sheet
Product Name: MESOMARK
Reference Number: 801-900
Version: 0 Revision Date: 03/2005
7 鈥? Handling and Storage
Handling
Follow Good Laboratory Practices. Wear disposable gloves, protective clothing
and protective glasses
Precautions to be taken: Avoid contact with skin and eyes and wash hands after
handling
Storage
Store reagents in original packaging at 2 to 8 掳 C or as otherwise stated in
instructions or on reagent labels
8 鈥? Exposure Control/Personal Protection
Eye Contact: Direct contact with the product may cause eye irritation. Wear
appropriate protective eye protection
Skin Contact: Prolonged and repeated contact with product may cause skin
irritation. Wear appropriate gloves and protective clothing
Inhalation: Reagent #3 May be harmful if inhaled in large quantities (Stop
Solution). No respiratory protection required if good ventilation is maintained
Material Safety Data Sheet
Product Name: MESOMARK
Reference Number: 801-900
Version: 0 Revision Date: 03/2005
9 鈥? Physical and Chemical Properties
Reagent # Description Physical Appearance pH Range
1 Wash Buffer Clear colorless liquid 7.1 to 7.5
2 Substrate Clear colorless to pale 3.7 to 3.9
blue liquid
3 Stop Solution Clear colorless liquid 0.5 to 1.5
4 Coated Plate Solid Support N/A
5 Conjugate Clear colorless liquid 6.0 鈥? 8.0
6 Calibrator/Diluent Clear light yellow to 6.0 鈥? 8.0
yellow liquid
7 Calibrators B to F Clear light yellow to 6.0 鈥? 8.0
yellow liquid
8 Controls Clear light yellow to 6.0 鈥? 8.0
yellow liquid
10 - Stability and Reactivity
Stable but may react with strong oxidizers. May emit toxic fumes under fire
Conditions.
11 鈥? Toxicological Information
N/A
12 鈥? Ecological Information
N/A
13 - Disposal Considerations
Dispose in accordance with applicable laws and regulations
Material Safety Data Sheet
Product Name: MESOMARK
Reference Number: 801-900
Version: 0 Revision Date: 03/2005
14 鈥? Transportation Information
N/A
15 鈥? Regulatory Information
Community regulations:
EU Directive 1999/45/EC; classification, packaging and labeling of dangerous
preparations
16 鈥? Other Information
In-vitro medical diagnostic use only
This product may require the handling of human specimens. It is recommended
that these reagents and human specimens be handled in accordance with the
OSHA Standard on Bloodborne Pathogens or other appropriate biosafety
practices.
The above information is believed to be correct, but does not purport to be all
inclusive and should be used as only a guide. CIS bio International and FDI shall
not be held liable for any damages resulting from handling or contact with the
above product. Users should determine the suitability of the information for their
particular purpose
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