#9900 MSDS Material Safety Data Sheet (MSDS) for
PD98059 (MEK1 Inhibitor) 166B Cummings Center I Beverly, MA 01915
Orders I 877-616-CELL (2355) Support I 877-678-TECH (8324) Web I www.cellsignal.com
orders@cellsignal.com info@cellsignal.com
Acute effects of overexposure: May be harmful if swallowed, inhaled,
I. Identification or absorbed through skin. Can cause severe irritation and neurotoxic effects.
Inhalation may be fatal as a result of spasm, inflammation and edema of the
Product name: PD98059 (MEK1 Inhibitor)
larynx and bronchi, chemical pneumonitis and pulmonary edema. Symptoms
Chemical names: of exposure may include burning sensation, coughing, wheezing, laryngitis,
2-(2-amino-3-methoxyphenyl)-4H-1-Benzopyran-4-one shortness of breath, headache, nausea and vomiting. To the best of our
2-(2'-Amino-3'-methoxy)-flavone knowledge, the chemical, physical and toxicological properties have not
2-(2-amino-3-methoxyphenyl)-chromone been thoroughly investigated.
CAS number: 167869-21-8 Chronic effects of overexposure: May be harmful. Allergic reactions in
certain sensitive individuals may develop.
Empirical formula: C16 H13 N03
Emergency and First Aid Procedures
Molecular weight: 267
Swallowing鈥擶ash out mouth with water, provided person is conscious.
Call a physician. Administer one to two glasses of milk or water to dilute
Chemical family: Chromones and Flavones
ingested material.
Skin鈥擨n case of contact, remove contaminated clothing and immediately
II. Physical Data wash skin with soap and copious amounts of water for at least 15 minutes.
Melting point: 166.7鈥?167.3掳C
Inhalation鈥擨f inhaled, remove to fresh air. If breathing becomes difficult,
Solubility in water: Insoluble give oxygen and obtain medical attention. If not breathing, give artificial res-
piration and obtain medical attention.
Solubility in DMSO: 6.5 mgs/ml
Eyes鈥擨n case of contact with eyes, flush with copious amounts of water for
Appearance: Yellow solid at least 15 minutes. Assure adequate flushing by separating eyelids with fin-
gers. Obtain medical attention.
III. Ingredients
VI. Reactivity Data
Material: 100% lyophilized yellow powder
Stability/Conditions to avoid: Stable, keep away from ignition sources.
IV. Fire and Explosion Hazard Data Incompatibility/Materials to avoid: Strong oxidizers.
Flash point: N/A (solid compound) Combustion/Decomposition products: Thermal decomposition may
produce carbon monoxide, carbon dioxide and nitrogen oxides.
Flammable limits in air (% by volume): None
Hazardous polymerization: Not susceptible to polymerization
Auto-ignition temperature: N/A
Extinguishing media: Dry chemical, water or carbon dioxide.
VII. Spill or Leak Procedures
Special fire fighting procedures: If involved in fire, don NIOSH/MSHA-
Steps to be taken if material is spilled or released: Wear self-
approved self-contained breathing apparatus, flame/chemical resistant.
contained breathing apparatus, rubber boots and heavy rubber gloves.
Wear protective clothing to prevent contact with skin and eyes.
Sweep up material. Place in a suitable container then hold for waste dispos-
Unusual fire and explosion hazards: Emits toxic fumes under fire al. Wash down the spill site and ventilate the area.
conditions.
Waste disposal method: Dissolve the material in a combustable solvent
漏 2001 Cell Signaling Technology, Inc.
and burn in an EPA-licensed chemical incinerator equipped with an after-
V. Health Hazard Data burner and scrubber.
Waste classification: Aromatic amine
Chemical listed as carcinogen or potential carcinogen: No
Other precautions: Observe all federal, state and local laws.
Threshold Limit Value (TLV) and source: Data not available.
OSHA Permissible Exposure Limit: None
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ACGIH Threshold Limit Value: None
I.A.R.C. Monographs: No
#9900 MSDS Material Safety Data Sheet (MSDS) for
MEK1 Inhibitor (PD98059) 166B Cummings Center I Beverly, MA 01915
Orders I 877-616-CELL (2355) Support I 877-678-TECH (8324) Web I www.cellsignal.com
orders@cellsignal.com info@cellsignal.com
VIII. Special Protection Information
Respiratory protection: Avoid inhalation. Use NIOSH/MSHA-approved
respirator.
Ventilation: Use mechanical exhaust.
Protective equipment: Wear suitable protective clothing, chemical
resistant (latex or rubber) gloves and lab safety glasses.
Other equipment: Safety shower and eye bath.
IX. Special Precautions
Precautions to be taken in handling and storage: This compound is
sold only for research use by personnel familiar with the toxicology of
organic chemicals and who are well trained in good laboratory habits, such
as avoiding spills, keeping hands clean at all times and not rubbing eyes
with hands while working in the laboratory.
This compound is sold only in milligram quantities for use in dilute solu-
tions in biological research. No other use is intended, and any other use
may involve substantial hazards.
This compound is to be stored as tightly stoppered solutions kept under
nitrogen or argon, or kept as supplied in a sealed glass ampule at 鈥?20掳C.
The above information is believed to be correct but does not purport to be
all inclusive and shall be used only as a guide for experienced personnel.
Cell Signaling Technology, Inc., shall not be held liable for any damage
resulting from the handling of or from contact with the above product. The
burden of safe use of this material rests entirely with the user.
Revised: July 2001
漏 2001 Cell Signaling Technology, Inc.
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