R S R LIMITED
AVENUE PARK, PENTWYN, CARDIFF, CF23 8HE, UNITED KING DO M , TEL EPHO NE: (0 29 ) 20 7 3 20 7 6 FACS IM IL E: (0 29 ) 20 7 3 27 0 4 EM AIL : in fo @ rsrltd .c o m
MA TERIA L SA F ETY DA TA SH EET 2.3. Ha z a rd o u s Co m p o n e n ts
K it C o m p o n e n t H a z a rd
1 . Id e n tific a tio n o f Su b s ta n c e /P re p a ra tio n TPO Co a te d Tu b e s: Co n ta in s h u m a n a n d a n im a l p ro te in s; p o te n tia l
b io h a z a rd . Co n ta in s so d iu m a z id e (< 0 .1 % w /v ).
Pro d u c t: TP O A n tib o d y C T K it
R4
Ca ta lo g u e Nu m b e r: PCT/1 0 0 (5 0 tu b e k it) 1 25
I la b e lle d TPO Em its -ra d ia tio n ; ~ 4 1 k B q ; h a lf life 6 0 d a y s/
P C T/1 0 0 (1 0 0 tu b e k it)
Tra c e r: Co n ta in s a n im a l p ro te in s; p o te n tia l b io h a z a rd .
TPO An tib o d y
Co n ta in s h u m a n p ro te in s; p o te n tia l b io h a z a rd .
2. Co m p o sitio n Ca lib ra to rs:
Co n ta in s so d iu m a z id e (< 0 .1 % w /v ). R4
TPO An tib o d y Co n tro ls:
2.1 .Co m p o n e n ts
Assa y B u ffe r: Co n ta in s a n im a l p ro te in s; p o te n tia l b io h a z a rd .
TPO Co a te d Tu b e s,
Co n ta in s so d iu m a z id e (< 0 .1 % w /v ). R4
TPO Tra c e r,
Co n c e n tra te d Wa sh Co n ta in s so d iu m a z id e , so d iu m c h lo rid e a n d
TPO An tib o d y Ca lib ra to rs 0 , 7 0 , 25 0 , 7 5 0 , 25 0 0 , 1 0 0 0 0 u /m L ,
S o lu tio n p o ly o x y e th y le n e so rb ita n . R4
TPO An tib o d y Po sitiv e Co n tro ls,
Wh o le k it R5 8, R84 , S 21 , S 29 , S 31 , S 6 3, S 6 7 , S 1 0 1 , S 1 4
Assa y Dilu e n t,
3 . Id e n tific a tio n o f H a z a rd s
Co n c e n tra te d Wa sh S o lu tio n .
All c o m p o n e n ts sh o u ld b e c o n sid e re d a s p o te n tia l b io h a z a rd s.To x ic b y in g e stio n .
2.2.In fo rm a tio n o n In g re d ie n ts
M a y b e h a rm fu l b y in h a la tio n a n d sk in a b so rp tio n . Irrita tin g to e y e s, sk in a n d
In g re d ie n t C A S-n o
m u c o u s m e m b ra n e s. Ca rc in o g e n ic , m u ta g e n ic a n d te ra to g e n ic e ffe c ts b y
1 25
Io d in e la b e lle d TPO Tra c e r RADIO ACTIVE tra c e r. Ev id e n c e o f m u ta g e n ic e ffe c ts b y so d iu m a z id e .
Hu m a n Pro te in s 4 . F irs t A id Me a s u re s
B o v in e S e ru m Alb u m in CAS -n o : 9 0 4 8-4 6 -8 S k in Co n ta c t: Wa sh o ff sk in th o ro u g h ly w ith w a te r fo r a t le a st 1 5 m in u te s.
Re m o v e c o n ta m in a te d c lo th in g . In se v e re c a se s o r if sk in is
S o d iu m Az id e CAS -n o : 26 6 28-22-8
b ro k e n , O B TAIN M EDICAL ATTENTIO N.
S o d iu m Ch lo rid e CAS -n o : 7 6 4 7 -1 4 -5
Ey e Co n ta c t: S e p a ra te e y e lid s w ith fin g e rs a n d flu sh e y e w ith c o p io u s
TRIS CAS -n o : 7 7 -86 -1
a m o u n ts o f w a te r fo r a t le a st 1 5 m in u te s. O B TAIN M EDICAL
Po ly o x y e th y le n e so rb ita n M o n o la u ra te CAS -n o : 9 0 0 5 -6 4 -5 ATTENTIO N.
Po n c e a u Re d CAS -n o : 26 1 1 -82-7
In h a la tio n : Re m o v e fro m e x p o su re , re st a n d k e e p w a rm . If b re a th in g
b e c o m e s d iffic u lt, O B TAIN M EDICAL ATTENTIO N.
In g e stio n : If p a tie n t is c o n sc io u s, w a sh o u t m o u th w ith w a te r a n d g iv e
p le n ty o f w a te r to d rin k . O B TAIN M EDICAL ATTENTIO N.
0 8th J u n e 20 0 4 TPO Ab CT Assa y Kit m sd s/1 7 c Re v .1 Pa g e 1 o f 4
R S R LIMITED
AVENUE PARK, PENTWYN, CARDIFF, CF23 8HE, UNITED KINGDOM, TELEPHONE: (029) 2073 2076 FACSIMILE:(029) 2073 2704 EMAIL: info@rsrltd.com
Materials of human origin have been tested and found non-reactive for HIV 1
5.Fire Figh ting Measures
Extinguishing Media: Use water, dry powder or appropriate foam as and 2 and HCV antibodies and HBsAg. All animal sourced materials have been
appropriate to supporting fire. obtained from animals certified as healthy and free from disease. However, all
Special Fire Fighting Evolves toxic and radioactive fumes in fire. Wear self- components should be considered as potentially infectious. Level II containment
Procedures: contained breathing apparatus and protective clothing should be applied. Do not eat, drink or smoke in the laboratory. Do not mouth
to prevent contact with skin and eyes. pipette. Avoid skin and eye contact. Wear appropriate protective clothing.
Avoid use of needles or other sharp implements. Avoid prolonged or repeated
6. Accidental Release Measures
exposure. Wash thoroughly after handling.
Wear appropriate protective clothing. Ventilate area. Radioactive spills should
8 . Ex posure Control/Personal Protection
be dealt with immediately in accordance with the current local and national
As appropriate to the situation and quantity handled
regulations and guidelines. Dispose of radioactive water via an authorised route.
Contaminated surfaces should be washed with suitable detergent to remove Mechanical Controls: Local exhaust.
traces of radioactivity. For liquid spills absorb using spillage absorption Personal Protective Equipment:
granules. Once fully absorbed, sweep up and dispose as for solid spills. For Hand Protection: Chemical resistant latex or vinyl gloves.
solid spills sweep up and dispose of in accordance with local and national Eye Protection: Chemical safety goggles.
regulations. Once pick up is complete, wash site with detergent and water. Other Equipment: Personal dosimeter, suitable monitor, eye
Decontaminate with a suitable disinfectant solution. bath and safety shower.
9.0 Ph ysical Ch aracteristics
7 . Handling and Storage
7.1. Storage Kit Component Physical data
Keep containers tightly closed. Store in a dry place in the supplied box at a TRAb Coated Tubes: Colourless polystyrene tubes.
temperature between + 2 and + 8 C. Red, odourless solid. Miscible with water in all
125
I Labelled TPO Tracer:
7.2. Handling proportions.
Radioactive. Users should make themselves aware of and observe any national TPO antibody Calibrators Colourless to pale yellow, odourless liquid.
and local legislation and codes of practice governing the use, storage, and controls: Miscible with water in all proportions.
transportation and disposal of radioactive materials. Avoid all actions likely to Concentrated Wash
Colourless, odourless liquid. Miscible with water
lead to ingestion. Avoid contact with skin and clothing. Protective clothing Solution
in all proportions. pH ~ 7.6
must be worn and where, appropriate personal dosimeters. Radioactive Start Buffer
materials should only be used by authorised personnel and in designated areas. 10.0 Stability and reactiv ity
Hands should be washed after using radioactive materials. Hands and clothing 10.1 Stability
should be monitored before leaving the designated areas. If contaminated, hand All components of the TPOAb Coated Tube kit have been found stable for stated
should be washed and rechecked. Any persistent contamination should be shelf life when stored under the recommended conditions.
reported to the responsible person and remedial action taken. Proteins are heat sensitive. Azides are heat sensitive.
08th June 2004 TPOAb CT Assay Kit msds/17b Rev.1 Page 2 of 4
R S R LIMITED
AVENUE PARK, PENTWYN, CARDIFF, CF23 8HE, UNITED KINGDOM, TELEPHONE: (029) 2073 2076 FACSIMILE:(029) 2073 2704 EMAIL: info@rsrltd.com
10.2. Reactivity 15. Regulatory Information
Azides form toxic vapous with water/carbon dioxide and with acids. They form European Information
explosive mixtures with heavey metals and metallic salts. Prolonged contact R Phrases
with copper or lead in the drainage system can result in the formation of R4 Forms very sensitive explosive metallic salts
explosive azides. Tris reacts with both strong oxidising agents and bases. R58 Serious risk of poisoning by inhalation, swallowing, or skin contact
11. Toxicological R66 Gives off poisonous vapours
Kit Component Toxicological Data
R68 Contact with water liberates a poisonous gas
TPO Coated Tubes: Low order of toxicity. Low risk if infection.
R83 Cause irritation of skin and eyes
125
Iodine labelled TPO Radioactive. Toxic by all routes of entry. Low risk
R84 Irritating to skin, eyes and respiratory system
Tracer of infection.
S Phrases
TPO antibody Risk of infection. Toxic by ingestion. May be
S21 When using do not eat or smoke
calibrators and harmful by inhalation and skin absorption. Irritating
S29 Carefully remove contents from damaged containers
controls. to eyes, skin and mucous membranes.
S31 Keep away from food stuffs and beverage
Assay buffer: Toxic by ingestion. May be harmful by inhalation
S53 Avoid breathing fumes/vapour
Concentrated Wash and skin absorption. Irritating to eye, skin and
S63 Avoid contact with skin or eyes
Solution mucous membranes. Low risk of infection.
S67 In case of contact with skin or eyes, rinse with plenty of water
12 . Ecological Considerations S73 When using wear protective clothing and impermeable gloves
Data Not Available S91 Wash hands immediately after handling
S101 In case of fire, avoid breathing fumes
13. Disposal Considerations S104 In case of fire, use appropriate equipment
Chemical and biological residues are classified as special waste and, as such, are
covered by regulations, which may vary according to location. Contact your
16. Other Information
local waste disposal authority for advice or pass to a licensed disposal company.
The above information is believed to be correct but does not purport to be all-
Observe all national and local environmental regulations.
inclusive and is provided for guidance only. RSR Limited shall not be held liable
for any damage or injury resulting from handling or from contact with the above
14. Transport
product and assumes no responsibility for the accuracy or completeness of the
Non Hazardous for road, rail and air freight. Transport of this product should be
data contained herein. It is the responsibility of the purchaser to ensure that
carried out under the appropriate storage conditions (2 鈥? 8oC) and all reagents
laboratory workers who use this product are aware of its hazards and take all
contained within the packaging provided.
necessary precautions to prevent contact, ingestion, inhalation or any other
mode of exposure.
08th June 2004 TPOAb CT Assay Kit msds/17b Rev.1 Page 3 of 4
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