#9905 MSDS Material Safety Data Sheet (MSDS) for
TPA (Phorbol-12-Myristate-13-Acetate) 166B Cummings Center I Beverly, MA 01915
Orders I 877-616-CELL (2355) Support I 877-678-TECH (8324) Web I www.cellsignal.com
orders@cellsignal.com info@cellsignal.com
Emergency and First Aid Procedures
I. Identification Swallowing鈥擨f swallowed, wash mouth out with water and call a physician.
Product name: TPA (Phorbol-12-Myristate-13-Acetate) Skin鈥擨f skin contact occurs, immediately wash skin with soap and water.
Synonyms: PMA Inhalation鈥擨f inhaled, remove to fresh air. If not breathing, perform CPR
and call a physician.
II. Ingredients Eyes鈥擨f eye contact occurs, flush eyes with water for at least 15 minutes.
Assure adequate flushing by separating eyelids with fingers. Consult a
Product is supplied as a 200 碌M solution in dimethyl sulfoxide (DMSO) physician.
Composition
Phorbol-12-Myristate-13-Acetate <0.1%
VI. Reactivity Data
CAS # 16561-29-8
Formula: C36 H56 O8 Stability: To the best of our knowledge, this product is stable under normal
Molecular weight: 616.84 g/mol working temperatures and pressures.
DMSO >99% Incompatibility/Materials to avoid: Oxidizing agents, reducing agents,
CAS # 67-68-5 strong acids and moisture.
Formula: C2 H6 OS
Combustion/Decomposition products: Carbon monoxide, carbon diox-
Molecular weight: 78.13 g/mol
ide and sulfur oxides.
Hazardous polymerization: To the best of our knowledge hazardous
III. Physical Data polymerization will not occur.
To the best of our knowledge, the physical properties of this product have
not been investigated. Values given are for dimethyl sulfoxide (DMSO).
VII. Spill or Leak Procedures
Boiling point: 189掳C
Steps to be taken if material is spilled or released: Wear protective
Melting point: 18.4掳C gloves, lab coat and safety glasses. Use vermiculite or another suitable
absorbent to clean up the spill. After cleanup, wash down the spill site with
Flash point: 95掳C
water and ventilate the area. Place all contaminated materials in an appropri-
Vapor pressure: 0 kPa (at 20掳C) ate waste container and dispose of in accordance with federal, state and
local regulations.
Vapor density: 2.71 (air = 1)
Waste disposal method: Add waste to a combustible solvent and burn
Specific gravity: 1.101 (water = 1)
in an EPA-licensed chemical incinerator equipped with an afterburner and
scrubber.
Density: 1.1 g/ml
Solubility in water: Miscible
VIII. Handling and Storage
Appearance: Clear solution
Handling: Avoid contact with skin, eyes and clothing. Protective gloves,
lab coat and safety glasses should be worn when handling this product.
IV. Fire and Explosion Hazard Data
This product is for research use only and is not intended for use in humans.
Storage: Store at or below 鈥?20掳C.
Extinguishing media: Carbon dioxide, dry chemical, water spray or
foam.
IX. Exposure Control/Personal
Special fire fighting procedures: If involved in fire, don NIOSH/MSHA
Protection Information
approved self-contained breathing apparatus, flame/chemical resistant.
Wear protective gloves, safety glasses and lab coat when working with this
Unusual fire and explosion hazards: DMSO is a combustible liquid.
product. An eyewash station and safety shower should be in proximity to the
This solution can emit toxic fumes under fire conditions.
work area. Use with mechanical exhaust and ensure that all ignition sources
are removed from the area before working with this product. Please dispose
V. Health Hazard Data of all waste in accordance with federal, state and local regulations.
漏 2002 Cell Signaling Technology, Inc.
This product is sold in small quantities for biological research. No other use
To the best of our knowledge the toxicological properties of this product
is intended, and any other use may involve substantial hazards. The user of
have not been investigated. Data given is for dimethyl sulfoxide (DMSO).
this product should be familiar with the toxicology of organic chemicals and
Acute toxicity: well trained in good laboratory habits.
LD50 oral rat: 14500 mg/kg
The above information is believed to be correct but does not purport to be
LD50 oral mouse: 7920 mg/kg
all inclusive and shall be used only as a guide for experienced personnel.
Acute effects of overexposure: May cause skin, eye and upper respira- Cell Signaling Technology, Inc., shall not be held liable to any damage
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tory irritation. May be harmful if swallowed or absorbed through skin. resulting from the handling of or from contact with the above product. The
burden of safe use of this material rests entirely with the user.
Chronic effects of overexposure: May be harmful to the skin and eyes.
Revised: October 2002
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